Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EBPL Gene

Aliases for EBPL Gene

  • Emopamil Binding Protein-Like 2 3
  • Emopamil-Binding-Related Protein 3 4
  • EBRP 3 4
  • Emopamil Binding Related Protein, Delta8-Delta7 Sterol Isomerase Related Protein 3
  • Emopamil-Binding Protein-Like 3
  • ERP 4

External Ids for EBPL Gene

Previous GeneCards Identifiers for EBPL Gene

  • GC13M048033
  • GC13M049132
  • GC13M050234
  • GC13M031028

Summaries for EBPL Gene

GeneCards Summary for EBPL Gene

EBPL (Emopamil Binding Protein-Like) is a Protein Coding gene. GO annotations related to this gene include cholestenol delta-isomerase activity. An important paralog of this gene is EBP.

UniProtKB/Swiss-Prot for EBPL Gene

  • Does not possess sterol isomerase activity and does not bind sigma ligands.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBPL Gene

Genomics for EBPL Gene

Regulatory Elements for EBPL Gene

Genomic Location for EBPL Gene

Start:
49,660,676 bp from pter
End:
49,691,487 bp from pter
Size:
30,812 bases
Orientation:
Minus strand

Genomic View for EBPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EBPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBPL Gene

Proteins for EBPL Gene

  • Protein details for EBPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY08-EBPL_HUMAN
    Recommended name:
    Emopamil-binding protein-like
    Protein Accession:
    Q9BY08
    Secondary Accessions:
    • A6NJ59
    • Q569H7
    • Q5JVN2
    • Q5JVN3
    • Q5JVN4
    • Q5JVN5
    • Q5JVN6

    Protein attributes for EBPL Gene

    Size:
    206 amino acids
    Molecular mass:
    23204 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for EBPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EBPL Gene

Proteomics data for EBPL Gene at MOPED

Post-translational modifications for EBPL Gene

No Post-translational modifications

Other Protein References for EBPL Gene

No data available for DME Specific Peptides for EBPL Gene

Domains for EBPL Gene

Protein Domains for EBPL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EBPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY08

UniProtKB/Swiss-Prot:

EBPL_HUMAN :
  • Q9BY08
Family:
  • Belongs to the EBP family.
genes like me logo Genes that share domains with EBPL: view

No data available for Gene Families for EBPL Gene

Function for EBPL Gene

Molecular function for EBPL Gene

UniProtKB/Swiss-Prot Function: Does not possess sterol isomerase activity and does not bind sigma ligands.

Gene Ontology (GO) - Molecular Function for EBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047750 cholestenol delta-isomerase activity IEA --
genes like me logo Genes that share ontologies with EBPL: view

Phenotypes for EBPL Gene

GenomeRNAi human phenotypes for EBPL:
genes like me logo Genes that share phenotypes with EBPL: view

miRNA for EBPL Gene

miRTarBase miRNAs that target EBPL

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EBPL Gene

Localization for EBPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBPL Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EBPL Gene COMPARTMENTS Subcellular localization image for EBPL gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for EBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EBPL: view

Pathways for EBPL Gene

SuperPathways for EBPL Gene

No Data Available

Interacting Proteins for EBPL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000242827%0d%0a9606.ENSP00000417052%0d%0a9606.ENSP00000265036%0d%0a
Selected Interacting proteins: ENSP00000242827 Q9BY08-EBPL_HUMAN for EBPL Gene via STRING I2D

Gene Ontology (GO) - Biological Process for EBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016125 sterol metabolic process IEA --
genes like me logo Genes that share ontologies with EBPL: view

No data available for Pathways by source for EBPL Gene

Transcripts for EBPL Gene

Unigene Clusters for EBPL Gene

Emopamil binding protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EBPL Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8: -

Relevant External Links for EBPL Gene

GeneLoc Exon Structure for
EBPL
ECgene alternative splicing isoforms for
EBPL

Expression for EBPL Gene

mRNA expression in normal human tissues for EBPL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EBPL Gene

SOURCE GeneReport for Unigene cluster for EBPL Gene Hs.433278

mRNA Expression by UniProt/SwissProt for EBPL Gene

Q9BY08-EBPL_HUMAN
Tissue specificity: Widely expressed with highest levels in liver, lung and kidney.
genes like me logo Genes that share expressions with EBPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EBPL Gene

Orthologs for EBPL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EBPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EBPL 35
  • 99.51 (n)
  • 99.03 (a)
EBPL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EBPL 35
  • 85.61 (n)
  • 80.87 (a)
EBPL 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EBPL 35
  • 82.04 (n)
  • 76.65 (a)
EBPL 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ebpl 35
  • 80.74 (n)
  • 75.73 (a)
Ebpl 16
Ebpl 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EBPL 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ebpl 35
  • 82.04 (n)
  • 77.18 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ebpl 35
  • 70.27 (n)
  • 72.73 (a)
zebrafish
(Danio rerio)
Actinopterygii ebpl 35
  • 68.48 (n)
  • 72.73 (a)
ebpl 36
  • 60 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03752 35
  • 53.58 (n)
  • 44.79 (a)
Species with no ortholog for EBPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EBPL Gene

ENSEMBL:
Gene Tree for EBPL (if available)
TreeFam:
Gene Tree for EBPL (if available)

Paralogs for EBPL Gene

Paralogs for EBPL Gene

Selected SIMAP similar genes for EBPL Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EBPL Gene

genes like me logo Genes that share paralogs with EBPL: view

Variants for EBPL Gene

Sequence variations from dbSNP and Humsavar for EBPL Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs734223 -- 49,676,763(+) AAGGG(C/T)GGGGC intron-variant
rs737250 -- 49,677,403(-) GTCAC(C/T)TGGAA intron-variant
rs737251 -- 49,677,485(-) GGCCT(A/G)TGTTT intron-variant
rs942030 -- 49,679,702(-) CATAA(C/T)GAGAC intron-variant
rs942031 -- 49,679,352(-) GAGCT(C/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EBPL Gene

Variant ID Type Subtype PubMed ID
nsv900071 CNV Gain 21882294

Relevant External Links for EBPL Gene

HapMap Linkage Disequilibrium report
EBPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBPL Gene

Disorders for EBPL Gene

No disorders were found for EBPL Gene.

No data available for UniProtKB/Swiss-Prot for EBPL Gene

Publications for EBPL Gene

  1. Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity. (PMID: 12760743) Moebius F.F. … Glossmann H. (Biochem. J. 2003) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3
  4. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PMID: 16806233) Ma J. … Liew C.C. (Atherosclerosis 2007) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for EBPL Gene

Sources for EBPL Gene

Back to Top

Content