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Aliases &
Descriptions
for EBI3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| IL-27B 3 | | IL27B 2, 3 |
| | | Descriptions |
|---|
| EBV-induced gene 3 protein 3 | | Epstein-Barr virus induced 3 2 | | Epstein-Barr virus induced gene 3 2 | | Epstein-Barr virus-induced gene 3 protein 3 | | IL-27 subunit beta 3 | | cytokine receptor 2 | | interleukin-27 subunit beta 2 |
|
| |
Search outside databases for aliases for EBI3 genePrevious GC identifers: GC19P004322 GC19P004169 |
Summaries
for EBI3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for EBI3:
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus
infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and
heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and
inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by
RefSeq]
UniProtKB/Swiss-Prot: IL27B_HUMAN, Q14213Function: Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell
development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype
switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells
are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector
cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive
but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger
interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor
WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic
activity with activation of production of antiangiogenic chemokinesGene Wiki entry for EBI3 |
Genomic Location
for EBI3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the EBI3 gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13EBI3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P004180:
(about GC identifiers)
Start:
|
4,180,495 bp from pter |
End:
|
4,188,525 bp from pter |
Size:
|
8,031 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins
for EBI3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IL27B_HUMAN, Q14213 (See
protein sequence)Recommended Name: Interleukin-27 subunit beta precursor Size: 229 amino acids; 25396 Da
Subunit: Heterodimer with IL27. IL-27 is an heterodimer composed IL27 and EBI3. EBI3 is also a
component of the IL-12 heterodimer. Interacts with SQSTM1
Subcellular location: Secreted
Secondary accessions: O75269REFSEQ proteins: NP_005746.2
ENSEMBL proteins: ENSP00000221847
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for EBI3:
Assays for EBI3: | Protein
Domains/
Families
for EBI3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14213
ProtoNet protein and cluster: Q14213 UniProtKB/Swiss-Prot: IL27B_HUMAN, Q14213Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamilySimilarity: Contains 2 fibronectin type-III domains | Gene Function
for EBI3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005755
 Applied Biosystems Silencer® siRNAs for EBI3
 Sigma-Aldrich siRNA and siRNA Panels for EBI3
Sigma-Aldrich shRNA Panels and shRNA for EBI3
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005755
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005755
untagged cDNA clone in CMV expression vector: NM_005755
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_005755
UniProtKB/Swiss-Prot: IL27B_HUMAN, Q14213Function: Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell
development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype
switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells
are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector
cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive
but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger
interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor
WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic
activity with activation of production of antiangiogenic chemokinesInduction: By EBV5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ebi3):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for EBI3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for EBI3
5/33 Interacting proteins for EBI3 (ENSP000002218473 Q142132) via UniProtKB, MINT, and/or STRING (see all 33
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds
for EBI3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for EBI3
|
Transcripts
for EBI3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005755
Sigma-Aldrich siRNA and siRNA Panels for EBI3
Sigma-Aldrich shRNA Panels and shRNA for EBI3
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_005755 REFSEQ mRNAs for EBI3 gene: NM_005755.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005755
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005755
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005755
untagged cDNA clone in CMV expression vector: NM_005755
Additional cDNA sequence: BC015364.1 BC046112.1 CR592116.1 CR592737.1 CR598195.1 CR602081.1 CR604910.1 CR606815.1 CR608081.1 CR610744.1 CR615391.1 CR615695.1 CR616709.1 CR626045.1 L08187.1 5 DOTS entries: DT.118357 DT.121459324 DT.121459311 DT.92389907 DT.91885972 24/187 AceView cDNA sequences (see all 187
):AL553060 AI656943 BM931385 BX280118 NM_005755 CR604910 CF527765 CR606815 AL553619 AL549396 BM675453 CR626045 BC046112 CR592116 BQ230610 T29429 CR592737 CR615695 CR615391 CR608081 BM694898 CR598195 CR602081 CR616709
 highest scoring ESTs for EBI3:AA029209 AA136862 AA151434 AA232676 AA406641 AA479074 AA495974 AA677747 AA708592 AI088447 Unigene Cluster for EBI3: Epstein-Barr virus induced 3 Hs.501452 [show with all ESTs]Unigene Representative Sequence: BM919170
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000221847
|
Expression
for EBI3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EBI3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EBI3
1 / 2 / 3 2 probe-sets matching EBI3 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCTCCCTACG
SOURCE GeneReport for Unigene cluster: Hs.501452
|
Orthologs
for EBI3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EBI3 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for EBI3
ENSEMBL Gene Tree for EBI3 | Paralogs
for EBI3(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for EBI3 gene
- IL11RA2 IL6R2 CNTFR2
|
SNPs/Variants
for EBI3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EBI3 (up to first 250kb)
|
Disorders & Mutations
for EBI3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605816
6  Novoseek disease relationships for EBI3 gene
About this table
|
Medical News
for EBI3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for EBI3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/43 PubMed articles for EBI3 gene (see all 43
):- A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. (PubMed id 8551575)2, 3, 4 Devergne O....Birkenbach M. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. (PubMed id 12121660)3, 4 Pflanz S....Kastelein R.A. (2002)
- Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. (PubMed id 9342359)1, 3 Devergne O....Kieff E. (1997)
- Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease. (PubMed id 15170639)1, 3 Gehlert T....Niedobitek G. (2004)
- Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor. (PubMed id 18336908)1, 3 Poleganov M.A....Muhl H. (2008)
- IL27: Its Roles in the Induction and Inhibition of Inflammation. (PubMed id 18784808)1, 3 Carl J.W. and Bai X.F. (2008)
- Expression of IL-27 in human Th1-associated granulomatous diseases. (PubMed id 14743498)1, 3 Larousserie F....Devergne O. (2004)
- Enhanced expression of IL-27 mRNA in human newborns. (PubMed id 18167155)1, 3 Krumbiegel D....Meyer C.U. (2008)
|
Search for EBI3
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EBI3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EBI3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EBI3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Interleukin_27 |
|
| | | About This Section
| --
| Services
for EBI3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for EBI3:
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