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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EDARADD Gene

protein-coding   GIFtS: 53
GCID: GC01P236511

EDAR-Associated Death Domain

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
EDAR-Associated Death Domain1 2     Crinkled Homolog2
EDAR-Associated Death Domain Protein2 3     Ectodysplasia A Receptor Associated Death Domain2
ED32 5     Ectodysplasin A Receptor Associated Adapter Protein2
EDA32 5     Ectodysplasin-A Receptor-Associated Adapter Protein2
ECTD11A2     Protein Crinkled Homolog3
ECTD11B2     

External Ids:    HGNC: 143411   Entrez Gene: 1281782   Ensembl: ENSG000001861977   OMIM: 6066035   UniProtKB: Q8WWZ33   

Export aliases for EDARADD gene to outside databases

Previous GC identifers: GC01P234691 GC01P232012 GC01P232808 GC01P233598 GC01P232884 GC01P232885 GC01P207012


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EDARADD Gene:
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by
defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death
domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for
the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in
epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this
protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced
transcript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for EDARADD Gene: 
EDARADD (EDAR-associated death domain) is a protein-coding gene. Diseases associated with EDARADD include ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive, and ectodermal dysplasia 11a, hypohidrotic/hair/nail type, autosomal dominant.

UniProtKB/Swiss-Prot: EDAD_HUMAN, Q8WWZ3
Function: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway
during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B

Gene Wiki entry for EDARADD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EDARADD gene promoter:
         AhR   SRY   FOXF2   AML1a   Sox9   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EDARADD promoter sequence
   Search SABiosciences Chromatin IP Primers for EDARADD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EDARADD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.3   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42.3

EDARADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDARADD gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P236511:  view genomic region     (about GC identifiers)

Start:
236,511,562 bp from pter      End:
236,648,214 bp from pter
Size:
136,653 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EDAD_HUMAN, Q8WWZ3 (See protein sequence)
Recommended Name: Ectodysplasin-A receptor-associated adapter protein  
Size: 215 amino acids; 24802 Da
Subunit: Self-associates and binds EDAR, TRAF1, TRAF2 and TRAF3
Subcellular location: Cytoplasm (Probable)
Secondary accessions: A2VCK5 A8K7B5 B1AL54 B9ZVW5 Q5VYJ7
Alternative splicing: 2 isoforms:  Q8WWZ3-1   Q8WWZ3-2   

Explore the universe of human proteins at neXtProt for EDARADD: NX_Q8WWZ3

Explore proteomics data for EDARADD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWZ3

  • EDARADD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EDARADD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_542776.1  NP_665860.2  

    ENSEMBL proteins: 
     ENSP00000405815   ENSP00000335076   ENSP00000352320  

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    Novus Biologicals EDARADD Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for EDARADD 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    EDARADD for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for EDARADD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry Q8WWZ3

    ProtoNet protein and cluster: Q8WWZ3

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: EDAD_HUMAN, Q8WWZ3
    Similarity: Contains 1 death domain


    EDARADD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EDAD_HUMAN, Q8WWZ3
    Function: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway
    during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    EDARADD for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Edaradd):
     behavior/neurological  craniofacial  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging 
     nervous system  pigmentation  reproductive system  respiratory system  vision/eye 

    EDARADD for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EDARADD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EDARADD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EDARADD 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidEDARADD 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDARADD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EDARADD

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for EDARADD (Q8WWZ33 ENSP000003350764) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EDARQ9UNE03, ENSP000002584434I2D: score=2 STRING: ENSP00000258443
    TRAF2Q129333, ENSP000002476684I2D: score=2 STRING: ENSP00000247668
    UVRAGQ9P2Y53, ENSP000003484554I2D: score=1 STRING: ENSP00000348455
    ATG5Q9H1Y03I2D: score=1 
    PIK3CGP487363I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0007165signal transduction IEA--
    GO:0030154cell differentiation IEA--
    GO:0042475odontogenesis of dentin-containing tooth IEA--
    GO:0061153trachea gland development IEA--

    EDARADD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EDARADD (EDAD)

    Search CenterWatch for drugs/clinical trials and news about EDARADD / EDAD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EDARADD gene (2 alternative transcripts): 
    NM_080738.3  NM_145861.2  

    Unigene Cluster for EDARADD:

    EDAR-associated death domain
    Hs.352224  [show with all ESTs]
    Unigene Representative Sequence: NM_080738
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439430 ENST00000334232 ENST00000359362(uc001hxu.1 uc001hxv.1)

    miRNA
    Products:
         
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate EDARADD (see all 26):
    hsa-miR-4291 hsa-miR-576-3p hsa-miR-34b* hsa-miR-328 hsa-miR-376b hsa-miR-2110 hsa-let-7a-2* hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidEDARADD 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EDARADD
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EDARADD
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EDARADD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EDARADD

    Additional mRNA sequence: 

    AK096339.1 AK290862.1 AK291930.1 AK314634.1 AY028913.1 AY028914.1 AY071862.1 BC006533.2 
    BC046928.1 BC114557.1 BC114560.1 BC128082.1 

    24/30 DOTS entries (see all 30):

    DT.40269519  DT.100044212  DT.100734628  DT.100662717  DT.100734673  DT.100734719  DT.92472726  DT.95167955 
    DT.121397993  DT.92386651  DT.92393969  DT.92472596  DT.95167907  DT.95167954  DT.97857337  DT.99990205 
    DT.100060472  DT.100642965  DT.100734605  DT.100734610  DT.100734614  DT.100734633  DT.100734682  DT.100734717 

    24/37 AceView cDNA sequences (see all 37):

    NM_080738 BQ436003 BX109179 AY071862 CA841301 BG679812 AI140628 AL705374 
    NM_145861 BQ631337 BG260205 CB123098 AI096404 AK096339 AY028913 AW245420 
    BG120587 BE904884 BE294841 BC046928 AY028914 BC006533 AW245779 CD516461 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EDARADD expression in normal human tissues (normalized intensities)      EDARADD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTCATC
    EDARADD Expression
    About this image


    EDARADD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             Secondary Enamel Knot Cells Enamel Knot
             visceral organ/oral region/upper jaw   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/naris   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Hair (Integumentary System)
             Primary Hair Placode Cells Hair Follicle
     
     Kidney (Urinary System)
             Metanephros

    See EDARADD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EDARADD

    SOURCE GeneReport for Unigene cluster: Hs.352224

    UniProtKB/Swiss-Prot: EDAD_HUMAN, Q8WWZ3
    Tissue specificity: Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus,
    prostate and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EDARADD gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Edaradd1 , 5 EDAR (ectodysplasin-A receptor)-associated death domain1, 5 82.06(n)1
    80.71(a)1
      13 (4.77 cM)5
    1712111  NM_133643.41  NP_598398.31 
     124712095 
    chicken
    (Gallus gallus)
    Aves EDARADD1 EDAR-associated death domain 70.65(n)
    66.3(a)
      497625  NM_001012405.2  NP_001012405.2 
    lizard
    (Anolis carolinensis)
    Reptilia EDARADD6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    1(219000268-219019479)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5667611 ectodysplasin-A receptor-associated adapter protein-like 55.81(n)
    51.69(a)
      566761  XM_690046.4  XP_695138.4 


    ENSEMBL Gene Tree for EDARADD (if available)
    TreeFam Gene Tree for EDARADD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EDARADD gene
    3 SIMAP similar genes for EDARADD using alignment to 4 protein entries:     EDAD_HUMAN (see all proteins):
    ENO1    ENO3    ENO2

    EDARADD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2318 SNPs in EDARADD are shown (see all 2318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0134824
    Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD11B)4--see VAR_0134822 E K mis40--------
    VAR_0545104
    Ectodermal dysplasia 11A, hypohidrotic/hair/nail type, autosomal dominant (ECTD11A)4--see VAR_0545102 L R mis40--------
    VAR_0648354
    Ectodermal dysplasia 11A, hypohidrotic/hair/nail type, autosomal dominant (ECTD11A)4--see VAR_0648352 D Y mis40--------
    rs743153091,2
    Cpathogenic1243447944(+) ATGACA/GAATTG 4 K E mis10--------
    rs787195081,2
    --207030121(+) TTCTTC/TTTTCT 2 -- int10--------
    rs24830671,2
    C--207046542(+) TGTAAT/ATTTTT 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1999403971,2
    --207046547(+) TTTTT-/TTAA  
            
    TTTAT
    2 -- int10--------
    rs1852377201,2
    --207046548(+) TTTTTA/TAATTT 2 -- int10--------
    rs1467819011,2
    C--207046568(+) ATTTT-/ATTTTA
            
    TTTTT
    2 -- int10--------
    rs715599561,2
    C--207046573(+) ATTTT-/A/TTTTTT 2 -- int11NA 2

    HapMap Linkage Disequilibrium report for EDARADD (236511562 - 236648214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for EDARADD (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725429CNV Deletion23290073
    esv2725418CNV Deletion23290073
    esv2666021CNV Deletion23128226
    dgv104e199CNV Deletion23128226
    nsv820827CNV Deletion20802225
    nsv159414CNV Loss16902084
    esv5800CNV Loss19470904
    dgv551n71CNV Gain21882294
    nsv516855CNV Gain19592680
    esv28853CNV Gain19812545


    Human Gene Mutation Database (HGMD): EDARADD
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606603   
    OMIM disorders: 224900  129490  
    UniProtKB/Swiss-Prot: EDAD_HUMAN, Q8WWZ3
  • Ectodermal dysplasia 11A, hypohidrotic/hair/nail type, autosomal dominant (ECTD11A) [MIM:614940]: A form
    of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal
    structures. It is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and
    hypohidrosis due to the absence of sweat glands. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD11B) [MIM:614941]: A
    disorder due to abnormal development of two or more ectodermal structures, and characterized by sparse hair
    (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat
    glands. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 11 diseases for EDARADD:    About MalaCards
    ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive    ectodermal dysplasia 11a, hypohidrotic/hair/nail type, autosomal dominant    hypohidrotic ectodermal dysplasia, autosomal    hypohidrotic ectodermal dysplasia
    anodontia    hypohidrosis    ectodermal dysplasia    clouston syndrome
    tooth agenesis    hypotrichosis    prostatitis

    4 diseases from the University of Copenhagen DISEASES database for EDARADD:
    Hypohidrotic ectodermal dysplasia     Hypohidrosis     Tooth agenesis     Clouston syndrome

    EDARADD for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for EDARADD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ectodermal dysplasia, hypohidrotic 95 5 20477971 (2), 17354266 (1), 20222921 (1), 19504606 (1)
    necrosis 20.9 2 15973734 (1), 20477971 (1)
    tumors 0 2 15973734 (1), 20477971 (1)

    GeneTests: EDARADD
    GeneReviews: EDARADD

    Export disorders for EDARADD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EDARADD gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with EDARADD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene defect in ectodermal dysplasia implicates a DEATH domain adapter in development. (PubMed id 11780064)1, 2, 3 Headon D.J.... Overbeek P.A. (2001)
    2. Mutations in EDARADD account for a small proportion o f hypohidrotic ectodermal dysplasia cases. (PubMed id 20222921)1, 2, 9 Chassaing N....Calvas P. (2010)
    3. Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. (PubMed id 20979233)1, 2 Cluzeau C.... Smahi A. (2011)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification of a novel DEATH domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice. (PubMed id 11882293)1, 2 Yan M....Dixit V.M. (2002)
    7. Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus. (PubMed id 17354266)2, 9 Bal E.... Smahi A. (2007)
    8. TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd. (PubMed id 16251197)1, 9 Morlon A....Smahi A. (2005)
    9. A case-control study of the association between tooth- development gene polymorphisms and non-syndromic hypodontia in the Chinese Han p opulation. (PubMed id 22984994)1 Liu H....Feng H. (2012)
    10. Isolated oligodontia associated with mutations in EDA RADD, AXIN2, MSX1, and PAX9 genes. (PubMed id 21626677)1 Bergendal B....Dahl N. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 128178 HGNC: 14341 AceView: EDARADD Ensembl:ENSG00000186197 euGenes: HUgn128178
    ECgene: EDARADD H-InvDB: EDARADD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EDARADD Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EDARADD

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EDARADD gene:
    Search GeneIP for patents involving EDARADD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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