Aliases for ECSCR Gene
External Ids for ECSCR Gene
Previous GeneCards Identifiers for ECSCR Gene
The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for ECSCR Gene
ECSCR (Endothelial Cell Surface Expressed Chemotaxis And Apoptosis Regulator) is a Protein Coding gene. An important paralog of this gene is ENSG00000279686.
UniProtKB/Swiss-Prot for ECSCR Gene
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.