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EDC3 Gene

protein-coding   GIFtS: 55
GCID: GC15M074922

Enhancer Of MRNA Decapping 3

(Previous names: yjeF domain containing (E.coli), LSM16 homolog (EDC3, S....)
(Previous symbols: YJDC, LSM16)
  See EDC3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Enhancer Of MRNA Decapping 31 2     YjeF Domain Containing (E.Coli)1
YJDC1 2 3 5     Enhancer Of MRNA Decapping 3 Homolog2
LSM161 2 3     Enhancer Of MRNA-Decapping Protein 32
LSM16 Homolog (EDC3, S. Cerevisiae)1 2     hYjeF_N2-15q232
YjeF Domain-Containing Protein 12 3     yjeF_N22
YjeF N-Terminal Domain-Containing Protein 22 3     YjeF Domain Containing2
YJEFN22 3     YjeF_N23
hYjeF_N22 3     LSM16 Homolog3
Enhancer Of MRNA Decapping 3 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 261141   Entrez Gene: 801532   Ensembl: ENSG000001791517   OMIM: 6098425   UniProtKB: Q96F863   

Export aliases for EDC3 gene to outside databases

Previous GC identifers: GC15M072712 GC15M051721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EDC3 Gene:
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its
degradation from the 5-prime end (Fenger-Gron et al., 2005 (PubMed 16364915)).(supplied by OMIM, Mar 2008)

GeneCards Summary for EDC3 Gene:
EDC3 (enhancer of mRNA decapping 3) is a protein-coding gene. Diseases associated with EDC3 include actinomycosis. GO annotations related to this gene include RNA binding and identical protein binding.

UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86
Function: Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May
play a role in spermiogenesis and oogenesis

Gene Wiki entry for EDC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the EDC3 gene promoter:
         Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEDC3 promoter sequence
   Search Chromatin IP Primers for EDC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EDC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

EDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDC3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M074922:  view genomic region     (about GC identifiers)

Start:
74,922,899 bp from pter      End:
74,988,633 bp from pter
Size:
65,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86 (See protein sequence)
Recommended Name: Enhancer of mRNA-decapping protein 3  
Size: 508 amino acids; 56078 Da
Subunit: Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within
this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36
5 PDB 3D structures from and Proteopedia for EDC3:
2VC8 (3D)        2WAX (3D)        2WAY (3D)        3D3J (3D)        3D3K (3D)    
Secondary accessions: B3KPH0 D3DW61 Q9H797

Explore the universe of human proteins at neXtProt for EDC3: NX_Q96F86

Explore proteomics data for EDC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys426
  • Modification sites at PhosphoSitePlus

  • See EDC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135915.1  NP_001135916.1  NP_079359.2  

    ENSEMBL proteins: 
     ENSP00000320503   ENSP00000454885   ENSP00000401343   ENSP00000455580   ENSP00000454736  
     ENSP00000455393   ENSP00000456805   ENSP00000457128   ENSP00000455503   ENSP00000455589  
     ENSP00000457523   ENSP00000455870   ENSP00000457170   ENSP00000454317   ENSP00000457156  
     ENSP00000455682  
    Reactome Protein details: Q96F86

    EDC3 Human Recombinant Protein Products:

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    Novus Biologicals EDC3 Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EDC3

     
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    antibodies-online proteins for EDC3 (5 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR025609 Lsm14_N
     IPR004443 YjeF_N_dom
     IPR019050 FDF_dom
     IPR025762 DFDF

    Graphical View of Domain Structure for InterPro Entry Q96F86

    ProtoNet protein and cluster: Q96F86

    1 Blocks protein domain: IPB004443 YjeF-related protein

    UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86
    Domain: The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6
    Similarity: Belongs to the EDC3 family
    Similarity: Contains 1 DFDF domain
    Similarity: Contains 1 YjeF N-terminal domain


    Find genes that share domains with EDC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EDC3_HUMAN, Q96F86
    Function: Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May
    play a role in spermiogenesis and oogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI16364915
    GO:0042802identical protein binding IPI18678652
         
    Find genes that share ontologies with EDC3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for EDC3:
     Elongated cells  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EDC3

    miRNA
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    miRTarBase miRNAs that target EDC3:
    hsa-mir-324-5p (MIRT043057), hsa-mir-22-3p (MIRT030653), hsa-mir-31-5p (MIRT049900), hsa-mir-744-5p (MIRT037536), hsa-mir-320c (MIRT036173), hsa-mir-320a (MIRT044648), hsa-mir-361-5p (MIRT020080), hsa-mir-615-3p (MIRT039932), hsa-mir-103a-3p (MIRT026990), hsa-mir-16-5p (MIRT031570), hsa-mir-99b-5p (MIRT044189)

    Block miRNA regulation of human, mouse, rat EDC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EDC3 (see all 44):
    hsa-miR-328 hsa-miR-3607-3p hsa-miR-4254 hsa-miR-29a hsa-miR-139-5p hsa-miR-30d hsa-miR-624 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidEDC3 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDC3
    Addgene plasmids for EDC3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EDC3_HUMAN, Q96F86: Cytoplasm, P-body. Note=Processing bodies (PB)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with EDC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EDC3 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control


    Find genes that share SuperPaths with EDC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EDC3
        Translational Control

    1 Reactome Pathway for EDC3
        mRNA decay by 5' to 3' exoribonuclease


    1 Kegg Pathway  (Kegg details for EDC3):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EDC3
    Interactions:

        Search GeneGlobe Interaction Network for EDC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EDC3 (Q96F861, 2, 3 ENSP000003205034) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50962 I2D: score=4 STRING: ENSP00000300161
    YWHAGP619812, 3, ENSP000003063304MINT-50853 I2D: score=4 STRING: ENSP00000306330
    ZFP36P266511, 3, ENSP000002486734EBI-997311,EBI-374248 I2D: score=2 STRING: ENSP00000248673
    SFNP319472, 3MINT-3976338 I2D: score=1 
    DDX6P261961, 3, ENSP000002640184EBI-997311,EBI-351257 I2D: score=2 STRING: ENSP00000264018
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--
    GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS--

    Find genes that share ontologies with EDC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EDC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EDC3 gene (3 alternative transcripts): 
    NM_001142443.1  NM_001142444.1  NM_025083.3  

    Unigene Cluster for EDC3:

    Enhancer of mRNA decapping 3 homolog (S. cerevisiae)
    Hs.96852  [show with all ESTs]
    Unigene Representative Sequence: NM_001142443
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315127(uc002ayn.3 uc002ayo.3 uc002aym.3) ENST00000565602
    ENST00000426797 ENST00000568176 ENST00000569606 ENST00000562174 ENST00000566219
    ENST00000562974 ENST00000563009 ENST00000569561 ENST00000566243 ENST00000566828
    ENST00000570138 ENST00000563292 ENST00000569007 ENST00000567813 ENST00000566119
    ENST00000562047
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EDC3 (see all 44):
    hsa-miR-328 hsa-miR-3607-3p hsa-miR-4254 hsa-miR-29a hsa-miR-139-5p hsa-miR-30d hsa-miR-624 hsa-miR-342-3p
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    Addgene plasmids for EDC3 
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      QuantiTect SYBR Green Assays in human, mouse, rat EDC3
      QuantiFast Probe-based Assays in human, mouse, rat EDC3

    Additional mRNA sequence: 

    AF193058.1 AK024781.1 AK056339.1 AK225099.1 AL133447.1 BC011534.1 BC021271.2 

    15 DOTS entries:

    DT.414479  DT.100791674  DT.99941570  DT.100791663  DT.100791665  DT.121044324  DT.92036559  DT.97813442 
    DT.100791675  DT.95165071  DT.100744007  DT.121044342  DT.121044349  DT.91660427  DT.95165049 

    Selected AceView cDNA sequences (see all 340):

    BQ651837 BI861912 BQ936451 BQ887416 BU687056 BQ219763 AI673346 BU542824 
    AI635567 BU542230 AL596992 BU182720 BM712519 BQ006337 BQ957044 BQ962197 
    CB852176 AA352126 BQ931302 BU154849 BM926212 BE743563 AI692578 BC021271 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EDC3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b ^ 11 ^ 12a ·
    SP1:                                -     -     -     -     -                       -                                               -                       -   
    SP2:                                -     -     -     -     -     -                 -     -                                         -                       -   
    SP3:                                -     -     -     -     -     -     -     -     -     -                                         -                       -   
    SP4:                                -     -     -     -     -     -                 -                                                                           
    SP5:                                -     -     -     -     -     -     -     -     -                                               -                           

    ExUns: 12b · 12c ^ 13a · 13b · 13c · 13d
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for EDC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EDC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTCTTAG
    EDC3 Expression
    About this image

    EDC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EDC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.96852

    UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86
    Tissue specificity: Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division
    part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary
    gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EDC3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Edc31 , 5 enhancer of mRNA decapping 3 homolog (S. cerevisiae)1, 5 89.63(n)1
    95.67(a)1
      9 (31.37 cM)5
    3531901  NM_153799.31  NP_722494.11 
     577085405 
    chicken
    (Gallus gallus)
    Aves EDC31 enhancer of mRNA decapping 3 homolog (S. cerevisiae) 80.76(n)
    88.74(a)
      415294  NM_001030385.1  NP_001025556.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    88(a)
    87(a)
    many → 1
    many → 1
    AAWZ02037994(739-12441)
    GL343721.1(141257-142918)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.37352 Transcribed sequences 77(n)    CF226350.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.53502 Transcribed sequences 75.46(n)    BG729698.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Edc31 Enhancer of decapping 3 47.49(n)
    41.18(a)
      39957  NM_140735.3  NP_648992.1 


    ENSEMBL Gene Tree for EDC3 (if available)
    TreeFam Gene Tree for EDC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EDC3 (see all 1007)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406261091,2
    --74923110(+) GTCCCA/GGTGCC 3 -- ut310--------
    rs1876716671,2
    --74923174(+) AGGCTA/GTCATC 3 -- ut310--------
    rs1932217941,2
    --74923218(+) CCAGGA/GTTGTT 3 -- ut310--------
    rs11286281,2
    C,F,H--74923335(-) CCTCTC/GTTGGC 3 -- ut31 ese313Minor allele frequency- G:0.21MN NA NS EA WA 1092
    rs1855979521,2
    --74923463(+) AAGATA/GAGAGG 3 -- ut310--------
    rs791717391,2
    C,F--74923511(+) CTATGT/ATCCTA 3 -- ut311Minor allele frequency- A:0.05WA 118
    rs1873747741,2
    --74923539(+) GCCTGA/GAACCC 3 -- ut310--------
    rs1921544031,2
    --74923850(+) GTGCTA/GGCCCC 3 -- ut310--------
    rs1846570761,2
    --74923982(+) CGTTTC/TAGGGG 3 -- ut310--------
    rs1457891351,2
    --74924370(+) ACTTGC/GATCAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EDC3 (74922899 - 74988633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for EDC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904380CNV Loss21882294
    nsv904379CNV Loss21882294
    nsv457204CNV Loss19166990
    nsv833055CNV Loss17160897
    esv28499CNV Gain19812545
    nsv817698CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EDC3
    DNA2.0 Custom Variant and Variant Library Synthesis for EDC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609842    OMIM disorders: --

    1 disease for EDC3:    
    About MalaCards
    actinomycosis

    1 disease from the University of Copenhagen DISEASES database for EDC3:
    Actinomycosis

    Find genes that share disorders with EDC3           About GenesLikeMe


    Export disorders for EDC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EDC3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with EDC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PubMed id 17533573)1, 2, 3 Rudolph C.... Schmitz G. (Horm. Metab. Res. 2007)
    2. mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription. (PubMed id 22483619)1, 3 Brannan K....Bentley D.L. (Mol. Cell 2012)
    3. Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. (PubMed id 19285948)1, 2 Tritschler F....Weichenrieder O. (Mol. Cell 2009)
    4. Crystal structure of human Edc3 and its functional implications. (PubMed id 18678652)1, 2 Ling S.H.... Song H. (Mol. Cell. Biol. 2008)
    5. A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. (PubMed id 17923697)1, 2 Tritschler F.... Weichenrieder O. (Mol. Cell. Biol. 2007)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (Mol. Cell 2005)
    8. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. (PubMed id 15225602)1, 3 Albrecht M. and Lengauer T. (FEBS Lett. 2004)
    9. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80153 HGNC: 26114 AceView: FLJ21128 Ensembl:ENSG00000179151 euGenes: HUgn80153
    ECgene: EDC3 Kegg: 80153 H-InvDB: EDC3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EDC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EDC3 gene:
    Search GeneIP for patents involving EDC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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