Aliases for EDEM1 Gene
External Ids for EDEM1 Gene
Previous GeneCards Identifiers for EDEM1 Gene
GeneCards Summary for EDEM1 Gene
EDEM1 (ER Degradation Enhancer, Mannosidase Alpha-Like 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR). GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is EDEM2.
UniProtKB/Swiss-Prot for EDEM1 Gene
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.