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EDAR Gene

protein-coding GIFtS: 57

GC02M108969

ectodysplasin A receptor
(Previous names: ectodysplasin 1, anhidrotic receptor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ED3, DL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DL ^², ³, ⁵
ED1R ^¹, ²
ED3 ^², ⁵
ED5 ^¹, ²
EDA-A1R ^²
EDA1R ^¹, ²
EDA3 ^¹, ², ⁵
Edar ^¹
FLJ94390 ^²
HRM1 ^², ⁵

Descriptions
Anhidrotic ectodysplasin receptor 1 ^³
Downless homolog ^³
EDA-A1 receptor ^³
Ectodermal dysplasia receptor ^³
Ectodysplasin-A receptor ^³
downless, mouse, homolog of ^²
ectodysplasin 1, anhidrotic receptor ^¹, ²
ectodysplasin A receptor ^²

External Ids
HGNC: 2895¹
Entrez Gene: 10913²
UniProtKB: Q9UNE0³
Ensembl: ENSG00000135960⁷

Search outside databases for aliases for EDAR gene

Previous GC identifers: GC02M107416 GC02M107989 GC02M109115 GC02M109132

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EDAR:

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane

protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear

factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the

development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in

autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq]

UniProtKB/Swiss-Prot: EDAR_HUMAN, Q9UNE0

Function: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of

NF-kappa-B and JNK. May promote caspase-independent cell death

Gene Wiki entry for EDAR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EDAR gene

Entrez Gene cytogenetic band: 2q11-q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13

EDAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M108969: (about GC identifiers)

Start:	108,877,359 bp from pter
End:	108,972,260 bp from pter
Size:	94,902 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022171.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EDAR_HUMAN, Q9UNE0 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member EDAR precursor

Size: 448 amino acids; 48582 Da

Subunit: Binds to EDARADD. Associates with TRAF1, TRAF2, TRAF3 and NIK

Subcellular location: Membrane; Single-pass type I membrane protein (Probable)

Developmental stage: Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal

skin 11 and 15 weeks after gestation

Secondary accessions: Q52LL5 Q9UND9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_071731.1

ENSEMBL proteins:

ENSP00000386371 ENSP00000365839 ENSP00000258443

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for EDAR
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EDAR)
	Human Recombinant Proteins from Abnova (EDAR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	NAS	10431241
GO:0045177	apical part of cell	IEA	--

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Antibodies for EDAR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EDAR
	R&D Systems Antibodies for EDAR
	Antibodies from Abcam (EDAR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EDAR)
	Novus Biologicals Antibodies for EDAR

Assays for EDAR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UNE0

ProtoNet protein and cluster: Q9UNE0

2 Blocks protein families:

IPB000488 Death domain

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: EDAR_HUMAN, Q9UNE0

Similarity: Contains 1 death domain

Similarity: Contains 3 TNFR-Cys repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDAR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDAR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022336

Applied Biosystems Silencer® siRNAs for EDAR

Sigma-Aldrich siRNA for EDAR

Sigma-Aldrich shRNA for EDAR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_022336
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022336
untagged cDNA clone in CMV expression vector: NM_022336

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022336

UniProtKB/Swiss-Prot: EDAR_HUMAN, Q9UNE0

Function: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of

NF-kappa-B and JNK. May promote caspase-independent cell death

6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Edar):

cellular	craniofacial	lethality-postnatal	limbs/digits/tail	skin/coat/nails
touch/vibrissae

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	NAS	10431241
GO:0005515	protein binding	IPI	11035039

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for EDAR

5/31 Interacting proteins for EDAR (ENSP00000365839³ Q9UNE0¹) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF3	Q13114¹	STRING (score=.812) EBI-529289, EBI-357631
EDA	Q92838¹	EBI-529289, EBI-529425
MAP3K14	Q99558¹	EBI-529289, EBI-358011
Traf1 Traf1 (xeno)	P39428¹	EBI-529289, EBI-520123
Traf2 Traf2 (xeno)	P39429¹	EBI-529289, EBI-520016

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001942	hair follicle development	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007431	salivary gland development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EDAR

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDAR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDAR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022336

Sigma-Aldrich siRNA for EDAR

Sigma-Aldrich shRNA for EDAR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_022336

REFSEQ mRNAs for EDAR gene:

NM_022336.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_022336

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022336
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022336
                                 untagged cDNA clone in CMV expression vector: NM_022336

Additional cDNA sequence:

AF130988.1 AK296936.1 AK313781.1 BC093870.1 BC093872.1 CR749352.1

1 DOTS entry:

DT.402912

12 AceView cDNA sequences:

AI888259 AI017384 W73914 AF130988 AA588273 AI341547 CR749352 AW751561

W77977 NM_022336 AI659436 AA478934

highest scoring ESTs for EDAR:

AF130988 AI659436 AA478934 AA588273 AI017384 AI341547 AI888259 AU185236 AW751561 BX112904

Unigene Cluster for EDAR:

Ectodysplasin A receptor

Hs.171971 [show with all ESTs]

Unigene Representative Sequence: CR749352

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000409271 ENST00000376651 ENST00000258443

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EDAR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EDAR

¹ / ² / ³

3 probe-sets matching EDAR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47323_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI659436	0.80	1.00	0.91	1
220048_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022336	0.60	1.00	0.82	1
220048_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.171971
UniProtKB/Swiss-Prot: EDAR_HUMAN, Q9UNE0
Tissue specificity: Detected in fetal kidney, lung, skin and cultured neonatal epidermal
keratinocytes. Not detected in lymphoblast and fibroblast cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EDAR gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EDAR¹	--	ectodysplasin A receptor	88.67(n) 93.06(a)	481305 XM_538426.2 XP_538426.2
chimpanzee (Pan troglodytes)	EDAR¹	--	ectodysplasin A receptor	99.63(n) 100(a)	735810 XM_001139583.1 XP_001139583.1
cow (Bos taurus)	EDAR¹	--	similar to ectodysplasin A receptor	84.57(n) 86.98(a)	613947 XM_865192.2 XP_870285.2
rat (Rattus norvegicus)	Edar¹	--	ectodysplasin-A receptor	85.49(n) 91.29(a)	365581 XM_345109.3 XP_345110.3
mouse (Mus musculus)	Edar^{1, 5}	10 (29.00 cM)⁵	ectodysplasin-A receptor^{1, 5}	86.46(n)¹ 91.52(a)¹	13608¹ NM_010100.2¹ NP_034230.1¹ AC078930⁵ AF160502⁵ (see all 8)

About this table Species with no ortholog for EDAR

ENSEMBL Gene Tree for EDAR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EDAR gene

TNFRSF19² EDA2R²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: EDAR_HUMAN, Q9UNE0

Polymorphism: Genetic variation in EDAR is associated with hair morphology type 1 (HRM1)

[MIM:612630]; also called variation in hair thickness. Besides skin color and facial features,

hair morphology is one of the most distinctive traits among human populations, and classical

classification of human population is based on such visible traits

10/581 NCBI SNPs in EDAR are shown (see all 581 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 230)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3749096^1,2	A,C,F,H	108878860(+)	`TTGAAG/ATGAAA`	1	--	ut3¹ ese³		8		EA EU WA NA	2030
	rs3749110^1,2	A,C,F,H	108972199(-)	`GTGCCT/CGCTCC`	1	--	ut5¹ ese³		12		EA EU WA NA	2446
	rs3827760^1,2	A,C,F,H	108880033(-)	`GGCTGC/TTGTGA`	1	V/A	mis¹ ese³		12		EA NA EU WA	2466
	rs7607563^1,2	C,F,H	108879753(+)	`GTTGGA/CTCCTT`	1	--	ut3¹		4		EU EA WA	400
	rs13001699^1,2	C,F,H	108878666(+)	`CGACAC/TCAAGC`	1	--	ut3¹		6		NA EA WA	438
	rs3749097^1,2	C,F,H	108879038(+)	`ATCCAA/GTTGCT`	1	--	ut3¹		10		EA NA EU WA	2222
	rs6749207^1,2	C,F,H	108973688(+)	`GGTTGC/TCTACC`	1	--	ng3¹		4		EU EA WA	396
	rs17037035^1,2	F,H	108877345(+)	`CATTAC/TGGTAG`	1	--	ng5¹		7		NA EU EA WA	556
--	rs1478517^1,2	A,C	108877369(+)	`TTAATA/GTGTTT`	1	--	ut3¹		0	--	--	--	--
	rs10206737^1,2	F,H	108878796(+)	`TATGCG/ATGGCT`	1	--	ut3¹ ese³		4		EU EA WA	394

About this table

HapMap Linkage Disequilibrium images for EDAR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604095 disorders: 129490 224900 612630

UniProtKB/Swiss-Prot: EDAR_HUMAN, Q9UNE0

Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also

known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a

heterogeneous group of disorders due to abnormal development of two or more ectodermal structures.

EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and

the inability to sweat due to the absence of sweat glands

Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3) [MIM:129490]; also

known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal

dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due

to the absence of sweat glands

4 Novoseek disease relationships for EDAR gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ectodermal dysplasia, hypohidrotic	95.85	13	11374782 (1), 11570810 (1), 16251197 (1), 17501952 (1) (see all 12)
ectodermal dysplasia	91.60	13	15280356 (2), 11035039 (2), 12270937 (2), 11374782 (1) (see all 9)
necrosis	40.29	13	11570810 (1), 17371397 (1), 14699584 (1), 15280356 (1) (see all 9)
tumors	11.45	13	11570810 (1), 17371397 (1), 14699584 (1), 15280356 (1) (see all 9)

About this table

GeneTests: EDAR

Hypohidrotic Ectodermal Dysplasia

Human Gene Mutation Database: EDAR

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/54 PubMed articles for EDAR gene (see all 54 ):

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia. (PubMed id 10431241)^{1, 2, 3, 4} Monreal A.W....Zonana J. (1999)
The ectodermal dysplasia receptor activates the nuclear factor- kappaB, JNK, and cell death pathways and binds to ectodysplasin A. (PubMed id 11035039)^{1, 3, 4} Kumar A.... Chaudhary P.M. (2001)
Mutation screening of the Ectodysplasin-A receptor gene EDAR in hypohidrotic ectodermal dysplasia. (PubMed id 18231121)^{1, 3, 4} van der Hout A.H....van Essen A.J. (2008)
Mutations in EDAR account for one-quarter of non-ED1-related hypohidrotic ectodermal dysplasia. (PubMed id 16435307)^{1, 3, 4} Chassaing N....Vincent M.C. (2006)
A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness. (PubMed id 18065779)^{1, 3, 4} Fujimoto A....Tokunaga K. (2008)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. (PubMed id 11039935)^{3, 4} Yan M.... Dixit V.M. (2000)
Autosomal dominant hypohidrotic ectodermal dysplasia in a large family. (PubMed id 9375732)^{2, 3} Aswegan A.L....Williams M.S. (1997)
Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form. (PubMed id 18561327)^{1, 3} Mou C....Headon D.J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10913	HGNC: 2895	AceView: EDAR	Ensembl:ENSG00000135960	euGenes: HUgn10913
ECgene: EDAR	H-InvDB: EDAR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=EDAR

Licensable Technologies for EDAR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EDAR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EDAR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EDAR		Antibodies for EDAR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EDAR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EDAR)
	Antibodies (EDAR)
	Chimera RNAi (EDAR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

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Search Tocris compounds for EDAR

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EDAR Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for EDAR

Summaries
for EDAR

Genomic Location
for EDAR

Proteins
for EDAR

Protein Domains/
Families
for EDAR

Gene Function
for EDAR

Pathways & Interactions
for EDAR

Drugs & Compounds
for EDAR

Transcripts
for EDAR

Expression
for EDAR

Orthologs
for EDAR

Paralogs
for EDAR

SNPs/Variants
for EDAR

Disorders & Mutations
for EDAR

Medical News
for EDAR

Publications
for EDAR

Search for EDAR

Genome Databases showing EDAR

Other Databases showing EDAR

Specialized Databases showing EDAR

Licensable Technologies
for EDAR

Services
for EDAR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EDAR Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor EDAR

Summariesfor EDAR

Genomic Locationfor EDAR

Proteinsfor EDAR

Protein Domains/Familiesfor EDAR

Gene Functionfor EDAR

Pathways & Interactionsfor EDAR

Drugs & Compoundsfor EDAR

Transcriptsfor EDAR

Expression for EDAR

Orthologsfor EDAR

Paralogsfor EDAR

SNPs/Variantsfor EDAR

Disorders & Mutationsfor EDAR

Medical Newsfor EDAR

Publicationsfor EDAR

Search for EDAR

Genome Databases showing EDAR

Other Databases showing EDAR

Specialized Databases showing EDAR

Licensable Technologiesfor EDAR

Servicesfor EDAR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EDAR

Summaries
for EDAR

Genomic Location
for EDAR

Proteins
for EDAR

Protein Domains/
Families
for EDAR

Gene Function
for EDAR

Pathways & Interactions
for EDAR

Drugs & Compounds
for EDAR

Transcripts
for EDAR

Expression
for EDAR

Orthologs
for EDAR

Paralogs
for EDAR

SNPs/Variants
for EDAR

Disorders & Mutations
for EDAR

Medical News
for EDAR

Publications
for EDAR

Licensable Technologies
for EDAR

Services
for EDAR