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ECM1 Gene

protein-coding GIFtS: 62

GC01P148747

extracellular matrix protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000014932 ^²
OTTHUMP00000014934 ^²

Descriptions
Secretory component p85 ^², ³
extracellular matrix protein 1 ^²

External Ids
HGNC: 3153¹
Entrez Gene: 1893²
UniProtKB: Q16610³
Ensembl: ENSG00000143369⁷

Search outside databases for aliases for ECM1 gene

Previous GC identifers: GC01P148322 GC01P146227 GC01P147255 GC01P147697 GC01P147293

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ECM1:

This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic

of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin

protein family. This gene maps outside of the epidermal differentiation complex (EDC), a cluster

of three gene families involved in epidermal differentiation. Alternatively spliced transcript

variants encoding distinct isoforms have been described. [provided by RefSeq]

Gene Wiki entry for ECM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ECM1 gene

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21

ECM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P148747: (about GC identifiers)

Start:	148,747,158 bp from pter
End:	148,752,660 bp from pter
Size:	5,503 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ECM1_HUMAN, Q16610 (See protein sequence)

Recommended Name: Extracellular matrix protein 1 precursor

Size: 540 amino acids; 60674 Da

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: A8K8S0 B4DW49 B4DY60 O43266 Q5T5G4 Q5T5G5 Q5T5G6 Q8IZ60

Alternative splicing: 4 isoforms: Q16610-1 Q16610-2 Q16610-3 Q16610-4

REFSEQ proteins (2 alternative transcripts):

NP_004416.2 NP_073155.2

ENSEMBL proteins:

ENSP00000358045 ENSP00000358043 ENSP00000271630

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ECM1 (ECM-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Secretory Component Glycoprotein)
	Human Recombinant Proteins from Abnova (ECM1)

OriGene Purified Recombinant Human Protein: ECM1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	NAS	9367673

About this table

Antibodies for ECM1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ECM1
	R&D Systems Antibodies for ECM1 (ECM-1)
	Antibodies from Abcam (Secretory Component Glycoprotein), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ECM1

Assays for ECM1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16610

ProtoNet protein and cluster: Q16610

1 Blocks protein family: IPB008605 Extracellular matrix 1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ECM1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004425

Applied Biosystems Silencer® siRNAs for ECM1

Sigma-Aldrich siRNA for ECM1

Sigma-Aldrich shRNA Panels and shRNA for ECM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ECM1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004425
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004425
untagged cDNA clones in CMV expression vector (see all 2): NM_004425

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004425

Genatlas biochemistry entry for ECM1:

extracellular matrix protein 1,with two alternative spliced isoform,1.8kb,expressed in

heart,placenta,1.4kb,in tonsils and keratinocytes

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ECM1

4 Interacting proteins for ECM1 (ENSP00000358045³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPG2	ENSP00000363827³	STRING (score=.979)
EFEMP1	ENSP00000347596³	STRING (score=.872)
HRAS	ENSP00000373382³	STRING (score=.804)
FBLN1	ENSP00000262723³	STRING (score=.783)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ECM1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ECM1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004425

Sigma-Aldrich siRNA for ECM1

Sigma-Aldrich shRNA Panels and shRNA for ECM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004425 NM_022664

REFSEQ mRNAs for ECM1 gene (2 alternative transcripts):

NM_004425.3 NM_022664.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004425 NM_022664

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004425
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004425
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004425

Additional cDNA sequence:

AK097046.1 AK097205.1 AK292435.1 AK301369.1 AK302279.1 AK316390.1 BC023505.2 CR590823.1

CR593353.1 CR596945.1 CR603901.1 CR606666.1 CR609963.1 CR616494.1 CR622085.1 CR624464.1

DQ010946.1 DQ112074.1 U65932.1 U68186.1 U68187.1

19 DOTS entries:

DT.100039263 DT.416060 DT.97854836 DT.100877718 DT.86847522 DT.97854835 DT.121430331 DT.121430352

DT.92441867 DT.95302878 DT.92441868 DT.95302900 DT.100877715 DT.121430323 DT.121430337 DT.121430369

DT.91941510 DT.121430360 DT.40225237

24/301 AceView cDNA sequences (see all 301 ):

BF354939 AK097205 BM919199 BQ682126 BM756612 CB126593 BU179328 CR590823

CB125632 AU077032 CR593353 CR596945 AI928501 BQ009866 CD674431 BQ680556

BM837393 BM854304 CA444482 BM785683 CR609963 CB528629 AI685519 BM929836

highest scoring ESTs for ECM1:

U68186 AI143076 AI200441 AI350435 AI375958 AI685519 AI872670 AK097046 AK097205 AL540725

Unigene Cluster for ECM1:

Extracellular matrix protein 1

Hs.81071 [show with all ESTs]

Unigene Representative Sequence: AK097205

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ECM1 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12
SP1:									-										-										-
SP2:									-										-										-								-		-
SP3:									-
SP4:									-										-
SP5:									-																				-

About this scheme

ECgene alternative splicing isoforms for ECM1

3 Ensembl transcripts including schematic representations:

ENST00000369049 ENST00000369047 ENST00000346569

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ECM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ECM1

¹ / ² / ³

3 probe-sets matching ECM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37600_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U68186	1.00	1.00	1.00	1
209365_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U65932	0.80	1.00	0.91	1
209365_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ECM1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTGCCCGCT

SOURCE GeneReport for Unigene cluster: Hs.81071
Expression variation in blood from EXPOLDB for ECM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ECM1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ECM1¹	--	extracellular matrix protein 1	83.68(n) 75.43(a)	608791 XM_845921.1 XP_851014.1
chimpanzee (Pan troglodytes)	ECM1¹	--	extracellular matrix protein 1	99.69(n) 99.26(a)	746939 XM_001169169.1 XP_001169169.1
cow (Bos taurus)	ECM1¹	--	extracellular matrix protein 1	84.02(n) 76.4(a)	524222 XM_879025.2 XP_884118.1
rat (Rattus norvegicus)	Ecm1¹	--	extracellular matrix protein 1	79.78(n) 70.69(a)	116662 NM_053882.1 NP_446334.1
mouse (Mus musculus)	Ecm1^{1, 5}	3 (45.40 cM)⁵	extracellular matrix protein 1^{1, 5}	79.22(n)¹ 69.57(a)¹	13601¹ NM_007899.1¹ NP_031925.1¹ AF029694⁵ AI663821⁵ (see all 13)

About this table Species with no ortholog for ECM1

ENSEMBL Gene Tree for ECM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/44 NCBI SNPs in ECM1 are shown (see all 44 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3737240^1,2	A,C,F,H	148749979(+)	`AGGAAC/TGCCAG`	2	T/M	mis¹		9		EA EU WA	2334
	rs3754217^1,2	A,C,F,H	148746997(+)	`CTCCTG/TGATTC`	2	--	ng5¹		10		EA NA MN EU WA	3098
	rs13294^1,2	A,C,F,H	148751611(+)	`ACATCG/AGTCGA`	2	G/S	mis¹ ese³		17		MN EA EU WA NA	2718
	rs12724450^1,2	C,F,H	148747195(+)	`AGCTGG/ATCCTG`	2	--	ng5¹ ese³		8		EU EA WA	838
	rs1050911^1,2	F,H	148752624(+)	`CCCATC/TTGAAC`	2	--	ut3¹		5		MN EU EA WA	582
	rs1050904^1,2	C,H	148752548(+)	`CACCTC/TTGAGC`	2	S/F	mis¹ ese³		5		MN EU EA WA	600
--	rs6704384^1,2	A	148753005(+)	`CCACAC/GCCCAG`	2	--	ng3¹		0	--	--	--	--
	rs1050901^1,2	H	148752526(+)	`CTGGAG/AGAACA`	2	R/G	mis¹ ese³		5		MN EU EA WA	590
	rs1050874^1,2	F	148750082(+)	`CGGCTG/CGATGG`	2	L/L	syn¹		1		MN	184
	rs11801190^1,2	C	148750628(+)	`TGCACA/GCGGCA`	2	T/T	syn¹ int¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ECM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602201 disorders: 247100

UniProtKB/Swiss-Prot: ECM1_HUMAN, Q16610

Defects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as

lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal

recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera.

Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.

Histologically, there is widespread deposition of hyaline material and disruption/reduplication of

basement membrane

10/12 Novoseek disease relationships for ECM1 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
proteinosis lipoid	98.02	52	12603844 (5), 17721643 (4), 17927570 (3), 15927815 (2) (see all 23)
lichen sclerosus	81.77	20	12867112 (7), 15173881 (4), 15927815 (3), 15347336 (2) (see all 6)
thyroid nodule	45.15	2	18374945 (1), 16135921 (1)
breast carcinoma	40.85	1	14715705 (1)
skin diseases	38.08	4	14723723 (2), 15068453 (1), 15173881 (1)
thyroid cancer	34.67	6	16135921 (4), 16688775 (1), 18374945 (1)
metastasis	30.00	10	16646403 (3), 18984970 (2), 19146682 (1), 11292659 (1)
carcinoma squamous cell	14.56	1	14550953 (1)
tumors	12.39	16	16646403 (3), 18374945 (3), 11292659 (2), 14550953 (1) (see all 7)
cancer	0.00	2	18984970 (1), 17884004 (1)

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1 PharmGKB disease relationship for ECM1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Human Gene Mutation Database: ECM1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/75 PubMed articles for ECM1 gene (see all 75 ):

The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization. (PubMed id 9367673)^{1, 2, 3, 4} Smits P.... Merregaert J. (1997)
Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21. (PubMed id 9501329)^{1, 2, 3, 4} Johnson M.R....Francomano C.A. (1997)
Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation. (PubMed id 12603844)^{1, 3, 4} Hamada T.... McGrath J.A. (2003)
Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). (PubMed id 11929856)^{1, 3, 4} Hamada T....McGrath J.A. (2002)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Interaction of extracellular matrix protein 1 with extracellular matrix components: ECM1 is a basement membrane protein of the skin. (PubMed id 18200062)^{1, 3} Sercu S....Merregaert J.H. (2008)
The molecular basis of lipoid proteinosis: mutations in extracellular matrix protein 1. (PubMed id 17927570)^{1, 3} Chan I....McGrath J.A. (2007)
Extracellular matrix protein 1 (ECM1) is over-expressed in malignant epithelial tumors. (PubMed id 14550953)^{1, 3} Wang L....Zhang L. (2003)
Homozygous missense mutation in the ECM1 gene in Chinese siblings with lipoid proteinosis. (PubMed id 17721643)^{1, 3} Han B....Zhu X. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1893	HGNC: 3153	AceView: ECM1	Ensembl:ENSG00000143369	euGenes: HUgn1893
ECgene: ECM1	H-InvDB: ECM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ECM1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ECM1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ECM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ECM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ECM1		Antibodies for ECM1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ECM1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ECM1)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Secretory Component Glycoprotein)
	Antibodies (Secretory Component Glycoprotein)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ECM1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ECM1

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ECM1 Gene at Home site.
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ECM1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ECM1

Summaries
for ECM1

Genomic Location
for ECM1

Proteins
for ECM1

Protein Domains/
Families
for ECM1

Gene Function
for ECM1

Pathways & Interactions
for ECM1

Drugs & Compounds
for ECM1

Transcripts
for ECM1

Expression
for ECM1

Orthologs
for ECM1

Paralogs
for ECM1

SNPs/Variants
for ECM1

Disorders & Mutations
for ECM1

Medical News
for ECM1

Publications
for ECM1

Search for ECM1

Genome Databases showing ECM1

Other Databases showing ECM1

Specialized Databases showing ECM1

Licensable Technologies
for ECM1

Services
for ECM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ECM1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ECM1

Summariesfor ECM1

Genomic Locationfor ECM1

Proteinsfor ECM1

Protein Domains/Familiesfor ECM1

Gene Functionfor ECM1

Pathways & Interactionsfor ECM1

Drugs & Compoundsfor ECM1

Transcriptsfor ECM1

Expression for ECM1

Orthologsfor ECM1

Paralogsfor ECM1

SNPs/Variantsfor ECM1

Disorders & Mutationsfor ECM1

Medical Newsfor ECM1

Publicationsfor ECM1

Search for ECM1

Genome Databases showing ECM1

Other Databases showing ECM1

Specialized Databases showing ECM1

Licensable Technologiesfor ECM1

Servicesfor ECM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ECM1

Summaries
for ECM1

Genomic Location
for ECM1

Proteins
for ECM1

Protein Domains/
Families
for ECM1

Gene Function
for ECM1

Pathways & Interactions
for ECM1

Drugs & Compounds
for ECM1

Transcripts
for ECM1

Expression
for ECM1

Orthologs
for ECM1

Paralogs
for ECM1

SNPs/Variants
for ECM1

Disorders & Mutations
for ECM1

Medical News
for ECM1

Publications
for ECM1

Licensable Technologies
for ECM1

Services
for ECM1