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Aliases for EDEM1 Gene

Aliases for EDEM1 Gene

  • ER Degradation Enhancing Alpha-Mannosidase Like Protein 1 2 3
  • ER Degradation Enhancer, Mannosidase Alpha-Like 1 2 3 5
  • EDEM 3 4
  • ER Degradation-Enhancing Alpha-Mannosidase-Like 1 3
  • KIAA0212 4

External Ids for EDEM1 Gene

Previous GeneCards Identifiers for EDEM1 Gene

  • GC03P005221
  • GC03P005204

Summaries for EDEM1 Gene

GeneCards Summary for EDEM1 Gene

EDEM1 (ER Degradation Enhancing Alpha-Mannosidase Like Protein 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Transport to the Golgi and subsequent modification. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is EDEM2.

UniProtKB/Swiss-Prot for EDEM1 Gene

  • Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Gene Wiki entry for EDEM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDEM1 Gene

Genomics for EDEM1 Gene

Regulatory Elements for EDEM1 Gene

Enhancers for EDEM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EDEM1 on UCSC Golden Path with GeneCards custom track

Promoters for EDEM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EDEM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EDEM1 Gene

Chromosome:
3
Start:
5,187,646 bp from pter
End:
5,219,965 bp from pter
Size:
32,320 bases
Orientation:
Plus strand

Genomic View for EDEM1 Gene

Genes around EDEM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EDEM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EDEM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDEM1 Gene

Proteins for EDEM1 Gene

  • Protein details for EDEM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92611-EDEM1_HUMAN
    Recommended name:
    ER degradation-enhancing alpha-mannosidase-like protein 1
    Protein Accession:
    Q92611
    Secondary Accessions:
    • A8K9C8
    • B4DXP3

    Protein attributes for EDEM1 Gene

    Size:
    657 amino acids
    Molecular mass:
    73768 Da
    Quaternary structure:
    • Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L.
    SequenceCaution:
    • Sequence=BAA13203.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EDEM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDEM1 Gene

Proteomics data for EDEM1 Gene at MOPED

Post-translational modifications for EDEM1 Gene

  • Ubiquitination at Lys 245, Lys 279, Lys 334, Lys 570, and Lys 596
  • Glycosylation at Asn 181, Asn 198, Asn 299, Asn 342, and Asn 624
  • Modification sites at PhosphoSitePlus

Other Protein References for EDEM1 Gene

Antibody Products

  • Abcam antibodies for EDEM1

No data available for DME Specific Peptides for EDEM1 Gene

Domains & Families for EDEM1 Gene

Protein Domains for EDEM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92611

UniProtKB/Swiss-Prot:

EDEM1_HUMAN :
  • Belongs to the glycosyl hydrolase 47 family.
Family:
  • Belongs to the glycosyl hydrolase 47 family.
genes like me logo Genes that share domains with EDEM1: view

No data available for Gene Families for EDEM1 Gene

Function for EDEM1 Gene

Molecular function for EDEM1 Gene

UniProtKB/Swiss-Prot Function:
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Gene Ontology (GO) - Molecular Function for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA,IMP 25092655
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with EDEM1: view

Phenotypes for EDEM1 Gene

genes like me logo Genes that share phenotypes with EDEM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EDEM1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EDEM1 Gene

Localization for EDEM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDEM1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EDEM1 Gene COMPARTMENTS Subcellular localization image for EDEM1 gene
Compartment Confidence
endoplasmic reticulum 5
lysosome 2
vacuole 2
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EDEM1: view

Pathways & Interactions for EDEM1 Gene

genes like me logo Genes that share pathways with EDEM1: view

Pathways by source for EDEM1 Gene

Gene Ontology (GO) - Biological Process for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0008152 metabolic process IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0030968 endoplasmic reticulum unfolded protein response IBA,TAS --
GO:0036510 trimming of terminal mannose on C branch IEA --
genes like me logo Genes that share ontologies with EDEM1: view

No data available for SIGNOR curated interactions for EDEM1 Gene

Drugs & Compounds for EDEM1 Gene

(1) Additional Compounds for EDEM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EDEM1: view

Transcripts for EDEM1 Gene

Unigene Clusters for EDEM1 Gene

ER degradation enhancer, mannosidase alpha-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EDEM1 Gene

No ASD Table

Relevant External Links for EDEM1 Gene

GeneLoc Exon Structure for
EDEM1
ECgene alternative splicing isoforms for
EDEM1

Expression for EDEM1 Gene

mRNA expression in normal human tissues for EDEM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EDEM1 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for EDEM1 Gene

This gene is overexpressed in Skin (54.2) and Urine (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EDEM1 Gene



SOURCE GeneReport for Unigene cluster for EDEM1 Gene Hs.224616

genes like me logo Genes that share expression patterns with EDEM1: view

Protein tissue co-expression partners for EDEM1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for EDEM1 Gene

Orthologs for EDEM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EDEM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EDEM1 35
  • 89.7 (n)
  • 95.28 (a)
EDEM1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EDEM1 35
  • 88.71 (n)
  • 92.64 (a)
EDEM1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Edem1 35
  • 88.44 (n)
  • 93.84 (a)
Edem1 16
Edem1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EDEM1 35
  • 99.37 (n)
  • 99.62 (a)
EDEM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Edem1 35
  • 88.7 (n)
  • 93.37 (a)
oppossum
(Monodelphis domestica)
Mammalia EDEM1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDEM1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves EDEM1 35
  • 78.05 (n)
  • 84.07 (a)
EDEM1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDEM1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia edem1 35
  • 71.72 (n)
  • 79.5 (a)
MGC76118 35
zebrafish
(Danio rerio)
Actinopterygii edem1 35
  • 68.24 (n)
  • 74.21 (a)
zgc55816 35
edem1 36
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C47E12.3 35
  • 56.12 (n)
  • 59.72 (a)
C47E12.3 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNL1 36
  • 27 (a)
OneToMany
MNL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27520 35
  • 51.99 (n)
  • 46.86 (a)
rice
(Oryza sativa)
Liliopsida Os02g0741300 35
  • 50.63 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mnl1 35
  • 50.4 (n)
  • 47.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7485 36
  • 63 (a)
OneToOne
Species with no ortholog for EDEM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EDEM1 Gene

ENSEMBL:
Gene Tree for EDEM1 (if available)
TreeFam:
Gene Tree for EDEM1 (if available)

Paralogs for EDEM1 Gene

Paralogs for EDEM1 Gene

(3) SIMAP similar genes for EDEM1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for EDEM1 Gene

genes like me logo Genes that share paralogs with EDEM1: view

Variants for EDEM1 Gene

Sequence variations from dbSNP and Humsavar for EDEM1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs341974 -- 5,193,041(-) CTTTC(C/T)ATGTT intron-variant
rs341980 -- 5,207,705(+) GTTTC(A/C)CTGTG intron-variant
rs341981 -- 5,203,461(-) ACCTT(A/C)CATTG intron-variant
rs341982 -- 5,201,199(-) gcctg(G/T)gtaac intron-variant
rs341984 -- 5,216,393(-) CTACT(C/T)GGGAG utr-variant-3-prime

Variation tolerance for EDEM1 Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EDEM1 Gene

Human Gene Mutation Database (HGMD)
EDEM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EDEM1 Gene

Disorders for EDEM1 Gene

Relevant External Links for EDEM1

Genetic Association Database (GAD)
EDEM1
Human Genome Epidemiology (HuGE) Navigator
EDEM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EDEM1

No disorders were found for EDEM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EDEM1 Gene

Publications for EDEM1 Gene

  1. Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. (PMID: 12610306) Molinari M. … Paganetti P. (Science 2003) 2 3 4 67
  2. A dual role for EDEM1 in the processing of rod opsin. (PMID: 19934218) Kosmaoglou M. … Cheetham M.E. (J. Cell Sci. 2009) 3 23
  3. EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin. (PMID: 16629899) Hosokawa N. … Nagata K. (Genes Cells 2006) 3 23
  4. A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. (PMID: 11375934) Hosokawa N. … Nagata K. (EMBO Rep. 2001) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for EDEM1 Gene

Sources for EDEM1 Gene

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