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Aliases & Descriptions for ECD
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases GCR2 1 , 2 HSGT1 2 OTTHUMP00000019795 2 SGT1 3 hSGT1 1 , 3
Descriptions Protein ecdysoneless homolog 3 Suppressor of GCR2 3 ecdysoneless homolog (Drosophila) 2 suppressor of S. cerevisiae gcr2 2
Search outside databases for aliases for ECD gene
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UniProtKB/Swiss-Prot: SGT1_HUMAN, O95905 Function : Novel regulator of p53 stability and function. May also be a transcriptional activatorrequired for the expression of glycolytic genes
Gene Wiki entry for ECD
Genomic Location for ECD
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
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Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ECD gene Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.3 ECD Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M074563:
(about GC identifiers )
Start:
74,564,289 bp from pter
End:
74,597,823 bp from pter
Size:
33,535 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000010.9 NT_008583.16 Proteins for ECD
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: SGT1_HUMAN, O95905 (See
protein sequence )Recommended Name: Protein SGT1 Size : 644 amino acids; 72758 Da
Subunit : Interacts with TP53 and MDM2
Subcellular location : Cytoplasm. Nucleus
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001129224.1 NP_001129225.1 NP_009196.1 ENSEMBL proteins: ENSP00000362070 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ECD: Assays for ECD:
Protein
Domains/ Families for ECD(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O95905 ProtoNet protein and cluster: O95905
1 Blocks protein family : IPB010770 SGT1 UniProtKB/Swiss-Prot: SGT1_HUMAN, O95905 Similarity : Belongs to the SGT1 family
Gene Function for ECD
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Clones , and
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Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_001135752 Applied Biosystems Silencer ® siRNAs for ECD Sigma-Aldrich siRNA for ECD Sigma-Aldrich shRNA for ECD Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135752                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135752                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001135752  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001135752 UniProtKB/Swiss-Prot: SGT1_HUMAN, O95905 Function : Novel regulator of p53 stability and function. May also be a transcriptional activatorrequired for the expression of glycolytic genes
1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003713 transcription coactivator activity
TAS 9928932
About this table
Pathways & Interactions for ECD
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for ECD (ENSP00000362070 3 ) via UniProtKB, MINT, and/or STRING About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for ECD (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ECD
Transcripts for ECD(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_001135752 Sigma-Aldrich siRNA for ECD Sigma-Aldrich shRNA for ECD Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001135752 NM_001135753 NM_007265
REFSEQ mRNAs for ECD gene (3 alternative transcripts): NM_001135752.1 NM_001135753.1 NM_007265.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001135752 NM_001135753 NM_007265
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135752                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135752                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001135752  
Additional cDNA sequence: AK022616.1 AK225519.1 AK315711.1 BC000721.2 BC103720.1 CR457407.1 D88208.1
16 DOTS entries : DT.91916541 DT.101980786 DT.100782194 DT.443126 DT.100694870 DT.102830443 DT.91758695 DT.91758697 DT.91938516 DT.100657820 DT.100782191 DT.100782195 DT.91758694 DT.91758703 DT.100782196 DT.86855228
24/232 AceView cDNA sequences (see all 232
):N70677 D88208 BG232035 AI890809 CB215450 AA457335 BU753567 AU124922 CF529380 AA894689 AA312695 BP356929 BM129820 BP359476 BM458876 BM129619 AI289462 AA767475 BP336714 BQ027657 BM681393 BM727744 CA415164 BC000721
highest scoring ESTs for ECD :D88208 AA306425 AA306721 AA312695 AK022616 AL520988 AU124922 AW955141 BC000721 BE279473
Unigene Cluster for ECD: Ecdysoneless homolog (Drosophila) Hs.631822 [show with all ESTs ] Unigene Representative Sequence: NM_001135752 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for ECD ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 SP1 :                                         SP2 :         -           -                       SP3 :         -                                 SP4 :   -   -   -                                  
About this scheme ECgene alternative splicing isoforms for ECD 1 Ensembl transcript including schematic representation : ENST00000372979
Expression for ECD
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ECD expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ECD 1 / 2 / 3
3 probe-sets matching ECD gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGAGTGCAGCSOURCE GeneReport for Unigene cluster: Hs.631822 UniProtKB/Swiss-Prot: SGT1_HUMAN, O95905 Tissue specificity : Highly expressed in muscle and heart
Orthologs for ECD
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ECD gene from 5/15 species (see all 15
)
About this table Species with no ortholog for ECD ENSEMBL Gene Tree for ECD Paralogs for ECD (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for ECD (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ECD (up to first 250kb)
Disorders & Mutations for ECD
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
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Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
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Medical News for ECD (Possibly Related Articles in
Doctor's Guide )
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Publications for ECD (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for ECD gene (see all 15
): A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae. (PubMed id 9928932) 1, 2, 3, 4 Sato T.... Uemura H. (1998) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis. (PubMed id 15128659) 2, 3 Gaziova I....Jindra M. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function. (PubMed id 16849563) 4 Zhang Y.... Band V. (2006) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 3 Oh J.H....Kim N.S. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. (PubMed id 12746458) 3 Nowotny M....Kuznicki J. (2003)
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Genome Databases showing ECD
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Specialized Databases showing ECD (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ECD:
Recombinant Proteins (SGT1 ) Antibodies (SGT1 )
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