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Aliases & Descriptions for EBNA1BP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EBP2 1, 2, 3 | | NOBP 1, 2 | | OTTHUMP00000008354 2 | | P40 1, 2 |
| | | Descriptions |
|---|
| EBNA1 binding protein 2 2 | | EBNA1-binding protein 2 1, 2, 3 | | Nucleolar protein p40 3 | | nuclear FGF3 binding protein 2 | nucleolar protein p40; homolog of yeast EBNA1-binding protein 2 |
|
| | Search outside databases for aliases for EBNA1BP2 genePrevious GC identifers: GC01M043572 GC01M042630 GC01M043059 GC01M043043 GC01M043298 |
Summaries for EBNA1BP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: EBP2_HUMAN, Q99848Function: Required for the processing of the 27S pre-rRNA (By similarity)Gene Wiki entry for EBNA1BP2 |
Genomic Location for EBNA1BP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EBNA1BP2 gene 
Entrez Gene cytogenetic band: 1p35-p33 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p35-p33EBNA1BP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M043402:
(about GC identifiers)
Start:
|
43,402,440 bp from pter |
End:
|
43,410,518 bp from pter |
Size:
|
8,079 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for EBNA1BP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: EBP2_HUMAN, Q99848 (See
protein sequence)Recommended Name: Probable rRNA-processing protein EBP2 Size: 306 amino acids; 34852 Da
Subunit: Specifically interacts with EBV EBNA1. The EBNA1-EBP2 interaction is important for the stable segregation of EBV episomes during cell division
Subcellular location: Nucleus, nucleolus
Secondary accessions: Q96A66Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001153408.1 NP_006815.2
ENSEMBL proteins: ENSP00000236051
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for EBNA1BP2: Assays for EBNA1BP2: | Protein
Domains/ Families for EBNA1BP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q99848
ProtoNet protein and cluster: Q99848 1 Blocks protein family: IPB008610 Eukaryotic rRNA processing
UniProtKB/Swiss-Prot: EBP2_HUMAN, Q99848Similarity: Belongs to the EBP2 family | Gene Function for EBNA1BP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006824
Applied Biosystems Silencer® siRNAs for EBNA1BP2
Sigma-Aldrich siRNA for EBNA1BP2  Sigma-Aldrich shRNA for EBNA1BP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006824                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006824                                  untagged cDNA clone in CMV expression vector: NM_006824 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006824
UniProtKB/Swiss-Prot: EBP2_HUMAN, Q99848Function: Required for the processing of the 27S pre-rRNA (By similarity)1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for EBNA1BP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for EBNA1BP2 
5/265 Interacting proteins for EBNA1BP2 (Q998481, 2 ENSP000002360513) via UniProtKB, MINT, and/or STRING (see all 265
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042254 | ribosome biogenesis |
IEA | -- | About this table
|
Drugs & Compounds for EBNA1BP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EBNA1BP2
|
Transcripts for EBNA1BP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006824
Sigma-Aldrich siRNA for EBNA1BP2  Sigma-Aldrich shRNA for EBNA1BP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006824 REFSEQ mRNAs for EBNA1BP2 gene (2 alternative transcripts): NM_001159936.1 NM_006824.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006824               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006824                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006824                                  untagged cDNA clone in CMV expression vector: NM_006824  Additional cDNA sequence: AB451256.1 AB451381.1 AK223455.1 AK295006.1 AK299476.1 AK307440.1 BC009175.2 BC073924.1 BT006920.1 CR456975.1 CR590575.1 CR605280.1 CR605987.1 CR613176.1 CR613349.1 CR614881.1 CR616272.1 U86602.1 14 DOTS entries: DT.450421 DT.100796220 DT.99962875 DT.101956902 DT.121381843 DT.92451472 DT.95148339 DT.86855213 DT.75186993 DT.95263508 DT.95263510 DT.40281073 DT.121381849 DT.95116093 24/619 AceView cDNA sequences (see all 619
):BQ446052 BQ440146 BM762305 BQ950757 BM552533 CR616272 BQ423641 BF063935 BM763119 BM464783 BQ648951 BM907162 AL542139 BM826343 BM761309 BM478144 CA431971 AW005739 BQ421234 BM452313 CB142476 CR613176 CA449601 CB122081
highest scoring ESTs for EBNA1BP2:U86602 AA029619 AA039747 AA053479 AA070097 AA083451 AA115617 AA131984 AA155869 AA216649 Unigene Cluster for EBNA1BP2: EBNA1 binding protein 2 Hs.346868 [show with all ESTs]Unigene Representative Sequence: CR605987
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EBNA1BP2 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for EBNA1BP2
1 Ensembl transcript including schematic representation: ENST00000236051
|
Expression for EBNA1BP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EBNA1BP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EBNA1BP2
1 / 2 / 3 3 probe-sets matching EBNA1BP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGTAAACAT
SOURCE GeneReport for Unigene cluster: Hs.346868
Expression variation in blood from EXPOLDB for EBNA1BP2 UniProtKB/Swiss-Prot: EBP2_HUMAN, Q99848Tissue specificity: Ubiquitous |
Orthologs for EBNA1BP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EBNA1BP2 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for EBNA1BP2
ENSEMBL Gene Tree for EBNA1BP2 | Paralogs for EBNA1BP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for EBNA1BP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EBNA1BP2 (up to first 250kb)
|
Disorders & Mutations for EBNA1BP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for EBNA1BP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EBNA1BP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for EBNA1BP2 gene (see all 26
):- EBP2, a human protein that interacts with sequences of the Epstein- Barr virus nuclear antigen 1 important for plasmid maintenance. (PubMed id 10074103)1, 2, 3, 4 Shire K.... Frappier L. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth. (PubMed id 11438656)2, 3 Reimers K....Kiefer P. (2001)
- Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2. (PubMed id 11327720)3, 4 Henning D. and Valdez B.C. (2001)
- Identification and partial characterization of a Mr 40,000 nucleolar antigen associated with cell proliferation. (PubMed id 2879624)3, 4 Chatterjee A.... Busch H. (1987)
- EBNA1 partitions Epstein-Barr virus plasmids in yeast cells by attaching to human EBNA1-binding protein 2 on mitotic chromosomes. (PubMed id 12768013)1, 3 Kapoor P. and Frappier L. (2003)
- Ectopic EBP2 expression enhances cyclin E1 expression and induces chromosome instability in HEK293 stable clones. (PubMed id 18959818)1, 3 Lee M.C....Tsai-Wu J.J. (2008)
- The budding yeast homolog of the human EBNA1-binding protein 2 (Ebp2p) is an essential nucleolar protein required for pre-rRNA processing. (PubMed id 10849420)1, 3 Huber M.D....McAlear M.A. (2000)
- EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. (PubMed id 15923612)1, 3 Kapoor P....Frappier L. (2005)
- Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. (PubMed id 19170763)3 Hirano Y....Horigome T. (2009)
|
Search for EBNA1BP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EBNA1BP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EBNA1BP2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EBNA1BP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EBNA1BP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EBNA1BP2:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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