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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EBF3 Gene

protein-coding   GIFtS: 53
GCID: GC10M131633

Early B-Cell Factor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Early B-Cell Factor 31 2 3     O/E-22 3
COE32 3 5     OE-22 3
Olf-1/EBF-Like 22 3     Transcription Factor COE32
EBF-32 3     

External Ids:    HGNC: 190871   Entrez Gene: 2537382   Ensembl: ENSG000001080017   OMIM: 6074075   UniProtKB: Q9H4W63   

Export aliases for EBF3 gene to outside databases

Previous GC identifers: GC00U908396 GC10M131109 GC20P002669 GC10M131524 GC10M125212


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EBF3 Gene:
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF
proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as
tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell
cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple
malignancies including glioblastoma multiforme and gastric carcinoma. (provided by RefSeq, Sep 2011)

GeneCards Summary for EBF3 Gene: 
EBF3 (early B-cell factor 3) is a protein-coding gene. Diseases associated with EBF3 include thyroid lymphoma, and glioblastoma. GO annotations related to this gene include protein dimerization activity and metal ion binding. An important paralog of this gene is EBF2.

UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008818.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EBF3 gene promoter:
         E2F-3a   E2F-4   E2F   FOXO4   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEBF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EBF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EBF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

EBF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EBF3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M131633:  view genomic region     (about GC identifiers)

Start:
131,633,547 bp from pter      End:
131,762,105 bp from pter
Size:
128,559 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6 (See protein sequence)
Recommended Name: Transcription factor COE3  
Size: 596 amino acids; 64864 Da
Subunit: Forms either a homodimer or a heterodimer with a related family member (By similarity)
Subcellular location: Nucleus (Potential)
2 PDB 3D structures from and Proteopedia for EBF3:
3MUJ (3D)        3N50 (3D)    
Secondary accessions: A0AUY1 Q5T6H9 Q9H4W5
Alternative splicing: 2 isoforms:  Q9H4W6-1   Q9H4W6-2   

Explore the universe of human proteins at neXtProt for EBF3: NX_Q9H4W6

Explore proteomics data for EBF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H4W6

  • EBF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EBF3 Protein Expression
    REFSEQ proteins: NP_001005463.1  
    ENSEMBL proteins: 
     ENSP00000357637   ENSP00000347463   ENSP00000387543  

    Human Recombinant Protein Products for EBF3: 
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    Novus Biologicals EBF3 Protein
    Novus Biologicals EBF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EBF3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    EBF3 for ontologies           About GeneDecksing



    EBF3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for EBF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR011598 bHLH_dom
     IPR002909 IPT_TIG_rcpt
     IPR018350 Transcription_factor_COE_CS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9H4W6

    ProtoNet protein and cluster: Q9H4W6

    3 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002909 Cell surface receptor IPT/TIG
    IPB003523 Transcription factor COE


    UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
    Similarity: Belongs to the COE family
    Similarity: Contains 1 IPT/TIG domain


    EBF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COE3_HUMAN, Q9H4W6
    Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'
    (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    EBF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EBF3:
     Decreased number of cells in m 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ebf3):
     mortality/aging  nervous system 

    EBF3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EBF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EBF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EBF3 
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    miRNA
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    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate EBF3 (see all 113):
    hsa-miR-300 hsa-miR-128 hsa-miR-4305 hsa-miR-30d hsa-miR-374a hsa-miR-3162-5p hsa-miR-3142 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEBF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EBF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EBF3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/20 Interacting proteins for EBF3 (Q9H4W61, 3 ENSP000003576374) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEN1O002551, 3, ENSP000003370884EBI-2111898,EBI-592789 I2D: score=1 STRING: ENSP00000337088
    ZNF423Q2M1K93, ENSP000002623834I2D: score=1 STRING: ENSP00000262383
    BPTFQ128303I2D: score=3 
    CDAN1Q8IWY93I2D: score=3 
    DDX51Q8N8A63I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IEA--

    EBF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EBF3 (COE3)

    Search CenterWatch for drugs/clinical trials and news about EBF3 / COE3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EBF3 gene: 
    NM_001005463.2  

    Unigene Cluster for EBF3:

    Early B-cell factor 3
    Hs.591374  [show with all ESTs]
    Unigene Representative Sequence: NM_001005463
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368648(uc001lki.2) ENST00000355311(uc021qav.1) ENST00000440978

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EBF3
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate EBF3 (see all 113):
    hsa-miR-300 hsa-miR-128 hsa-miR-4305 hsa-miR-30d hsa-miR-374a hsa-miR-3162-5p hsa-miR-3142 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEBF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EBF3 (NM_001005463)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EBF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EBF3
    Sirion Biotech Customized lentivirus for stable overexpression of EBF3 
                         Customized lentivirus expression plasmids for stable overexpression of EBF3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EBF3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EBF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EBF3

    Additional mRNA sequence: 

    AK055710.1 AK097335.1 AK098025.1 AL713797.1 AL832828.1 BC126130.1 BC130479.1 

    5 DOTS entries:

    DT.453113  DT.97843441  DT.100009068  DT.65287643  DT.87046887 

    24/72 AceView cDNA sequences (see all 72):

    AA424135 AL832828 BQ009895 BM722813 BQ188129 BM713178 BQ446939 BI916246 
    BM681085 AK098025 BQ002251 CB994928 AA424426 BE644904 AI828848 AL713797 
    BE349587 BM716978 BM722713 BM727653 BX097567 AI075738 BF592034 AA906181 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EBF3 expression in normal human tissues (normalized intensities)      EBF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCACTTG
    EBF3 Expression
    About this image


    EBF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Eye (Sensory Organs)    fully expand to see all 9 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem 4D20.8, NCr-fac Progenitor
             sensory organ/nose/vomeronasal organ   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Normal Human osteoblasts (NHOST)   

    See EBF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EBF3

    SOURCE GeneReport for Unigene cluster: Hs.591374

    UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
    Tissue specificity: Expressed in brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EBF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EBF3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ebf31 , 5 early B cell factor 31, 5 94.25(n)1
    99.46(a)1
      7 (82.26 cM)5
    135931  NM_001113415.11  NP_001106886.11 
     1371936735 
    chicken
    (Gallus gallus)
    Aves EBF36
    early B-cell factor 3
    84(a)
    1 ↔ 1
    6(33682903-33790682)
    lizard
    (Anolis carolinensis)
    Reptilia EBF26
    --
    --
    96(a)
    95(a)
    1 ↔ 1
    possible ortholog
    GL343422.1(686763-721256)
    3(55729466-55929656)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6322 Xenopus laevis XEBF-3 protein (Xebf-3) mRNA, complete more 84.65(n)    AF040994.3 
    zebrafish
    (Danio rerio)
    Actinopterygii ebf31 early B-cell factor 3 81.6(n)
    96.89(a)
      567751  NM_001080602.1  NP_001074071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kn6
    knot
    50(a)
    1 → many
    2R(10660152-10694566)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-36
    Transcription factor unc-3
    52(a)
    1 → many
    X(14773538-14783564)


    ENSEMBL Gene Tree for EBF3 (if available)
    TreeFam Gene Tree for EBF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EBF3 gene
    EBF22  EBF42  EBF12  
    4 SIMAP similar genes for EBF3 using alignment to 2 protein entries:     COE3_HUMAN (see all proteins):
    EBF2    EBF1    DKFZp667I0324    EBF4

    EBF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2741 SNPs in EBF3 are shown (see all 2741)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114525111,2
    C--125222841(+) TTTTT-/T/TT  
            
    ACTAT
    1 -- int11NA 2
    rs780442001,2
    --125223760(+) TATGGA/GAAAAA 1 -- int10--------
    rs46175031,2
    C,F,A,H--125255585(+) CTTAAA/GAAGCA 1 -- int111Minor allele frequency- G:0.29NS EA WA NA CSA 784
    rs761185981,2
    C--125255617(+) ATCACG/TTGAAC 1 -- int10--------
    rs1855557091,2
    C--125255627(+) CCCAGC/GAGGTG 1 -- int10--------
    rs792847761,2
    C--125255683(+) CAACAC/GAGTGA 1 -- int10--------
    rs751668681,2
    C--125255690(+) GTGAAA/GATCGG 1 -- int10--------
    rs741625201,2
    C--125256043(+) TACCAT/CTACCC 1 -- int11Minor allele frequency- C:0.00WA 2
    rs110169991,2
    C,A--125256044(+) ACCACC/TACCCA 1 -- int11Minor allele frequency- T:0.00WA 2
    rs1496109181,2
    C--125337581(+) TTTCC-/TTTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for EBF3 (131633547 - 131762105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for EBF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1978602CNV Deletion18987734
    nsv7618CNV Insertion18451855
    nsv896103CNV Loss21882294
    nsv896105CNV Loss21882294
    nsv825626CNV Loss20364138
    nsv832024CNV Loss17160897
    nsv896104CNV Loss21882294
    nsv825621CNV Gain20364138
    dgv181n67CNV Gain20364138
    nsv832023CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EBF3
    DNA2.0 Custom Variant and Variant Library Synthesis for EBF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607407    OMIM disorders: --

    6 diseases for EBF3:    About MalaCards
    thyroid lymphoma    glioblastoma    alcoholism    thyroiditis
    squamous cell carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for EBF3:
    Thyroid lymphoma

    EBF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EBF3
    Human Genome Epidemiology (HuGE) Navigator: EBF3 (2 documents)

    Export disorders for EBF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EBF3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with EBF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. (PubMed id 12355068)1, 2, 3 Zardo G.... Costello J.F. (2002)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. (PubMed id 18559491)1, 9 Bennett K.L....Plass C. (2008)
    4. Aberrant DNA methylation and tumor suppressive activi ty of the EBF3 gene in gastric carcinoma. (PubMed id 21387304)1 Kim J....Kim W.H. (2012)
    5. Structural determination of functional domains in ear ly B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif. (PubMed id 20592035)2 Siponen M.I....Berglund H. (2010)
    6. HPV status-independent association of alcohol and tob acco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinom as. (PubMed id 20029986)1 Bennett K.L....Eng C. (2010)
    7. Emerging roles of the EBF family of transcription fac tors in tumor suppression. (PubMed id 19996307)1 Liao D. (2009)
    8. Association studies of 22 candidate SNPs with late-ons et Alzheimer's disease. (PubMed id 18780302)4 Figgins J.A....Kamboh M.I. (2009)
    9. [Construction of eukaryotic expression vector for EBF 3 and EGFP fusion protein and its expression in HepG2 cells] (PubMed id 18845077)1 Mao L.P....Wang X.Y. (2008)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 253738 HGNC: 19087 AceView: DKFZp667B0210 Ensembl:ENSG00000108001 euGenes: HUgn253738
    ECgene: EBF3 H-InvDB: EBF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EBF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EBF3 gene:
    Search GeneIP for patents involving EBF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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