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Aliases for EBF4 Gene

Aliases for EBF4 Gene

  • Early B-Cell Factor 4 2 3 4 5
  • Olf-1/EBF-Like 4 3 4
  • EBF-4 3 4
  • O/E-4 3 4
  • COE4 3 4
  • OE-4 3 4
  • RP5-860F19.3 3
  • KIAA1442 4

External Ids for EBF4 Gene

Previous GeneCards Identifiers for EBF4 Gene

  • GC20P002629
  • GC20P002630
  • GC20P002673
  • GC20P002662
  • GC20P002718
  • GC20P002729

Summaries for EBF4 Gene

Entrez Gene Summary for EBF4 Gene

  • EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008]

GeneCards Summary for EBF4 Gene

EBF4 (Early B-Cell Factor 4) is a Protein Coding gene. Diseases associated with EBF4 include Gestational Choriocarcinoma. GO annotations related to this gene include transcription factor binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is EBF2.

UniProtKB/Swiss-Prot for EBF4 Gene

  • Transcriptional factor which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBF4 Gene

Genomics for EBF4 Gene

Regulatory Elements for EBF4 Gene

Enhancers for EBF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EBF4 on UCSC Golden Path with GeneCards custom track

Promoters for EBF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EBF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for EBF4 Gene

2,692,878 bp from pter
2,760,108 bp from pter
67,231 bases
Plus strand

Genomic View for EBF4 Gene

Genes around EBF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBF4 Gene

Proteins for EBF4 Gene

  • Protein details for EBF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor COE4
    Protein Accession:
    Secondary Accessions:
    • Q1MTP7
    • Q5JY53
    • Q9NUB6
    • Q9P2A6

    Protein attributes for EBF4 Gene

    602 amino acids
    Molecular mass:
    64473 Da
    Quaternary structure:
    • Forms either a homodimer or a heterodimer with a related family member.

    Alternative splice isoforms for EBF4 Gene


neXtProt entry for EBF4 Gene

Proteomics data for EBF4 Gene at MOPED

Post-translational modifications for EBF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EBF4 Gene

No data available for DME Specific Peptides for EBF4 Gene

Domains & Families for EBF4 Gene

Suggested Antigen Peptide Sequences for EBF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IPT/TIG domain.
  • Belongs to the COE family.
  • Contains 1 IPT/TIG domain.
  • Belongs to the COE family.
genes like me logo Genes that share domains with EBF4: view

No data available for Gene Families for EBF4 Gene

Function for EBF4 Gene

Molecular function for EBF4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

Gene Ontology (GO) - Molecular Function for EBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with EBF4: view

Phenotypes for EBF4 Gene

GenomeRNAi human phenotypes for EBF4:
genes like me logo Genes that share phenotypes with EBF4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EBF4 Gene

Localization for EBF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBF4 Gene

Subcellular locations from

Jensen Localization Image for EBF4 Gene COMPARTMENTS Subcellular localization image for EBF4 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for EBF4 Gene

Pathways & Interactions for EBF4 Gene

SuperPathways for EBF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IBA --
genes like me logo Genes that share ontologies with EBF4: view

No data available for Pathways by source and SIGNOR curated interactions for EBF4 Gene

Drugs & Compounds for EBF4 Gene

No Compound Related Data Available

Transcripts for EBF4 Gene

Unigene Clusters for EBF4 Gene

Early B-cell factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EBF4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - -

Relevant External Links for EBF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EBF4 Gene

mRNA expression in normal human tissues for EBF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EBF4 Gene

SOURCE GeneReport for Unigene cluster for EBF4 Gene Hs.471955

genes like me logo Genes that share expression patterns with EBF4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EBF4 Gene

Orthologs for EBF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for EBF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EBF4 35
  • 93.63 (n)
  • 97.49 (a)
EBF4 36
  • 97 (a)
(Canis familiaris)
Mammalia EBF4 35
  • 93.97 (n)
  • 97.49 (a)
EBF4 36
  • 97 (a)
(Mus musculus)
Mammalia Ebf4 35
  • 90.68 (n)
  • 95.45 (a)
Ebf4 16
Ebf4 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Ebf4 35
  • 89.96 (n)
  • 95.62 (a)
(Monodelphis domestica)
Mammalia EBF4 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
(Pan troglodytes)
Mammalia EBF4 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
-- 36
  • 95 (a)
(Danio rerio)
Actinopterygii si:ch211-207n2.6 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta kn 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea unc-3 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for EBF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EBF4 Gene

Gene Tree for EBF4 (if available)
Gene Tree for EBF4 (if available)

Paralogs for EBF4 Gene

Paralogs for EBF4 Gene

(4) SIMAP similar genes for EBF4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EBF4: view

Variants for EBF4 Gene

Sequence variations from dbSNP and Humsavar for EBF4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1003523 -- 2,754,980(-) CCCTG(G/T)CGGGG intron-variant
rs1003524 -- 2,754,979(-) CCTGG(C/G/T)GGGGG intron-variant
rs1003525 -- 2,754,865(-) GGCTG(C/T)GGCTT intron-variant
rs1005304 -- 2,754,536(-) AATGC(C/T)CTCAG intron-variant
rs1028405 -- 2,740,483(+) GACAG(A/T)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EBF4 Gene

Variant ID Type Subtype PubMed ID
nsv470535 CNV Gain 18288195
nsv458852 CNV Loss 19166990
nsv519426 CNV Loss 19592680
esv28668 CNV Loss 19812545
nsv833895 CNV Loss 17160897
nsv522009 CNV Gain 19592680
nsv510780 CNV Loss 20534489
nsv912602 CNV Loss 21882294

Variation tolerance for EBF4 Gene

Gene Damage Index Score: 1.32; 26.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EBF4 Gene

Disorders for EBF4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EBF4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gestational choriocarcinoma
  • gestational chorionepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search EBF4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EBF4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EBF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EBF4 Gene

Publications for EBF4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Biochemical and computational analysis of LNX1 interacting proteins. (PMID: 22087225) Wolting C.D. … McGlade C.J. (PLoS ONE 2011) 3
  4. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PMID: 22094256) Anders L. … Sicinski P. (Cancer Cell 2011) 3
  5. Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection. (PMID: 12139918) Wang S.S. … Reed R.R. (Mol. Cell. Neurosci. 2002) 3

Products for EBF4 Gene

Sources for EBF4 Gene