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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EBF3 Gene

protein-coding   GIFtS: 51
GCID: GC10M131633

early B-cell factor 3
 Explore 7 diseases affiliated with
EBF3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EBF3    

Aliases
for EBF3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Early B-Cell Factor 31 2 3     O/E-22 3
COE31 2 3 5     OE-22 3
Olf-1/EBF-Like 22 3     DKFZp667B02101
EBF-32 3     Transcription Factor COE32

External Ids:    HGNC: 190871   Entrez Gene: 2537382   Ensembl: ENSG000001080017   OMIM: 6074075   UniProtKB: Q9H4W63   

Export aliases for EBF3 gene to outside databases

Previous GC identifers: GC00U908396 GC10M131109 GC20P002669 GC10M131524 GC10M125212


Summaries
for EBF3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EBF3:
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins
are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors.
The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and
apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including
glioblastoma multiforme and gastric carcinoma. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By
similarity)




Genomic Views
for EBF3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EBF3 gene promoter:
         E2F-3a   E2F-4   E2F   FOXO4   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EBF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EBF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EBF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

EBF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EBF3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M131633:  view genomic region     (about GC identifiers)

Start:
 131,633,547 bp from pter      End:
 131,762,538 bp from pter
Size:
 128,992 bases      Orientation:
 minus strand

Proteins
for EBF3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6 (See protein sequence)
Recommended Name: Transcription factor COE3  
Size: 596 amino acids; 64864 Da
Subunit: Forms either a homodimer or a heterodimer with a related family member (By similarity)
Subcellular location: Nucleus (Potential)
2 PDB 3D structures from and Proteopedia for EBF3:
3MUJ (3D)        3N50 (3D)    
Secondary accessions: A0AUY1 Q5T6H9 Q9H4W5
Alternative splicing: 2 isoforms:  Q9H4W6-1   Q9H4W6-2   

Explore the universe of human proteins at neXtProt for EBF3: NX_Q9H4W6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H4W6

    • EBF3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001005463.1  
    ENSEMBL proteins: 
     ENSP00000347463   ENSP00000357637   ENSP00000387543  

    Human Recombinant Protein Products: 
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    Novus Biologicals EBF3 Protein
    Novus Biologicals EBF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EBF3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    EBF3 for ontologies           About GeneDecksing



    EBF3 Antibody Products: 
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    Uscn ELISAs and CLIAs for EBF3

    Protein Domains /
    Families
    for EBF3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EBF3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR014756 Ig_E-set
     IPR011598 HLH_dom
     IPR002909 IPT_TIG_rcpt
     IPR018350 Transcription_factor_COE_CS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9H4W6

    ProtoNet protein and cluster: Q9H4W6

    3 Blocks protein families:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002909 Cell surface receptor IPT/TIG
    IPB003523 Transcription factor COE


    UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
    Similarity: Belongs to the COE family
    Similarity: Contains 1 IPT/TIG domain


    Function
    for EBF3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
    Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By
    similarity)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EBF3
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate EBF3 (see all 113):
    hsa-miR-300 hsa-miR-128 hsa-miR-4305 hsa-miR-30d hsa-miR-374a hsa-miR-3162-5p hsa-miR-3142 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: EBF3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EBF3 (see all 7)
    OriGene shRNA RFP: EBF3
    OriGene siRNA: EBF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EBF3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EBF3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EBF3 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EBF3 

    Cell Line
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    Search LifeMap BioReagents cell lines for EBF3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EBF3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
    GO:0046983protein dimerization activity IEA--


    EBF3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for EBF3:
     Decreased number of cells in m 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ebf3):
     mortality/aging  nervous system 

    EBF3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EBF3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EBF3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/20 Interacting proteins for EBF3 (Q9H4W61, 3 ENSP000003576374) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEN1O002551, 3, ENSP000003370884EBI-2111898,EBI-592789 I2D: score=1 STRING: ENSP00000337088
    ZNF423Q2M1K93, ENSP000002623834I2D: score=1 STRING: ENSP00000262383
    BPTFQ128303I2D: score=3 
    CDAN1Q8IWY93I2D: score=3 
    DDX51Q8N8A63I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IEA--


    EBF3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EBF3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EBF3
    Search CenterWatch for drugs/clinical trials and news about EBF3 / COE3 

    Transcripts
    for EBF3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EBF3 gene: 
    NM_001005463.2  

    Unigene Cluster for EBF3:

    Early B-cell factor 3
    Hs.591374  [show with all ESTs]
    Unigene Representative Sequence: NM_001005463
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355311(uc021qav.1) ENST00000368648(uc001lki.2) ENST00000440978
    ENST00000471715(uc010qur.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: EBF3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EBF3
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate EBF3 (see all 113):
    hsa-miR-300 hsa-miR-128 hsa-miR-4305 hsa-miR-30d hsa-miR-374a hsa-miR-3162-5p hsa-miR-3142 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: EBF3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EBF3 (see all 7)
    OriGene shRNA RFP: EBF3
    OriGene siRNA: EBF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EBF3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EBF3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EBF3 (NM_001005463)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EBF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EBF3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EBF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EBF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EBF3

    Additional cDNA sequence: 

    AK055710.1 AK097335.1 AK098025.1 AL713797.1 AL832828.1 BC126130.1 BC130479.1 

    5 DOTS entries:

    DT.453113  DT.97843441  DT.100009068  DT.65287643  DT.87046887 

    24/72 AceView cDNA sequences (see all 72):

    BQ009895 BM722813 BI916246 BM681085 AA424135 AK098025 BQ002251 CB994928 
    BQ446939 AL832828 BQ188129 BM713178 AI125905 BM716978 BM684704 AI240363 
    BM727653 AI301368 AI015088 BF222565 BE349587 AI218182 AA452279 AA330620 

    GeneLoc Exon Structure


    Expression
    for EBF3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EBF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTCACTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EBF3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    EyeGanglion Cell LayerImmature Ganglion CellsGanglion, Retina
    EyeInner Nuclear LayerCone Bipolar Precursor CellsBipolar, Retina
    EyeInner Nuclear LayerEarly Immature Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerLate Immature Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerSEG Amacrine CellsAmacrine, Retina
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Definitive endoderm-like cells (A scalable, suspensi...)
    Beating cell clusters (Spontaneous differen...)

    See EBF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EBF3

    SOURCE GeneReport for Unigene cluster: Hs.591374

    UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
    Tissue specificity: Expressed in brain

        SABiosciences Custom PCR Arrays for EBF3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EBF3

    Orthologs
    for EBF3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EBF3 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NNP7_CHICK6
    		 Uncharacterized protein
    		 84(a)
    		 1 ↔ 1
    		 6(36166779-36201015)
    lizard
    (Anolis carolinensis)    		 Reptilia EBF46
    EBF26
    (see all 3)    		 --
    		 97(a)
    96(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 GL344110.1(4004-42082)
    GL343422.1(704770-721252)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.6322 Xenopus laevis XEBF-3 protein (Xebf-3) mRNA, complete more 84.65(n)    AF040994.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii ebf31 early B-cell factor 3 81.6(n)
    96.89(a)    		   567751  NM_001080602.1  NP_001074071.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kn6
    		 knot
    		 50(a)
    		 1 → many
    		 2R(10660152-10694566)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-36
    		 Transcription factor unc-3
    		 50(a)
    		 1 → many
    		 X(14773297-14783495)


    ENSEMBL Gene Tree for EBF3 (if available)
    TreeFam Gene Tree for EBF3 (if available) 

    Paralogs
    for EBF3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EBF3 gene
    EBF22  EBF42  EBF12  
    4 SIMAP similar genes for EBF3 using alignment to 2 protein entries:     COE3_HUMAN (see all proteins):
    EBF2    EBF1    DKFZp667I0324    EBF4

    EBF3 for paralogs           About GeneDecksing



    Genomic Variants
    for EBF3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2227 NCBI SNPs in EBF3 are shown (see all 2227)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1124169641,2
    		--125211669(+) TGGAAC/TCCAAC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs788526131,2
    		--125211750(+) CAGAAG/ACAGAG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs745624191,2
    		F,--125212529(+) AGCCAG/AACTGT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs2001815051,2
    		C--125212730(+) AGAAAA/GAAAAA 1 -- ut310--------
    rs733817371,2
    		C,--125214239(+) AAGCAG/ATNNNN 1 -- ut312Minor allele frequency- A:0.02WA 120
    rs802805451,2
    		F,--125214282(+) TCCTCA/CTCATA 1 -- ut311Minor allele frequency- C:0.05WA 118
    rs412828861,2
    		C,F,--125214484(+) ACACAT/CANNNN 1 -- ut311Minor allele frequency- C:0.05NA 120
    rs1139791831,2
    		C,--125214667(+) TAAAAC/TCTTTA 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs733817401,2
    		C,--125214899(+) TCCCGC/TCAACG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs774988531,2
    		F,--125216256(+) CACTCG/ACAAGT 1 -- int11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for EBF3 (131633547 - 131762538 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for EBF3
         1 CNV: 4716
         1 Indel: 44688

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EBF3
    DNA2.0 Custom Variant and Variant Library Synthesis for EBF3

    Disorders / Diseases
    for EBF3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EBF3 for disorders           About GeneDecksing

    OMIM gene information: 607407    OMIM disorders: --

    7 diseases for EBF3:    About MalaCards
    carcinoma    glioblastoma    squamous cell carcinoma    thyroid lymphoma
    thyroiditis    neuronitis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for EBF3:
    Thyroid lymphoma
    Human Genome Epidemiology (HuGE) Navigator: EBF3 (2 documents)

    Export disorders for EBF3 gene to outside databases

    Publications
    for EBF3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EBF3 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with EBF3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. (PubMed id 12355068)1, 2, 3 Zardo G.... Costello J.F. (2002)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. (PubMed id 18559491)1, 9 Bennett K.L....Plass C. (2008)
    4. Aberrant DNA methylation and tumor suppressive activi ty of the EBF3 gene in gastric carcinoma. (PubMed id 21387304)1 Kim J....Kim W.H. (2012)
    5. HPV status-independent association of alcohol and tob acco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinom as. (PubMed id 20029986)1 Bennett K.L....Eng C. (2010)
    6. Structural determination of functional domains in ear ly B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif. (PubMed id 20592035)2 Siponen M.I....Berglund H. (2010)
    7. Emerging roles of the EBF family of transcription fac tors in tumor suppression. (PubMed id 19996307)1 Liao D. (2009)
    8. [Construction of eukaryotic expression vector for EBF 3 and EGFP fusion protein and its expression in HepG2 cells] (PubMed id 18845077)1 Mao L.P....Wang X.Y. (2008)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    10. An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. (PubMed id 17018599)1 Zhao L.Y....Liao D. (2006)

    External Searches for EBF3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing EBF3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 253738 HGNC: 19087 AceView: DKFZp667B0210 Ensembl:ENSG00000108001 euGenes: HUgn253738
    ECgene: EBF3 H-InvDB: EBF3

    Other Databases showing EBF3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EBF3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EBF3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EBF3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EBF3 gene:
    Search GeneIP for patents involving EBF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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