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Aliases for EBF3 Gene

Aliases for EBF3 Gene

  • Early B-Cell Factor 3 2 3 4
  • COE3 3 4 6
  • Olf-1/EBF-Like 2 3 4
  • EBF-3 3 4
  • O/E-2 3 4
  • OE-2 3 4
  • Transcription Factor COE3 3

External Ids for EBF3 Gene

Previous GeneCards Identifiers for EBF3 Gene

  • GC00U908396
  • GC10M131109
  • GC20P002669
  • GC10M131524
  • GC10M131633
  • GC10M125212

Summaries for EBF3 Gene

Entrez Gene Summary for EBF3 Gene

  • This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]

GeneCards Summary for EBF3 Gene

EBF3 (Early B-Cell Factor 3) is a Protein Coding gene. Diseases associated with EBF3 include glioblastoma multiforme and glioblastoma. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is EBF2.

UniProtKB/Swiss-Prot for EBF3 Gene

  • Transcriptional activator which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBF3 Gene

Genomics for EBF3 Gene

Regulatory Elements for EBF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EBF3 Gene

Start:
129,835,232 bp from pter
End:
129,964,282 bp from pter
Size:
129,051 bases
Orientation:
Minus strand

Genomic View for EBF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EBF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBF3 Gene

Proteins for EBF3 Gene

  • Protein details for EBF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4W6-COE3_HUMAN
    Recommended name:
    Transcription factor COE3
    Protein Accession:
    Q9H4W6
    Secondary Accessions:
    • A0AUY1
    • Q5T6H9
    • Q9H4W5

    Protein attributes for EBF3 Gene

    Size:
    596 amino acids
    Molecular mass:
    64864 Da
    Quaternary structure:
    • Forms either a homodimer or a heterodimer with a related family member.

    Three dimensional structures from OCA and Proteopedia for EBF3 Gene

    Alternative splice isoforms for EBF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EBF3 Gene

Proteomics data for EBF3 Gene at MOPED

Post-translational modifications for EBF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EBF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBF3 Gene

Domains for EBF3 Gene

Suggested Antigen Peptide Sequences for EBF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4W6

UniProtKB/Swiss-Prot:

COE3_HUMAN :
  • Q9H4W6
Domain:
  • Contains 1 IPT/TIG domain.
Family:
  • Belongs to the COE family.
genes like me logo Genes that share domains with EBF3: view

No data available for Gene Families for EBF3 Gene

Function for EBF3 Gene

Molecular function for EBF3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

Gene Ontology (GO) - Molecular Function for EBF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with EBF3: view

Phenotypes for EBF3 Gene

genes like me logo Genes that share phenotypes with EBF3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EBF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EBF3 Gene

Localization for EBF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EBF3 Gene COMPARTMENTS Subcellular localization image for EBF3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for EBF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EBF3: view

Pathways for EBF3 Gene

SuperPathways for EBF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EBF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with EBF3: view

No data available for Pathways by source for EBF3 Gene

Transcripts for EBF3 Gene

Unigene Clusters for EBF3 Gene

Early B-cell factor 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EBF3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EBF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EBF3 Gene

No ASD Table

Relevant External Links for EBF3 Gene

GeneLoc Exon Structure for
EBF3
ECgene alternative splicing isoforms for
EBF3

Expression for EBF3 Gene

mRNA expression in normal human tissues for EBF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EBF3 Gene

This gene is overexpressed in Adipose - Subcutaneous (6.6) and Adipose - Visceral (Omentum) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EBF3 Gene

SOURCE GeneReport for Unigene cluster for EBF3 Gene Hs.591374

mRNA Expression by UniProt/SwissProt for EBF3 Gene

Q9H4W6-COE3_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expressions with EBF3: view

In Situ Assay Products

Orthologs for EBF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EBF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EBF3 35
  • 99.7 (n)
  • 99.82 (a)
EBF3 36
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EBF3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EBF3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ebf3 35
  • 94.25 (n)
  • 99.46 (a)
Ebf3 16
Ebf3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EBF3 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EBF3 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ebf3 35
  • 93.89 (n)
  • 99.46 (a)
chicken
(Gallus gallus)
Aves EBF3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EBF3 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.632 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ebf3 35
  • 83.55 (n)
  • 97.1 (a)
MGC75916 35
zebrafish
(Danio rerio)
Actinopterygii ebf3 35
  • 81.6 (n)
  • 96.89 (a)
ebf3 36
  • 97 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011437 35
  • 67.67 (n)
  • 78.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta kn 35
  • 68.43 (n)
  • 79.13 (a)
kn 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-3 36
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for EBF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EBF3 Gene

ENSEMBL:
Gene Tree for EBF3 (if available)
TreeFam:
Gene Tree for EBF3 (if available)

Paralogs for EBF3 Gene

Paralogs for EBF3 Gene

Selected SIMAP similar genes for EBF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EBF3: view

Variants for EBF3 Gene

Sequence variations from dbSNP and Humsavar for EBF3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs477493 -- 129,922,908(-) CGGGG(G/T)GGCCT intron-variant
rs499376 -- 129,925,638(-) tgtaa(A/G)catca intron-variant
rs506336 -- 129,915,491(-) TGTGT(G/T)TGTGT intron-variant
rs509203 -- 129,937,751(-) CAGCC(C/T)GGGAC intron-variant
rs514488 -- 129,927,724(-) GGGGA(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EBF3 Gene

Variant ID Type Subtype PubMed ID
nsv832023 CNV Gain+Loss 17160897
nsv896103 CNV Loss 21882294
nsv896104 CNV Loss 21882294
esv1978602 CNV Deletion 18987734
nsv825621 CNV Gain 20364138
nsv7618 CNV Insertion 18451855
dgv181n67 CNV Gain 20364138
nsv825626 CNV Loss 20364138
nsv896105 CNV Loss 21882294
nsv832024 CNV Loss 17160897

Relevant External Links for EBF3 Gene

HapMap Linkage Disequilibrium report
EBF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBF3 Gene

Disorders for EBF3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for EBF3 Gene including...

Search for EBF3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for EBF3 Gene

Relevant External Links for EBF3

Genetic Association Database (GAD)
EBF3
Human Genome Epidemiology (HuGE) Navigator
EBF3
genes like me logo Genes that share disorders with EBF3: view

No data available for UniProtKB/Swiss-Prot for EBF3 Gene

Publications for EBF3 Gene

  1. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. (PMID: 12355068) Zardo G. … Costello J.F. (Nat. Genet. 2002) 2 3 4
  2. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. (PMID: 18559491) Bennett K.L. … Plass C. (Cancer Res. 2008) 3 23
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. (PMID: 17018599) Zhao L.Y. … Liao D. (Cancer Res. 2006) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for EBF3 Gene

Sources for EBF3 Gene

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