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EDC3 Gene

protein-coding GIFtS: 51

GC15M072712

enhancer of mRNA decapping 3 homolog (S. cerevisiae)
(Previous names: yjeF domain containing (E.coli), LSM16 homolog (EDC3, S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: YJDC, LSM16)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ21128 ^¹, ²
FLJ31777 ^²
LSM16 ^², ³
YJDC ^², ³
YJEFN2 ^¹, ², ³
YjeF_N2 ^³
hYjeF_N2 ^³
hYjeF_N2-15q23 ^¹, ²

Descriptions
LSM16 homolog ^³
LSM16 homolog (EDC3, S. cerevisiae) ^¹, ²
YjeF N-terminal domain-containing protein 2 ^³
YjeF domain-containing protein 1 ^³
enhancer of mRNA decapping 3 ^²
enhancer of mRNA decapping 3 homolog (S. cerevisiae) ^²
yjeF domain containing ^²
yjeF domain containing (E.coli) ^¹

External Ids
HGNC: 26114¹
Entrez Gene: 80153²
UniProtKB: Q96F86³
Ensembl: ENSG00000179151⁷

Search outside databases for aliases for EDC3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EDC3:

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA

prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed

16364915]).[supplied by OMIM]

UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86

Function: In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in

spermiogenesis and oogenesis

Gene Wiki entry for EDC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EDC3 gene

Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

EDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M072712: (about GC identifiers)

Start:	72,709,952 bp from pter
End:	72,775,413 bp from pter
Size:	65,462 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86 (See protein sequence)

Recommended Name: Enhancer of mRNA-decapping protein 3

Size: 508 amino acids; 56078 Da

Subunit: Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly

interacts with DCP1A and DDX6. Interacts with ZFP36

Subcellular location: Cytoplasm, P-body. Note=Processing bodies (PB)

PDB structures from and Proteopedia :

2VC8 (3D)

2WAX (3D)

2WAY (3D)

3D3J (3D)

3D3K (3D)

Secondary accessions: Q9H797

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001135915.1 NP_001135916.1 NP_079359.2

ENSEMBL proteins:

ENSP00000320503

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EDC3)
	Human Recombinant Proteins from Abnova (LSM16)

OriGene Purified Recombinant Human Protein: EDC3

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for EDC3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EDC3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (EDC3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LSM16)
	Novus Biologicals Antibodies for EDC3

Assays for EDC3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96F86

ProtoNet protein and cluster: Q96F86

1 Blocks protein family: IPB004443 YjeF-related protein

UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86

Similarity: Belongs to the EDC3 family

Similarity: Contains 1 YjeF N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LSM16)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_025083

Applied Biosystems Silencer® siRNAs for EDC3

Sigma-Aldrich siRNA for EDC3

Sigma-Aldrich shRNA for EDC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EDC3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001142443
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001142443
untagged cDNA clones in CMV expression vector (see all 4): NM_001142443

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001142444

UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86

Function: In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in

spermiogenesis and oogenesis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16364915 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/16 Interacting proteins for EDC3 (Q96F86^{1, 2} ENSP00000320503³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDX6	P26196¹, ENSP00000264018³	EBI-997311, EBI-351257 STRING (score=.975)
ZFP36	P26651¹, ENSP00000248673³	EBI-997311, EBI-374248 STRING (score=.702)
YWHAB	P31946¹^,²	EBI-997311, EBI-359815 MINT-50962 EBI-997311, EBI-359815 MINT-50962
YWHAG	P61981¹^,²	EBI-997311, EBI-359832 MINT-50853 EBI-997311, EBI-359832 MINT-50853
YWHAZ	P63104¹^,²	EBI-997311, EBI-347088 MINT-3320046 EBI-997311, EBI-347088 MINT-3320046

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EDC3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LSM16)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_025083

Sigma-Aldrich siRNA for EDC3

Sigma-Aldrich shRNA for EDC3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142443 NM_001142444 NM_025083

REFSEQ mRNAs for EDC3 gene (3 alternative transcripts):

NM_001142443.1 NM_001142444.1 NM_025083.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142443 NM_001142444 NM_025083

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001142443
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001142443
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001142443

Additional cDNA sequence:

AF193058.1 AK024781.1 AK056339.1 AK225099.1 AL133447.1 BC011534.1 BC021271.2

15 DOTS entries:

DT.414479 DT.100791674 DT.99941570 DT.100791663 DT.100791665 DT.92036559 DT.121044324 DT.97813442

DT.100791675 DT.95165071 DT.100744007 DT.121044342 DT.121044349 DT.91660427 DT.95165049

24/340 AceView cDNA sequences (see all 340 ):

AI692578 AI653427 BC011534 D81794 AA302883 BQ944676 BQ944680 BP351702

BU543885 BP337315 BQ218764 BQ935576 BE743563 BE388280 CA430814 BQ936767

BU543570 BU543582 NM_025083 BQ931302 BU542106 CB128393 BQ219763 BQ895881

highest scoring ESTs for EDC3:

AF193058 AI436560 AK024781 AK056339 AL530931 AL596992 AW016187 AW250096 BC011534 BC021271

Unigene Cluster for EDC3:

Enhancer of mRNA decapping 3 homolog (S. cerevisiae)

Hs.96852 [show with all ESTs]

Unigene Representative Sequence: NM_001142443

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for EDC3 (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9	^	10a	·	10b	^	11	^	12a	·
SP1:											-		-		-		-		-								-																-								-
SP2:											-		-		-		-		-		-						-		-														-								-
SP3:											-		-		-		-		-		-		-		-		-		-														-								-
SP4:											-		-		-		-		-		-						-
SP5:											-		-		-		-		-		-		-		-		-																-

ExUns:	12b	·	12c	^	13a	·	13b	·	13c	·	13d
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for EDC3

1 Ensembl transcript including schematic representation:

ENST00000315127

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EDC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EDC3

¹ / ² / ³

7 probe-sets matching EDC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54839_at²^{, 3}	U95-C	1	1.00	1.00	0.58	1.12	N51702	0.80	1.00	0.91	1
56298_at²^{, 3}	U95-B	1	1.00	1.00	0.88	0.88	AI436560	0.80	1.00	0.91	1
43416_s_at²^{, 3}	U95-B	2	1.00	0.97	0.81	0.99	AW016187	0.80	1.00	0.91	1
226042_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL563608	0.60	1.00	0.82	1
219207_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_025083	0.60	1.00	0.82	1
226042_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219207_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.96852
UniProtKB/Swiss-Prot: EDC3_HUMAN, Q96F86
Tissue specificity: Expressed in theca and granulosa cells in ovary, and in spermatids of the
meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also
expressed in brain and mammary gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EDC3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EDC3¹	--	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	91.73(n) 96.46(a)	487647 XM_861987.1 XP_867080.1
cow (Bos taurus)	EDC3¹	--	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	93.8(n) 95.81(a)	517979 NM_001031758.1 NP_001026928.1
mouse (Mus musculus)	Edc3^{1, 5}	9⁵	enhancer of mRNA decapping 3 homolog (S. cerevisiae)^{1, 5}	89.63(n)¹ 95.67(a)¹	353190¹ NM_153799.2¹ NP_722494.1¹ AA517853⁵ AI450825⁵ (see all 20)
chicken (Gallus gallus)	EDC3¹	--	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	80.79(n) 88.91(a)	415294 NM_001030385.1 NP_001025556.1
zebrafish (Danio rerio)	Dr.5350²	--	Transcribed sequences	75.46(n)	BG729698.1

About this table Species with no ortholog for EDC3

ENSEMBL Gene Tree for EDC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/180 NCBI SNPs in EDC3 are shown (see all 180 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 21)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1128628^1,2	C,F,H	72710388(-)	`CCTCTC/GTTGGC`	1	--	ut3¹ ese³		12		MN NA EU EA WA	1150
--	rs7170734^1,2	A,C	72776459(+)	`actctC/Tggtgt`	1	--	ng3¹		0	--	--	--	--
	rs4128436^1,2	A,C,F,H	72722947(-)	`ACTGCG/ATCCCA`	1	--	int¹		7		NA EU EA WA	546
	rs11072498^1,2	A,C,F,H	72741240(+)	`GGAAAG/TGAGTA`	1	--	int¹ trp³		6		EU EA WA	598
	rs7497342^1,2	A,C,F,H	72735116(+)	`ACCTGA/GTGCAA`	1	--	int¹		7		NA EU EA WA	560
	rs7161903^1,2	A,C,F,H	72727323(+)	`AGAATA/GACATC`	1	--	int¹		8		EU EA WA	838
	rs11072497^1,2	A,C,F,H	72738410(+)	`CACAGC/ACAGCT`	1	--	int¹		4		EU EA WA	416
	rs6495119^1,2	A,C,F,H	72721493(+)	`GGCTAT/CAGCTT`	1	--	int¹		4		EU EA WA	420
	rs11072499^1,2	C,F,H	72755926(+)	`GACATC/TATAGA`	1	--	int¹		4		EU EA WA	416
	rs7497749^1,2	C,F,H	72729812(+)	`GAATAT/CCTTCC`	1	--	int¹ trp³		4		EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for EDC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609842

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/19 PubMed articles for EDC3 gene (see all 19 ):

ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PubMed id 17533573)^{2, 3, 4} Rudolph C....Schmitz G. (2007)
A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. (PubMed id 17923697)^{3, 4} Tritschler F....Weichenrieder O. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)^{3, 4} Fenger-Groen M.... Lykke-Andersen J. (2005)
Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. (PubMed id 15225602)^{2, 3} Albrecht M. and Lengauer T. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. (PubMed id 19285948)³ Tritschler F....Weichenrieder O. (2009)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 80153	HGNC: 26114	AceView: FLJ21128	Ensembl:ENSG00000179151	euGenes: HUgn80153
ECgene: EDC3	H-InvDB: EDC3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for EDC3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EDC3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EDC3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EDC3		Antibodies for EDC3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EDC3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LSM16)
	Antibodies (LSM16)
	Chimera RNAi (LSM16)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (EDC3)
	Antibodies (EDC3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for EDC3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EDC3

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EDC3 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for EDC3

Summaries
for EDC3

Genomic Location
for EDC3

Proteins
for EDC3

Protein Domains/
Families
for EDC3

Gene Function
for EDC3

Pathways & Interactions
for EDC3

Drugs & Compounds
for EDC3

Transcripts
for EDC3

Expression
for EDC3

Orthologs
for EDC3

Paralogs
for EDC3

SNPs/Variants
for EDC3

Disorders & Mutations
for EDC3

Medical News
for EDC3

Publications
for EDC3

Search for EDC3

Genome Databases showing EDC3

Other Databases showing EDC3

Specialized Databases showing EDC3

Licensable Technologies
for EDC3

Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EDC3 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor EDC3

Summariesfor EDC3

Genomic Locationfor EDC3

Proteinsfor EDC3

Protein Domains/Familiesfor EDC3

Gene Functionfor EDC3

Pathways & Interactionsfor EDC3

Drugs & Compoundsfor EDC3

Transcriptsfor EDC3

Expression for EDC3

Orthologsfor EDC3

Paralogsfor EDC3

SNPs/Variantsfor EDC3

Disorders & Mutationsfor EDC3

Medical Newsfor EDC3

Publicationsfor EDC3

Search for EDC3

Genome Databases showing EDC3

Other Databases showing EDC3

Specialized Databases showing EDC3

Licensable Technologiesfor EDC3

Servicesfor EDC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EDC3

Summaries
for EDC3

Genomic Location
for EDC3

Proteins
for EDC3

Protein Domains/
Families
for EDC3

Gene Function
for EDC3

Pathways & Interactions
for EDC3

Drugs & Compounds
for EDC3

Transcripts
for EDC3

Expression
for EDC3

Orthologs
for EDC3

Paralogs
for EDC3

SNPs/Variants
for EDC3

Disorders & Mutations
for EDC3

Medical News
for EDC3

Publications
for EDC3

Licensable Technologies
for EDC3

Services
for EDC3