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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ECM2 Gene

protein-coding   GIFtS: 50
GCID: GC09M095257

Extracellular Matrix Protein 2, Female Organ And Adipocyte...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Extracellular Matrix Protein 2, Female Organ And Adipocyte Specific1 2
Matrix Glycoprotein SC1/ECM21 2 3
Extracellular Matrix Protein 22

External Ids:    HGNC: 31541   Entrez Gene: 18422   Ensembl: ENSG000001068237   OMIM: 6034795   UniProtKB: O947693   

Export aliases for ECM2 gene to outside databases

Previous GC identifers: GC09M086084 GC09M086985 GC09M088556 GC09M090599 GC09M090597 GC09M092335 GC09M094297 GC09M064935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ECM2 Gene:
ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known
extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2010)

GeneCards Summary for ECM2 Gene: 
ECM2 (extracellular matrix protein 2, female organ and adipocyte specific) is a protein-coding gene. Diseases associated with ECM2 include leiomyoma, and among its related super-pathways are FAK1 Signaling and MAPK Signaling. GO annotations related to this gene include collagen V binding and heparin binding. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769
Function: Promotes matrix assembly and cell adhesiveness (By similarity)

Gene Wiki entry for ECM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ECM2 gene promoter:
         TBP   ISGF-3   AML1a   HSF1 (long)   Nkx2-5   S8   E2F-1   E2F   TFIID   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidECM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ECM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ECM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.3

ECM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ECM2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095257:  view genomic region     (about GC identifiers)

Start:
95,255,829 bp from pter      End:
95,298,937 bp from pter
Size:
43,109 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769 (See protein sequence)
Recommended Name: Extracellular matrix protein 2 precursor  
Size: 699 amino acids; 79789 Da
Subunit: Interacts with numerous extracellular matrix proteins (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence caution: Sequence=CAD97940.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R730 E2PU11 Q5T9F2 Q7Z3D0
Alternative splicing: 2 isoforms:  O94769-1   O94769-2   

Explore the universe of human proteins at neXtProt for ECM2: NX_O94769

Explore proteomics data for ECM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94769

  • ECM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ECM2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001184224.1  NP_001184225.1  NP_001384.1  

    ENSEMBL proteins: 
     ENSP00000344758   ENSP00000364690   ENSP00000378905   ENSP00000393971  

    Human Recombinant Protein Products for ECM2: 
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    OriGene Protein Over-expression Lysate for ECM2
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    Novus Biologicals ECM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ECM2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix TAS9790758
    GO:0005614interstitial matrix IEA--
    GO:0031012extracellular matrix ----

    ECM2 for ontologies           About GeneDecksing



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    Assay Products for ECM2: 
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    Cloud-Clone Corp. ELISAs for ECM2 
    Cloud-Clone Corp. CLIAs for ECM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry O94769

    ProtoNet protein and cluster: O94769

    1 Blocks protein domain: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily
    Similarity: Contains 13 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain
    Similarity: Contains 1 VWFC domain


    ECM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ECM2_HUMAN, O94769
    Function: Promotes matrix assembly and cell adhesiveness (By similarity)

         Genatlas biochemistry entry for ECM2:
    extracellular matrix 2,predominantly expressed in adipose tissue,mammary gland,ovary and uterus

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005178integrin binding TAS9790758
    GO:0005515protein binding ----
    GO:0005518collagen binding ----
    GO:0008201heparin binding IEA--
         
    ECM2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ECM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ECM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ECM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ECM2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ECM2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ECM2:
    hsa-miR-3152-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-29a* hsa-miR-3143 hsa-miR-518f* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidECM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ECM2
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ECM2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ECM2 (see all 11)
    OriGene ORF clones in mouse, rat for ECM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ECM2 (NM_001197296)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ECM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECM2
    Sirion Biotech Customized lentivirus for stable overexpression of ECM2 
                         Customized lentivirus expression plasmids for stable overexpression of ECM2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ECM2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3PTEN Pathway
    PTEN Pathway0.56
    Phospholipase-C Pathway0.56

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ECM2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ECM2

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006963positive regulation of antibacterial peptide biosynthetic process IEA--
    GO:0007160cell-matrix adhesion TAS9790758
    GO:0007352zygotic specification of dorsal/ventral axis IEA--
    GO:0008063Toll signaling pathway IEA--
    GO:0009620response to fungus IEA--

    ECM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ECM2

    Search CenterWatch for drugs/clinical trials and news about ECM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ECM2 gene (3 alternative transcripts): 
    NM_001197295.1  NM_001197296.1  NM_001393.3  

    Unigene Cluster for ECM2:

    Extracellular matrix protein 2, female organ and adipocyte specific
    Hs.117060  [show with all ESTs]
    Unigene Representative Sequence: NM_001393
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344604(uc010mqz.2 uc004asf.4 uc011lty.2 uc004asg.3)
    ENST00000375540(uc004asi.3) ENST00000395534(uc011ltz.1) ENST00000444490

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ECM2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ECM2:
    hsa-miR-3152-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-29a* hsa-miR-3143 hsa-miR-518f* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidECM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ECM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ECM2
    Clone
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    OriGene clones in human, mouse for ECM2 (see all 11)
    OriGene ORF clones in mouse, rat for ECM2
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    GenScript: all cDNA clones in your preferred vector (see all 3): ECM2 (NM_001197296)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECM2
    Sirion Biotech Customized lentivirus for stable overexpression of ECM2 
                         Customized lentivirus expression plasmids for stable overexpression of ECM2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ECM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ECM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ECM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ECM2

    Additional mRNA sequence: 

    AB011792.1 AK296458.1 AK298278.1 AK303922.1 AK308485.1 AK312820.1 BC036806.2 BC105958.1 
    BC107493.1 BX537976.1 

    9 DOTS entries:

    DT.307831  DT.40219665  DT.121154242  DT.101981464  DT.40128605  DT.100678234  DT.100742270  DT.40269779 
    DT.100642041 

    24/61 AceView cDNA sequences (see all 61):

    AI814725 CA420271 AA677468 CA436989 BF431290 AI090981 CB162823 BX642447 
    C16120 CB162125 BX537976 AW058335 BM805085 BM972177 AI123569 CD000459 
    N45178 AL711993 AW779895 AI761978 CB962137 AI923371 AI057125 BC036806 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ECM2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12
    SP1:                                      -     -                 -     -                                       
    SP2:                                      -     -           -                                                   
    SP3:                                                        -     -     -                                       
    SP4:                                                                                                            
    SP5:              -                                                                                             


    ECgene alternative splicing isoforms for ECM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ECM2 expression in normal human tissues (normalized intensities)      ECM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAAATTA
    ECM2 Expression
    About this image


    ECM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Zeugopod Epiphyseal End
             TGFbeta3+BMP7-induced chondrocytes
             Human Calvarial Osteoblasts (HCO)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             TGFbeta3+BMP7-induced chondrocytes
             Normal Human Articular chondrocytes (NHAC)   
     
     Fibroblast
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Ciliary Ganglion   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon

    See ECM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ECM2

    SOURCE GeneReport for Unigene cluster: Hs.117060

    UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769
    Tissue specificity: Expressed predominantly in adipose tissue as well as female-specific organs such as mammary
    gland, ovary, and uterus

        SABiosciences Custom PCR Arrays for ECM2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ECM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ECM2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ecm21 , 5 extracellular matrix protein 2, female organ and adipocyte more1, 5 80.9(n)1
    76.24(a)1
      13 (25.29 cM)5
    4078001  NM_001012324.21  NP_001012324.11 
     495048105 
    chicken
    (Gallus gallus)
    Aves ECM21 extracellular matrix protein 2, female organ and adipocyte more 66.91(n)
    60.97(a)
      415953  XM_414297.3  XP_414297.2 
    lizard
    (Anolis carolinensis)
    Reptilia ECM26
    extracellular matrix protein 2, female organ and a...
    55(a)
    1 ↔ 1
    2(156115417-156143897)
    zebrafish
    (Danio rerio)
    Actinopterygii ecm21 extracellular matrix protein 2, female organ and adipocyte more 56.18(n)
    52.09(a)
      558224  XM_681415.2  XP_686507.2 


    ENSEMBL Gene Tree for ECM2 (if available)
    TreeFam Gene Tree for ECM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ECM2 gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  FLRT32  OMD2  
    ASPN2  BGN2  DCN2  FLRT22  LUM2  
    7 SIMAP similar genes for ECM2 using alignment to 5 protein entries:     ECM2_HUMAN (see all proteins):
    COL1A1    COL3A1    ASPN    MST161    DCN    COL5A2
    LRIG3

    ECM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in ECM2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0520114
    ----see VAR_0520112 R Q mis40--------
    VAR_0246464
    ----see VAR_0246462 Q P mis40--------
    VAR_0520104
    ----see VAR_0520102 T S mis40--------

    HapMap Linkage Disequilibrium report for ECM2 (95255829 - 95298937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ECM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1019101CNV Insertion17803354
    nsv527206CNV Loss19592680
    nsv893573CNV Gain21882294


    Human Gene Mutation Database (HGMD): ECM2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ECM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ECM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603479    OMIM disorders: --

    2 diseases for ECM2:    About MalaCards
    leiomyoma    


    ECM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ECM2

    Export disorders for ECM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ECM2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ECM2)
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    world of online information

    1. Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3. (PubMed id 9790758)1, 2, 3, 9 Nishiu J.... Nakamura Y. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. (PubMed id 9345023)1, 9 Oritani K....Kincade P.W. (1997)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1842 HGNC: 3154 AceView: ECM2 Ensembl:ENSG00000106823 euGenes: HUgn1842
    ECgene: ECM2 H-InvDB: ECM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ECM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ECM2 gene:
    Search GeneIP for patents involving ECM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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