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Aliases for EBNA1BP2 Gene

Aliases for EBNA1BP2 Gene

  • EBNA1 Binding Protein 2 2 3 5
  • EBNA1-Binding Protein 2 2 4
  • Nucleolar Protein P40 3 4
  • EBP2 3 4
  • Nucleolar Protein P40; Homolog Of Yeast EBNA1-Binding Protein 3
  • Probable RRNA-Processing Protein EBP2 3
  • Nuclear FGF3 Binding Protein 3
  • NOBP 3
  • P40 3

External Ids for EBNA1BP2 Gene

Previous GeneCards Identifiers for EBNA1BP2 Gene

  • GC01M043572
  • GC01M042630
  • GC01M043059
  • GC01M043043
  • GC01M043298
  • GC01M043402
  • GC01M041749

Summaries for EBNA1BP2 Gene

GeneCards Summary for EBNA1BP2 Gene

EBNA1BP2 (EBNA1 Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for EBNA1BP2 Gene

  • Required for the processing of the 27S pre-rRNA.

Gene Wiki entry for EBNA1BP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBNA1BP2 Gene

Genomics for EBNA1BP2 Gene

Regulatory Elements for EBNA1BP2 Gene

Enhancers for EBNA1BP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G043293 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -24.1 -24137 3.8 HDGF TBP KLF17 RAD21 YY1 FOS RELB ETV6 IKZF2 ZNF362 MED8 EBNA1BP2 MPL LOC105378687 CDC20 ELOVL1 ENSG00000229431 SZT2 FAM183A ATP6V0B
GH01G043371 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -102.1 -102107 3.3 GTF2F1 JUN BRCA1 FOSL1 ZNF316 GATA2 RCOR1 NFE2 FOS TCF7L2 MED8 MPL EBNA1BP2 CFAP57 ELOVL1 SZT2
GH01G043471 1.4 Ensembl ENCODE dbSUPER 9.8 -203.6 -203631 6.8 ATF1 SIN3A ARID4B GATA2 FOS YY2 REST KAT8 SMARCA4 MXD3 MED8 SZT2 KDM4A-AS1 PTPRF ELOVL1 LOC105378687 CDC20 MPL PPIH ST3GAL3
GH01G043120 1.2 Ensembl ENCODE 11 +149.7 149657 1.9 ATF1 CREB3L1 FEZF1 ZNF2 ZNF121 FOS KLF7 SP3 YY2 REST FAM183A CFAP57 EBNA1BP2 ENSG00000277513
GH01G043147 1.1 Ensembl ENCODE 11.4 +123.0 123036 1.0 HDAC1 PKNOX1 ARID4B KLF17 SIN3A BMI1 ETS1 ZNF121 GLIS2 SP3 CFAP57 EBNA1BP2 FAM183A GC01P043162
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EBNA1BP2 on UCSC Golden Path with GeneCards custom track

Promoters for EBNA1BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005567 36 201 PKNOX1 NR2F1 MAX RBBP5 ZEB2 ZNF316 POLR2A EGR1 CREB1 KLF9

Genomic Location for EBNA1BP2 Gene

43,164,174 bp from pter
43,270,936 bp from pter
106,763 bases
Minus strand

Genomic View for EBNA1BP2 Gene

Genes around EBNA1BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBNA1BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBNA1BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBNA1BP2 Gene

Proteins for EBNA1BP2 Gene

  • Protein details for EBNA1BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable rRNA-processing protein EBP2
    Protein Accession:
    Secondary Accessions:
    • Q96A66

    Protein attributes for EBNA1BP2 Gene

    306 amino acids
    Molecular mass:
    34852 Da
    Quaternary structure:
    • Specifically interacts with EBV EBNA1. The EBNA1-EBP2 interaction is important for the stable segregation of EBV episomes during cell division (PubMed:10074103). Interacts with WDR46.

neXtProt entry for EBNA1BP2 Gene

Post-translational modifications for EBNA1BP2 Gene

  • Ubiquitination at Lys33, Lys187, and isoforms=209
  • Modification sites at PhosphoSitePlus

Other Protein References for EBNA1BP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBNA1BP2 Gene

Domains & Families for EBNA1BP2 Gene

Protein Domains for EBNA1BP2 Gene


Suggested Antigen Peptide Sequences for EBNA1BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EBP2 family.
  • Belongs to the EBP2 family.
genes like me logo Genes that share domains with EBNA1BP2: view

No data available for Gene Families for EBNA1BP2 Gene

Function for EBNA1BP2 Gene

Molecular function for EBNA1BP2 Gene

UniProtKB/Swiss-Prot Function:
Required for the processing of the 27S pre-rRNA.

Gene Ontology (GO) - Molecular Function for EBNA1BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with EBNA1BP2: view
genes like me logo Genes that share phenotypes with EBNA1BP2: view

Animal Model Products

CRISPR Products

miRNA for EBNA1BP2 Gene

miRTarBase miRNAs that target EBNA1BP2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EBNA1BP2 Gene

Localization for EBNA1BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBNA1BP2 Gene

Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EBNA1BP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for EBNA1BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 16263084
GO:0030687 preribosome, large subunit precursor IBA --
GO:0034399 nuclear periphery IBA --
genes like me logo Genes that share ontologies with EBNA1BP2: view

Pathways & Interactions for EBNA1BP2 Gene

SuperPathways for EBNA1BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EBNA1BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0042254 ribosome biogenesis IEA --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with EBNA1BP2: view

No data available for Pathways by source and SIGNOR curated interactions for EBNA1BP2 Gene

Drugs & Compounds for EBNA1BP2 Gene

No Compound Related Data Available

Transcripts for EBNA1BP2 Gene

Unigene Clusters for EBNA1BP2 Gene

EBNA1 binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBNA1BP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - - - - - - - - - -

Relevant External Links for EBNA1BP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EBNA1BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EBNA1BP2 Gene

Protein differential expression in normal tissues from HIPED for EBNA1BP2 Gene

This gene is overexpressed in Lung (18.8), Adrenal (12.0), Breast (7.1), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EBNA1BP2 Gene

Protein tissue co-expression partners for EBNA1BP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EBNA1BP2 Gene:


SOURCE GeneReport for Unigene cluster for EBNA1BP2 Gene:


mRNA Expression by UniProt/SwissProt for EBNA1BP2 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EBNA1BP2 Gene

  • Skin(4.7)
  • Liver(4.3)
  • Nervous system(4)
  • Lung(3.4)
  • Intestine(2.9)
  • Pancreas(2.7)
genes like me logo Genes that share expression patterns with EBNA1BP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EBNA1BP2 Gene

Orthologs for EBNA1BP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EBNA1BP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EBNA1BP2 35
  • 100 (a)
(Canis familiaris)
Mammalia EBNA1BP2 34 35
  • 89.29 (n)
(Bos Taurus)
Mammalia EBNA1BP2 34 35
  • 88.96 (n)
(Rattus norvegicus)
Mammalia Ebna1bp2 34
  • 85.53 (n)
(Mus musculus)
Mammalia Ebna1bp2 34 16 35
  • 84.32 (n)
(Monodelphis domestica)
Mammalia EBNA1BP2 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia EBNA1BP2 35
  • 70 (a)
(Gallus gallus)
Aves EBNA1BP2 34 35
  • 69.71 (n)
(Anolis carolinensis)
Reptilia EBNA1BP2 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730438 34
  • 68.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398544 34
(Danio rerio)
Actinopterygii ebna1bp2 34 35
  • 61.39 (n)
wufa12d07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7195 34
fruit fly
(Drosophila melanogaster)
Insecta CG1542 36 34 35
  • 53.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011383 34
  • 50.88 (n)
(Caenorhabditis elegans)
Secernentea C18A3.3 36 34 35
  • 50.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EBP2 35 37
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4836 35
  • 43 (a)
Species where no ortholog for EBNA1BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EBNA1BP2 Gene

Gene Tree for EBNA1BP2 (if available)
Gene Tree for EBNA1BP2 (if available)

Paralogs for EBNA1BP2 Gene

No data available for Paralogs for EBNA1BP2 Gene

Variants for EBNA1BP2 Gene

Sequence variations from dbSNP and Humsavar for EBNA1BP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000165339 -- 43,170,516(+) GGGAC(C/T)ACACT intron-variant, upstream-variant-2KB
rs1001063133 -- 43,165,994(+) CTCTA(C/T)CATAG intron-variant
rs1001410962 -- 43,166,274(+) AATCA(A/G)CTTTA intron-variant
rs1001461199 -- 43,165,203(+) TGTAA(C/T)GTAAT intron-variant
rs1001513304 -- 43,164,719(+) CATCA(C/T)AGCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for EBNA1BP2 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV loss 17160897

Variation tolerance for EBNA1BP2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EBNA1BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBNA1BP2 Gene

Disorders for EBNA1BP2 Gene

Relevant External Links for EBNA1BP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EBNA1BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EBNA1BP2 Gene

Publications for EBNA1BP2 Gene

  1. EBP2, a human protein that interacts with sequences of the Epstein- Barr virus nuclear antigen 1 important for plasmid maintenance. (PMID: 10074103) Shire K. … Frappier L. (J. Virol. 1999) 2 3 4 22 64
  2. Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. (PMID: 19170763) Hirano Y. … Horigome T. (Genes Cells 2009) 3 4 64
  3. Ectopic EBP2 expression enhances cyclin E1 expression and induces chromosome instability in HEK293 stable clones. (PMID: 18959818) Lee M.C. … Tsai-Wu J.J. (BMB Rep 2008) 3 22 64
  4. EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. (PMID: 15923612) Kapoor P. … Frappier L. (Mol. Cell. Biol. 2005) 3 22 64
  5. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson M.P. … Clurman B.E. (Biochem. Biophys. Res. Commun. 2005) 3 22 64

Products for EBNA1BP2 Gene

Sources for EBNA1BP2 Gene

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