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Aliases for EBLN1 Gene

Aliases for EBLN1 Gene

  • Endogenous Bornavirus-Like Nucleoprotein 1 2 3 5
  • Endogenous Borna-Like N Element-1 3 4
  • EBLN-1 3 4
  • Endogenous Borna-Like N Element-Containing Protein 1 3
  • Endogenous Borna-Like N Element 1 2

External Ids for EBLN1 Gene

Previous GeneCards Identifiers for EBLN1 Gene

  • GC10M022499

Summaries for EBLN1 Gene

GeneCards Summary for EBLN1 Gene

EBLN1 (Endogenous Bornavirus-Like Nucleoprotein 1) is a Protein Coding gene. An important paralog of this gene is EBLN2.

UniProtKB/Swiss-Prot for EBLN1 Gene

  • May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBLN1 Gene

Genomics for EBLN1 Gene

Regulatory Elements for EBLN1 Gene

Enhancers for EBLN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G022228 1.7 FANTOM5 Ensembl ENCODE 2.6 -19.7 -19674 3.0 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 BMI1 COMMD3 DNAJC1 EBLN1 TRN-GTT2-3 LOC105376446
GH10G022339 1.4 FANTOM5 ENCODE 1.7 -130.7 -130726 2.0 CREB3L1 ARNT WRNIP1 SIN3A ZNF2 ZNF766 ZNF143 ZNF207 FOS ZNF263 EBLN1 DNAJC1 ENSG00000272366 SPAG6
GH10G022528 1 FANTOM5 1.9 -318.3 -318311 0.1 ATF1 PKNOX1 ARNT CREB3L1 FEZF1 ZNF2 ZNF766 ELK1 FOS SP3 EBLN1 TRP-GGG1-1 LOC105376450
GH10G021912 0.7 FANTOM5 ENCODE 2.6 +297.3 297277 0.5 ATF2 EBLN1 RN7SKP37 ENSG00000279623
GH10G021737 0.8 FANTOM5 ENCODE 1.5 +472.7 472748 1.0 ARID1B CBX3 PKNOX1 CBX5 TAL1 TRIM24 MIR1915 CASC10 RNU6-15P EBLN1 GC10P021711 RN7SKP219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EBLN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EBLN1 Gene

22,208,814 bp from pter
22,210,021 bp from pter
1,208 bases
Minus strand

Genomic View for EBLN1 Gene

Genes around EBLN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBLN1 Gene

Proteins for EBLN1 Gene

  • Protein details for EBLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endogenous Bornavirus-like nucleoprotein 1
    Protein Accession:
    Secondary Accessions:
    • S4R316

    Protein attributes for EBLN1 Gene

    366 amino acids
    Molecular mass:
    40313 Da
    Quaternary structure:
    No Data Available
    • Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-1 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

neXtProt entry for EBLN1 Gene

Post-translational modifications for EBLN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EBLN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBLN1 Gene

Domains & Families for EBLN1 Gene

Suggested Antigen Peptide Sequences for EBLN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EBLN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for EBLN1 Gene

Function for EBLN1 Gene

Molecular function for EBLN1 Gene

UniProtKB/Swiss-Prot Function:
May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).

Phenotypes for EBLN1 Gene

GenomeRNAi human phenotypes for EBLN1:
genes like me logo Genes that share phenotypes with EBLN1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EBLN1 Gene

Localization for EBLN1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EBLN1 Gene

Pathways & Interactions for EBLN1 Gene

SuperPathways for EBLN1 Gene

No Data Available

Interacting Proteins for EBLN1 Gene

Gene Ontology (GO) - Biological Process for EBLN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for EBLN1 Gene

Drugs & Compounds for EBLN1 Gene

No Compound Related Data Available

Transcripts for EBLN1 Gene

mRNA/cDNA for EBLN1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EBLN1 Gene

Endogenous Bornavirus-like nucleoprotein 1:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBLN1 Gene

No ASD Table

Relevant External Links for EBLN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EBLN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EBLN1 Gene

mRNA differential expression in normal tissues according to GTEx for EBLN1 Gene

This gene is overexpressed in Testis (x33.3).

NURSA nuclear receptor signaling pathways regulating expression of EBLN1 Gene:


SOURCE GeneReport for Unigene cluster for EBLN1 Gene:


mRNA Expression by UniProt/SwissProt for EBLN1 Gene:

Tissue specificity: Expression detected by RT-PCR in a few cell lines, including OL, HEK293T and MOLT-4. Not observed in HeLa cells (PubMed:20054395).
genes like me logo Genes that share expression patterns with EBLN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EBLN1 Gene

Orthologs for EBLN1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for EBLN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EBLN1 34
  • 98.54 (n)
(Mus musculus)
Mammalia LOC102636291 34
  • 52.8 (n)
Species where no ortholog for EBLN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EBLN1 Gene

Gene Tree for EBLN1 (if available)
Gene Tree for EBLN1 (if available)

Paralogs for EBLN1 Gene

Paralogs for EBLN1 Gene

(1) SIMAP similar genes for EBLN1 Gene using alignment to 1 proteins: Pseudogenes for EBLN1 Gene

genes like me logo Genes that share paralogs with EBLN1: view

Variants for EBLN1 Gene

Sequence variations from dbSNP and Humsavar for EBLN1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000350251 -- 22,210,331(+) TTTAA(A/G)CTCAA upstream-variant-2KB
rs1001448761 -- 22,210,680(+) GAACA(C/T)ATTTC upstream-variant-2KB
rs1001853304 -- 22,208,911(+) AACCG(C/T)GAAGG reference, missense
rs1001919703 -- 22,210,355(+) TAATA(C/T)TGTAA upstream-variant-2KB
rs1002566736 -- 22,208,424(+) GAAAT(C/G)AACAG downstream-variant-500B

Variation tolerance for EBLN1 Gene

Gene Damage Index Score: 19.77; 98.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EBLN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EBLN1 Gene

Disorders for EBLN1 Gene

Relevant External Links for EBLN1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EBLN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EBLN1 Gene

Publications for EBLN1 Gene

  1. Endogenous non-retroviral RNA virus elements in mammalian genomes. (PMID: 20054395) Horie M. … Tomonaga K. (Nature 2010) 2 3 4 64
  2. Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. (PMID: 20686665) Belyi V.A. … Skalka A.M. (PLoS Pathog. 2010) 2 3 64
  3. Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells. (PMID: 27023521) He P. … Xie P. (Int J Mol Sci 2016) 3 64
  4. Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes. (PMID: 23938751) Horie M. … Tomonaga K. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2013) 3 64
  5. No evidence for natural selection on endogenous borna-like nucleoprotein elements after the divergence of Old World and New World monkeys. (PMID: 21912690) Kobayashi Y. … Suzuki Y. (PLoS ONE 2011) 3 64

Products for EBLN1 Gene

Sources for EBLN1 Gene

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