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Aliases & Descriptions for EDEM2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases C20orf31 2 , 3 C20orf49 2 , 3 FLJ10783 1 , 2 OTTHUMP00000030728 2 bA4204.1 1 , 2
Descriptions ER degradation enhancer, mannosidase alpha-like 2 2 ER degradation-enhancing-mannosidase-like protein 2 2 chromosome 20 open reading frame 31 1
Search outside databases for aliases for EDEM2 gene
Summaries for EDEM2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for EDEM2 : In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol anddegraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongsto a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed15537790]).[supplied by OMIM] Gene Wiki entry for EDEM2
Genomic Location for EDEM2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the EDEM2 gene Entrez Gene cytogenetic band: 20q11.22 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.22 EDEM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M033167:
(about GC identifiers )
Start:
33,166,831 bp from pter
End:
33,198,828 bp from pter
Size:
31,998 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000020.9 NT_028392.5 Proteins for EDEM2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: EDEM2_HUMAN, Q9BV94 (See
protein sequence )Recommended Name: ER degradation-enhancing alpha-mannosidase-like 2 precursor Size : 578 amino acids; 64753 Da
Subcellular location : Secreted (Potential)
Secondary accessions : Q6GU33 Q6IA89 Q6UWZ4 Q9H4U0 Q9H886 Q9NTL9 Q9NVE6Alternative splicing : 2 isoforms : Q9BV94-1 Q9BV94-2
REFSEQ proteins (2 alternative transcripts):
NP_001138497.1 NP_060687.2 ENSEMBL proteins: ENSP00000363616 ENSP00000363615 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: EDEM2 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA -- GO:0016020 membrane
IEA --
About this table Antibodies for EDEM2: Assays for EDEM2:
Protein
Domains/ Families for EDEM2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9BV94 ProtoNet protein and cluster: Q9BV94
1 Blocks protein family : IPB001382 Glycosyl hydrolase family 47 signature UniProtKB/Swiss-Prot: EDEM2_HUMAN, Q9BV94 Similarity : Belongs to the glycosyl hydrolase 47 family
Gene Function for EDEM2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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RNAi Products ,
Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NR_026728 Applied Biosystems Silencer ® siRNAs for EDEM2 Sigma-Aldrich siRNA for EDEM2 Sigma-Aldrich shRNA for EDEM2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145025                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145025                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001145025  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018217 2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
IEA -- GO:0005509 calcium ion binding
IEA --
About this table
Pathways & Interactions for EDEM2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for EDEM2 (Your Favorite Gene powered by Ingenuity) 5 Interacting proteins for EDEM2 (Q9BV94 2 ENSP00000363616 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for EDEM2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for EDEM2
Transcripts for EDEM2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NR_026728 Sigma-Aldrich siRNA for EDEM2 Sigma-Aldrich shRNA for EDEM2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_018217
REFSEQ mRNAs for EDEM2 gene (2 alternative transcripts): NM_001145025.1 NM_018217.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018217
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145025                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145025                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001145025  
Additional cDNA sequence: AF086313.1 AK001645.1 AK023931.1 AK096016.1 AK296878.1 AK298794.1 AK300212.1 AY007088.1 AY358580.1 BC001371.2 BC016184.1 BC103840.1 BC133653.1 CR457266.1 CR590035.1 CR591753.1 CR593253.1 CR594587.1 CR598404.1 CR600513.1 CR601922.1 CR602215.1 CR610779.1 CR612837.1 CR615992.1 CR624527.1 CR625751.1 XM_001130700.1
24/37 DOTS entries (see all 37
): DT.445883 DT.100703523 DT.100720205 DT.447267 DT.95280269 DT.120830406 DT.92441802 DT.100820856 DT.120830342 DT.120830494 DT.100844454 DT.91969069 DT.95074569 DT.97845990 DT.95146194 DT.120830318 DT.100844459 DT.91737497 DT.120830416 DT.65287049 DT.100038418 DT.100844462 DT.100844469 DT.120830519
24/367 AceView cDNA sequences (see all 367
):BQ933418 BQ058216 CA487605 BM822970 BI829386 BQ642190 BM842053 BM773355 BQ893922 AU141822 BC016184 CR600513 CR602215 BQ222086 AK023931 BQ061510 BU149362 BQ057954 BU931330 BQ935352 BQ061766 BU526886 BI824035 BU174185
highest scoring ESTs for EDEM2 :AI364618 BU148537 AA321441 AI421662 AW166086 BF183479 BG015984 BX331549 R59996 AL703210
Unigene Cluster for EDEM2: ER degradation enhancer, mannosidase alpha-like 2 Hs.356273 [show with all ESTs ] Unigene Representative Sequence: AK296878 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for EDEM2 (see all 12
) ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 SP1 :       -   -     -             -                         SP2 :       -   -   -   -             -                         SP3 :             -   -           -                         SP4 :       -   -     -                                     SP5 :       -   -     -           -   -   -   -   -                  
About this scheme ECgene alternative splicing isoforms for EDEM2 2 Ensembl transcripts including schematic representations : ENST00000374492
ENST00000374491
Expression for EDEM2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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EDEM2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for EDEM2 1 / 2 / 3
3 probe-sets matching EDEM2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ACCAGGCAAGSOURCE GeneReport for Unigene cluster: Hs.356273
Orthologs for EDEM2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for EDEM2 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for EDEM2 ENSEMBL Gene Tree for EDEM2 Paralogs for EDEM2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for EDEM2 gene EDEM1 2 EDEM3 2 Pseudogenes 1 related pseudogene
SNPs/Variants for EDEM2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for EDEM2 (up to first 250kb)
Disorders & Mutations for EDEM2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 610302
Medical News for EDEM2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for EDEM2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/11 PubMed articles for EDEM2 gene (see all 11
): A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation. (PubMed id 15579471) 1, 2, 3 Olivari S....Molinari M. (2005) Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. (PubMed id 15537790) 2, 3 Mast S.W....Moremen K.W. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3, 4 Clark H.F....Gray A. (2003) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 3, 4 Deloukas P....Rogers J. (2001) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 3 Stelzl U....Wanker E.E. (2005) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 3 Suzuki Y.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Large-scale concatenation cDNA sequencing. (PubMed id 9110174) 3 Yu W....Gibbs R.A. (1997)
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Genome Databases showing EDEM2
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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(According to HUGE )
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--
Specialized Databases showing EDEM2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for EDEM2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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