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GPR183 Gene

protein-coding   GIFtS: 43

GC13M098745
G protein-coupled receptor 183
(Previous name: Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EBI2)
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Aliases &
Descriptions
for GPR183

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EBI2 2, 3
OTTHUMP00000018611 2
Descriptions
EBV-induced G protein-coupled receptor 2 2
EBV-induced G-protein coupled receptor 2 3
Epstein-Barr virus induced gene 2 (lymphocyte-specific G
protein-coupled receptor) 1, 2
G protein-coupled receptor 183 2
External Ids
HGNC: 31281
Entrez Gene: 18802
UniProtKB: P322493
Ensembl: ENSG000001695087
Search outside databases for aliases for GPR183 gene

Summaries
for GPR183

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for GPR183:
This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection
of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is
most closely related to the thrombin receptor. Expression of this gene was detected in
B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral
blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq]

UniProtKB/Swiss-Prot: GP183_HUMAN, P32249
Function: Orphan receptor. Probable mediator of EBV effects on B lymphocytes or of normal
lymphocyte functions. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha

Gene Wiki entry for GPR183 (EBI2)

Genomic Location
for GPR183

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.3

GPR183 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M098745:     (about GC identifiers)

Start:
 98,744,790 bp from pter
End:
 98,757,695 bp from pter
Size:
 12,906 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000013.9  NT_009952.14  

Proteins
for GPR183

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: GP183_HUMAN, P32249 (See protein sequence)
Recommended Name: G-protein coupled receptor 183  
Size: 361 amino acids; 41224 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Secondary accessions: B2R8N5 Q53F99 Q5JUH7

REFSEQ proteins: NP_004942.1  

ENSEMBL proteins: 
ENSP00000365596 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (EBV Induced Gene 2)
Human Recombinant Proteins from Abnova (EBI2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0005887 integral to plasma membrane TAS8383238
About this table

Antibodies for GPR183: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (EBV Induced Gene 2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (EBI2)
Novus Biologicals Antibodies for GPR183

Assays for GPR183: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for GPR183

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR000276 7TM_GPCR_Rhodpsn
 IPR002286 P2_purnocptor


   GeneDecks  GPR183 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P32249

ProtoNet protein and cluster: P32249

UniProtKB/Swiss-Prot: GP183_HUMAN, P32249
Similarity: Belongs to the G-protein coupled receptor 1 family

Gene Function
for GPR183

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GPR183)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (EBI2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004951

              Applied Biosystems Silencer® siRNAs for GPR183

              Sigma-Aldrich siRNA and siRNA Panels for GPR183  
                     Sigma-Aldrich shRNA Panels and shRNA for GPR183  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for GPR183
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004951
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004951
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004951 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_004951

UniProtKB/Swiss-Prot: GP183_HUMAN, P32249
Function: Orphan receptor. Probable mediator of EBV effects on B lymphocytes or of normal
lymphocyte functions. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha
Induction: By EBV

1 MGI phenotypic allele for Gpr183 (no phenotypes)


3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity TAS8383238
GO:0045028 purinergic nucleotide receptor activity, G-protein coupled IEA--
About this table

Pathways & Interactions
for GPR183

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



1 Interacting protein for GPR183 (P322492) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
MTA1Q133302MINT-63668
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006955 immune response TAS8383238
GO:0007165 signal transduction IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway TAS8383238
About this table

Drugs & Compounds
for GPR183

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GPR183

Transcripts
for GPR183

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GPR183)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (EBI2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004951

              Sigma-Aldrich siRNA and siRNA Panels for GPR183  
                     Sigma-Aldrich shRNA Panels and shRNA for GPR183  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_004951  

REFSEQ mRNAs for GPR183 gene: 

NM_004951.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_004951  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004951
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004951
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004951 

Additional cDNA sequence: 

AK223390.1 AK292091.1 AK313443.1 BC020752.1 CR592718.1 CR597919.1 CR609579.1 CR614065.1 
L08177.1 

7 DOTS entries:

DT.100775387  DT.110848  DT.100775386  DT.100650201  DT.120766180  DT.92034996  DT.120766226 

24/90 AceView cDNA sequences (see all 90 ):

T29782 BQ003741 BM128329 AL532537 CR609579 H88656 BX279588 BX417963 
NM_004951 AW574697 BP367552 BC020752 CR597919 AL547762 CR614065 CR592718 
CD686410 BM549799 BG483806 BX431867 CD692042 AL709174 AV758010 BE670057 

Unigene Cluster for GPR183:

G protein-coupled receptor 183
Hs.784  [show with all ESTs]
Unigene Representative Sequence: NM_004951


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000376414  

Expression
for GPR183

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GPR183 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for GPR183

1 / 2

3 probe-sets matching GPR183 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
931_at2 U95-A 1 1.00 1.00 1.00 1.00 -- -- -- -- --

205419_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

205419_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  GPR183 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TAAAGGGTAT

SOURCE GeneReport for Unigene cluster: Hs.784

UniProtKB/Swiss-Prot: GP183_HUMAN, P32249
Tissue specificity: Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in
B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly
expressed in the urogenital system and brain

Orthologs
for GPR183

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for GPR183 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 GPR1831   -- G protein-coupled receptor 183 99.82(n)
99.72(a)		 467308  XM_001146657.1  XP_001146657.1 
cow
(Bos taurus)		 EBI21   -- Epstein-Barr virus induced gene 2 (lymphocyte-specific more 88.61(n)
91.67(a)		 540287  NM_001046472.1  NP_001039937.1 
rat
(Rattus norvegicus)		 Gpr1831   -- G protein-coupled receptor 183 81.14(n)
87.96(a)		 679975  XM_001054002.1  XP_001054002.1 
mouse
(Mus musculus)		 Gpr1831, 5 145
 G protein-coupled receptor 1831, 5 81.89(n)1
87.96(a)1		 3210191  NM_183031.21  NP_898852.21 
 AK0879515  AK1386935  (see all 14)
chicken
(Gallus gallus)		 EBI21   -- Epstein-Barr virus induced gene 2 (lymphocyte-specific more 71.6(n)
70.71(a)		 769212  XM_001231943.1  XP_001231944.1 
About this table        Species with no ortholog for GPR183

ENSEMBL Gene Tree for GPR183

Paralogs
for GPR183

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for GPR183 gene
GPR172  

SNPs/Variants
for GPR183

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for GPR183

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 605741

Medical News
for GPR183

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for GPR183

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/11 PubMed articles for GPR183 gene (see all 11 ):

Search for GPR183

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing GPR183

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 1880 HGNC: 3128 AceView: EBI2 Ensembl:ENSG00000169508 euGenes: HUgn1880
ECgene: GPR183 H-InvDB: GPR183

Other Databases showing GPR183

(According to HUGE)
About This Section

   --

Specialized Databases showing GPR183

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for GPR183

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for GPR183

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for GPR183:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GPR183-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for GPR183 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for GPR183 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (EBI2)
 Antibodies (EBI2)
 Chimera RNAi (EBI2)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(EBV Induced Gene 2)
 Antibodies (EBV Induced Gene 2)
 Search OriGene for GPR183
 Search Tocris compounds for GPR183




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for GPR183

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