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EBP Gene

protein-coding GIFtS: 56

GC0XP048264

emopamil binding protein (sterol isomerase)
(Previous name: emopamil-binding protein (sterol isomerase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CDPX2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
3-beta-hydroxysteroid-delta-8,delta-7-isomerase ^²
CDPX2 ^², ⁵
CHO2 ^¹, ²
CPX ^¹, ², ⁵
CPXD ^¹, ², ⁵
EC 5.3.3.5 ^³

Descriptions
Cholestenol Delta-isomerase ^³
Chondrodysplasia punctata-2, X-linked dominant (Happle syndrome) ^²
D8-D7 sterol isomerase ^³
Delta(8)-Delta(7) sterol isomerase ^³
Emopamil-binding protein ^³
emopamil binding protein (sterol isomerase) ^²
emopamil-binding protein (sterol isomerase) ^¹, ²
sterol 8-isomerase ^²

External Ids
HGNC: 3133¹
Entrez Gene: 10682²
UniProtKB: Q15125³
Ensembl: ENSG00000147155⁷

Search outside databases for aliases for EBP gene

Previous GC identifers: GC0XP047183 GC0XP046640 GC0XP047427 GC0XP047428 GC0XP048136

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EBP:

The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It

is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist

[3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may

be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum

of different tissues. This protein shares structural features with bacterial and eukaryontic drug

transporting proteins. It has four putative transmembrane segments and contains two conserved

glutamate residues which may be involved in the transport of cationic amphiphilics. Another

prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in

its transmembrane segments. These aromatic amino acid residues have been suggested to be involved

in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia

punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq]

UniProtKB/Swiss-Prot: EBP_HUMAN, Q15125

Function: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EBP gene

Entrez Gene cytogenetic band: Xp11.23-p11.22 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23-p11.22

EBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP048264: (about GC identifiers)

Start:	48,265,177 bp from pter
End:	48,272,048 bp from pter
Size:	6,872 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EBP_HUMAN, Q15125 (See protein sequence)

Recommended Name: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Size: 230 amino acids; 26353 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Miscellaneous: Binds to the phenylalkylamine calcium-ion antagonist emopamil, an anti-ischemic drug

Secondary accessions: Q6IBI9

REFSEQ proteins: NP_006570.1

ENSEMBL proteins:

ENSP00000276096

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	7706302
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	IEA	--
GO:0005887	integral to plasma membrane	TAS	7706302
GO:0016020	membrane	IEA	--

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Antibodies for EBP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EBP
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for EBP

Assays for EBP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15125

ProtoNet protein and cluster: Q15125

1 Blocks protein family: IPB007905 Emopamil-binding

UniProtKB/Swiss-Prot: EBP_HUMAN, Q15125

Similarity: Belongs to the EBP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EBP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EBP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006579

Applied Biosystems Silencer® siRNAs for EBP

Sigma-Aldrich siRNA and siRNA Panels for EBP

Sigma-Aldrich shRNA for EBP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EBP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006579
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006579
untagged cDNA clones in CMV expression vector (see all 2): NM_006579

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006579

UniProtKB/Swiss-Prot: EBP_HUMAN, Q15125

Function: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers

Catalytic activity: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol

Enzyme Number (IUBMB): EC 5.3.3.5

Genatlas biochemistry entry for EBP:

3 hydroxysteroid-delta 8-delta 7-isomerase beta ,cholesterol biosynthesis pathway, homodimerizing

in the endoplasmic reticulum,converting cholesterol 8(9)-en 3 beta to bathosterol (cholest-7en-3

beta-ol),also binding emopamil,lamoxifen

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ebp):

growth/size

lethality-postnatal

lethality-prenatal/perinatal

skin/coat/nails

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000247	C-8 sterol isomerase activity	IEA	--
GO:0004769	steroid delta-isomerase activity	TAS	10391219
GO:0004888	transmembrane receptor activity	TAS	7706302
GO:0015238	drug transporter activity	TAS	7706302
GO:0016853	isomerase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for EBP (Your Favorite Gene powered by Ingenuity)

C21-Steroid Hormone Metabolism
Biosynthesis of Steroids
Androgen and Estrogen Metabolism

GeneDecks EBP for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: EBP_HUMAN, Q15125

Pathway: Steroid biosynthesis; cholesterol biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for EBP

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	10391219
GO:0006695	cholesterol biosynthetic process	IEA	--
GO:0030097	hemopoiesis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for EBP:

Inhibitor

Browse Tocris compounds for EBP
6 Novoseek chemical compound relationships for EBP gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sr 31747a	91.21	7	12569389 (2), 9618436 (1)
kalinin	78.07	4	9730919 (1), 9618436 (1)
sterol	72.89	15	8798407 (3), 12133002 (2), 12569389 (1), 11171067 (1) (see all 8)
lanosterol	69.54	1	11493318 (1)
3beta-hydroxysteroid	57.84	1	15452860 (1)
cholesterol	52.77	19	12503101 (1), 17949453 (1), 9034197 (1), 11171067 (1) (see all 12)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EBP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EBP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006579

Sigma-Aldrich siRNA and siRNA Panels for EBP

Sigma-Aldrich shRNA for EBP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006579

REFSEQ mRNAs for EBP gene:

NM_006579.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006579

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006579
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006579
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006579

Additional cDNA sequence:

BC001549.1 BC001572.1 BC046501.1 CR456815.1 CR542094.1 CR601932.1 CR603434.1 CR609847.1

CR615017.1 CR616138.1 CR619002.1 Z37986.1

17 DOTS entries:

DT.92016558 DT.455094 DT.100821263 DT.40286237 DT.95176938 DT.101979561 DT.121315719 DT.121315747

DT.121315785 DT.95191312 DT.95295065 DT.97846529 DT.100821264 DT.121315795 DT.95176929 DT.91986977

DT.92435882

24/248 AceView cDNA sequences (see all 248 ):

BM684662 CA487692 BU674619 BC001572 AV685537 BU169609 CB159316 CR542094

CR603434 CF130850 CR616138 BU687302 BC046501 BF981841 BQ646014 BQ021443

CR619002 BM856155 CD673242 AW591319 BQ011077 AU107557 BU616151 CR609847

highest scoring ESTs for EBP:

Z37986 AA033514 AA312226 BQ323643 BQ355317 AA916298 AI026104 AI630430 AL562158 AW062916

Unigene Cluster for EBP:

Emopamil binding protein (sterol isomerase)

Hs.30619 [show with all ESTs]

Unigene Representative Sequence: BE253850

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for EBP

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:									-						-
SP2:					-				-						-
SP3:															-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for EBP

1 Ensembl transcript including schematic representation:

ENST00000276096

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EBP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EBP

¹ / ² / ³

5 probe-sets matching EBP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32536_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Z37986	0.80	0.80	0.80	1
213787_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AV702405	0.60	0.75	0.68	1
202735_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_006579	0.40	0.67	0.55	1
213787_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202735_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks EBP for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCAGGCACA

SOURCE GeneReport for Unigene cluster: Hs.30619
Expression variation in blood from EXPOLDB for EBP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EBP gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC609430¹	--	similar to 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase more	88.74(n) 91.23(a)	609430 XM_845931.1 XP_851024.1
cow (Bos taurus)	EBP¹	--	emopamil binding protein (sterol isomerase)	86.67(n) 85.22(a)	515569 NM_001034500.1 NP_001029672.1
rat (Rattus norvegicus)	Ebp¹	--	emopamil binding protein (sterol isomerase)	81.16(n) 80.87(a)	117278 NM_057137.1 NP_476478.1
mouse (Mus musculus)	Ebp^{1, 5}	X (2.00 cM)⁵	phenylalkylamine Ca2+ antagonist (emopamil) binding more^{1, 5}	80(n)¹ 77.83(a)¹	13595¹ NM_007898.2¹ NP_031924.1¹ AI255399⁵ AK008113⁵ (see all 11)
zebrafish (Danio rerio)	zgc:91895¹	--	zgc:91895	60.06(n) 59.91(a)	436600 NM_001002328.1 NP_001002328.1

About this table Species with no ortholog for EBP

ENSEMBL Gene Tree for EBP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EBP gene

EBPL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/29 NCBI SNPs in EBP are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 19)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4824450^1,2	F,H	48272409(+)	`TCCTCC/ACATGG`	1	--	ng3¹		4		EU EA WA	418
	rs3048^1,2	C,F,H	48267118(+)	`AACGCG/TGGCCC`	1	A/A	syn¹ ese³		7		MN EU EA WA NA	692
--	rs11797195^1,2	A,C	48266883(+)	`tccgtC/Ttgaaa`	1	--	int¹		0	--	--	--	--
	rs3177777^1,2	--	48272042(+)	`TCTTGA/CCTCTA`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs55772377^1,2	--	48267061(+)	`TTTTT-/TAACTT`	1	--	ut5¹		0	--	--	--	--
	rs1049435^1,2	--	48271973(+)	`AGAACA/CCAGAT`	1	--	ut3¹ ese³		1		MN	184
	rs28936073^1,2	--	48267341(+)	`TGATCA/GAGGGC`	1	E/K	mis¹		0	--	--	--	--
	rs28465617^1,2	--	48264729(+)	`CTGAAC/GAGCTG`	1	--	ng5¹ ese³		0	--	--	--	--
--	rs60331197^1,2	--	48264985(+)	`TTGGCC/GCGTCC`	1	--	ng5¹		0	--	--	--	--
--	rs35265835^1,2	--	48267296(-)	`CAGGG-/CACAGT`	1	S/V	fra¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for EBP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300205 disorders: 302960

UniProtKB/Swiss-Prot: EBP_HUMAN, Q15125

Defects in EBP are the cause of chondrodysplasia punctata X-linked dominant type 2 (CDPX2)

[MIM:302960]; also known as Conradi-Hunermann-Happle syndrome. CDP is a clinically and genetically

heterogeneous disorder characterized by punctiform calcification of the bones. The key clinical

features of CDPX2 are chondrodysplasia punctata, linear ichthyosis, cataracts and short stature.

CDPX2 is a rare disorder of defective cholesterol biosynthesis, biochemically characterized by an

increased amount of 8-dehydrocholesterol and cholest-8(9)-en-3-beta-ol in the plasma and tissues

3 Novoseek disease relationships for EBP gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cdpx2	98.71	50	17949453 (4), 11038443 (4), 15953085 (3), 12509714 (3) (see all 18)
chondrodysplasia punctata	96.49	9	12509714 (2), 18395876 (2), 11038443 (1), 12483303 (1)
child syndrome	81.00	2	17625999 (1), 10710235 (1)

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Human Gene Mutation Database: EBP
Human Genome Epidemiology Navigator: EBP (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Researchers Discover DNA Sequence Controlling Obesity Gene

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/51 PubMed articles for EBP gene (see all 51 ):

Phenylalkylamine Ca2+ antagonist binding protein. Molecular cloning, tissue distribution, and heterologous expression. (PubMed id 7706302)^{2, 3, 4} Hanner M....Glossmann H. (1995)
Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity. (PubMed id 12760743)^{1, 3, 4} Moebius F.F....Glossmann H. (2003)
The Conradi-Hunermann-Happle syndrome (CDPX2) and emopamil binding protein: novel mutations, and somatic and gonadal mosaicism. (PubMed id 10942423)^{1, 3, 4} Has C.... Traupe H. (2000)
Mutations in a delta(8)-delta(7) sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. (PubMed id 10391218)^{1, 3, 4} Derry J.M.J.... Herman G.E. (1999)
Identification of a novel mutation in 3beta-hydroxysteroid-Delta8- Delta7-isomerase in a case of Conradi-Hunermann-Happle syndrome. (PubMed id 11493318)^{1, 3, 4} Becker K.... Karpati S. (2001)
Mutations in the gene encoding 3-beta-hydroxysteroid- delta(8),delta(7)-isomerase cause X-linked dominant Conradi-Hunermann syndrome. (PubMed id 10391219)^{1, 3, 4} Braverman N.... Valle D. (1999)
Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol delta 8-delta 7 isomerization. (PubMed id 9894009)^{1, 3, 4} Moebius F.F....Glossmann H. (1999)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval. (PubMed id 8938429)^{2, 3} Schindelhauer D....Meindl A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10682	HGNC: 3133	AceView: EBP	Ensembl:ENSG00000147155	euGenes: HUgn10682
ECgene: EBP	H-InvDB: EBP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=EBP

Licensable Technologies for EBP
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EBP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EBP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EBP		Antibodies for EBP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EBP		Small molecules for EBP
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for EBP

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Search Novus for antibodies for EBP

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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EBP Gene at Home site.
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EBP Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for EBP

Summaries
for EBP

Genomic Location
for EBP

Proteins
for EBP

Protein Domains/
Families
for EBP

Gene Function
for EBP

Pathways & Interactions
for EBP

Drugs & Compounds
for EBP

Transcripts
for EBP

Expression
for EBP

Orthologs
for EBP

Paralogs
for EBP

SNPs/Variants
for EBP

Disorders & Mutations
for EBP

Medical News
for EBP

Publications
for EBP

Search for EBP

Genome Databases showing EBP

Other Databases showing EBP

Specialized Databases showing EBP

Licensable Technologies
for EBP

Services
for EBP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EBP Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor EBP

Summariesfor EBP

Genomic Locationfor EBP

Proteinsfor EBP

Protein Domains/Familiesfor EBP

Gene Functionfor EBP

Pathways & Interactionsfor EBP

Drugs & Compoundsfor EBP

Transcriptsfor EBP

Expression for EBP

Orthologsfor EBP

Paralogsfor EBP

SNPs/Variantsfor EBP

Disorders & Mutationsfor EBP

Medical Newsfor EBP

Publicationsfor EBP

Search for EBP

Genome Databases showing EBP

Other Databases showing EBP

Specialized Databases showing EBP

Licensable Technologiesfor EBP

Servicesfor EBP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EBP

Summaries
for EBP

Genomic Location
for EBP

Proteins
for EBP

Protein Domains/
Families
for EBP

Gene Function
for EBP

Pathways & Interactions
for EBP

Drugs & Compounds
for EBP

Transcripts
for EBP

Expression
for EBP

Orthologs
for EBP

Paralogs
for EBP

SNPs/Variants
for EBP

Disorders & Mutations
for EBP

Medical News
for EBP

Publications
for EBP

Licensable Technologies
for EBP

Services
for EBP