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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ECM2 Gene

protein-coding GIFtS: 50
GCID: GC09M095257

extracellular matrix protein 2, female organ and adipocyte...

Explore 1 disease affiliated with
ECM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Extracellular Matrix Protein 2, Female Organ And Adipocyte Specific¹ ²
Matrix Glycoprotein SC1/ECM2² ³
Extracellular Matrix Protein 2²

External Ids:	HGNC: 3154¹	Entrez Gene: 1842²	Ensembl: ENSG00000106823⁷	OMIM: 603479⁵	UniProtKB: O94769³

Export aliases for ECM2 gene to outside databases

Previous GC identifers: GC09M086084 GC09M086985 GC09M088556 GC09M090599 GC09M090597 GC09M092335 GC09M094297 GC09M064935

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ECM2:

ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar

matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769

Function: Promotes matrix assembly and cell adhesiveness (By similarity)

Gene Wiki entry for ECM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ECM2 gene promoter:
TBP ISGF-3 AML1a HSF1 (long) Nkx2-5 S8 E2F-1 E2F TFIID HSF1short
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ECM2 promoter sequence

Search SABiosciences Chromatin IP Primers for ECM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ECM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q22.3

ECM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ECM2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M095257: view genomic region (about GC identifiers)

Start:	95,256,365 bp from pter	End:	95,298,937 bp from pter
Size:	42,573 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769 (See protein sequence)

Recommended Name: Extracellular matrix protein 2 precursor

Size: 699 amino acids; 79789 Da

Subunit: Interacts with numerous extracellular matrix proteins (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Sequence caution: Sequence=CAD97940.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B2R730 E2PU11 Q5T9F2 Q7Z3D0

Alternative splicing: 2 isoforms: O94769-1 O94769-2

Explore the universe of human proteins at neXtProt for ECM2: NX_O94769

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94769

ECM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001184224.1 NP_001184225.1 NP_001384.1

ENSEMBL proteins:

ENSP00000344758 ENSP00000364690 ENSP00000378905 ENSP00000393971

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ECM2 OriGene Custom Protein Services for ECM2
	GenScript Custom Purified and Recombinant Proteins Services for ECM2
	Novus Biologicals ECM2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ECM2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	TAS	9790758
GO:0005614	interstitial matrix	IEA	--
GO:0031012	extracellular matrix	--	--

ECM2 for ontologies About GeneDecksing

ECM2 Antibody Products:

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	Novus Biologicals ECM2 Antibody
	Search for Antibodies for ECM2 at Abcam
	Uscn Antibodies for ECM2
	Search ThermoFisher Antibodies for ECM2

Assay Products for ECM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ECM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ECM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ECM2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR001007 VWF_C

Graphical View of Domain Structure for InterPro Entry O94769

ProtoNet protein and cluster: O94769

1 Blocks protein family: IPB001007 von Willebrand factor

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769

Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily

Similarity: Contains 13 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRNT domain

Similarity: Contains 1 VWFC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769

Function: Promotes matrix assembly and cell adhesiveness (By similarity)

Genatlas biochemistry entry for ECM2:

extracellular matrix 2,predominantly expressed in adipose tissue,mammary gland,ovary and uterus

miRNA Products:		OriGene 3'-UTR Clone: ECM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ECM2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate ECM2:
		hsa-miR-3152-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-29a* hsa-miR-3143 hsa-miR-518f* hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: ECM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ECM2 (see all 4) OriGene shRNA RFP: ECM2 OriGene siRNA: ECM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ECM2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ECM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ECM2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ECM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ECM2 (NM_001197296)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ECM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ECM2
		Search LifeMap BioReagents cell lines for ECM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECM2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	TAS	9790758
GO:0005518	collagen binding	--	--
GO:0008201	heparin binding	IEA	--
GO:0070052	collagen V binding	IEA	--

ECM2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ECM2 (see all 13)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ECM2

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007160	cell-matrix adhesion	TAS	9790758
GO:0010811	positive regulation of cell-substrate adhesion	IEA	--
GO:0030198	extracellular matrix organization	IEA	--

ECM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ECM2
Search CenterWatch for drugs/clinical trials and news about ECM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ECM2 gene (3 alternative transcripts):

NM_001197295.1 NM_001197296.1 NM_001393.3

Unigene Cluster for ECM2:

Extracellular matrix protein 2, female organ and adipocyte specific

Hs.117060 [show with all ESTs]

Unigene Representative Sequence: NM_001393

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000344604(uc010mqz.2 uc004asf.4 uc011lty.2 uc004asg.3)

ENST00000375540(uc004asi.3) ENST00000395534(uc011ltz.1) ENST00000444490

miRNA Products:		OriGene 3'-UTR Clone: ECM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ECM2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate ECM2:
		hsa-miR-3152-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-29a* hsa-miR-3143 hsa-miR-518f* hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: ECM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ECM2 (see all 4) OriGene shRNA RFP: ECM2 OriGene siRNA: ECM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ECM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ECM2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ECM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ECM2 (NM_001197296)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ECM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ECM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ECM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ECM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ECM2

Additional cDNA sequence:

AB011792.1 AK296458.1 AK298278.1 AK303922.1 AK308485.1 AK312820.1 BC036806.2 BC105958.1

BC107493.1 BX537976.1

8 DOTS entries:

DT.307831 DT.40219665 DT.121154242 DT.101981464 DT.100678234 DT.40269779 DT.100742270 DT.40128605

24/61 AceView cDNA sequences (see all 61):

BX642447 CA420271 CB162125 C16120 CA436989 AW058335 CB162823 AI814725

BX537976 AA677468 AI090981 BF431290 AL705981 AW779895 BM805085 CA414686

CD557432 AI057125 BX509899 BM972177 CB962137 BC036806 AI761978 AI061071

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ECM2 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	·	11d	^	12
SP1:													-		-						-		-
SP2:													-		-				-
SP3:																			-		-		-
SP4:
SP5:					-

ECgene alternative splicing isoforms for ECM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ECM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAAAATTA

About this image

ECM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primordial Follicle

Pre-Granulosa Cells

Ovary

Bone

Zeugopod Epiphyseal End

Bone

Brain

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

See ECM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ECM2

SOURCE GeneReport for Unigene cluster: Hs.117060

UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769

Tissue specificity: Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland,

ovary, and uterus

SABiosciences Custom PCR Arrays for ECM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ECM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ECM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ECM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ECM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ECM2 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ECM2¹	extracellular matrix protein 2, female organ and adipocyte more	66.91(n) 60.97(a)		415953 XM_414297.3 XP_414297.2
lizard (Anolis carolinensis)	Reptilia	ECM2⁶	--	54(a)	1 ↔ 1	2(156120922-156142568)
zebrafish (Danio rerio)	Actinopterygii	ecm2¹	extracellular matrix protein 2, female organ and adipocyte more	56.18(n) 52.09(a)		558224 XM_681415.2 XP_686507.2

ENSEMBL Gene Tree for ECM2 (if available)
TreeFam Gene Tree for ECM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ECM2 gene

OGN² OPTC² PODN² PODNL1² FMOD² PRELP² KERA² ASPN²

OMD² BGN² DCN² EPYC² LUM²

7 SIMAP similar genes for ECM2 using alignment to 5 protein entries: ECM2_HUMAN (see all proteins):

COL1A1 COL3A1 ASPN MST161 DCN COL5A2

LRIG3

ECM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144654401^1,2		--	95255480(+)	`TGATGA/TGAGCA`	2	--	int¹		0	--	--	--	--
rs117148427^1,2	F,	--	95255681(+)	`TCCTGG/ATGTAG`	2	--	int¹		1		EA	120
rs186914898^1,2		--	95255812(+)	`CAAAGA/GCAAGA`	2	--	int¹		0	--	--	--	--
rs191759471^1,2		--	95255813(+)	`AAAGAC/GAAGAC`	2	--	int¹		0	--	--	--	--
rs115693996^1,2		--	95255860(+)	`ACTTCT/GTTAGT`	2	--	int¹ ut3¹		1		WA	118
rs7869742^1,2	C,F,A,H,	--	95256174(+)	`GACATG/ACACAG`	2	--	int¹ ut3¹		25		NS EA NA WA CSA	2355
rs183266211^1,2		--	95256189(+)	`CCCACA/CGTGCG`	2	--	ut3¹ int¹		0	--	--	--	--
rs145750718^1,2		--	95256288(+)	`TGCTCA/GTCGCA`	2	--	ut3¹ int¹		0	--	--	--	--
rs331380^1,2	C,F,O,A,H,	--	95256519(+)	`ACTCAC/TCTTAT`	2	--	int¹		23		EA NA NS WA	2484
rs11788523^1,2	C,F,A,H,	--	95256593(+)	`TCAATG/ATGTTT`	2	--	int¹		10		NA WA CSA EA	372

HapMap Linkage Disequilibrium report for ECM2 (95256365 - 95298937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ECM2: --
Human Gene Mutation Database (HGMD): ECM2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ECM2

DNA2.0 Custom Variant and Variant Library Synthesis for ECM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ECM2 for disorders           About GeneDecksing

OMIM gene information: 603479    OMIM disorders: --

1 disease for ECM2:    About MalaCards

leiomyoma

Export disorders for ECM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ECM2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ECM2)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3. (PubMed id 9790758)^{1, 2, 3, 9} Nishiu J.... Nakamura Y. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. (PubMed id 9345023)^{1, 9} Oritani K....Kincade P.W. (1997)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)¹ Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1842	HGNC: 3154	AceView: ECM2	Ensembl:ENSG00000106823	euGenes: HUgn1842
ECgene: ECM2	H-InvDB: ECM2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ECM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ECM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ECM2 gene:
Search GeneIP for patents involving ECM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ECM2 Gene

extracellular matrix protein 2, female organ and adipocyte...

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