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ECM2 Gene

protein-coding   GIFtS: 53
GCID: GC09M095257

Extracellular Matrix Protein 2, Female Organ And Adipocyte...

  Search for ECM2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Extracellular Matrix Protein 2, Female Organ And Adipocyte Specific1 2
Matrix Glycoprotein SC1/ECM21 2 3
Extracellular Matrix Protein 22

External Ids:    HGNC: 31541   Entrez Gene: 18422   Ensembl: ENSG000001068237   OMIM: 6034795   UniProtKB: O947693   

Export aliases for ECM2 gene to outside databases

Previous GC identifers: GC09M086084 GC09M086985 GC09M088556 GC09M090599 GC09M090597 GC09M092335 GC09M094297 GC09M064935


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ECM2 Gene:
ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known
extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2010)

GeneCards Summary for ECM2 Gene:
ECM2 (extracellular matrix protein 2, female organ and adipocyte specific) is a protein-coding gene. GO annotations related to this gene include integrin binding and heparin binding. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769
Function: Promotes matrix assembly and cell adhesiveness (By similarity)

Gene Wiki entry for ECM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ECM2 gene promoter:
         TBP   ISGF-3   AML1a   HSF1 (long)   Nkx2-5   S8   E2F-1   E2F   TFIID   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidECM2 promoter sequence
   Search Chromatin IP Primers for ECM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ECM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.3

ECM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ECM2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095257:  view genomic region     (about GC identifiers)

Start:
95,255,829 bp from pter      End:
95,298,937 bp from pter
Size:
43,109 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769 (See protein sequence)
Recommended Name: Extracellular matrix protein 2 precursor  
Size: 699 amino acids; 79789 Da
Subunit: Interacts with numerous extracellular matrix proteins (By similarity)
Sequence caution: Sequence=CAD97940.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R730 E2PU11 Q5T9F2 Q7Z3D0
Alternative splicing: 2 isoforms:  O94769-1   O94769-2   

Explore the universe of human proteins at neXtProt for ECM2: NX_O94769

Explore proteomics data for ECM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn378, Asn449, Asn506
  • Modification sites at PhosphoSitePlus

  • See ECM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001184224.1  NP_001184225.1  NP_001384.1  

    ENSEMBL proteins: 
     ENSP00000344758   ENSP00000364690   ENSP00000378905   ENSP00000393971  

    ECM2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ECM2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ECM2
    GenScript Custom Purified and Recombinant Proteins Services for ECM2
    Novus Biologicals ECM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ECM2

     
    Search eBioscience for Proteins for ECM2 

    ECM2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ECM2
    Novus Biologicals ECM2 Antibody
    Abcam antibodies for ECM2
    Cloud-Clone Corp. Antibodies for ECM2
    Search ThermoFisher Antibodies for ECM2
    LSBio Antibodies in human, mouse, rat for ECM2

    ECM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ECM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ECM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ECM2
    Cloud-Clone Corp. CLIAs for ECM2
    Search eBioscience for ELISAs for ECM2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry O94769

    ProtoNet protein and cluster: O94769

    1 Blocks protein domain: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily
    Similarity: Contains 13 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with ECM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ECM2_HUMAN, O94769
    Function: Promotes matrix assembly and cell adhesiveness (By similarity)

         Genatlas biochemistry entry for ECM2:
    extracellular matrix 2,predominantly expressed in adipose tissue,mammary gland,ovary and uterus

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding TAS9790758
    GO:0005515protein binding ----
    GO:0005518collagen binding ----
    GO:0008201heparin binding IEA--
    GO:0070052collagen V binding IEA--
         
    Find genes that share ontologies with ECM2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ECM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ECM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ECM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ECM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ECM2:
    hsa-mir-877-3p (MIRT037131), hsa-mir-98-5p (MIRT027441)

    Block miRNA regulation of human, mouse, rat ECM2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ECM2:
    hsa-miR-3152-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-29a* hsa-miR-3143 hsa-miR-518f* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidECM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ECM2
    Predesigned siRNA for gene silencing in human, mouse, rat ECM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ECM2

    Clone
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    OriGene clones in human, mouse for ECM2 (see all 13)
    OriGene ORF clones in mouse, rat for ECM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ECM2 (NM_001197296)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ECM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECM2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ECM2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ECM2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ECM2_HUMAN, O94769: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix TAS9790758
    GO:0005614interstitial matrix IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with ECM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ECM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ECM2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ECM2
    Interactions:

        Search GeneGlobe Interaction Network for ECM2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ECM2 (ENSP000003447584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    RBM22ENSP000001998144STRING: ENSP00000199814
    PDE8AENSP000003114534STRING: ENSP00000311453
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion TAS9790758
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization IEA--

    Find genes that share ontologies with ECM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ECM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ECM2 gene (3 alternative transcripts): 
    NM_001197295.1  NM_001197296.1  NM_001393.3  

    Unigene Cluster for ECM2:

    Extracellular matrix protein 2, female organ and adipocyte specific
    Hs.117060  [show with all ESTs]
    Unigene Representative Sequence: NM_001393
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344604(uc010mqz.2 uc004asf.4 uc011lty.2 uc004asg.3)
    ENST00000375540(uc004asi.3) ENST00000395534(uc011ltz.1) ENST00000444490

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ECM2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ECM2:
    hsa-miR-3152-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-29a* hsa-miR-3143 hsa-miR-518f* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidECM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ECM2
    Predesigned siRNA for gene silencing in human, mouse, rat ECM2
    Clone
    Products:
         
    OriGene clones in human, mouse for ECM2 (see all 13)
    OriGene ORF clones in mouse, rat for ECM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ECM2 (NM_001197296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ECM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECM2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ECM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ECM2
      QuantiTect SYBR Green Assays in human, mouse, rat ECM2
      QuantiFast Probe-based Assays in human, mouse, rat ECM2

    Additional mRNA sequence: 

    AB011792.1 AK296458.1 AK298278.1 AK303922.1 AK308485.1 AK312820.1 BC036806.2 BC105958.1 
    BC107493.1 BX537976.1 

    9 DOTS entries:

    DT.307831  DT.40219665  DT.121154242  DT.101981464  DT.40128605  DT.100678234  DT.100742270  DT.40269779 
    DT.100642041 

    Selected AceView cDNA sequences (see all 61):

    BX537976 CA420271 C16120 AI814725 CA436989 AA677468 CB162125 AW058335 
    CB162823 BX642447 AI090981 BF431290 CD557432 AI061071 BM805085 CA414686 
    BM972177 AI057125 BX509899 AL705981 BX490742 BC036806 BQ181757 AW779895 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ECM2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12
    SP1:                                      -     -                 -     -                                       
    SP2:                                      -     -           -                                                   
    SP3:                                                        -     -     -                                       
    SP4:                                                                                                            
    SP5:              -                                                                                             


    ECgene alternative splicing isoforms for ECM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ECM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAAATTA
    ECM2 Expression
    About this image


    ECM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Zeugopod Epiphyseal End
             TGFbeta3+BMP7-induced chondrocytes
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem MEL2, NCr-fac Progenitor
    ECM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ECM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.117060

    UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769
    Tissue specificity: Expressed predominantly in adipose tissue as well as female-specific organs such as mammary
    gland, ovary, and uterus

        Custom PCR Arrays for ECM2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ECM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ECM2
    QuantiTect SYBR Green Assays in human, mouse, rat ECM2
    QuantiFast Probe-based Assays in human, mouse, rat ECM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ECM2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ecm21 , 5 extracellular matrix protein 2, female organ and adipocyte more1, 5 81.05(n)1
    76.24(a)1
      13 (25.29 cM)5
    4078001  NM_001012324.21  NP_001012324.11 
     495048105 
    chicken
    (Gallus gallus)
    Aves ECM21 extracellular matrix protein 2, female organ and adipocyte more 65.98(n)
    59.8(a)
      415953  XM_414297.4  XP_414297.2 
    lizard
    (Anolis carolinensis)
    Reptilia ECM26
    extracellular matrix protein 2, female organ and a...
    55(a)
    1 ↔ 1
    2(156115417-156143897)
    zebrafish
    (Danio rerio)
    Actinopterygii ecm21 extracellular matrix protein 2, female organ and adipocyte more 56.5(n)
    53.31(a)
      558224  XM_681415.3  XP_686507.3 


    ENSEMBL Gene Tree for ECM2 (if available)
    TreeFam Gene Tree for ECM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ECM2 gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  FLRT32  OMD2  
    ASPN2  BGN2  DCN2  FLRT22  LOC1005090912  LUM2  
    7 SIMAP similar genes for ECM2 using alignment to 5 protein entries:     ECM2_HUMAN (see all proteins):
    COL1A1    COL3A1    ASPN    MST161    DCN    COL5A2
    LRIG3

    Find genes that share paralogs with ECM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for ECM2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347585051,2,4
    ----see VAR_0520112 mis40--------
    rs101202101,2,4
    ----see VAR_0246462 mis40--------
    rs354967431,2,4
    ----see VAR_0520102 mis40--------

    HapMap Linkage Disequilibrium report for ECM2 (95255829 - 95298937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ECM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1019101CNV Insertion17803354
    nsv527206CNV Loss19592680
    nsv893573CNV Gain21882294

    Human Gene Mutation Database (HGMD): ECM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ECM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ECM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603479    OMIM disorders: --


    Find genes that share disorders with ECM2           About GenesLikeMe

    Genetic Association Database (GAD): ECM2

    Export disorders for ECM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ECM2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ECM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3. (PubMed id 9790758)1, 2, 3, 9 Nishiu J.... Nakamura Y. (Genomics 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. (PubMed id 9345023)1, 9 Oritani K....Kincade P.W. (Blood 1997)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1842 HGNC: 3154 AceView: ECM2 Ensembl:ENSG00000106823 euGenes: HUgn1842
    ECgene: ECM2 H-InvDB: ECM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ECM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ECM2 gene:
    Search GeneIP for patents involving ECM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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