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Aliases & Descriptions for EDC4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Ge-1 1, 2 | | HEDLS 1, 2, 3 | | Hedls 3 | | RCD-8 1, 2 | | autoantigen 2 |
| | | Descriptions |
|---|
| Autoantigen Ge-1 3 | | Autoantigen RCD-8 3 | | Human enhancer of decapping large subunit 3 | | autoantigen RCD8 2 | | enhancer of mRNA decapping 4 2 |
|
| | Search outside databases for aliases for EDC4 gene |
Summaries for EDC4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: EDC4_HUMAN, Q6P2E9Function: In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro) |
Genomic Location for EDC4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EDC4 gene 
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1EDC4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P066465:
(about GC identifiers)
Start:
|
66,464,456 bp from pter |
End:
|
66,475,907 bp from pter |
Size:
|
11,452 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010498.15
| Proteins for EDC4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: EDC4_HUMAN, Q6P2E9 (See
protein sequence)Recommended Name: Enhancer of mRNA-decapping protein 4 Size: 1401 amino acids; 151661 Da
Subunit: Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2
Subcellular location: Cytoplasm, P-body. Nucleus
Sequence caution: Sequence=AAA21833.1; Type=Frameshift; Positions=1189;
Secondary accessions: A6NGM1 Q13025 Q13826 Q6ZR12 Q7Z6H7Alternative splicing: 2 isoforms: Q6P2E9-1 Q6P2E9-2 Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055144.3
ENSEMBL proteins: ENSP00000384736 ENSP00000041337 ENSP00000351811
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for EDC4: Assays for EDC4: | Protein
Domains/ Families for EDC4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6P2E9
ProtoNet protein and cluster: Q6P2E9 UniProtKB/Swiss-Prot: EDC4_HUMAN, Q6P2E9Similarity: Belongs to the WD repeat EDC4 familySimilarity: Contains 4 WD repeats | Gene Function for EDC4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014329
Applied Biosystems Silencer® siRNAs for EDC4
Sigma-Aldrich siRNA for EDC4  Sigma-Aldrich shRNA for EDC4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014329                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014329                                  untagged cDNA clone in CMV expression vector: NM_014329 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014329
UniProtKB/Swiss-Prot: EDC4_HUMAN, Q6P2E9Function: In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for EDC4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for EDC4 
5/7 Interacting proteins for EDC4 (Q6P2E91 ENSP000003518113) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for EDC4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EDC4
|
Transcripts for EDC4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014329
Sigma-Aldrich siRNA for EDC4  Sigma-Aldrich shRNA for EDC4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014329 REFSEQ mRNAs for EDC4 gene: NM_014329.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014329               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014329                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014329                                  untagged cDNA clone in CMV expression vector: NM_014329  Additional cDNA sequence: AK291049.1 AK302563.1 BC043616.1 BC053598.1 BC064567.1 CR594351.1 CR601781.1 CR618363.1 L26339.1 U17474.1 U93216.1 16 DOTS entries: DT.116400 DT.100790256 DT.92018122 DT.101984176 DT.95376211 DT.95376217 DT.95376220 DT.95137068 DT.100643826 DT.100790246 DT.120715923 DT.75189749 DT.95334997 DT.95348035 DT.95376219 DT.97854601 24/250 AceView cDNA sequences (see all 250
):BM464234 AY358782 CR618363 NM_198443 BE296550 BQ226185 BC064567 BX377983 BC053598 BF432145 BM454289 BP373142 BU181407 BQ955297 CR594351 CA392332 Z41467 BQ002387 AA581635 BQ223036 BE933369 AL547368 BE350088 CA309930
highest scoring ESTs for EDC4:L26339 AA149177 AA328981 AA469056 AA481276 AA554047 AA582014 AA622610 AA694492 AA705074 Unigene Cluster for EDC4: Enhancer of mRNA decapping 4 Hs.75682 [show with all ESTs]Unigene Representative Sequence: NM_014329
GeneLoc Exon Structure
5/23 Alternative Splicing Database (ASD) splice patterns (SP) for EDC4 (see all 23
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | · | 20d | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | · | 25c | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | · | 27d | · | 27e | ^ | 28 | ^ | 29a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 29b | · | 29c | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33a | · | 33b | · | 33c | · | 33d | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for EDC4
3 Ensembl transcripts including schematic representations: ENST00000401697
ENST00000041337
ENST00000358933
|
Expression for EDC4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EDC4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EDC4
1 / 2 / 3 4 probe-sets matching EDC4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTCCTTTTTA
SOURCE GeneReport for Unigene cluster: Hs.75682
|
Orthologs for EDC4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EDC4 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for EDC4
ENSEMBL Gene Tree for EDC4 | Paralogs for EDC4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for EDC4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EDC4 (up to first 250kb)
|
Disorders & Mutations for EDC4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606030
|
Medical News for EDC4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EDC4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for EDC4 gene (see all 16
): |
Search for EDC4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EDC4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EDC4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EDC4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EDC4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EDC4:

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| | Recombinant Proteins (EDC4) | | Antibodies (EDC4) |
| | | Search Tocris compounds for EDC4 |
|
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Incremental update: 13 Oct 2009
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