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EBF4 Gene

protein-coding   GIFtS: 46

GC20P002629
early B-cell factor 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for EBF4

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
COE4 1, 2, 3
EBF-4 3
KIAA1442 1, 2, 3, 5
O/E-4 1, 2, 3
OE-4 3
RP5-860F19.3 1
Descriptions
Olf-1/EBF-like 4 3
early B-cell factor 4 2, 3
External Ids
HGNC: 292781
Entrez Gene: 575932
UniProtKB: Q9BQW33
Ensembl: ENSG000000888817
Search outside databases for aliases for EBF4 gene

Summaries
for EBF4

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for EBF4:
EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of
which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed
12139918]).[supplied by OMIM]

UniProtKB/Swiss-Prot: COE4_HUMAN, Q9BQW3
Function: Transcriptional factor which recognizes variations of the palindromic sequence
5'-ATTCCCNNGGGAATT-3' (By similarity)

Genomic Location
for EBF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

EBF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P002629:     (about GC identifiers)

Start:
 2,621,524 bp from pter
End:
 2,688,754 bp from pter
Size:
 67,231 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000020.9  NT_011387.8  

Proteins
for EBF4

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: COE4_HUMAN, Q9BQW3 (See protein sequence)
Recommended Name: Transcription factor COE4  
Size: 602 amino acids; 64473 Da
Subunit: Forms either a homodimer or a heterodimer with a related family member (By similarity)
Subcellular location: Nucleus (Potential)
Secondary accessions: Q1MTP7 Q5JY53 Q9NUB6 Q9P2A6
Alternative splicing: 2 isoforms:  Q9BQW3-2   Q9BQW3-1   

REFSEQ proteins: NP_001103984.1  

ENSEMBL proteins: 
ENSP00000345030 ENSP00000370022 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Ebf4)
Human Recombinant Proteins from Abnova (RP5-860F19.3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
About this table

Antibodies for EBF4: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for EBF4
Browse R&D Systems for Antibodies
Antibodies from Abcam (Ebf4), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RP5-860F19.3)
Novus Biologicals Antibody for EBF4

Assays for EBF4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for EBF4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR002909 IPT_TIG_rcpt
 IPR018350 Transcription_factor_COE_CS
 IPR013783 Ig-like_fold
 IPR003523 Transcription_factor_COE


   GeneDecks  EBF4 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9BQW3

ProtoNet protein and cluster: Q9BQW3

3 Blocks protein families:
IPB001092 Basic helix-loop-helix dimerization domain bHLH
IPB002909 Cell surface receptor IPT/TIG
IPB003523 Transcription factor COE


UniProtKB/Swiss-Prot: COE4_HUMAN, Q9BQW3
Similarity: Belongs to the COE family
Similarity: Contains 1 IPT/TIG domain

Gene Function
for EBF4

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (EBF4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for EBF4

              Sigma-Aldrich siRNA for EBF4  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for EBF4
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001110514
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001110514
                                 untagged cDNA clones in CMV expression vector (see all 3): BC054347 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001110514

UniProtKB/Swiss-Prot: COE4_HUMAN, Q9BQW3
Function: Transcriptional factor which recognizes variations of the palindromic sequence
5'-ATTCCCNNGGGAATT-3' (By similarity)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

Pathways & Interactions
for EBF4

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0007275 multicellular organismal development IEA--
About this table

Drugs & Compounds
for EBF4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EBF4

Transcripts
for EBF4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (EBF4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for EBF4  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001110514  XM_001713721  

REFSEQ mRNAs for EBF4 gene: 

NM_001110514.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001110514  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001110514
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001110514
                                 untagged cDNA clones in CMV expression vector (see all 3): BC054347 

Additional cDNA sequence: 

BC010557.1 BC019106.2 BC037555.1 BC054347.1 XM_001713721.1 

7 DOTS entries:

DT.97773243  DT.95110990  DT.304671  DT.120808677  DT.120808683  DT.92418866  DT.92068071 

24/53 AceView cDNA sequences (see all 53 ):

BC019106 BX094782 AI791687 AI733349 AL110311 AW469130 AI648468 AI689882 
BE467510 BF002828 AL110312 AI733393 BF515857 BC054347 BE673283 AI791805 
BE503959 BC010557 BM460333 BF509243 BM546235 BM712873 BG913853 BE326437 

Unigene Cluster for EBF4:

Early B-cell factor 4
Hs.471955  [show with all ESTs]
Unigene Representative Sequence: NM_001110514


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for EBF4

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
SP1:                                                                          -                             -     -                           
SP2:                                                                          -                             -                                 
SP3:                                                                                                                                          
SP4:                                                                                                                                          

About this scheme

ECgene alternative splicing isoforms for EBF4

2 Ensembl transcripts including schematic representations:
ENST00000342725  ENST00000380648  

Expression
for EBF4

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EBF4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for EBF4

1 / 2

3 probe-sets matching EBF4 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
88906_at2 U95-E 1 1.00 1.00 1.00 1.00 -- -- -- -- --

233850_s_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

233850_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  EBF4 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.471955

Orthologs
for EBF4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for EBF4 gene from 3 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 EBF41   -- early B-cell factor 4 93.73(n)
97.25(a)		 485803  XM_845332.1  XP_850425.1 
rat
(Rattus norvegicus)		 Ebf41   -- early B-cell factor 4 89.56(n)
94.93(a)		 680751  XM_001059875.1  XP_001059875.1 
mouse
(Mus musculus)		 Ebf41, 5 25
 early B-cell factor 41, 5 90.49(n)1
94.59(a)1		 2285981  NM_152993.11  NP_694538.11 
 AF3876305  AF3876315  (see all 14)
About this table        Species with no ortholog for EBF4

ENSEMBL Gene Tree for EBF4

Paralogs
for EBF4

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for EBF4 gene
EBF32  EBF22  EBF12  

SNPs/Variants
for EBF4

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/485 NCBI SNPs in EBF4 are shown (see all 485 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 163)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs20731251,2
A,C,F,H2687583(-) GAGTGA/GAACTT 2 F/F syn1 ut31 ese39Minor allele frequency- G:0.38EA EU WA NA 1888
rs61155621,2
H2620324(+) AGAGGG/TCCTCT 1 -- ng511Minor allele frequency- T:0.00EU 120
--
rs22358131,2
C2680902(-) ggctcC/Gggccc 2 P/P syn1 ese30--------
rs8746891,2
A,C,F,H,O2625226(-) TGGAGT/ACAGAC 1 -- int15Minor allele frequency- A:0.35MN EU EA WA 602
rs18838081,2
A,C,F,H,O2651692(+) gcatgA/Cgtttt 1 -- int15Minor allele frequency- C:0.25MN EU EA WA 600
rs10053041,2
A,C,F,H,O2683182(-) AATGCC/TCTCAG 1 -- int113Minor allele frequency- N:0.00MN EU EA WA NA 1222
--
rs60513411,2
A,C,F,H2662824(+) agagaA/Tgggca 1 -- int17Minor allele frequency- T:0.40EU EA WA NA 536
rs60513481,2
A,C,F,H2665526(+) GCAGCC/TGAAGC 1 -- int17Minor allele frequency- T:0.17EU EA WA NA 562
rs72701811,2
A,C,F,H2664617(+) AAAATA/GTTCTG 1 -- int14Minor allele frequency- G:0.36EU EA WA 412
rs60841481,2
A,C,F,H2660329(+) TCCTAC/TGAACA 1 -- int112Minor allele frequency- T:0.38EU EA WA NA 1048
About this table

HapMap Linkage Disequilibrium images for EBF4 (up to first 250kb)

Disorders & Mutations
for EBF4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 609935

Medical News
for EBF4

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for EBF4

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for EBF4 gene:

Search for EBF4

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing EBF4

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 57593 HGNC: 29278 AceView: KIAA1442 Ensembl:ENSG00000088881 euGenes: HUgn57593
ECgene: EBF4 H-InvDB: EBF4

Other Databases showing EBF4

(According to HUGE)
About This Section
HUGE: KIAA1442

Specialized Databases showing EBF4

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for EBF4

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for EBF4

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for EBF4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for EBF4-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for EBF4 Antibodies for EBF4
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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 Recombinant & Natural Proteins  

 Recombinant Proteins (RP5-860F19.3)
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 Search OriGene for EBF4
 Search Tocris compounds for EBF4




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 Antibodies for EBF4

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