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Aliases for EBNA1BP2 Gene

Aliases for EBNA1BP2 Gene

  • EBNA1 Binding Protein 2 2 3 5
  • EBNA1-Binding Protein 2 2 3 4
  • Nucleolar Protein P40 3 4
  • EBP2 3 4
  • Nucleolar Protein P40; Homolog Of Yeast EBNA1-Binding Protein 3
  • Nuclear FGF3 Binding Protein 3
  • NOBP 3
  • P40 3

External Ids for EBNA1BP2 Gene

Previous GeneCards Identifiers for EBNA1BP2 Gene

  • GC01M043572
  • GC01M042630
  • GC01M043059
  • GC01M043043
  • GC01M043298
  • GC01M043402
  • GC01M041749

Summaries for EBNA1BP2 Gene

GeneCards Summary for EBNA1BP2 Gene

EBNA1BP2 (EBNA1 Binding Protein 2) is a Protein Coding gene. Diseases associated with EBNA1BP2 include intracranial hypotension. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for EBNA1BP2 Gene

  • Required for the processing of the 27S pre-rRNA.

Gene Wiki entry for EBNA1BP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBNA1BP2 Gene

Genomics for EBNA1BP2 Gene

Regulatory Elements for EBNA1BP2 Gene

Promoters for EBNA1BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EBNA1BP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EBNA1BP2 Gene

Chromosome:
1
Start:
43,164,174 bp from pter
End:
43,270,936 bp from pter
Size:
106,763 bases
Orientation:
Minus strand

Genomic View for EBNA1BP2 Gene

Genes around EBNA1BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBNA1BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBNA1BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBNA1BP2 Gene

Proteins for EBNA1BP2 Gene

  • Protein details for EBNA1BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99848-EBP2_HUMAN
    Recommended name:
    Probable rRNA-processing protein EBP2
    Protein Accession:
    Q99848
    Secondary Accessions:
    • Q96A66

    Protein attributes for EBNA1BP2 Gene

    Size:
    306 amino acids
    Molecular mass:
    34852 Da
    Quaternary structure:
    • Specifically interacts with EBV EBNA1. The EBNA1-EBP2 interaction is important for the stable segregation of EBV episomes during cell division (PubMed:10074103). Interacts with WDR46.

neXtProt entry for EBNA1BP2 Gene

Proteomics data for EBNA1BP2 Gene at MOPED

Post-translational modifications for EBNA1BP2 Gene

  • Ubiquitination at Lys 33, Lys 187, and Lys 209
  • Modification sites at PhosphoSitePlus

Other Protein References for EBNA1BP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBNA1BP2 Gene

Domains & Families for EBNA1BP2 Gene

Protein Domains for EBNA1BP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EBNA1BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99848

UniProtKB/Swiss-Prot:

EBP2_HUMAN :
  • Belongs to the EBP2 family.
Family:
  • Belongs to the EBP2 family.
genes like me logo Genes that share domains with EBNA1BP2: view

No data available for Gene Families for EBNA1BP2 Gene

Function for EBNA1BP2 Gene

Molecular function for EBNA1BP2 Gene

UniProtKB/Swiss-Prot Function:
Required for the processing of the 27S pre-rRNA.
genes like me logo Genes that share phenotypes with EBNA1BP2: view

Animal Model Products

CRISPR Products

miRNA for EBNA1BP2 Gene

miRTarBase miRNAs that target EBNA1BP2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EBNA1BP2 Gene

Localization for EBNA1BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBNA1BP2 Gene

Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EBNA1BP2 Gene COMPARTMENTS Subcellular localization image for EBNA1BP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for EBNA1BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS --
genes like me logo Genes that share ontologies with EBNA1BP2: view

Pathways & Interactions for EBNA1BP2 Gene

SuperPathways for EBNA1BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EBNA1BP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EBNA1BP2 Gene

Drugs & Compounds for EBNA1BP2 Gene

No Compound Related Data Available

Transcripts for EBNA1BP2 Gene

Unigene Clusters for EBNA1BP2 Gene

EBNA1 binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBNA1BP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - - - - - - - - - -
SP6:

Relevant External Links for EBNA1BP2 Gene

GeneLoc Exon Structure for
EBNA1BP2
ECgene alternative splicing isoforms for
EBNA1BP2

Expression for EBNA1BP2 Gene

mRNA expression in normal human tissues for EBNA1BP2 Gene

Protein differential expression in normal tissues from HIPED for EBNA1BP2 Gene

This gene is overexpressed in Lung (18.8), Adrenal (12.0), Breast (7.1), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EBNA1BP2 Gene



SOURCE GeneReport for Unigene cluster for EBNA1BP2 Gene Hs.346868

mRNA Expression by UniProt/SwissProt for EBNA1BP2 Gene

Q99848-EBP2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with EBNA1BP2: view

Protein tissue co-expression partners for EBNA1BP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EBNA1BP2 Gene

Orthologs for EBNA1BP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EBNA1BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EBNA1BP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EBNA1BP2 36
  • 90 (a)
OneToOne
EBNA1BP2 35
  • 88.96 (n)
  • 90.49 (a)
dog
(Canis familiaris)
Mammalia EBNA1BP2 35
  • 89.29 (n)
  • 91.15 (a)
EBNA1BP2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ebna1bp2 16
Ebna1bp2 36
  • 85 (a)
OneToOne
Ebna1bp2 35
  • 84.32 (n)
  • 85.86 (a)
oppossum
(Monodelphis domestica)
Mammalia EBNA1BP2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EBNA1BP2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912375 35
  • 85.53 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves EBNA1BP2 36
  • 68 (a)
OneToOne
EBNA1BP2 35
  • 69.71 (n)
  • 71.93 (a)
lizard
(Anolis carolinensis)
Reptilia EBNA1BP2 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398544 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730438 35
  • 68.31 (n)
  • 71.48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7195 35
zebrafish
(Danio rerio)
Actinopterygii ebna1bp2 36
  • 58 (a)
OneToOne
ebna1bp2 35
  • 61.39 (n)
  • 59.41 (a)
wufa12d07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011383 35
  • 50.88 (n)
  • 45.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1542 36
  • 40 (a)
OneToOne
CG1542 37
  • 43 (a)
CG1542 35
  • 53.33 (n)
  • 47.91 (a)
worm
(Caenorhabditis elegans)
Secernentea C18A3.3 35
  • 50.78 (n)
  • 45.7 (a)
C18A3.3 36
  • 34 (a)
OneToOne
C18A3.3 37
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EBP2 36
  • 23 (a)
OneToOne
EBP2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4836 36
  • 43 (a)
OneToOne
Species with no ortholog for EBNA1BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EBNA1BP2 Gene

ENSEMBL:
Gene Tree for EBNA1BP2 (if available)
TreeFam:
Gene Tree for EBNA1BP2 (if available)

Paralogs for EBNA1BP2 Gene

No data available for Paralogs for EBNA1BP2 Gene

Variants for EBNA1BP2 Gene

Sequence variations from dbSNP and Humsavar for EBNA1BP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7163 - 43,166,865(-) ACAGC(A/G/T)CAAGA reference, missense
rs674341 -- 43,170,087(+) atacc(A/G)aatac intron-variant
rs1010629 -- 43,168,536(+) CCAAA(C/T)CAGGA intron-variant
rs1049401 -- 43,164,449(-) AGAAC(A/C)CACTA reference, synonymous-codon
rs1615025 -- 43,170,167(+) TTTGC(A/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EBNA1BP2 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV Loss 17160897

Variation tolerance for EBNA1BP2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EBNA1BP2 Gene

HapMap Linkage Disequilibrium report
EBNA1BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBNA1BP2 Gene

Disorders for EBNA1BP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EBNA1BP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intracranial hypotension
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EBNA1BP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EBNA1BP2
genes like me logo Genes that share disorders with EBNA1BP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EBNA1BP2 Gene

Publications for EBNA1BP2 Gene

  1. EBP2, a human protein that interacts with sequences of the Epstein- Barr virus nuclear antigen 1 important for plasmid maintenance. (PMID: 10074103) Shire K. … Frappier L. (J. Virol. 1999) 2 3 4 23 67
  2. Ectopic EBP2 expression enhances cyclin E1 expression and induces chromosome instability in HEK293 stable clones. (PMID: 18959818) Lee M.C. … Tsai-Wu J.J. (BMB Rep 2008) 3 23
  3. EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. (PMID: 15923612) Kapoor P. … Frappier L. (Mol. Cell. Biol. 2005) 3 23
  4. EBNA1 partitions Epstein-Barr virus plasmids in yeast cells by attaching to human EBNA1-binding protein 2 on mitotic chromosomes. (PMID: 12768013) Kapoor P. … Frappier L. (J. Virol. 2003) 3 23
  5. NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth. (PMID: 11438656) Reimers K. … Kiefer P. (Mol. Cell. Biol. 2001) 2 3

Products for EBNA1BP2 Gene

Sources for EBNA1BP2 Gene

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