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Aliases for ECT2L Gene

Aliases for ECT2L Gene

  • Epithelial Cell Transforming 2 Like 2 3 5
  • Epithelial Cell Transforming Sequence 2 Oncogene-Like 2 3
  • Lung Specific F-Box And DH Domain Containing Protein 2 3
  • Lung-Specific F-Box And DH Domain-Containing Protein 3 4
  • Putative Guanine Nucleotide Exchange Factor LFDH 3 4
  • F-Box Protein 49 2 3
  • C6orf91 3 4
  • LFDH 3 4
  • Chromosome 6 Open Reading Frame 91 2
  • DJ509I19.2 3
  • DJ509I19.3 3
  • DJ509I19.5 3
  • ECT2-Like 3
  • ARHGEF32 3
  • FBXO49 3

External Ids for ECT2L Gene

Previous HGNC Symbols for ECT2L Gene

  • C6orf91

Previous GeneCards Identifiers for ECT2L Gene

  • GC00U914183
  • GC06U900635
  • GC06P139158
  • GC06P139117
  • GC06P136678

Summaries for ECT2L Gene

GeneCards Summary for ECT2L Gene

ECT2L (Epithelial Cell Transforming 2 Like) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is FBXO16.

UniProtKB/Swiss-Prot for ECT2L Gene

  • May act as a guanine nucleotide exchange factor (GEF).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ECT2L Gene

Genomics for ECT2L Gene

Regulatory Elements for ECT2L Gene

Promoters for ECT2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ECT2L on UCSC Golden Path with GeneCards custom track

Genomic Location for ECT2L Gene

Chromosome:
6
Start:
138,795,926 bp from pter
End:
138,904,070 bp from pter
Size:
108,145 bases
Orientation:
Plus strand

Genomic View for ECT2L Gene

Genes around ECT2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ECT2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ECT2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECT2L Gene

Proteins for ECT2L Gene

  • Protein details for ECT2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q008S8-ECT2L_HUMAN
    Recommended name:
    Epithelial cell-transforming sequence 2 oncogene-like
    Protein Accession:
    Q008S8
    Secondary Accessions:
    • B2RUV6
    • Q5JWK2
    • Q5JWK3
    • Q5JWK4

    Protein attributes for ECT2L Gene

    Size:
    904 amino acids
    Molecular mass:
    104880 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=ABI98401.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ECT2L Gene

Proteomics data for ECT2L Gene at MOPED

Post-translational modifications for ECT2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ECT2L Gene

No data available for DME Specific Peptides for ECT2L Gene

Domains & Families for ECT2L Gene

Protein Domains for ECT2L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ECT2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q008S8

UniProtKB/Swiss-Prot:

ECT2L_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with ECT2L: view

Function for ECT2L Gene

Molecular function for ECT2L Gene

UniProtKB/Swiss-Prot Function:
May act as a guanine nucleotide exchange factor (GEF).

Phenotypes for ECT2L Gene

GenomeRNAi human phenotypes for ECT2L:
genes like me logo Genes that share phenotypes with ECT2L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ECT2L Gene

Localization for ECT2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ECT2L Gene COMPARTMENTS Subcellular localization image for ECT2L gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ECT2L Gene

Pathways & Interactions for ECT2L Gene

SuperPathways for ECT2L Gene

No Data Available

Interacting Proteins for ECT2L Gene

Gene Ontology (GO) - Biological Process for ECT2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ECT2L: view

No data available for Pathways by source and SIGNOR curated interactions for ECT2L Gene

Drugs & Compounds for ECT2L Gene

(3) Drugs for ECT2L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ECT2L: view

Transcripts for ECT2L Gene

mRNA/cDNA for ECT2L Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ECT2L Gene

Epithelial cell transforming sequence 2 oncogene-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ECT2L Gene

No ASD Table

Relevant External Links for ECT2L Gene

GeneLoc Exon Structure for
ECT2L
ECgene alternative splicing isoforms for
ECT2L

Expression for ECT2L Gene

mRNA expression in normal human tissues for ECT2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ECT2L Gene

This gene is overexpressed in Lung (x4.2), Heart - Left Ventricle (x4.1), and Cervix - Endocervix (x4.1).

Protein differential expression in normal tissues from HIPED for ECT2L Gene

This gene is overexpressed in Lung (43.2), Platelet (13.6), and Fetal Liver (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ECT2L Gene



SOURCE GeneReport for Unigene cluster for ECT2L Gene Hs.660603

genes like me logo Genes that share expression patterns with ECT2L: view

Protein tissue co-expression partners for ECT2L Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ECT2L Gene

Orthologs for ECT2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ECT2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ECT2L 35
  • 99.71 (n)
  • 99.56 (a)
ECT2L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ECT2L 36
  • 87 (a)
OneToOne
ECT2L 35
  • 88.13 (n)
  • 86.73 (a)
dog
(Canis familiaris)
Mammalia ECT2L 35
  • 87.66 (n)
  • 83.91 (a)
mouse
(Mus musculus)
Mammalia Ect2l 16
Ect2l 35
  • 80.51 (n)
  • 78.51 (a)
Ect2l 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ECT2L 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ECT2L 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ect2l 35
  • 80.27 (n)
  • 76.57 (a)
lizard
(Anolis carolinensis)
Reptilia ECT2L 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ECT2L 36
  • 46 (a)
OneToOne
ect2l 35
  • 54.15 (n)
  • 47.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for ECT2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ECT2L Gene

ENSEMBL:
Gene Tree for ECT2L (if available)
TreeFam:
Gene Tree for ECT2L (if available)

Paralogs for ECT2L Gene

Paralogs for ECT2L Gene

(1) SIMAP similar genes for ECT2L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ECT2L: view

Variants for ECT2L Gene

Sequence variations from dbSNP and Humsavar for ECT2L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1529151 - 138,876,472(+) TTCAG(A/G)AAAGA reference, missense
rs11968285 - 138,881,071(+) ATGTC(A/G)CACCA reference, missense
rs12198781 - 138,865,153(+) CTGCA(G/T)AAGAG reference, missense
rs733973 -- 138,812,234(+) aactg(G/T)gagaa intron-variant, upstream-variant-2KB
rs733974 -- 138,812,245(+) aataa(A/G)tttct intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ECT2L Gene

Variant ID Type Subtype PubMed ID
nsv5500 CNV Insertion 18451855
esv2665720 CNV Deletion 23128226

Variation tolerance for ECT2L Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.14; 84.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ECT2L Gene

HapMap Linkage Disequilibrium report
ECT2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECT2L Gene

Disorders for ECT2L Gene

Relevant External Links for ECT2L

Genetic Association Database (GAD)
ECT2L
Human Genome Epidemiology (HuGE) Navigator
ECT2L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ECT2L

No disorders were found for ECT2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ECT2L Gene

Publications for ECT2L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ECT2L Gene

Sources for ECT2L Gene

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