 |
 | Services
| |
 |
Aliases & Descriptions for ECM2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC126355 2 | | MGC126356 2 | | OTTHUMP00000021654 2 | | OTTHUMP00000063687 2 |
| | | Descriptions |
|---|
| Matrix glycoprotein SC1/ECM2 2, 3 | | extracellular matrix protein 2 2 | extracellular matrix protein 2, female organ and adipocyte specific 2 |
|
| | Search outside databases for aliases for ECM2 genePrevious GC identifers: GC09M086084 GC09M086985 GC09M088556 GC09M090599 GC09M090597 GC09M092335 |
Summaries for ECM2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ECM2: ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix protiens. [provided by RefSeq] UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769Function: Promotes matrix assembly and cell adhesiveness (By similarity)Gene Wiki entry for ECM2 |
Genomic Location for ECM2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ECM2 gene 
Entrez Gene cytogenetic band: 9q22.3 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q22.3ECM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M094297:
(about GC identifiers)
Start:
|
94,295,657 bp from pter |
End:
|
94,338,158 bp from pter |
Size:
|
42,502 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008470.18
| Proteins for ECM2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769 (See
protein sequence)Recommended Name: Extracellular matrix protein 2 precursor Size: 699 amino acids; 79789 Da
Subunit: Interacts with numerous extracellular matrix proteins (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: B2R730 Q5T9F2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001384.1
ENSEMBL proteins: ENSP00000344758 ENSP00000378905 ENSP00000364690
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ECM2: Assays for ECM2: | Protein
Domains/ Families for ECM2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O94769
ProtoNet protein and cluster: O94769 1 Blocks protein family: IPB001007 von Willebrand factor
UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamilySimilarity: Contains 14 LRR (leucine-rich) repeatsSimilarity: Contains 1 VWFC domain | Gene Function for ECM2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001393
Applied Biosystems Silencer® siRNAs for ECM2
Sigma-Aldrich siRNA for ECM2  Sigma-Aldrich shRNA Panels and shRNA for ECM2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001393                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001393                                  untagged cDNA clone in CMV expression vector: NM_001393 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001393
UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769Function: Promotes matrix assembly and cell adhesiveness (By similarity)Genatlas biochemistry entry for ECM2:extracellular matrix 2,predominantly expressed in adipose tissue,mammary gland,ovary and uterus2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ECM2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for ECM2 (ENSP000003447583) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for ECM2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ECM2
|
Transcripts for ECM2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001393
Sigma-Aldrich siRNA for ECM2  Sigma-Aldrich shRNA Panels and shRNA for ECM2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001393 REFSEQ mRNAs for ECM2 gene: NM_001393.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001393               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001393                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001393                                  untagged cDNA clone in CMV expression vector: NM_001393  Additional cDNA sequence: AB011792.1 AK296458.1 AK298278.1 AK303922.1 AK308485.1 AK312820.1 BC036806.2 BC105958.1 BC107493.1 BX537976.1 10 DOTS entries: DT.307831 DT.40219665 DT.101981464 DT.121154242 DT.40128605 DT.97837799 DT.100642041 DT.100678234 DT.100742270 DT.40269779 24/61 AceView cDNA sequences (see all 61
):CA436989 AW058335 AI090981 AI814725 C16120 CB162125 CA420271 CB162823 AA677468 BX537976 BF431290 BX642447 N45178 AW779895 AL711993 BX509899 AI123569 AI057125 AB011792 CB962137 CD000459 AI923371 CA414686 BQ181757
highest scoring ESTs for ECM2:AB011792 AI057125 AI061071 AI761978 AI767691 AI829266 AI923371 AL705981 AL711993 AW058335 Unigene Cluster for ECM2: Extracellular matrix protein 2, female organ and adipocyte specific Hs.117060 [show with all ESTs]Unigene Representative Sequence: AB011792
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ECM2 (see all 7
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ECM2
3 Ensembl transcripts including schematic representations: ENST00000344604
ENST00000395534
ENST00000375540
|
Expression for ECM2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ECM2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ECM2
1 / 2 / 3 6 probe-sets matching ECM2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTAAAATTA
SOURCE GeneReport for Unigene cluster: Hs.117060
Expression variation in blood from EXPOLDB for ECM2 UniProtKB/Swiss-Prot: ECM2_HUMAN, O94769Tissue specificity: Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus |
Orthologs for ECM2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ECM2 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for ECM2
ENSEMBL Gene Tree for ECM2 | Paralogs for ECM2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ECM2 gene
- BGN2 DCN2 ASPN2
|
SNPs/Variants for ECM2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations for ECM2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603479
|
Medical News for ECM2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ECM2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for ECM2 gene (see all 13
):- Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3. (PubMed id 9790758)1, 2, 3, 4 Nishiu J.... Nakamura Y. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. (PubMed id 9345023)1, 3 Oritani K....Kincade P.W. (1997)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)4 Ota T....Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3 Wiemann S.... Poustka A. (2001)
- DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)3 Hartley J.L....Brasch M.A. (2000)
|
Search for ECM2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ECM2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ECM2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ECM2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ECM2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ECM2:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for ECM2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|