Aliases for EBI3 Gene
External Ids for EBI3 Gene
Previous GeneCards Identifiers for EBI3 Gene
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
GeneCards Summary for EBI3 Gene
EBI3 (Epstein-Barr Virus Induced 3) is a Protein Coding gene. Diseases associated with EBI3 include Hypersensitivity Reaction Type Ii Disease. Among its related pathways are Innate Immune System and IL27-mediated signaling events. GO annotations related to this gene include cytokine activity and interleukin-27 receptor binding. An important paralog of this gene is CNTFR.
UniProtKB/Swiss-Prot for EBI3 Gene
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.