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Aliases & Descriptions for ECEL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DINE 1, 2 | | EC 3.4.24.- 3 | | ECEX 2 | | OTTHUMP00000164361 2 | | XCE 1, 2, 3, 5 |
| | | Descriptions |
|---|
| X converting enzyme 2 | | Xce protein 3 | | damage induced neuronal endopeptidase 2 | | endothelin converting enzyme-like 1 2 |
|
| | Search outside databases for aliases for ECEL1 genePrevious GC identifers: GC02M231401 GC02M232073 GC02M233308 GC02M233547 GC02M233170 |
Summaries for ECEL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ECEL1: This gene encodes a member of the M13 family of endopeptidases. In general, M13 family members are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. This gene is expressed specifically in the central nervous system and its protein localizes predominately to the endoplasmic reticulum or, in trace amounts, to the cell surface. Disruption of this gene in mouse embryonic stem cells results in neonatal lethality due to respiratory failure shortly after birth. Based on the specific expression of this gene and the phenotype of the gene deficiency in mouse embryos, it is suggested that this protein plays a critical role in neural regulation of the respiratory system. This gene has multiple pseudogenes. [provided by RefSeq] UniProtKB/Swiss-Prot: ECEL1_HUMAN, O95672Function: May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptidesGene Wiki entry for ECEL1 |
Genomic Location for ECEL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ECEL1 gene 
Entrez Gene cytogenetic band: 2q36-q37 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1ECEL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M233052:
(about GC identifiers)
Start:
|
233,052,781 bp from pter |
End:
|
233,060,782 bp from pter |
Size:
|
8,002 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for ECEL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ECEL1_HUMAN, O95672 (See
protein sequence)Recommended Name: Endothelin-converting enzyme-like 1 Size: 775 amino acids; 87791 Da
Cofactor: Binds 1 zinc ion (By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: Q45UD9 Q53RF9 Q6UW86 Q86TH4 Q9NY95Alternative splicing: 2 isoforms: O95672-1 O95672-2 Post-translational modifications:
N-glycosylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004817.2
ENSEMBL proteins: ENSP00000302051 ENSP00000386333
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ECEL1: Assays for ECEL1: | Protein
Domains/ Families for ECEL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95672
ProtoNet protein and cluster: O95672 2 Blocks protein families: IPB000718 Neprilysin metalloprotease (M13) family signature IPB008753 Peptidase M13
UniProtKB/Swiss-Prot: ECEL1_HUMAN, O95672Similarity: Belongs to the peptidase M13 family | Gene Function for ECEL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004826
Applied Biosystems Silencer® siRNAs for ECEL1
Sigma-Aldrich siRNA and siRNA Panels for ECEL1  Sigma-Aldrich shRNA for ECEL1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004826                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004826                                  untagged cDNA clones in CMV expression vector (see all 2): BC050453 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004826
UniProtKB/Swiss-Prot: ECEL1_HUMAN, O95672Function: May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptidesEnzyme Number (IUBMB): EC 3.4.24.- 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ecel1):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ECEL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for ECEL1 (ENSP000003020513) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for ECEL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ECEL1 1 Novoseek chemical compound relationship for ECEL1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
37.52 |
6 |
10698686 (2), 9931490 (1) |
About this table
|
Transcripts for ECEL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004826
Sigma-Aldrich siRNA and siRNA Panels for ECEL1  Sigma-Aldrich shRNA for ECEL1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004826 REFSEQ mRNAs for ECEL1 gene: NM_004826.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004826               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004826                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004826                                  untagged cDNA clones in CMV expression vector (see all 2): BC050453  Additional cDNA sequence: AB030579.1 AB073895.1 AY358923.1 BC050453.1 DQ114476.1 Y16187.1 4 DOTS entries: DT.207419 DT.121006016 DT.100749473 DT.100749474 24/37 AceView cDNA sequences (see all 37
):BM556407 BM704287 CD107739 BC050453 BM711866 BM564570 NM_004826 BF663245 BM690531 BU189672 BF514928 Y16187 BQ008324 BM665679 CD106880 BM473899 AB030579 AY358923 BX091205 BU726047 BE777813 R61395 AW247923 BE782599
highest scoring ESTs for ECEL1:AB030579 AI625488 AY358923 BC050453 Y16187 AA523527 AA974635 AI559588 AI564376 AW247923 Unigene Cluster for ECEL1: Endothelin converting enzyme-like 1 Hs.26880 [show with all ESTs]Unigene Representative Sequence: AB030579
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ECEL1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · | 19c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ECEL1
2 Ensembl transcripts including schematic representations: ENST00000304546
ENST00000409941
|
Expression for ECEL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ECEL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ECEL1
1 / 2 / 3 3 probe-sets matching ECEL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.26880 UniProtKB/Swiss-Prot: ECEL1_HUMAN, O95672Tissue specificity: Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus |
Orthologs for ECEL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ECEL1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for ECEL1
ENSEMBL Gene Tree for ECEL1 | Paralogs for ECEL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ECEL1 gene
- ECE22 ECE12
|
SNPs/Variants for ECEL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ECEL1 (up to first 250kb)
|
Disorders & Mutations for ECEL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605896
|
Medical News for ECEL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ECEL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for ECEL1 gene (see all 11
):- XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS. (PubMed id 9931490)1, 2, 3, 4 Valdenaire O.... Schweizer A. (1999)
- Organization and chromosomal localization of the human ECEL1 (XCE) gene encoding a zinc metallopeptidase involved in the nervous control of respiration. (PubMed id 10698686)1, 3, 4 Valdenaire O....Meijers C. (2000)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1. (PubMed id 11352565)2, 3 Rump A....Rosenthal A. (2001)
- Endothelin-converting enzyme-like 1 (ECEL1) is present both in the plasma membrane and in the endoplasmic reticulum. (PubMed id 14992683)1, 3 Benoit A....Boileau G. (2004)
- Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons. (PubMed id 18192274)3 Kiryu-Seo S....Kiyama H. (2008)
- High expression of the novel endothelin-converting enzyme genes, Nbla03145/ECEL1alpha and beta, is associated with favorable prognosis in human neuroblastomas. (PubMed id 12632073)3 Kawamoto T.... Nakagawara A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for ECEL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ECEL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ECEL1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ECEL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ECEL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ECEL1:

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Incremental update: 13 Oct 2009
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