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Aliases for EBI3 Gene

Aliases for EBI3 Gene

  • Epstein-Barr Virus Induced 3 2 3
  • Epstein-Barr Virus-Induced Gene 3 Protein 3 4
  • EBV-Induced Gene 3 Protein 3 4
  • IL-27 Subunit Beta 3 4
  • IL35 Subunit 2 3
  • IL27 Subunit 2 3
  • IL-27B 3 4
  • IL27B 3 4
  • Epstein-Barr Virus Induced Gene 3 3
  • Cytokine Receptor 3

External Ids for EBI3 Gene

Previous GeneCards Identifiers for EBI3 Gene

  • GC19P004322
  • GC19P004169
  • GC19P004180
  • GC19P003992

Summaries for EBI3 Gene

Entrez Gene Summary for EBI3 Gene

  • This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

GeneCards Summary for EBI3 Gene

EBI3 (Epstein-Barr Virus Induced 3) is a Protein Coding gene. Among its related pathways are Th1 Differentiation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. GO annotations related to this gene include cytokine activity and interleukin-27 receptor binding. An important paralog of this gene is IL11RA.

UniProtKB/Swiss-Prot for EBI3 Gene

  • Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

Gene Wiki entry for EBI3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBI3 Gene

Genomics for EBI3 Gene

Regulatory Elements for EBI3 Gene

Genomic Location for EBI3 Gene

Chromosome:
19
Start:
4,229,302 bp from pter
End:
4,237,542 bp from pter
Size:
8,241 bases
Orientation:
Plus strand

Genomic View for EBI3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EBI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBI3 Gene

Proteins for EBI3 Gene

  • Protein details for EBI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14213-IL27B_HUMAN
    Recommended name:
    Interleukin-27 subunit beta
    Protein Accession:
    Q14213
    Secondary Accessions:
    • A0N0N2
    • O75269

    Protein attributes for EBI3 Gene

    Size:
    229 amino acids
    Molecular mass:
    25396 Da
    Quaternary structure:
    • Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.

neXtProt entry for EBI3 Gene

Proteomics data for EBI3 Gene at MOPED

Post-translational modifications for EBI3 Gene

  • Glycosylation at Asn 55 and Asn 105

Other Protein References for EBI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for EBI3 (IL-27/IL-35 EBI3 Subunit)

No data available for DME Specific Peptides for EBI3 Gene

Domains & Families for EBI3 Gene

Protein Domains for EBI3 Gene

Suggested Antigen Peptide Sequences for EBI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14213

UniProtKB/Swiss-Prot:

IL27B_HUMAN :
  • Contains 2 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
Domain:
  • Contains 2 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
genes like me logo Genes that share domains with EBI3: view

Function for EBI3 Gene

Molecular function for EBI3 Gene

UniProtKB/Swiss-Prot Function:
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV).

Gene Ontology (GO) - Molecular Function for EBI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IPI 9342359
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 9342359
GO:0045523 interleukin-27 receptor binding IEA --
genes like me logo Genes that share ontologies with EBI3: view
genes like me logo Genes that share phenotypes with EBI3: view

Animal Models for EBI3 Gene

MGI Knock Outs for EBI3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EBI3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EBI3 Gene

Localization for EBI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBI3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EBI3 Gene COMPARTMENTS Subcellular localization image for EBI3 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for EBI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS 8551575
GO:0016020 membrane --
genes like me logo Genes that share ontologies with EBI3: view

Pathways & Interactions for EBI3 Gene

genes like me logo Genes that share pathways with EBI3: view

Pathways by source for EBI3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat

Gene Ontology (GO) - Biological Process for EBI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006959 humoral immune response TAS 8551575
GO:0019221 cytokine-mediated signaling pathway IPI 9342359
GO:0042088 T-helper 1 type immune response TAS 14743498
GO:0042098 T cell proliferation IEA --
GO:0045078 positive regulation of interferon-gamma biosynthetic process TAS 14743498
genes like me logo Genes that share ontologies with EBI3: view

No data available for SIGNOR curated interactions for EBI3 Gene

Drugs & Compounds for EBI3 Gene

No Compound Related Data Available

Transcripts for EBI3 Gene

mRNA/cDNA for EBI3 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(187) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EBI3 Gene

Epstein-Barr virus induced 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EBI3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBI3 Gene

No ASD Table

Relevant External Links for EBI3 Gene

GeneLoc Exon Structure for
EBI3
ECgene alternative splicing isoforms for
EBI3

Expression for EBI3 Gene

mRNA expression in normal human tissues for EBI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EBI3 Gene

This gene is overexpressed in Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for EBI3 Gene

This gene is overexpressed in Placenta (59.3) and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EBI3 Gene



SOURCE GeneReport for Unigene cluster for EBI3 Gene Hs.501452

genes like me logo Genes that share expression patterns with EBI3: view

Protein tissue co-expression partners for EBI3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EBI3 Gene

Orthologs for EBI3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EBI3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EBI3 35
  • 79.11 (n)
  • 73.78 (a)
EBI3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EBI3 35
  • 79.62 (n)
  • 74.24 (a)
EBI3 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ebi3 35
  • 72.75 (n)
  • 63.01 (a)
Ebi3 16
Ebi3 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EBI3 35
  • 99.42 (n)
  • 99.13 (a)
EBI3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ebi3 35
  • 72.02 (n)
  • 63.3 (a)
oppossum
(Monodelphis domestica)
Mammalia EBI3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EBI3 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EBI3 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ebi3 35
  • 50.42 (n)
  • 45.73 (a)
zebrafish
(Danio rerio)
Actinopterygii ebi3 35
  • 44.91 (n)
  • 35.75 (a)
ebi3 36
  • 24 (a)
OneToOne
Species with no ortholog for EBI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EBI3 Gene

ENSEMBL:
Gene Tree for EBI3 (if available)
TreeFam:
Gene Tree for EBI3 (if available)

Paralogs for EBI3 Gene

Paralogs for EBI3 Gene

genes like me logo Genes that share paralogs with EBI3: view

Variants for EBI3 Gene

Sequence variations from dbSNP and Humsavar for EBI3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4740 - 4,236,999(+) ACTAC(A/G)TCCAA missense, reference
rs4905 -- 4,237,070(+) GCCAC(A/G)ATGAG reference, synonymous-codon
rs6613 -- 4,237,428(+) ctggg(A/T)agccg utr-variant-3-prime
rs171335 -- 4,232,097(+) gcacg(A/C/G/T)gcctg intron-variant
rs353702 -- 4,237,958(+) ccagc(C/G/T)tgggc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for EBI3 Gene

Variant ID Type Subtype PubMed ID
nsv833716 CNV Loss 17160897
nsv910817 CNV Loss 21882294
nsv910818 CNV Loss 21882294
nsv910819 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
esv2717997 CNV Deletion 23290073
esv2717998 CNV Deletion 23290073
esv2717999 CNV Deletion 23290073
nsv910820 CNV Gain 21882294

Variation tolerance for EBI3 Gene

Residual Variation Intolerance Score: 59.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EBI3 Gene

HapMap Linkage Disequilibrium report
EBI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBI3 Gene

Disorders for EBI3 Gene

Relevant External Links for EBI3

Human Genome Epidemiology (HuGE) Navigator
EBI3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EBI3
genes like me logo Genes that share disorders with EBI3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EBI3 Gene

Publications for EBI3 Gene

  1. Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. (PMID: 18779924) Igawa T. … Yoshida H. (Mod Rheumatol 2009) 23 67
  2. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. (PMID: 19275692) Gee K. … Kumar A. (Inflamm Allergy Drug Targets 2009) 23 67
  3. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. (PMID: 19933857) CrabAc S. … Gauchat J.F. (J. Immunol. 2009) 23 67
  4. [Expression of human IL-35-IgG4 (Fc) fusion protein in CHO/DG44 cells]. (PMID: 19441235) Tang J. … Liu Q. (Sheng Wu Gong Cheng Xue Bao 2009) 23 67
  5. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. (PMID: 19686419) Li C.S. … Chae S.C. (J. Gastroenterol. Hepatol. 2009) 23 67

Products for EBI3 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate EBI3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for EBI3
  • Block miRNA regulation of EBI3 using miScript Target Protectors

Sources for EBI3 Gene

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