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Aliases & Descriptions for ECSIT
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Descriptions ECSIT homolog (Drosophila) 2 Protein SITPEC 3 evolutionarily conserved signaling intermediate in Toll pathway 2 likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved 2 signaling intermediate in Toll pathway evolutionarily conserved ortholog 2 signaling intermediate in Toll pathway, evolutionarily conserved 2
Search outside databases for aliases for ECSIT gene
Summaries for ECSIT (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: ECSIT_HUMAN, Q9BQ95 Function : Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved inthe activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved inthe BMP signaling pathway. Required for normal embryonic development (By similarity). Required forefficient assembly of mitochondrial NADH:ubiquinone oxidoreductase
Genomic Location for ECSIT
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2 ECSIT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M011478:
(about GC identifiers )
Start:
11,477,744 bp from pter
End:
11,500,952 bp from pter
Size:
23,209 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000019.8 NT_011295.10 Proteins for ECSIT
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ECSIT_HUMAN, Q9BQ95 (See
protein sequence )Recommended Name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialprecursor Size : 431 amino acids; 49148 Da
Subunit : Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (Bysimilarity). Interacts with NDUFAF1
Subcellular location : Cytoplasm. Nucleus. Mitochondrion
Secondary accessions : Q96HQ7 Q9NYI1Alternative splicing : 2 isoforms : Q9BQ95-1 Q9BQ95-2
REFSEQ proteins (3 alternative transcripts):
NP_001135936.1 NP_001135937.1 NP_057665.2 ENSEMBL proteins: ENSP00000270517 ENSP00000252440 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ECSIT: Assays for ECSIT:
Protein
Domains/ Families for ECSIT(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9BQ95 ProtoNet protein and cluster: Q9BQ95
UniProtKB/Swiss-Prot: ECSIT_HUMAN, Q9BQ95 Similarity : Belongs to the ECSIT family
Gene Function for ECSIT
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_016581 Applied Biosystems Silencer ® siRNAs for ECSIT Sigma-Aldrich siRNA for ECSIT Sigma-Aldrich shRNA for ECSIT Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142464                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142464                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001142464  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016581 UniProtKB/Swiss-Prot: ECSIT_HUMAN, Q9BQ95 Function : Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved inthe activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved inthe BMP signaling pathway. Required for normal embryonic development (By similarity). Required forefficient assembly of mitochondrial NADH:ubiquinone oxidoreductase
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ecsit) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for ECSIT
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ECSIT (Your Favorite Gene powered by Ingenuity) 5/6 Interacting proteins for ECSIT (ENSP00000270517 3 ) via UniProtKB, MINT, and/or STRING (see all 6
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for ECSIT (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ECSIT
Transcripts for ECSIT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_016581 Sigma-Aldrich siRNA for ECSIT Sigma-Aldrich shRNA for ECSIT Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001142464 NM_001142465 NM_016581
REFSEQ mRNAs for ECSIT gene (3 alternative transcripts): NM_001142464.1 NM_001142465.1 NM_016581.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001142464 NM_001142465 NM_016581
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142464                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142464                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001142464  
Additional cDNA sequence: AF243044.1 AK131241.1 AK314905.1 BC000193.1 BC005119.1 BC008279.1 CR457204.1 CR592177.1 CR594733.1 CR596229.1 CR599347.1 CR602583.1 CR604665.1 CR605421.1 CR608548.1 CR610188.1 CR613109.1 CR614297.1 CR615551.1 CR616028.1 CR616122.1 CR616948.1 CR618925.1 CR621338.1 CR624195.1 CR625388.1
19 DOTS entries : DT.65288585 DT.100883844 DT.100883840 DT.91768315 DT.40132921 DT.100838513 DT.95369914 DT.102828211 DT.121505203 DT.121505216 DT.95369907 DT.95369917 DT.100758182 DT.100768066 DT.100883829 DT.121505201 DT.121505227 DT.95125006 DT.101980316
24/409 AceView cDNA sequences (see all 409
):AW025376 CB270007 BC016816 BI764621 BE295484 CD636537 BI771251 AI919416 BU151303 CR599347 BQ276345 BC005119 BU731526 BC008279 BM662700 BM832426 AA027849 BF513504 CD743136 BQ957282 BP429879 BI819267 CR608548 CR616948
highest scoring ESTs for ECSIT :AI922726 AA424927 AA442559 AW245212 BC000193 BC005119 BC008279 BE254899 BE384996 BE408896
Unigene Cluster for ECSIT: ECSIT homolog (Drosophila) Hs.515146 [show with all ESTs ] Unigene Representative Sequence: AK131241 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ECSIT (see all 11
) ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c SP1 :           -   -   -   -                 -               SP2 :           -   -   -   -                 -     -           SP3 :                                               SP4 :               -   -                 -               SP5 :                                 -              
About this scheme ECgene alternative splicing isoforms for ECSIT 2 Ensembl transcripts including schematic representations : ENST00000270517
ENST00000252440
Expression for ECSIT
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ECSIT expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ECSIT 1 / 2 / 3
3 probe-sets matching ECSIT gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGATGCCCTTSOURCE GeneReport for Unigene cluster: Hs.515146
Orthologs for ECSIT
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ECSIT gene from 5/10 species (see all 10
)
About this table Species with no ortholog for ECSIT ENSEMBL Gene Tree for ECSIT Paralogs for ECSIT (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for ECSIT (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ECSIT (up to first 250kb)
Disorders & Mutations for ECSIT
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608388
Medical News for ECSIT (Possibly Related Articles in
Doctor's Guide )
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Publications for ECSIT (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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8 PubMed articles for ECSIT gene :
Search for ECSIT
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ECSIT
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ECSIT
(According to HUGE )
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Specialized Databases showing ECSIT (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ECSIT (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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