Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ECD Gene

Aliases for ECD Gene

  • Ecdysoneless Cell Cycle Regulator 2 3 5
  • Human Suppressor Of GCR Two 3 4
  • HSGT1 3 4
  • Ecdysoneless Homolog (Drosophila) 2
  • Suppressor Of S. Cerevisiae Gcr2 3
  • Protein Ecdysoneless Homolog 3
  • Ecdysoneless Homolog 3
  • Suppressor Of GCR2 3
  • Protein SGT1 3
  • GCR2 3
  • SGT1 3

External Ids for ECD Gene

Previous GeneCards Identifiers for ECD Gene

  • GC10M074563
  • GC10M074889
  • GC10M068888

Summaries for ECD Gene

GeneCards Summary for ECD Gene

ECD (Ecdysoneless Cell Cycle Regulator) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for ECD Gene

  • Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).

Gene Wiki entry for ECD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ECD Gene

Genomics for ECD Gene

Regulatory Elements for ECD Gene

Enhancers for ECD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G072241 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 46.2 +919.3 919255 16.8 MLX CREB3L1 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 ECD ASCC1 DNAJB12 DDIT4 DNAJC9 ENSG00000200170 ANAPC16 RPL17P50 ENSG00000272599 ENSG00000272630
GH10G072270 1.5 ENCODE dbSUPER 52.5 +894.3 894289 8.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 ECD DNAJC9 ENSG00000227540 ASCC1 RPL17P50 DNAJB12 ENSG00000200170 ANAPC16 ENSG00000272599 CHST3
GH10G073964 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 22 -798.1 -798145 6.2 PKNOX1 SIN3A FEZF1 ZNF2 YY1 FOS SP3 JUNB REST ZNF592 GLUD1P3 ENSG00000272140 DUSP8P5 BMS1P4 AP3M1 ENSG00000242288 ECD ZSWIM8 RPL17P50 DNAJC9
GH10G072352 1.4 ENCODE dbSUPER 32 +814.8 814816 3.0 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 MEF2D ECD DNAJB12 CHST3 RPL17P50 DNAJC9 P4HA1 ENSG00000269926
GH10G072294 2.1 FANTOM5 Ensembl ENCODE dbSUPER 20.9 +871.9 871945 5.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 SIN3A ZNF2 ZNF766 ZNF143 DNAJB12 ECD PSAP RPL17P50 DDIT4 ENSG00000269926
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ECD on UCSC Golden Path with GeneCards custom track

Promoters for ECD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029804 855 2001 PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ECD Gene

Chromosome:
10
Start:
73,130,155 bp from pter
End:
73,169,055 bp from pter
Size:
38,901 bases
Orientation:
Minus strand

Genomic View for ECD Gene

Genes around ECD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ECD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ECD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECD Gene

Proteins for ECD Gene

  • Protein details for ECD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95905-ECD_HUMAN
    Recommended name:
    Protein ecdysoneless homolog
    Protein Accession:
    O95905
    Secondary Accessions:
    • C9JX46
    • E9PAW8

    Protein attributes for ECD Gene

    Size:
    644 amino acids
    Molecular mass:
    72758 Da
    Quaternary structure:
    • Interacts with TP53, MDM2, TXNIP (PubMed:16849563, PubMed:23880345). Interacts (phosphorylated) with PIH1D1. Interacts with RUVBL1 mediating the PIH1D1-independent association with the R2TP complex (PubMed:24656813, PubMed:26711270). Interacts with RB1, RBL1 and RBL2; ECD competes with E2F1 for binding to hypophospshorylated RB1 (PubMed:19640839). Interacts with EP300 (PubMed:19919181).

    Alternative splice isoforms for ECD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ECD Gene

Post-translational modifications for ECD Gene

  • Phosphorylated predominantly by CK2 on two serine-containing clusters; involved in cell cycle regulation activity.
  • Ubiquitination at isoforms=2, 3347
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ECD Gene

Domains & Families for ECD Gene

Protein Domains for ECD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ECD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95905

UniProtKB/Swiss-Prot:

ECD_HUMAN :
  • Belongs to the ECD family.
Family:
  • Belongs to the ECD family.
genes like me logo Genes that share domains with ECD: view

No data available for Gene Families for ECD Gene

Function for ECD Gene

Molecular function for ECD Gene

UniProtKB/Swiss-Prot Function:
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).

Gene Ontology (GO) - Molecular Function for ECD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9928932
GO:0005515 protein binding IPI 23880345
GO:0035035 histone acetyltransferase binding IDA 19919181
genes like me logo Genes that share ontologies with ECD: view
genes like me logo Genes that share phenotypes with ECD: view

Animal Models for ECD Gene

MGI Knock Outs for ECD:
  • Ecd tm1.1Viba

Animal Model Products

CRISPR Products

miRNA for ECD Gene

miRTarBase miRNAs that target ECD

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ECD Gene

Localization for ECD Gene

Subcellular locations from UniProtKB/Swiss-Prot for ECD Gene

Cytoplasm. Nucleus. Note=Predominantly is located in the cytoplasm. {ECO:0000269 PubMed:16849563, ECO:0000269 PubMed:19919181, ECO:0000269 PubMed:26711270}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ECD gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ECD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19919181
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 19919181
GO:0005829 cytosol IDA --
GO:0097255 colocalizes_with R2TP complex IDA 26711270
genes like me logo Genes that share ontologies with ECD: view

Pathways & Interactions for ECD Gene

No Data Available

Gene Ontology (GO) - Biological Process for ECD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS 9928932
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9928932
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with ECD: view

No data available for Pathways by source and SIGNOR curated interactions for ECD Gene

Drugs & Compounds for ECD Gene

(36) Drugs for ECD Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
Everolimus Approved Pharma mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 1940
Methylprednisolone Approved, Vet_approved Pharma Apoptosis inducer,GR agonist, Glucocorticoid receptor agonist 1193
Miconazole Approved, Investigational, Vet_approved Pharma Antagonist, Pore Blocker 3706
Prednisolone Approved, Vet_approved Pharma Agonist 1193
genes like me logo Genes that share compounds with ECD: view

Transcripts for ECD Gene

Unigene Clusters for ECD Gene

Ecdysoneless homolog (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ECD Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for ECD Gene

GeneLoc Exon Structure for
ECD
ECgene alternative splicing isoforms for
ECD

Expression for ECD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ECD Gene

Protein differential expression in normal tissues from HIPED for ECD Gene

This gene is overexpressed in Testis (21.1), Pancreas (18.7), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ECD Gene



Protein tissue co-expression partners for ECD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ECD Gene:

ECD

SOURCE GeneReport for Unigene cluster for ECD Gene:

Hs.631822

mRNA Expression by UniProt/SwissProt for ECD Gene:

O95905-ECD_HUMAN
Tissue specificity: Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers.

Evidence on tissue expression from TISSUES for ECD Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with ECD: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ECD Gene

Orthologs for ECD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ECD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ECD 34
  • 96.53 (n)
cow
(Bos Taurus)
Mammalia ECD 34 35
  • 89.46 (n)
dog
(Canis familiaris)
Mammalia ECD 34 35
  • 88.91 (n)
mouse
(Mus musculus)
Mammalia Ecd 34 16 35
  • 82.12 (n)
rat
(Rattus norvegicus)
Mammalia Ecd 34
  • 79.78 (n)
oppossum
(Monodelphis domestica)
Mammalia ECD 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ECD 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ECD 34 35
  • 64.37 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 71 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ecd 34
  • 64.21 (n)
Str.6089 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15386 34
zebrafish
(Danio rerio)
Actinopterygii ecd 34 35
  • 57.67 (n)
wufi43e02 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005814 34
  • 47.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta ecd 34 35
  • 46.42 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65490 34
  • 47.67 (n)
rice
(Oryza sativa)
Liliopsida Os08g0447200 34
  • 45.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7722 34
Species where no ortholog for ECD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ECD Gene

ENSEMBL:
Gene Tree for ECD (if available)
TreeFam:
Gene Tree for ECD (if available)

Paralogs for ECD Gene

No data available for Paralogs for ECD Gene

Variants for ECD Gene

Sequence variations from dbSNP and Humsavar for ECD Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000023644 -- 73,146,028(+) ACATA(C/G)AGGAG intron-variant
rs1000118910 -- 73,157,151(+) TTCAG(C/G)CAATT intron-variant
rs1000140418 -- 73,147,620(+) CTTTA(A/T)CATCA intron-variant
rs1000162490 -- 73,166,089(+) GCCAT(C/T)CTTAT intron-variant
rs1000199532 -- 73,138,116(+) TACAA(C/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ECD Gene

Variant ID Type Subtype PubMed ID
nsv1120224 CNV tandem duplication 24896259
nsv1127125 CNV deletion 24896259
nsv514574 CNV loss 21397061
nsv527219 CNV loss 19592680
nsv7132 CNV deletion 18451855

Variation tolerance for ECD Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.34; 97.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ECD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ECD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECD Gene

Disorders for ECD Gene

Relevant External Links for ECD

Genetic Association Database (GAD)
ECD
Human Genome Epidemiology (HuGE) Navigator
ECD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ECD

No disorders were found for ECD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ECD Gene

Publications for ECD Gene

  1. A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae. (PMID: 9928932) Sato T. … Uemura H. (Mol. Gen. Genet. 1999) 2 3 4 22 64
  2. A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. (PMID: 26711270) Mir R.A. … Band V. (Mol. Cell. Biol. 2015) 3 4 64
  3. Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex. (PMID: 24656813) HoA9ejA!A- Z. … Boulton S.J. (Cell Rep 2014) 3 4 64
  4. TXNIP interacts with hEcd to increase p53 stability and activity. (PMID: 23880345) Suh H.W. … Choi I. (Biochem. Biophys. Res. Commun. 2013) 3 4 64
  5. Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients. (PMID: 22270930) Zhao X. … Band V. (Breast Cancer Res. Treat. 2012) 3 4 64

Products for ECD Gene

Sources for ECD Gene

Content
Loading form....