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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EDA2R Gene

protein-coding   GIFtS: 60
GCID: GC0XM065732

ectodysplasin A2 receptor

 Explore 7 diseases affiliated with
EDA2R via our new
 Human Malady Compendium 
Biological research products
for EDA2R
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ectodysplasin A2 Receptor1 2     EDA-A2 Receptor2 3
XEDAR1 2 3 5     X-Linked Ectodysplasin-A2 Receptor2 3
TNFRSF271 2 3     Tumor Necrosis Factor Receptor Superfamily Member 272
EDAA2R1 2 5     Tumor Necrosis Factor Receptor Superfamily Member XEDAR2
EDA-A2R1 2     EDAR25

External Ids:    HGNC: 177561   Entrez Gene: 604012   Ensembl: ENSG000001310807   OMIM: 3002765   UniProtKB: Q9HAV53   

Export aliases for EDA2R gene to outside databases

Previous GC identifers: GC0XM065598 GC0XM059642


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EDA2R:
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene.
Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein
encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the
TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane
domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this
gene.(provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: TNR27_HUMAN, Q9HAV5
Function: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK
pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6

Gene Wiki entry for EDA2R (Ectodysplasin A2 receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011669.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EDA2R gene promoter:
         FOXC1   SREBP-1a   AP-1   SREBP-1c   E47   C/EBPalpha   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EDA2R promoter sequence
   Search SABiosciences Chromatin IP Primers for EDA2R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EDA2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq12   Ensembl cytogenetic band:  Xq12   HGNC cytogenetic band: Xq11.1

EDA2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDA2R gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM065732:  view genomic region     (about GC identifiers)

Start:
65,815,479 bp from pter      End:
65,859,108 bp from pter
Size:
43,630 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR27_HUMAN, Q9HAV5 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 27  
Size: 297 amino acids; 32759 Da
Subunit: Associates with TRAF1, TRAF3 and TRAF6
Subcellular location: Membrane; Single-pass type III membrane protein
Secondary accessions: Q5VYX9 Q5VYY0 Q6UWM2 Q8IZA6
Alternative splicing: 3 isoforms:  Q9HAV5-1   Q9HAV5-2   Q9HAV5-3   

Explore the universe of human proteins at neXtProt for EDA2R: NX_Q9HAV5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HAV5

  • EDA2R Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186616.1  NP_001229239.1  NP_068555.1  

    ENSEMBL proteins: 
     ENSP00000363851   ENSP00000253392   ENSP00000379365   ENSP00000393935   ENSP00000402929  
     ENSP00000415242  

    Human Recombinant Protein Products: 
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    Novus Biologicals EDA2R Proteins
    Novus Biologicals EDA2R Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EDA2R

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--
    GO:0016021integral to membrane IC12270937


    EDA2R for ontologies           About GeneDecksing



    EDA2R Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    EDA2R for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022319 TNFR_27

    Graphical View of Domain Structure for InterPro Entry Q9HAV5

    ProtoNet protein and cluster: Q9HAV5

    1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR27_HUMAN, Q9HAV5
    Similarity: Contains 3 TNFR-Cys repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TNR27_HUMAN, Q9HAV5
    Function: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK
    pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EDA2R
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    hsa-miR-3926 hsa-miR-4251 hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidEDA2R 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDA2R

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA11039935
    GO:0005031tumor necrosis factor-activated receptor activity NAS11039935
    GO:0005515protein binding IPI11039935


    EDA2R for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for EDA2R:
     Decreased viability of wild-ty  Increased 8N DNA content  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Eda2rtm1Vmd for EDA2R
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Eda2r):
     normal 

    EDA2R for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.26
    2TRAF Pathway
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.08

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for EDA2R
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions



    1         Kegg Pathway  (Kegg details for EDA2R):
        Cytokine-cytokine receptor interaction


    EDA2R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EDA2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for EDA2R (Q9HAV53 ENSP000003638514) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147903, ENSP000003512734I2D: score=1 STRING: ENSP00000351273
    TRAF3Q131143, ENSP000003324684I2D: score=3 STRING: ENSP00000332468
    EDAQ928383, ENSP000003636804I2D: score=1 STRING: ENSP00000363680
    FADDQ131583, ENSP000003018384I2D: score=2 STRING: ENSP00000301838
    TRAF6Q9Y4K33I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development NAS11039935
    GO:0009790embryo development NAS12270937
    GO:0030154cell differentiation IEA--
    GO:0033209tumor necrosis factor-mediated signaling pathway NAS11039935
    GO:0046330positive regulation of JNK cascade IDA12270937


    EDA2R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EDA2R
    Search CenterWatch for drugs/clinical trials and news about EDA2R / TNR27 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EDA2R gene (5 alternative transcripts): 
    NM_001199687.2  NM_001242310.1  NM_021783.3  NM_001199688.1  NM_001199689.1  

    Unigene Cluster for EDA2R:

    Ectodysplasin A2 receptor
    Hs.302017  [show with all ESTs]
    Unigene Representative Sequence: NM_001199687
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374719(uc004dwt.2 uc004dwr.3 uc004dws.3 uc011mpb.2 uc011mpc.2 uc004dwq.3)
    ENST00000253392 ENST00000396050(uc022byh.1) ENST00000456230 ENST00000450752
    ENST00000451436

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EDA2R
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EDA2R

    Additional cDNA sequence: 

    AF298812.1 AK296264.1 AK299018.1 AK314881.1 AY152724.1 AY358735.1 AY358736.1 BC034919.1 

    3 DOTS entries:

    DT.40233794  DT.100021704  DT.102822312 

    24/33 AceView cDNA sequences (see all 33):

    BX104198 CB216003 BC034919 AI805813 NM_021783 AI185703 AX775690 AY152724 
    AY358736 AA329106 AX775694 BU689709 BX647039 AY358735 BP358500 BQ772070 
    AF298812 BX095818 BP362600 AX775692 BG257323 BF735341 BQ778317 AI813293 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EDA2R (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                                                  -     -                                             
    SP2:                                                  -                                                   
    SP3:        -                                                                                             
    SP4:        -                 -     -           -     -     -                                             
    SP5:                                            -     -     -                                             


    ECgene alternative splicing isoforms for EDA2R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EDA2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTAGATACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See EDA2R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EDA2R

    SOURCE GeneReport for Unigene cluster: Hs.302017
        SABiosciences Expression via Pathway-Focused PCR Arrays including EDA2R: 
              TNF Ligands & Receptors in human mouse rat
              Necrosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDA2R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EDA2R gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eda2r1 , 5 ectodysplasin A2 receptor1, 5 84.23(n)1
    80.74(a)1
      X (42.74 cM)5
    2455271  NM_175540.51  NP_780749.31 
     973338405 
    chicken
    (Gallus gallus)
    Aves EDA2R1 ectodysplasin A2 receptor 58.59(n)
    49.49(a)
      422166  NM_001083360.1  NP_001076829.1 
    lizard
    (Anolis carolinensis)
    Reptilia EDA2R6
    --
    39(a)
    1 ↔ 1
    AAWZ02038412(1497-4239)


    ENSEMBL Gene Tree for EDA2R (if available)
    TreeFam Gene Tree for EDA2R (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EDA2R gene
    TNFRSF192  EDAR2  
    1 SIMAP similar gene for EDA2R using alignment to 2 protein entries:     TNR27_HUMAN (see all proteins):
    TNFRSF19

    EDA2R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/540 NCBI SNPs in EDA2R are shown (see all 540    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs4136251,2
    H--65815013(-) AAGAGA/CCCACC 3 -- int1 ds50014Minor allele frequency- C:0.00NS EA 412
    rs1387131091,2
    --65815244(+) CACAAC/TAATTT 3 -- int1 ds50010--------
    rs133629591,2
    C,H--65815465(+) AGTAGA/GGGAAT 3 -- ds5001 int14Minor allele frequency- G:0.00NS EA 418
    rs1896339281,2
    --65815487(+) TTGGAC/TATATT 3 -- ut310--------
    rs14856821,2
    C,F,H,--65815591(-) ATAGAA/GATTTT 3 -- ut3123Minor allele frequency- G:0.67EA NA NS WA CSA 1981
    rs110939581,2
    C,F,A,H,--65815817(+) CCCAGA/GCTCCC 3 -- ut31 ese316Minor allele frequency- G:0.46NS EA NA CSA 1647
    rs1827618971,2
    --65815855(+) TGGAGA/GGAAAA 3 -- ut310--------
    rs1413957581,2
    --65816008(+) TATCAA/GGTGTA 3 -- ut310--------
    rs1873614051,2
    --65816377(+) ATTATG/TATTAT 3 -- ut310--------
    rs1918277531,2
    --65816438(+) GGCTTG/TAACCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EDA2R (65815479 - 65859108 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for EDA2R
         2 CNVs: 53017 34417
    Human Gene Mutation Database (HGMD): EDA2R

    Locus Specific Mutation Databases (LSDB): EDA2R

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    EDA2R for disorders           About GeneDecksing

    OMIM gene information: 300276    OMIM disorders: --

    7 diseases for EDA2R:    About MalaCards
    ectodermal dysplasia    hypohidrotic ectodermal dysplasia    androgenetic alopecia    alopecia
    osteosarcoma    rabies    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for EDA2R:
    Hypohidrotic ectodermal dysplasia     Alopecia

    3 Novoseek disease relationships for EDA2R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ectodermal dysplasia 88.2 5 15280356 (1), 19543321 (1), 12270937 (1), 17693991 (1) (see all 5)
    necrosis 40.5 7 15280356 (2), 15294294 (1), 12692542 (1), 12270937 (1) (see all 6)
    tumors 26.2 13 20145163 (5), 15280356 (2), 15294294 (1), 12692542 (1) (see all 7)

    Human Genome Epidemiology (HuGE) Navigator: EDA2R (2 documents)

    Export disorders for EDA2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EDA2R gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with EDA2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. (PubMed id 11039935)1, 2, 3, 9 Yan M.... Dixit V.M. (2000)
    2. Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. (PubMed id 12270937)1, 2, 9 Sinha S.K.... Chaudhary P.M. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. (PubMed id 19543321)1, 9 Tanikawa C....Matsuda K. (2009)
    6. Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism. (PubMed id 15280356)1, 9 Sinha S.K. and Chaudhary P.M. (2004)
    7. Recent positive selection of a human androgen recepto r/ectodysplasin A2 receptor haplotype and its relationship to male pattern bald ness. (PubMed id 19373488)1, 9 Hillmer A.M....NAPthen M.M. (2009)
    8. Repertoire of mouse ectodysplasin-A (EDA-A) isoforms. (PubMed id 16423472)1, 9 Hashimoto T....Schlessinger D. (2006)
    9. Investigation of the male pattern baldness major genet ic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss. (PubMed id 22309448)1 Redler S....Betz R.C. (2012)
    10. Analysis of genetic polymorphisms in skeletal Class I crowding. (PubMed id 21724072)1 Ting T.Y....Rabie A.B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60401 HGNC: 17756 AceView: EDA2R Ensembl:ENSG00000131080 euGenes: HUgn60401
    ECgene: EDA2R Kegg: 60401 H-InvDB: EDA2R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EDA2R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EDA2R Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EDA2R gene:
    Search GeneIP for patents involving EDA2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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