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Aliases for EDEM1 Gene

Aliases for EDEM1 Gene

  • ER Degradation Enhancer, Mannosidase Alpha-Like 1 2 3
  • EDEM 3 4
  • ER Degradation-Enhancing Alpha-Mannosidase-Like 1 3
  • KIAA0212 4

External Ids for EDEM1 Gene

Previous GeneCards Identifiers for EDEM1 Gene

  • GC03P005221
  • GC03P005204

Summaries for EDEM1 Gene

GeneCards Summary for EDEM1 Gene

EDEM1 (ER Degradation Enhancer, Mannosidase Alpha-Like 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR). GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is EDEM2.

UniProtKB/Swiss-Prot for EDEM1 Gene

  • Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Gene Wiki entry for EDEM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDEM1 Gene

Genomics for EDEM1 Gene

Regulatory Elements for EDEM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EDEM1 Gene

Chromosome:
3
Start:
5,187,646 bp from pter
End:
5,219,965 bp from pter
Size:
32,320 bases
Orientation:
Plus strand

Genomic View for EDEM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EDEM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDEM1 Gene

Proteins for EDEM1 Gene

  • Protein details for EDEM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92611-EDEM1_HUMAN
    Recommended name:
    ER degradation-enhancing alpha-mannosidase-like protein 1
    Protein Accession:
    Q92611
    Secondary Accessions:
    • A8K9C8
    • B4DXP3

    Protein attributes for EDEM1 Gene

    Size:
    657 amino acids
    Molecular mass:
    73768 Da
    Quaternary structure:
    • Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L.
    SequenceCaution:
    • Sequence=BAA13203.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EDEM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDEM1 Gene

Proteomics data for EDEM1 Gene at MOPED

Post-translational modifications for EDEM1 Gene

  • Ubiquitination at Lys 245, Lys 279, Lys 334, Lys 570, and Lys 596
  • Glycosylation at Asn 181, Asn 198, Asn 299, Asn 342, and Asn 624
  • Modification sites at PhosphoSitePlus

Other Protein References for EDEM1 Gene

Antibody Products

No data available for DME Specific Peptides for EDEM1 Gene

Domains & Families for EDEM1 Gene

Protein Domains for EDEM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92611

UniProtKB/Swiss-Prot:

EDEM1_HUMAN :
  • Belongs to the glycosyl hydrolase 47 family.
Family:
  • Belongs to the glycosyl hydrolase 47 family.
genes like me logo Genes that share domains with EDEM1: view

No data available for Gene Families for EDEM1 Gene

Function for EDEM1 Gene

Molecular function for EDEM1 Gene

UniProtKB/Swiss-Prot Function:
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Gene Ontology (GO) - Molecular Function for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA --
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP 25092655
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16449189
GO:0051787 misfolded protein binding IDA 19524542
genes like me logo Genes that share ontologies with EDEM1: view

Phenotypes for EDEM1 Gene

GenomeRNAi human phenotypes for EDEM1:
genes like me logo Genes that share phenotypes with EDEM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EDEM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EDEM1 Gene

Localization for EDEM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDEM1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EDEM1 Gene COMPARTMENTS Subcellular localization image for EDEM1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IMP 21062743
GO:0005789 endoplasmic reticulum membrane --
GO:0016020 membrane --
GO:0030176 integral component of endoplasmic reticulum membrane ISS --
GO:0044322 endoplasmic reticulum quality control compartment TAS --
genes like me logo Genes that share ontologies with EDEM1: view

Pathways & Interactions for EDEM1 Gene

genes like me logo Genes that share pathways with EDEM1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006491 N-glycan processing IBA --
GO:0008152 metabolic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process ISS --
genes like me logo Genes that share ontologies with EDEM1: view

No data available for SIGNOR curated interactions for EDEM1 Gene

Drugs & Compounds for EDEM1 Gene

(1) Additional Compounds for EDEM1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
mannose
genes like me logo Genes that share compounds with EDEM1: view

Transcripts for EDEM1 Gene

Unigene Clusters for EDEM1 Gene

ER degradation enhancer, mannosidase alpha-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EDEM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EDEM1 Gene

No ASD Table

Relevant External Links for EDEM1 Gene

GeneLoc Exon Structure for
EDEM1
ECgene alternative splicing isoforms for
EDEM1

Expression for EDEM1 Gene

mRNA expression in normal human tissues for EDEM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EDEM1 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for EDEM1 Gene

This gene is overexpressed in Skin (54.2) and Urine (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EDEM1 Gene



SOURCE GeneReport for Unigene cluster for EDEM1 Gene Hs.224616

genes like me logo Genes that share expression patterns with EDEM1: view

Protein tissue co-expression partners for EDEM1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EDEM1 Gene

Orthologs for EDEM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EDEM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EDEM1 35
  • 89.7 (n)
  • 95.28 (a)
EDEM1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EDEM1 35
  • 88.71 (n)
  • 92.64 (a)
EDEM1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Edem1 35
  • 88.44 (n)
  • 93.84 (a)
Edem1 16
Edem1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EDEM1 35
  • 99.37 (n)
  • 99.62 (a)
EDEM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Edem1 35
  • 88.7 (n)
  • 93.37 (a)
oppossum
(Monodelphis domestica)
Mammalia EDEM1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDEM1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves EDEM1 35
  • 78.05 (n)
  • 84.07 (a)
EDEM1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDEM1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia edem1 35
  • 71.72 (n)
  • 79.5 (a)
MGC76118 35
zebrafish
(Danio rerio)
Actinopterygii edem1 35
  • 68.24 (n)
  • 74.21 (a)
zgc55816 35
edem1 36
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C47E12.3 35
  • 56.12 (n)
  • 59.72 (a)
C47E12.3 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNL1 36
  • 27 (a)
OneToMany
MNL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27520 35
  • 51.99 (n)
  • 46.86 (a)
rice
(Oryza sativa)
Liliopsida Os02g0741300 35
  • 50.63 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mnl1 35
  • 50.4 (n)
  • 47.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7485 36
  • 63 (a)
OneToOne
Species with no ortholog for EDEM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EDEM1 Gene

ENSEMBL:
Gene Tree for EDEM1 (if available)
TreeFam:
Gene Tree for EDEM1 (if available)

Paralogs for EDEM1 Gene

Paralogs for EDEM1 Gene

(3) SIMAP similar genes for EDEM1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for EDEM1 Gene

genes like me logo Genes that share paralogs with EDEM1: view

Variants for EDEM1 Gene

Sequence variations from dbSNP and Humsavar for EDEM1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs163766 -- 5,201,430(-) gctca(C/T)gcctg intron-variant
rs341974 -- 5,193,041(-) CTTTC(C/T)ATGTT intron-variant
rs341980 -- 5,207,705(+) GTTTC(A/C)CTGTG intron-variant
rs341981 -- 5,203,461(-) ACCTT(A/C)CATTG intron-variant
rs341982 -- 5,201,199(-) gcctg(G/T)gtaac intron-variant

Variation tolerance for EDEM1 Gene

Residual Variation Intolerance Score: 11.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EDEM1 Gene

HapMap Linkage Disequilibrium report
EDEM1
Human Gene Mutation Database (HGMD)
EDEM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EDEM1 Gene

Disorders for EDEM1 Gene

Relevant External Links for EDEM1

Genetic Association Database (GAD)
EDEM1
Human Genome Epidemiology (HuGE) Navigator
EDEM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EDEM1
genes like me logo Genes that share disorders with EDEM1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EDEM1 Gene

Publications for EDEM1 Gene

  1. [Proteasome degradation of protein C and plasmin inhibitor mutants: molecular mechanism of congenital protein deficiency]. (PMID: 19764408) Nishio M. … Hirosawa S. (Rinsho Byori 2009) 23 67
  2. Chemical approaches toward understanding glycan-mediated protein quality control. (PMID: 19822453) Takeda Y. … Ito Y. (Curr Opin Chem Biol 2009) 23 67
  3. A dual role for EDEM1 in the processing of rod opsin. (PMID: 19934218) Kosmaoglou M. … Cheetham M.E. (J. Cell Sci. 2009) 23 67
  4. Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. (PMID: 19735704) Yang W. … Son I.H. (Toxicol. Lett. 2009) 23 67
  5. ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER. (PMID: 18653895) Ushioda R. … Nagata K. (Science 2008) 23 67

Products for EDEM1 Gene

Sources for EDEM1 Gene

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