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Aliases for ECI2 Gene

Aliases for ECI2 Gene

  • Enoyl-CoA Delta Isomerase 2 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 88 2 3 4
  • Diazepam-Binding Inhibitor-Related Protein 1 3 4
  • Acyl-Coenzyme A Binding Domain Containing 2 2 3
  • Peroxisomal 3,2-Trans-Enoyl-CoA Isomerase 3 4
  • Delta(3),Delta(2)-Enoyl-CoA Isomerase 3 4
  • Peroxisomal D3,D2-Enoyl-CoA Isomerase 2 3
  • Renal Carcinoma Antigen NY-REN-1 3 4
  • D3,D2-Enoyl-CoA Isomerase 3 4
  • Dodecenoyl-CoA Isomerase 3 4
  • DBI-Related Protein 1 3 4
  • DRS-1 3 4
  • HCA88 3 4
  • DRS1 3 4
  • PECI 3 4
  • Testicular Secretory Protein Li 33 3
  • DJ1013A10.3 3
  • EC 5.3.3.8 4
  • ACBD2 3

External Ids for ECI2 Gene

Previous HGNC Symbols for ECI2 Gene

  • PECI

Summaries for ECI2 Gene

Entrez Gene Summary for ECI2 Gene

  • This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]

GeneCards Summary for ECI2 Gene

ECI2 (Enoyl-CoA Delta Isomerase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty acid metabolism. GO annotations related to this gene include receptor binding and dodecenoyl-CoA delta-isomerase activity. An important paralog of this gene is CDY1B.

UniProtKB/Swiss-Prot for ECI2 Gene

  • Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).

Gene Wiki entry for ECI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ECI2 Gene

Genomics for ECI2 Gene

Regulatory Elements for ECI2 Gene

Enhancers for ECI2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ECI2 on UCSC Golden Path with GeneCards custom track

Promoters for ECI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ECI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ECI2 Gene

Chromosome:
6
Start:
4,115,689 bp from pter
End:
4,135,597 bp from pter
Size:
19,909 bases
Orientation:
Minus strand

Genomic View for ECI2 Gene

Genes around ECI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ECI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ECI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECI2 Gene

Proteins for ECI2 Gene

  • Protein details for ECI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75521-ECI2_HUMAN
    Recommended name:
    Enoyl-CoA delta isomerase 2, mitochondrial
    Protein Accession:
    O75521
    Secondary Accessions:
    • Q5JYK5
    • Q5JYK7
    • Q7L124
    • Q8N0X0
    • Q9BUE9
    • Q9H0T9
    • Q9NQH1
    • Q9NYH7
    • Q9UN55

    Protein attributes for ECI2 Gene

    Size:
    394 amino acids
    Molecular mass:
    43585 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC19317.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD34173.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF66247.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH02668.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH16781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH17474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH33841.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH34702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG52068.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ECI2 Gene

    Alternative splice isoforms for ECI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ECI2 Gene

Proteomics data for ECI2 Gene at MOPED

Post-translational modifications for ECI2 Gene

  • Ubiquitination at Lys 92
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ECI2 Gene

Domains & Families for ECI2 Gene

Suggested Antigen Peptide Sequences for ECI2 Gene

Graphical View of Domain Structure for InterPro Entry

O75521

UniProtKB/Swiss-Prot:

ECI2_HUMAN :
  • Contains 1 ACB (acyl-CoA-binding) domain.
  • In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Domain:
  • Contains 1 ACB (acyl-CoA-binding) domain.
Family:
  • In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
genes like me logo Genes that share domains with ECI2: view

No data available for Gene Families for ECI2 Gene

Function for ECI2 Gene

Molecular function for ECI2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.
UniProtKB/Swiss-Prot Function:
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).

Enzyme Numbers (IUBMB) for ECI2 Gene

Gene Ontology (GO) - Molecular Function for ECI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with ECI2: view
genes like me logo Genes that share phenotypes with ECI2: view

Animal Model Products

miRNA for ECI2 Gene

miRTarBase miRNAs that target ECI2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ECI2 Gene

Localization for ECI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ECI2 Gene

Isoform 1: Mitochondrion.
Isoform 2: Peroxisome matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ECI2 Gene COMPARTMENTS Subcellular localization image for ECI2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ECI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ECI2: view

Pathways & Interactions for ECI2 Gene

genes like me logo Genes that share pathways with ECI2: view

Pathways by source for ECI2 Gene

Gene Ontology (GO) - Biological Process for ECI2 Gene

None

No data available for SIGNOR curated interactions for ECI2 Gene

Drugs & Compounds for ECI2 Gene

(2) Drugs for ECI2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma Target 0
Propionyl-CoA Experimental Pharma 0

(33) Additional Compounds for ECI2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ECI2: view

Transcripts for ECI2 Gene

Unigene Clusters for ECI2 Gene

Enoyl-CoA delta isomerase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ECI2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2: - - - - - -
SP3:
SP4: -
SP5: - - -

Relevant External Links for ECI2 Gene

GeneLoc Exon Structure for
ECI2
ECgene alternative splicing isoforms for
ECI2

Expression for ECI2 Gene

mRNA expression in normal human tissues for ECI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ECI2 Gene

This gene is overexpressed in Fetal ovary (8.0), Heart (6.7), and Liver (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ECI2 Gene



SOURCE GeneReport for Unigene cluster for ECI2 Gene Hs.15250

mRNA Expression by UniProt/SwissProt for ECI2 Gene

O75521-ECI2_HUMAN
Tissue specificity: Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.
genes like me logo Genes that share expression patterns with ECI2: view

Protein tissue co-expression partners for ECI2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ECI2 Gene

Orthologs for ECI2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ECI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ECI2 35
  • 75.24 (n)
  • 75.06 (a)
PECI 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ECI2 35
  • 83.2 (n)
  • 80.65 (a)
ECI2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eci2 35
  • 78.77 (n)
  • 73.4 (a)
Eci2 16
Eci2 36
  • 73 (a)
OneToMany
Eci3 36
  • 66 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ECI2 35
  • 98.98 (n)
  • 98.21 (a)
ECI2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eci2 35
  • 78.35 (n)
  • 74.42 (a)
oppossum
(Monodelphis domestica)
Mammalia ECI2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ECI2 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ECI2 35
  • 67.01 (n)
  • 65.98 (a)
ECI2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ECI2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eci2 35
  • 66.2 (n)
  • 64.99 (a)
Str.13785 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14349 35
zebrafish
(Danio rerio)
Actinopterygii zgc:92030 35
  • 62.72 (n)
  • 62.63 (a)
eci2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13890 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ech-4 35
  • 52.41 (n)
  • 47.88 (a)
B0272.4 36
  • 38 (a)
OneToMany
ech-4 36
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 36
  • 27 (a)
ManyToMany
ECI1 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.414 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2179 36
  • 47 (a)
OneToOne
Species with no ortholog for ECI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ECI2 Gene

ENSEMBL:
Gene Tree for ECI2 (if available)
TreeFam:
Gene Tree for ECI2 (if available)

Paralogs for ECI2 Gene

Paralogs for ECI2 Gene

(11) SIMAP similar genes for ECI2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ECI2: view

Variants for ECI2 Gene

Sequence variations from dbSNP and Humsavar for ECI2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3177253 - 4,133,621(-) TCAAT(A/G/T)AATCA nc-transcript-variant, reference, missense
VAR_058494 -
rs10085196 -- 4,131,746(+) cagct(A/G)cttgg intron-variant
rs6935587 -- 4,132,368(+) CACCT(C/G)TGCAT intron-variant
rs12660546 -- 4,132,822(+) tgcag(G/T)ggcgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ECI2 Gene

Variant ID Type Subtype PubMed ID
esv2422231 CNV Deletion 17116639
esv2422457 CNV Deletion 17116639

Variation tolerance for ECI2 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.19; 93.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ECI2 Gene

Disorders for ECI2 Gene

Relevant External Links for ECI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ECI2

No disorders were found for ECI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ECI2 Gene

Publications for ECI2 Gene

  1. Characterization of PECI, a novel monofunctional D3,D2-enoyl-CoA isomerase of mammalian peroxisomes. (PMID: 10419495) Geisbrecht B.V. … Gould S.J. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. (PMID: 15217832) Feng X. … Nakao S. (Blood 2004) 3 23
  3. Human I9A^,I9A^-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10. (PMID: 25515061) Onwukwe G.U. … Wierenga R.K. (FEBS J. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ECI2 Gene

Sources for ECI2 Gene

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