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Aliases for EDEM1 Gene

Aliases for EDEM1 Gene

  • ER Degradation Enhancer, Mannosidase Alpha-Like 1 2 3
  • EDEM 3 4 6
  • KIAA0212 4 6
  • ER Degradation-Enhancing Alpha-Mannosidase-Like Protein 1 3
  • ER Degradation-Enhancing Alpha-Mannosidase-Like 1 3

External Ids for EDEM1 Gene

Previous GeneCards Identifiers for EDEM1 Gene

  • GC03P005221
  • GC03P005204

Summaries for EDEM1 Gene

GeneCards Summary for EDEM1 Gene

EDEM1 (ER Degradation Enhancer, Mannosidase Alpha-Like 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include calcium ion binding and misfolded protein binding. An important paralog of this gene is EDEM2.

UniProtKB/Swiss-Prot for EDEM1 Gene

  • Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Gene Wiki entry for EDEM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDEM1 Gene

Genomics for EDEM1 Gene

Regulatory Elements for EDEM1 Gene

Genomic Location for EDEM1 Gene

Start:
5,187,646 bp from pter
End:
5,219,965 bp from pter
Size:
32,320 bases
Orientation:
Plus strand

Genomic View for EDEM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EDEM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDEM1 Gene

Proteins for EDEM1 Gene

  • Protein details for EDEM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92611-EDEM1_HUMAN
    Recommended name:
    ER degradation-enhancing alpha-mannosidase-like protein 1
    Protein Accession:
    Q92611
    Secondary Accessions:
    • A8K9C8
    • B4DXP3

    Protein attributes for EDEM1 Gene

    Size:
    657 amino acids
    Molecular mass:
    73768 Da
    Quaternary structure:
    • Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L.
    SequenceCaution:
    • Sequence=BAA13203.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EDEM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDEM1 Gene

Proteomics data for EDEM1 Gene at MOPED

Post-translational modifications for EDEM1 Gene

  • Ubiquitination at Lys245, Lys279, Lys334, Lys570, and Lys596
  • Glycosylation at Asn181, Asn198, Asn299, Asn342, and Asn624
  • Modification sites at PhosphoSitePlus

Other Protein References for EDEM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EDEM1 Gene

Domains for EDEM1 Gene

Protein Domains for EDEM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92611

UniProtKB/Swiss-Prot:

EDEM1_HUMAN :
  • Q92611
Family:
  • Belongs to the glycosyl hydrolase 47 family.
genes like me logo Genes that share domains with EDEM1: view

No data available for Gene Families for EDEM1 Gene

Function for EDEM1 Gene

Molecular function for EDEM1 Gene

UniProtKB/Swiss-Prot Function: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Gene Ontology (GO) - Molecular Function for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004571 NOT mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA 12610306
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16449189
GO:0051787 misfolded protein binding IDA 19524542
genes like me logo Genes that share ontologies with EDEM1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for EDEM1 Gene

Localization for EDEM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDEM1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EDEM1 Gene COMPARTMENTS Subcellular localization image for EDEM1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1
extracellular 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 24200403
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0030176 integral component of endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with EDEM1: view

Pathways for EDEM1 Gene

genes like me logo Genes that share pathways with EDEM1: view

Gene Ontology (GO) - Biological Process for EDEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0008152 metabolic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process ISS --
genes like me logo Genes that share ontologies with EDEM1: view

Compounds for EDEM1 Gene

(1) Novoseek inferred chemical compound relationships for EDEM1 Gene

Compound -log(P) Hits PubMed IDs
mannose 60.7 1
genes like me logo Genes that share compounds with EDEM1: view

Transcripts for EDEM1 Gene

Unigene Clusters for EDEM1 Gene

ER degradation enhancer, mannosidase alpha-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EDEM1 Gene

No ASD Table

Relevant External Links for EDEM1 Gene

GeneLoc Exon Structure for
EDEM1
ECgene alternative splicing isoforms for
EDEM1

Expression for EDEM1 Gene

mRNA expression in normal human tissues for EDEM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EDEM1 Gene

This gene is overexpressed in Liver (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EDEM1 Gene

SOURCE GeneReport for Unigene cluster for EDEM1 Gene Hs.224616

genes like me logo Genes that share expressions with EDEM1: view

No data available for mRNA Expression by UniProt/SwissProt for EDEM1 Gene

Orthologs for EDEM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EDEM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EDEM1 35
  • 99.37 (n)
  • 99.62 (a)
EDEM1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EDEM1 35
  • 89.7 (n)
  • 95.28 (a)
EDEM1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EDEM1 35
  • 88.71 (n)
  • 92.64 (a)
EDEM1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Edem1 35
  • 88.44 (n)
  • 93.84 (a)
Edem1 16
Edem1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EDEM1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDEM1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Edem1 35
  • 88.7 (n)
  • 93.37 (a)
chicken
(Gallus gallus)
Aves EDEM1 35
  • 78.05 (n)
  • 84.07 (a)
EDEM1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDEM1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia edem1 35
  • 71.72 (n)
  • 79.5 (a)
MGC76118 35
zebrafish
(Danio rerio)
Actinopterygii edem1 35
  • 68.24 (n)
  • 74.21 (a)
edem1 36
  • 73 (a)
OneToOne
zgc55816 35
worm
(Caenorhabditis elegans)
Secernentea C47E12.3 35
  • 56.12 (n)
  • 59.72 (a)
C47E12.3 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNL1 36
  • 27 (a)
OneToMany
MNL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27520 35
  • 51.99 (n)
  • 46.86 (a)
rice
(Oryza sativa)
Liliopsida Os02g0741300 35
  • 50.63 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mnl1 35
  • 50.4 (n)
  • 47.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7485 36
  • 63 (a)
OneToOne
Species with no ortholog for EDEM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EDEM1 Gene

ENSEMBL:
Gene Tree for EDEM1 (if available)
TreeFam:
Gene Tree for EDEM1 (if available)

Paralogs for EDEM1 Gene

Paralogs for EDEM1 Gene

Selected SIMAP similar genes for EDEM1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for EDEM1 Gene

genes like me logo Genes that share paralogs with EDEM1: view

Variants for EDEM1 Gene

Sequence variations from dbSNP and Humsavar for EDEM1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs163766 -- 5,201,430(-) gctca(C/T)gcctg intron-variant
rs180733 -- 5,188,658(-) AAGGG(C/G)TCGGA intron-variant
rs341974 -- 5,193,041(-) CTTTC(C/T)ATGTT intron-variant
rs341980 -- 5,207,705(+) GTTTC(A/C)CTGTG intron-variant
rs341981 -- 5,203,461(-) ACCTT(A/C)CATTG intron-variant

Relevant External Links for EDEM1 Gene

HapMap Linkage Disequilibrium report
EDEM1
Human Gene Mutation Database (HGMD)
EDEM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EDEM1 Gene

Disorders for EDEM1 Gene

Relevant External Links for EDEM1

Genetic Association Database (GAD)
EDEM1
Human Genome Epidemiology (HuGE) Navigator
EDEM1
genes like me logo Genes that share disorders with EDEM1: view

No data available for UniProtKB/Swiss-Prot for EDEM1 Gene

Publications for EDEM1 Gene

  1. A dual role for EDEM1 in the processing of rod opsin. (PMID: 19934218) Kosmaoglou M. … Cheetham M.E. (J. Cell Sci. 2009) 3 4 23
  2. Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. (PMID: 12610306) Molinari M. … Paganetti P. (Science 2003) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  5. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. (PMID: 16449189) Oda Y. … Mori K. (J. Cell Biol. 2006) 3 4

Products for EDEM1 Gene

Sources for EDEM1 Gene

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