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ECHDC2 Gene

protein-coding   GIFtS: 50
GCID: GC01M053361

Enoyl CoA Hydratase Domain Containing 2

(Previous name: enoyl Coenzyme A hydratase domain containing 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Enoyl CoA Hydratase Domain Containing 21 2
Enoyl Coenzyme A Hydratase Domain Containing 21 2
Enoyl-CoA Hydratase Domain-Containing Protein 2, Mitochondrial2

External Ids:    HGNC: 234081   Entrez Gene: 552682   Ensembl: ENSG000001213107   UniProtKB: Q86YB73   

Export aliases for ECHDC2 gene to outside databases

Previous GC identifers: GC01M053074 GC01M051477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ECHDC2 Gene:
ECHDC2 (enoyl CoA hydratase domain containing 2) is a protein-coding gene. GO annotations related to this gene include lyase activity. An important paralog of this gene is CDY2A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ECHDC2 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidECHDC2 promoter sequence
   Search Chromatin IP Primers for ECHDC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ECHDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

ECHDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ECHDC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053361:  view genomic region     (about GC identifiers)

Start:
53,361,582 bp from pter      End:
53,392,884 bp from pter
Size:
31,303 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ECHD2_HUMAN, Q86YB7 (See protein sequence)
Recommended Name: Enoyl-CoA hydratase domain-containing protein 2, mitochondrial precursor  
Size: 292 amino acids; 31126 Da
Secondary accessions: D3DQ36 Q9NV38
Alternative splicing: 2 isoforms:  Q86YB7-1   Q86YB7-2   

Explore the universe of human proteins at neXtProt for ECHDC2: NX_Q86YB7

Explore proteomics data for ECHDC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ECHDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001185890.1  NP_001185891.1  NP_060751.2  

    ENSEMBL proteins: 
     ENSP00000360577   ENSP00000360575   ENSP00000351125   ENSP00000446190   ENSP00000441962  
     ENSP00000439906   ENSP00000438535   ENSP00000439264   ENSP00000445358  

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    Novus Biologicals ECHDC2 Protein
    Novus Biologicals ECHDC2 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ECHDC2

     
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    Cloud-Clone Corp. ELISAs for ECHDC2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018376 Enoyl-CoA_hyd/isom_CS
     IPR001753 Crotonase_core_superfam
     IPR014748 Crontonase_C

    Graphical View of Domain Structure for InterPro Entry Q86YB7

    ProtoNet protein and cluster: Q86YB7

    1 Blocks protein domain: IPB001753 Enoyl-CoA hydratase/isomerase

    UniProtKB/Swiss-Prot: ECHD2_HUMAN, Q86YB7
    Similarity: Belongs to the enoyl-CoA hydratase/isomerase family


    Find genes that share domains with ECHDC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0016829lyase activity IEA--
         
    Find genes that share ontologies with ECHDC2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ECHDC2:
     Cells with protrusions  Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ECHDC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ECHDC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ECHDC2

    miRNA
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    miRTarBase miRNAs that target ECHDC2:
    hsa-mir-484 (MIRT041810)

    Block miRNA regulation of human, mouse, rat ECHDC2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ECHDC2:
    hsa-miR-203 hsa-miR-3611 hsa-miR-1237 hsa-miR-3065-3p hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidECHDC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ECHDC2

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    GenScript: all cDNA clones in your preferred vector (see all 3): ECHDC2 (NM_001198962)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECHDC2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECHDC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ECHD2_HUMAN, Q86YB7: Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with ECHDC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ECHDC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty Acid Biosynthesis
    Fatty Acid Biosynthesis


    1 BioSystems Pathway for ECHDC2
        Fatty Acid Biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ECHDC2
    Interactions:

        Search GeneGlobe Interaction Network for ECHDC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ECHDC2 (Q86YB73 ENSP000003511254) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEC1O607323, ENSP000002858794I2D: score=2 STRING: ENSP00000285879
    SPTAN1Q138133I2D: score=1 
    SCP2ENSP000003605694STRING: ENSP00000360569
    AGLENSP000002947244STRING: ENSP00000294724
    ARTNENSP000003919984STRING: ENSP00000391998
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0008152metabolic process ----

    Find genes that share ontologies with ECHDC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ECHDC2 (ECHD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ECHDC2 gene (3 alternative transcripts): 
    NM_001198961.1  NM_001198962.1  NM_018281.3  

    Unigene Cluster for ECHDC2:

    Enoyl CoA hydratase domain containing 2
    Hs.476319  [show with all ESTs]
    Unigene Representative Sequence: BC038389
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000371522(uc001cup.4 uc001cuo.4 uc021onl.1) ENST00000460612(uc010onl.1 uc010onm.1 uc010onn.1)
    ENST00000539680 ENST00000479183 ENST00000543419 ENST00000463923 ENST00000371520(uc001cun.3)
    ENST00000358358 ENST00000498544 ENST00000476477 ENST00000479593 ENST00000467988
    ENST00000487866 ENST00000486170 ENST00000487851 ENST00000488268 ENST00000544365
    ENST00000495920
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ECHDC2:
    hsa-miR-203 hsa-miR-3611 hsa-miR-1237 hsa-miR-3065-3p hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidECHDC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ECHDC2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ECHDC2 (NM_001198962)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ECHDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ECHDC2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ECHDC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ECHDC2
      QuantiTect SYBR Green Assays in human, mouse, rat ECHDC2
      QuantiFast Probe-based Assays in human, mouse, rat ECHDC2

    Additional mRNA sequence: 

    AK001810.1 AK299834.1 AK300896.1 AK307381.1 AK309535.1 AK310650.1 AK315906.1 BC038389.1 
    BC044574.1 

    23 DOTS entries:

    DT.100014157  DT.91713948  DT.100039018  DT.95286454  DT.75125291  DT.431154  DT.100039020  DT.311844 
    DT.95286392  DT.91656919  DT.70104440  DT.121332326  DT.97795641  DT.40317315  DT.100816117  DT.101979943 
    DT.121332282  DT.95286409  DT.99946437  DT.100740866  DT.121332267  DT.95187267  DT.97794698 

    Selected AceView cDNA sequences (see all 296):

    BM689137 CD722801 AA317298 CB216956 C05231 AI798643 BU785506 BE676756 
    AI801093 AI024769 BU679980 BX283786 BM666884 CB164723 AW952885 AW439101 
    BG164862 AW071570 CB161597 BC051887 AA974499 BP431924 N27730 CB242336 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ECHDC2 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -   
    SP2:                                      -     -     -                       -     -     -     -     -     -     -                                         -   
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -   
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -   
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -   

    ExUns: 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:        -           -                       -                                 
    SP2:  -     -           -                       -                                 
    SP3:  -     -           -                       -                                 
    SP4:                    -                       -     -                           
    SP5:  -     -           -                 -     -                                 


    ECgene alternative splicing isoforms for ECHDC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ECHDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGAAGAG
    ECHDC2 Expression
    About this image


    ECHDC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Thymus (Hematopoietic System)
             Thymus
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
    ECHDC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ECHDC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476319
        Custom PCR Arrays for ECHDC2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ECHDC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ECHDC2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Echdc21 , 5 enoyl Coenzyme A hydratase domain containing 21, 5 84.13(n)1
    86.3(a)1
      4 (50.30 cM)5
    524301  NM_026728.41  NP_081004.21 
     1081654375 
    chicken
    (Gallus gallus)
    Aves ECHDC21 enoyl CoA hydratase domain containing 2 69.96(n)
    77.95(a)
      424646  XM_422480.4  XP_422480.1 
    lizard
    (Anolis carolinensis)
    Reptilia ECHDC26
    enoyl CoA hydratase domain containing 2
    68(a)
    1 ↔ 1
    4(114844414-114854955)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX716802.12   -- 72.43(n)    BX716802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc83b022 Danio rerio mRNA similar to DNA segment, Chr 4, ERATO more 77.59(n)    BC047862.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87786
    --
    51(a)
    1 → many
    2R(8538806-8539987)
    worm
    (Caenorhabditis elegans)
    Secernentea ech-56
    Protein ECH-5 (ech-5) mRNA, complete cds
    48(a)
    1 → many
    IV(797023-799855) WBGene00001154


    ENSEMBL Gene Tree for ECHDC2 (if available)
    TreeFam Gene Tree for ECHDC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ECHDC2 gene
    CDY2A2  ECI22  CDY2B2  CDYL22  AUH2  ECHDC32  ECHS12  CDY1B2  
    CDYL2  ECH12  CDY12  
    4 SIMAP similar genes for ECHDC2 using alignment to 9 protein entries:     ECHD2_HUMAN (see all proteins):
    AUH    ECHDC3    ECHS1    ECH1

    Find genes that share paralogs with ECHDC2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ECHDC2
    PGOHUM00000258665


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ECHDC2 (see all 549)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907588811,2
    --51504887(+) TTGGTC/TTCGAA 3 -- us2k10--------
    rs1387358051,2
    C--53361116(+) TTGCCC/TATTTC 3 -- int10--------
    rs614461251,2
    F--53361139(+) TCTTTC/GCATTA 3 -- int12Minor allele frequency- G:0.03CSA WA 120
    rs2007393971,2
    C--53361422(+) GGAGG-/CTGCAG 3 -- int10--------
    rs97829751,2
    C,F,A--53361431(+) agtgaC/Gctgag 3 -- int15Minor allele frequency- G:0.16NA WA CSA 125
    rs1895369091,2
    --53361442(+) ATGGCA/GCCACT 3 -- int10--------
    rs1819266471,2
    --53361555(+) ATTTCA/GTTTGG 3 -- int10--------
    rs767398621,2
    C,F--53361822(+) CTTAAA/CATCTT 3 -- ut311Minor allele frequency- C:0.05WA 118
    rs1422301511,2
    --53361838(+) ATCTCC/TAATGA 3 -- ut310--------
    rs10443651,2
    C,F,H--53361928(-) TCTACT/CTGAAT 3 -- ut31 ese330Minor allele frequency- C:0.06EA NS NA WA CSA 4378

    HapMap Linkage Disequilibrium report for ECHDC2 (53361582 - 53392884 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ECHDC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829859CNV Loss17160897
    nsv871800CNV Loss21882294
    nsv870582CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ECHDC2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ECHDC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    5. Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6). (PubMed id 17137291)1 Cho H.J....Simpson A.J. (Cancer Immun. 2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55268 HGNC: 23408 AceView: FLJ10948 Ensembl:ENSG00000121310 euGenes: HUgn55268
    ECgene: ECHDC2 H-InvDB: ECHDC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ECHDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ECHDC2 gene:
    Search GeneIP for patents involving ECHDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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