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Aliases & Descriptions for ECHDC2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ10948 1, 2 | | OTTHUMP00000010482 2 |
| | | Descriptions |
|---|
| enoyl Coenzyme A hydratase domain containing 2 2 |
|
| | Search outside databases for aliases for ECHDC2 gene |
Summaries for ECHDC2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for ECHDC2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ECHDC2 gene 
Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3ECHDC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M053074:
(about GC identifiers)
Start:
|
53,134,492 bp from pter |
End:
|
53,160,034 bp from pter |
Size:
|
25,543 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for ECHDC2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ECHD2_HUMAN, Q86YB7 (See
protein sequence)Recommended Name: Enoyl-CoA hydratase domain-containing protein 2, mitochondrial precursor Size: 292 amino acids; 31126 Da
Subcellular location: Mitochondrion (Potential)
Secondary accessions: Q9NV38Alternative splicing: 2 isoforms: Q86YB7-1 Q86YB7-2 REFSEQ proteins: NP_060751.2
ENSEMBL proteins: ENSP00000351125 ENSP00000360575 ENSP00000360577
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | About this table
Antibodies for ECHDC2: Assays for ECHDC2: | Protein
Domains/ Families for ECHDC2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q86YB7
ProtoNet protein and cluster: Q86YB7 1 Blocks protein family: IPB001753 Enoyl-CoA hydratase/isomerase
UniProtKB/Swiss-Prot: ECHD2_HUMAN, Q86YB7Similarity: Belongs to the enoyl-CoA hydratase/isomerase family | Gene Function for ECHDC2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018281
Applied Biosystems Silencer® siRNAs for ECHDC2
Sigma-Aldrich siRNA for ECHDC2  Sigma-Aldrich shRNA for ECHDC2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018281                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018281                                  untagged cDNA clone in CMV expression vector: NM_018281 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018281
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016829 | lyase activity |
IEA | -- | About this table | Pathways & Interactions for ECHDC2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/16 Interacting proteins for ECHDC2 (ENSP000003605773) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006629 | lipid metabolic process |
IEA | -- | | GO:0006631 | fatty acid metabolic process |
IEA | -- | | GO:0008152 | metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for ECHDC2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ECHDC2
|
Transcripts for ECHDC2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018281
Sigma-Aldrich siRNA for ECHDC2  Sigma-Aldrich shRNA for ECHDC2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018281 REFSEQ mRNAs for ECHDC2 gene: NM_018281.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018281               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018281                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018281                                  untagged cDNA clone in CMV expression vector: NM_018281  Additional cDNA sequence: AF258590.1 AK001810.1 AK299834.1 AK300896.1 AK302285.1 AK307381.1 AK309535.1 AK310650.1 AK315906.1 AL832874.1 BC038389.1 BC044574.1 BC051887.1 BX648522.1 CR614256.1 23 DOTS entries: DT.100014157 DT.91713948 DT.100039018 DT.431154 DT.95286454 DT.70104440 DT.75125291 DT.100039020 DT.95286392 DT.91656919 DT.311844 DT.91924163 DT.100816117 DT.121332326 DT.97795641 DT.101979943 DT.121332282 DT.95286409 DT.97794698 DT.99946437 DT.100740866 DT.121332267 DT.95187267 24/296 AceView cDNA sequences (see all 296
):AI215705 BP431924 BM695024 CR614256 CA450358 BU785506 AI298655 AI810968 BI963726 BI870480 AA700546 CB163700 AI798643 CB164723 BE676756 BG749464 BG164862 AA345229 AL603043 CF528553 BM673239 AI682312 AA317298 CA396460
highest scoring ESTs for ECHDC2:AA504193 AA632135 AI478342 AK001810 AW025350 BC038389 BC044574 BC051887 BG164862 BG743057 Unigene Cluster for ECHDC2: Enoyl Coenzyme A hydratase domain containing 2 Hs.476319 [show with all ESTs]Unigene Representative Sequence: BC051887
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for ECHDC2 (see all 21
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | |
| SP1: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |
| SP5: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   |
| ExUns: | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | · | 18d | |
| SP1: | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | - |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | - |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | - |   | - |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ECHDC2
3 Ensembl transcripts including schematic representations: ENST00000358358
ENST00000371520
ENST00000371522
|
Expression for ECHDC2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ECHDC2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ECHDC2
1 / 2 / 3 6 probe-sets matching ECHDC2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCCTGAAGAG
SOURCE GeneReport for Unigene cluster: Hs.476319
|
Orthologs for ECHDC2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ECHDC2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for ECHDC2
ENSEMBL Gene Tree for ECHDC2 | Paralogs for ECHDC2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ECHDC2 gene
- AUH2 ECHS12
|
SNPs/Variants for ECHDC2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ECHDC2 (up to first 250kb)
|
Disorders & Mutations for ECHDC2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for ECHDC2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ECHDC2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 3 PubMed articles for ECHDC2 gene: |
Search for ECHDC2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ECHDC2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ECHDC2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ECHDC2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ECHDC2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ECHDC2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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