Aliases for EDEM2 Gene
External Ids for EDEM2 Gene
Previous HGNC Symbols for EDEM2 Gene
Previous GeneCards Identifiers for EDEM2 Gene
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]
GeneCards Summary for EDEM2 Gene
EDEM2 (ER Degradation Enhancer, Mannosidase Alpha-Like 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Protein processing in endoplasmic reticulum. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is EDEM3.
UniProtKB/Swiss-Prot for EDEM2 Gene
Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.