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Aliases for EBPL Gene

Aliases for EBPL Gene

  • Emopamil Binding Protein-Like 2 3
  • Emopamil-Binding-Related Protein 3 4
  • EBRP 3 4
  • Emopamil Binding Related Protein, Delta8-Delta7 Sterol Isomerase Related Protein 3
  • ERP 4

External Ids for EBPL Gene

Previous GeneCards Identifiers for EBPL Gene

  • GC13M048033
  • GC13M049132
  • GC13M050234
  • GC13M031028

Summaries for EBPL Gene

GeneCards Summary for EBPL Gene

EBPL (Emopamil Binding Protein-Like) is a Protein Coding gene. GO annotations related to this gene include cholestenol delta-isomerase activity. An important paralog of this gene is EBP.

UniProtKB/Swiss-Prot for EBPL Gene

  • Does not possess sterol isomerase activity and does not bind sigma ligands.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBPL Gene

Genomics for EBPL Gene

Regulatory Elements for EBPL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EBPL Gene

Chromosome:
13
Start:
49,660,676 bp from pter
End:
49,691,487 bp from pter
Size:
30,812 bases
Orientation:
Minus strand

Genomic View for EBPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EBPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBPL Gene

Proteins for EBPL Gene

  • Protein details for EBPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY08-EBPL_HUMAN
    Recommended name:
    Emopamil-binding protein-like
    Protein Accession:
    Q9BY08
    Secondary Accessions:
    • A6NJ59
    • Q569H7
    • Q5JVN2
    • Q5JVN3
    • Q5JVN4
    • Q5JVN5
    • Q5JVN6

    Protein attributes for EBPL Gene

    Size:
    206 amino acids
    Molecular mass:
    23204 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for EBPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EBPL Gene

Proteomics data for EBPL Gene at MOPED

Post-translational modifications for EBPL Gene

No Post-translational modifications

Other Protein References for EBPL Gene

No data available for DME Specific Peptides for EBPL Gene

Domains & Families for EBPL Gene

Protein Domains for EBPL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EBPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY08

UniProtKB/Swiss-Prot:

EBPL_HUMAN :
  • Contains 1 EXPERA domain.
  • Belongs to the EBP family.
Domain:
  • Contains 1 EXPERA domain.
Family:
  • Belongs to the EBP family.
genes like me logo Genes that share domains with EBPL: view

No data available for Gene Families for EBPL Gene

Function for EBPL Gene

Molecular function for EBPL Gene

UniProtKB/Swiss-Prot Function:
Does not possess sterol isomerase activity and does not bind sigma ligands.

Gene Ontology (GO) - Molecular Function for EBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047750 cholestenol delta-isomerase activity IEA --
genes like me logo Genes that share ontologies with EBPL: view

Phenotypes for EBPL Gene

genes like me logo Genes that share phenotypes with EBPL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EBPL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EBPL Gene

Localization for EBPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBPL Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EBPL Gene COMPARTMENTS Subcellular localization image for EBPL gene
Compartment Confidence
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for EBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EBPL: view

Pathways & Interactions for EBPL Gene

SuperPathways for EBPL Gene

No Data Available

Interacting Proteins for EBPL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000242827%0d%0a9606.ENSP00000417052%0d%0a9606.ENSP00000265036%0d%0a
Selected Interacting proteins: Q9BY08-EBPL_HUMAN ENSP00000242827 for EBPL Gene via I2D STRING

Gene Ontology (GO) - Biological Process for EBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016125 sterol metabolic process IEA --
genes like me logo Genes that share ontologies with EBPL: view

No data available for Pathways by source and SIGNOR curated interactions for EBPL Gene

Drugs & Compounds for EBPL Gene

No Compound Related Data Available

Transcripts for EBPL Gene

Unigene Clusters for EBPL Gene

Emopamil binding protein-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EBPL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBPL Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8: -

Relevant External Links for EBPL Gene

GeneLoc Exon Structure for
EBPL
ECgene alternative splicing isoforms for
EBPL

Expression for EBPL Gene

mRNA expression in normal human tissues for EBPL Gene

Protein differential expression in normal tissues from HIPED for EBPL Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EBPL Gene



SOURCE GeneReport for Unigene cluster for EBPL Gene Hs.433278

mRNA Expression by UniProt/SwissProt for EBPL Gene

Q9BY08-EBPL_HUMAN
Tissue specificity: Widely expressed with highest levels in liver, lung and kidney.
genes like me logo Genes that share expression patterns with EBPL: view

Protein tissue co-expression partners for EBPL Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EBPL Gene

Orthologs for EBPL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EBPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EBPL 35
  • 85.61 (n)
  • 80.87 (a)
EBPL 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EBPL 35
  • 82.04 (n)
  • 76.65 (a)
EBPL 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ebpl 35
  • 80.74 (n)
  • 75.73 (a)
Ebpl 16
Ebpl 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EBPL 35
  • 99.51 (n)
  • 99.03 (a)
EBPL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ebpl 35
  • 82.04 (n)
  • 77.18 (a)
oppossum
(Monodelphis domestica)
Mammalia EBPL 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ebpl 35
  • 70.27 (n)
  • 72.73 (a)
zebrafish
(Danio rerio)
Actinopterygii ebpl 35
  • 68.48 (n)
  • 72.73 (a)
ebpl 36
  • 60 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03752 35
  • 53.58 (n)
  • 44.79 (a)
Species with no ortholog for EBPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EBPL Gene

ENSEMBL:
Gene Tree for EBPL (if available)
TreeFam:
Gene Tree for EBPL (if available)

Paralogs for EBPL Gene

Paralogs for EBPL Gene

(1) SIMAP similar genes for EBPL Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EBPL Gene

genes like me logo Genes that share paralogs with EBPL: view

Variants for EBPL Gene

Structural Variations from Database of Genomic Variants (DGV) for EBPL Gene

Variant ID Type Subtype PubMed ID
nsv900071 CNV Gain 21882294

Variation tolerance for EBPL Gene

Residual Variation Intolerance Score: 43.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EBPL Gene

HapMap Linkage Disequilibrium report
EBPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EBPL Gene

Disorders for EBPL Gene

Relevant External Links for EBPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EBPL
genes like me logo Genes that share disorders with EBPL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EBPL Gene

Publications for EBPL Gene

  1. Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen. (PMID: 19858303) Seling A. … Kraiczy P. (Infect. Immun. 2010) 23 67
  2. Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infection. (PMID: 18248770) Brissette C.A. … Stevenson B. (Int. J. Med. Microbiol. 2008) 23 67
  3. Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity. (PMID: 12760743) Moebius F.F. … Glossmann H. (Biochem. J. 2003) 23 67
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  5. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PMID: 16806233) Ma J. … Liew C.C. (Atherosclerosis 2007) 67

Products for EBPL Gene

Sources for EBPL Gene

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