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Aliases for EBNA1BP2 Gene

Aliases for EBNA1BP2 Gene

  • EBNA1 Binding Protein 2 2 3 5
  • EBNA1-Binding Protein 2 2 4
  • Nucleolar Protein P40 3 4
  • EBP2 3 4
  • Nucleolar Protein P40; Homolog Of Yeast EBNA1-Binding Protein 3
  • Probable RRNA-Processing Protein EBP2 3
  • Nuclear FGF3 Binding Protein 3
  • NOBP 3
  • P40 3

External Ids for EBNA1BP2 Gene

Previous GeneCards Identifiers for EBNA1BP2 Gene

  • GC01M043572
  • GC01M042630
  • GC01M043059
  • GC01M043043
  • GC01M043298
  • GC01M043402
  • GC01M041749

Summaries for EBNA1BP2 Gene

GeneCards Summary for EBNA1BP2 Gene

EBNA1BP2 (EBNA1 Binding Protein 2) is a Protein Coding gene. Diseases associated with EBNA1BP2 include Early-Onset Familial Alzheimer Disease. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for EBNA1BP2 Gene

  • Required for the processing of the 27S pre-rRNA.

Gene Wiki entry for EBNA1BP2 Gene

Additional gene information for EBNA1BP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBNA1BP2 Gene

Genomics for EBNA1BP2 Gene

Regulatory Elements for EBNA1BP2 Gene

Enhancers for EBNA1BP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H043293 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -24.1 -24137 3 HDGF FOXA2 KLF17 RAD21 YY1 ATF7 ETV6 RUNX3 IKZF2 USF2 MED8 EBNA1BP2 MPL CDC20 LOC105378687 ELOVL1 ENSG00000229431 SZT2 FAM183A ATP6V0B
GH01H043371 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -102.1 -102107 3 GTF2F1 JUN BRCA1 FOSL1 ZNF316 RCOR1 FOS NFE2 TCF7L2 STAT1 MED8 MPL EBNA1BP2 CFAP57 ELOVL1 SZT2
GH01H043471 1.4 Ensembl ENCODE dbSUPER 9.8 -203.6 -203631 6 ELF3 ATF1 INSM2 ZNF76 SIN3A ZEB1 RARA RCOR1 FOS ATF7 MED8 SZT2 PTPRF ELOVL1 CDC20 LOC105378687 MPL ST3GAL3 EBNA1BP2 CFAP57
GH01H043120 1.2 Ensembl ENCODE 11 +149.7 149657 1 ATF1 FEZF1 ZNF2 ZNF121 FOS KLF7 ATF7 SP3 YY2 REST FAM183A CFAP57 EBNA1BP2 ENSG00000277513
GH01H043147 1.1 Ensembl ENCODE 11.4 +123.0 123036 1 HDAC1 PKNOX1 ARID4B KLF17 SIN3A BMI1 RFX5 ETS1 ZNF121 GLIS2 CFAP57 EBNA1BP2 FAM183A GC01P043162
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EBNA1BP2 on UCSC Golden Path with GeneCards custom track

Promoters for EBNA1BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005567 36 201 PKNOX1 MAX ZEB2 RFX5 CTBP1 ZNF316 POLR2A EGR1 CREB1 KLF9

Genomic Location for EBNA1BP2 Gene

Chromosome:
1
Start:
43,164,174 bp from pter
End:
43,270,936 bp from pter
Size:
106,763 bases
Orientation:
Minus strand

Genomic View for EBNA1BP2 Gene

Genes around EBNA1BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBNA1BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBNA1BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBNA1BP2 Gene

Proteins for EBNA1BP2 Gene

  • Protein details for EBNA1BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99848-EBP2_HUMAN
    Recommended name:
    Probable rRNA-processing protein EBP2
    Protein Accession:
    Q99848
    Secondary Accessions:
    • Q96A66

    Protein attributes for EBNA1BP2 Gene

    Size:
    306 amino acids
    Molecular mass:
    34852 Da
    Quaternary structure:
    • Specifically interacts with EBV EBNA1. The EBNA1-EBP2 interaction is important for the stable segregation of EBV episomes during cell division (PubMed:10074103). Interacts with WDR46.

neXtProt entry for EBNA1BP2 Gene

Post-translational modifications for EBNA1BP2 Gene

  • Ubiquitination at posLast=3333, posLast=187187, and posLast=209209
  • Modification sites at PhosphoSitePlus

Other Protein References for EBNA1BP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBNA1BP2 Gene

Domains & Families for EBNA1BP2 Gene

Gene Families for EBNA1BP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EBNA1BP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EBNA1BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99848

UniProtKB/Swiss-Prot:

EBP2_HUMAN :
  • Belongs to the EBP2 family.
Family:
  • Belongs to the EBP2 family.
genes like me logo Genes that share domains with EBNA1BP2: view

Function for EBNA1BP2 Gene

Molecular function for EBNA1BP2 Gene

UniProtKB/Swiss-Prot Function:
Required for the processing of the 27S pre-rRNA.

Gene Ontology (GO) - Molecular Function for EBNA1BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 10074103
genes like me logo Genes that share ontologies with EBNA1BP2: view
genes like me logo Genes that share phenotypes with EBNA1BP2: view

Animal Model Products

CRISPR Products

miRNA for EBNA1BP2 Gene

miRTarBase miRNAs that target EBNA1BP2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EBNA1BP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EBNA1BP2 Gene

Localization for EBNA1BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBNA1BP2 Gene

Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EBNA1BP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EBNA1BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 16263084
GO:0030687 preribosome, large subunit precursor IBA --
GO:0034399 nuclear periphery IBA --
genes like me logo Genes that share ontologies with EBNA1BP2: view

Pathways & Interactions for EBNA1BP2 Gene

SuperPathways for EBNA1BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EBNA1BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0042254 ribosome biogenesis IEA --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with EBNA1BP2: view

No data available for Pathways by source and SIGNOR curated interactions for EBNA1BP2 Gene

Drugs & Compounds for EBNA1BP2 Gene

No Compound Related Data Available

Transcripts for EBNA1BP2 Gene

Unigene Clusters for EBNA1BP2 Gene

EBNA1 binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EBNA1BP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EBNA1BP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - - - - - - - - - -
SP6:

Relevant External Links for EBNA1BP2 Gene

GeneLoc Exon Structure for
EBNA1BP2
ECgene alternative splicing isoforms for
EBNA1BP2

Expression for EBNA1BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EBNA1BP2 Gene

Protein differential expression in normal tissues from HIPED for EBNA1BP2 Gene

This gene is overexpressed in Lung (18.8), Adrenal (12.0), Breast (7.1), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EBNA1BP2 Gene



Protein tissue co-expression partners for EBNA1BP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EBNA1BP2 Gene:

EBNA1BP2

SOURCE GeneReport for Unigene cluster for EBNA1BP2 Gene:

Hs.346868

mRNA Expression by UniProt/SwissProt for EBNA1BP2 Gene:

Q99848-EBP2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EBNA1BP2 Gene

  • Skin(4.7)
  • Liver(4.3)
  • Nervous system(4)
  • Lung(3.4)
  • Intestine(2.9)
  • Pancreas(2.7)
genes like me logo Genes that share expression patterns with EBNA1BP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EBNA1BP2 Gene

Orthologs for EBNA1BP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EBNA1BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EBNA1BP2 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EBNA1BP2 33 34
  • 89.29 (n)
cow
(Bos Taurus)
Mammalia EBNA1BP2 33 34
  • 88.96 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912375 33
  • 85.53 (n)
mouse
(Mus musculus)
Mammalia Ebna1bp2 33 16 34
  • 84.32 (n)
oppossum
(Monodelphis domestica)
Mammalia EBNA1BP2 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EBNA1BP2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves EBNA1BP2 33 34
  • 69.71 (n)
lizard
(Anolis carolinensis)
Reptilia EBNA1BP2 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730438 33
  • 68.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398544 33
zebrafish
(Danio rerio)
Actinopterygii ebna1bp2 34 33
  • 61.39 (n)
OneToOne
wufa12d07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7195 33
fruit fly
(Drosophila melanogaster)
Insecta CG1542 35 33 34
  • 53.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011383 33
  • 50.88 (n)
worm
(Caenorhabditis elegans)
Secernentea C18A3.3 35 33 34
  • 50.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EBP2 34 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4836 34
  • 43 (a)
OneToOne
Species where no ortholog for EBNA1BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EBNA1BP2 Gene

ENSEMBL:
Gene Tree for EBNA1BP2 (if available)
TreeFam:
Gene Tree for EBNA1BP2 (if available)

Paralogs for EBNA1BP2 Gene

No data available for Paralogs for EBNA1BP2 Gene

Variants for EBNA1BP2 Gene

Sequence variations from dbSNP and Humsavar for EBNA1BP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000165339 -- 43,170,516(+) GGGAC(C/T)ACACT intron-variant, upstream-variant-2KB
rs1001063133 -- 43,165,994(+) CTCTA(C/T)CATAG intron-variant
rs1001410962 -- 43,166,274(+) AATCA(A/G)CTTTA intron-variant
rs1001461199 -- 43,165,203(+) TGTAA(C/T)GTAAT intron-variant
rs1001513304 -- 43,164,719(+) CATCA(C/T)AGCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for EBNA1BP2 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV loss 17160897

Variation tolerance for EBNA1BP2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EBNA1BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EBNA1BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBNA1BP2 Gene

Disorders for EBNA1BP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EBNA1BP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
early-onset familial alzheimer disease
  • eofad
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EBNA1BP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EBNA1BP2
genes like me logo Genes that share disorders with EBNA1BP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EBNA1BP2 Gene

Publications for EBNA1BP2 Gene

  1. EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance. (PMID: 10074103) Shire K … Frappier L (Journal of virology 1999) 2 3 4 22 60
  2. Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. (PMID: 19170763) Hirano Y … Horigome T (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 4 60
  3. Ectopic EBP2 expression enhances cyclin E1 expression and induces chromosome instability in HEK293 stable clones. (PMID: 18959818) Lee MC … Tsai-Wu JJ (BMB reports 2008) 3 22 60
  4. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson MP … Clurman BE (Biochemical and biophysical research communications 2005) 3 22 60
  5. EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. (PMID: 15923612) Kapoor P … Frappier L (Molecular and cellular biology 2005) 3 22 60

Products for EBNA1BP2 Gene

Sources for EBNA1BP2 Gene

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