V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ECE2 Gene

protein-coding GIFtS: 60

GC03P185451

endothelin converting enzyme 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ECE-2 ^³
KIAA0604 ^¹, ², ³
MGC17664 ^²
MGC2408 ^¹, ²
MGC78487 ^²

Descriptions
endothelin converting enzyme 2 ^²

External Ids
HGNC: 13275¹
Entrez Gene: 9718²
UniProtKB: O60344³
Ensembl: ENSG00000145194⁷

Search outside databases for aliases for ECE2 gene

Previous GC identifers: GC03M180604 GC03P184962 GC03P185370 GC03P185289 GC03P185290

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ECE2:

Endothelin-converting enzymes, such as ECE2 (EC 3.4.24.71), are type II metalloproteases that

generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et

al., 2001 [PubMed 11718899]).[supplied by OMIM]

UniProtKB/Swiss-Prot: ECE2_HUMAN, O60344

Function: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various

neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived

peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain.

May also have methyltransferase activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ECE2 gene

Entrez Gene cytogenetic band: 3q27.1|. Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27.1

ECE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P185451: (about GC identifiers)

Start:	185,450,139 bp from pter
End:	185,493,513 bp from pter
Size:	43,375 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ECE2_HUMAN, O60344 (See protein sequence)

Recommended Name: Endothelin-converting enzyme 2

Size: 883 amino acids; 99773 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By

similarity). Cytoplasmic granule membrane; Single-pass type II membrane protein (By similarity)

PDB structures from and Proteopedia :

2PXX (3D)

Secondary accessions: Q6NTG7 Q96NX3 Q96NX4 Q9BRZ8

Alternative splicing: 4 isoforms: O60344-1 O60344-2 O60344-3 O60344-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001032401.1 NP_001093590.1 NP_001093591.1 NP_055508.3 NP_115707.2

ENSEMBL proteins:

ENSP00000384223 ENSP00000314295 ENSP00000344204 ENSP00000350066 ENSP00000352052 ENSP00000385846

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ECE2 (ECE-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MGC2408)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030659	cytoplasmic vesicle membrane	IDA	11718899

About this table

Antibodies for ECE2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for ECE2 (ECE-2)
	Antibodies from Abcam (MGC2408), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ECE2

Assays for ECE2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O60344

ProtoNet protein and cluster: O60344

3 Blocks protein families:

IPB000221 Protamine P1

IPB000718 Neprilysin metalloprotease (M13) family signature

IPB008753 Peptidase M13

UniProtKB/Swiss-Prot: ECE2_HUMAN, O60344

Similarity: In the N-terminal section; belongs to the methyltransferase superfamily

Similarity: In the C-terminal section; belongs to the peptidase M13 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ECE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ECE2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 10): NM_001037324

Applied Biosystems Silencer® siRNAs for ECE2

Sigma-Aldrich siRNA and siRNA Panels for ECE2

Sigma-Aldrich shRNA for ECE2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ECE2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001037324
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001037324
untagged cDNA clones in CMV expression vector (see all 6): NM_001037324

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014693

UniProtKB/Swiss-Prot: ECE2_HUMAN, O60344

Function: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various

neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived

peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain.

May also have methyltransferase activity

Catalytic activity: Hydrolysis of the 21-Trp- -Val-22 bond in big endothelin to form endothelin 1

Biophysicochemical properties: Kinetic parameters: KM=0.4 uM for big ET-1; KM=1.4 uM for peptide E;

KM=27.4 uM for bradykinin; KM=48.4 uM for dynorphin B; pH dependence: Optimum pH is 5.0-5.5.

Inactive at neutral pH;

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ece2):

	craniofacial	embryogenesis	hearing/vestibular/ear	lethality-prenatal/perinatal
nervous system	normal	skeleton

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IDA	11718899
GO:0008168	methyltransferase activity	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ECE2 (Your Favorite Gene powered by Ingenuity)

Lysine Degradation
Endothelin-1 Signaling

GeneDecks ECE2 for the pathways selected above

About GeneDecksing

5 Interacting proteins for ECE2 (ENSP00000350066³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDN1	ENSP00000368683³	STRING (score=.849)
EDNRA	ENSP00000315011³	STRING (score=.806)
EDN2	ENSP00000361668³	STRING (score=.785)
EDNRB	ENSP00000366416³	STRING (score=.763)
EDN3	ENSP00000360067³	STRING (score=.734)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007267	cell-cell signaling	TAS	11718899
GO:0007420	brain development	ISS	--
GO:0007507	heart development	ISS	--
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ECE2

Browse Small Molecules at Sigma-Aldrich

Compounds for ECE2 available from Tocris Bioscience

Compound	Action	CAS number
CGS 35066	Endothelin-converting enzyme (ECE) inhibitor	[261619-50-5]

About this table

1 Novoseek chemical compound relationship for ECE2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	20.16	3	18507370 (1), 8530372 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ECE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ECE2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 10): NM_001037324

Sigma-Aldrich siRNA and siRNA Panels for ECE2

Sigma-Aldrich shRNA for ECE2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001037324 NM_001100120 NM_001100121 NM_014693 NM_032331

REFSEQ mRNAs for ECE2 gene (5 alternative transcripts):

NM_001037324.2 NM_001100120.1 NM_001100121.1 NM_014693.3 NM_032331.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001037324 NM_001100120 NM_001100121 NM_014693 NM_032331

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001037324
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001037324
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_001037324

Additional cDNA sequence:

AB011176.1 AF192531.1 AF428263.1 AF428264.1 AF521189.1 AK293713.1 AK293891.1 AK295270.1

AK296541.1 AK309236.1 AY359003.1 BC005835.2 BC012449.1 BC069005.1 BC142950.1 CR595932.1

CR620009.1

6 DOTS entries:

DT.426551 DT.95337716 DT.205131 DT.92417173 DT.100001396 DT.95163242

24/118 AceView cDNA sequences (see all 118 ):

CR595932 BI966695 BM558455 CK903529 AF428264 AA366404 BE792314 NM_014693

BU739636 BU622982 AA760767 AF192531 AF428263 CR620009 AB011176 BM766109

BM547706 AY359003 BX283356 AW245264 CR625277 AF521189 AI951872 BG219927

highest scoring ESTs for ECE2:

AB011176 AI951872 AV708732 AW305020 BM713622 BU739636 BX116474 R38978 AF192531 AF428264

Unigene Cluster for ECE2:

Endothelin converting enzyme 2

Hs.146161 [show with all ESTs]

Unigene Representative Sequence: NM_014693

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ECE2 (see all 9 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·
SP1:																			-				-														-
SP2:																							-														-
SP3:							-		-		-		-		-		-		-				-														-
SP4:																	-		-				-														-
SP5:																	-		-

ExUns:	17b	^	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b	·	22c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ECE2

6 Ensembl transcripts including schematic representations:

ENST00000402825 ENST00000324557 ENST00000351385 ENST00000357474 ENST00000359140 ENST00000404464

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ECE2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ECE2

¹ / ² / ³

7 probe-sets matching ECE2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
82913_at²^{, 3}	U95-E	1	1.00	1.00	0.70	1.01	AA760767	0.60	0.40	0.51	2
35536_at²^{, 3}	U95-A	2	1.00	0.97	0.83	0.99	AB011176	1.00	0.80	0.91	1
227103_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE646208	0.20	0.17	0.18	2
206728_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_014693	0.60	0.83	0.73	1
227103_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555306_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206728_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks ECE2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACCAATACA

SOURCE GeneReport for Unigene cluster: Hs.146161
Expression variation in blood from EXPOLDB for ECE2
UniProtKB/Swiss-Prot: ECE2_HUMAN, O60344
Tissue specificity: Expressed in brain. Strongly down-regulated in inferior parietal lobe from
Alzheimer disase patients (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ECE2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ECE2¹	--	endothelin converting enzyme 2	90.51(n) 95.3(a)	488105 XM_844517.1 XP_849610.1
chimpanzee (Pan troglodytes)	ECE2¹	--	endothelin converting enzyme 2	99.58(n) 99.09(a)	471026 XM_001147750.1 XP_001147750.1
cow (Bos taurus)	ECE2¹	--	endothelin converting enzyme 2	90.77(n) 94.41(a)	281134 NM_177956.1 NP_808871.1
rat (Rattus norvegicus)	Ece2¹	--	endothelin-converting enzyme 2	87.95(n) 92.66(a)	408243 NM_001002815.1 NP_001002815.1
mouse (Mus musculus)	Ece2^{1, 5}	16⁵	endothelin converting enzyme 2^{1, 5}	87.68(n)¹ 91.8(a)¹	107522¹ NM_139293.1¹ NP_647454.1¹ AA929549⁵ AF396699⁵ (see all 24)

About this table Species with no ortholog for ECE2

ENSEMBL Gene Tree for ECE2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ECE2 gene

ECE1² ECEL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/223 NCBI SNPs in ECE2 are shown (see all 223 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 92)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6767237^1,2	A,C,F,H	185458935(+)	`GCGGGA/GAGCTC`	2	K/E	mis¹ int¹		4	EU EA WA	412
	rs3892286^1,2	A,C,F,H	185492924(+)	`AGAGCC/TCCCAC`	4	--	ut3¹ ese³		5	MN EU EA WA	592
	rs3914188^1,2	A,C,F,H	185492742(-)	`GCTGGG/CCATTT`	4	--	ut3¹		8	MN NA EU EA WA	736
--	rs11546878^1,2	C,F	185458797(+)	`GAGGCC/TGGTTT`	2	R/W	mis¹ int¹		4	EU EA WA	420
	rs7633387^1,2	C,H	185458059(+)	`CTCGCT/CATGCC`	2	Y/H	mis¹		7	EU EA WA	694
	rs35875049^1,2	F	185488413(-)	`TTTGCC/TGGTCA`	4	R/Q	mis¹		1	NA	76
	rs12486506^1,2	H	185493281(+)	`TCCTGC/TTGCCC`	4	--	ut3¹ ese³		4	EU EA WA	418
	rs902415^1,2	A,C,F,H	185458802(-)	`GAGATA/GAACCG`	2	F/F	syn¹ int¹		6	MN EU EA WA	1326
	rs3752904^1,2	A,C,F,H	185478762(-)	`GAGTCA/GGCACT`	4	A/A	syn¹ ese³		10	EA EU WA NA	2404
	rs2272472^1,2	F	185477875(-)	`CCATCG/AGGCAG`	4	P/P	syn¹ ese³		1	EA	1498

About this table

HapMap Linkage Disequilibrium images for ECE2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610145

2 Novoseek disease relationships for ECE2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma renal cell	32.98	2	7510000 (2)
tumors	0.00	1	15139053 (1)

About this table

Human Genome Epidemiology Navigator: ECE2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/36 PubMed articles for ECE2 gene (see all 36 ):

Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. (PubMed id 11718899)^{1, 2, 3, 4} Lorenzo M.-N....Marsden P.A. (2001)
Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. (PubMed id 17188679)^{1, 3, 4} Weeraratna A.T.... Taub D.D. (2007)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{3, 4} Nagase T....Ohara O. (1998)
Cellular expression of isoforms of endothelin-converting enzyme-1 (ECE-1c, ECE-1b and ECE-1a) and endothelin-converting enzyme-2. (PubMed id 11078322)^{1, 3} Davenport A.P. and Kuc R.E. (2000)
Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects. (PubMed id 16567585)^{1, 3} Iemitsu M....Matsuda M. (2006)
An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene. (PubMed id 19089949)^{1, 3} Tempel W....Bochkarev A. (2009)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)⁴ Muzny D.M....Gibbs R.A. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)⁴ Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Characterization of endothelin-converting enzyme-2. Implication for a role in the nonclassical processing of regulatory peptides. (PubMed id 12560336)⁴ Mzhavia N.... Devi L.A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9718	HGNC: 13275	AceView: ECE2	Ensembl:ENSG00000145194	euGenes: HUgn9718
ECgene: ECE2	H-InvDB: ECE2

(According to HUGE)
About This Section

HUGE: KIAA0604

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ECE2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ECE2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ECE2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ECE2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ECE2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (ECE2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MGC2408)
	Antibodies (MGC2408)

Search OriGene for ECE2

Tocris compounds for ECE2

	Drugs for ECE2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ECE2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ECE2 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

ECE2 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ECE2

Summaries
for ECE2

Genomic Location
for ECE2

Proteins
for ECE2

Protein Domains/
Families
for ECE2

Gene Function
for ECE2

Pathways & Interactions
for ECE2

Drugs & Compounds
for ECE2

Transcripts
for ECE2

Expression
for ECE2

Orthologs
for ECE2

Paralogs
for ECE2

SNPs/Variants
for ECE2

Disorders & Mutations
for ECE2

Medical News
for ECE2

Publications
for ECE2

Search for ECE2

Genome Databases showing ECE2

Other Databases showing ECE2

Specialized Databases showing ECE2

Licensable Technologies
for ECE2

Services
for ECE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ECE2 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ECE2

Summariesfor ECE2

Genomic Locationfor ECE2

Proteinsfor ECE2

Protein Domains/Familiesfor ECE2

Gene Functionfor ECE2

Pathways & Interactionsfor ECE2

Drugs & Compoundsfor ECE2

Transcriptsfor ECE2

Expression for ECE2

Orthologsfor ECE2

Paralogsfor ECE2

SNPs/Variantsfor ECE2

Disorders & Mutationsfor ECE2

Medical Newsfor ECE2

Publicationsfor ECE2

Search for ECE2

Genome Databases showing ECE2

Other Databases showing ECE2

Specialized Databases showing ECE2

Licensable Technologiesfor ECE2

Servicesfor ECE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ECE2

Summaries
for ECE2

Genomic Location
for ECE2

Proteins
for ECE2

Protein Domains/
Families
for ECE2

Gene Function
for ECE2

Pathways & Interactions
for ECE2

Drugs & Compounds
for ECE2

Transcripts
for ECE2

Expression
for ECE2

Orthologs
for ECE2

Paralogs
for ECE2

SNPs/Variants
for ECE2

Disorders & Mutations
for ECE2

Medical News
for ECE2

Publications
for ECE2

Licensable Technologies
for ECE2

Services
for ECE2