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EBF3 Gene

protein-coding   GIFtS: 52
GCID: GC10M131633

Early B-Cell Factor 3

  See EBF3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Early B-Cell Factor 31 2 3     O/E-22 3
COE32 3 5     OE-22 3
Olf-1/EBF-Like 22 3     Transcription Factor COE32
EBF-32 3     

External Ids:    HGNC: 190871   Entrez Gene: 2537382   Ensembl: ENSG000001080017   OMIM: 6074075   UniProtKB: Q9H4W63   

Export aliases for EBF3 gene to outside databases

Previous GC identifers: GC00U908396 GC10M131109 GC20P002669 GC10M131524 GC10M125212


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EBF3 Gene:
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF
proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as
tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell
cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple
malignancies including glioblastoma multiforme and gastric carcinoma. (provided by RefSeq, Sep 2011)

GeneCards Summary for EBF3 Gene:
EBF3 (early B-cell factor 3) is a protein-coding gene. Diseases associated with EBF3 include glioblastoma multiforme, and thyroid lymphoma. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is EBF2.

UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EBF3 gene promoter:
         E2F-3a   E2F-4   E2F   FOXO4   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEBF3 promoter sequence
   Search Chromatin IP Primers for EBF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EBF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

EBF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EBF3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M131633:  view genomic region     (about GC identifiers)

Start:
131,633,547 bp from pter      End:
131,762,105 bp from pter
Size:
128,559 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6 (See protein sequence)
Recommended Name: Transcription factor COE3  
Size: 596 amino acids; 64864 Da
Subunit: Forms either a homodimer or a heterodimer with a related family member (By similarity)
2 PDB 3D structures from and Proteopedia for EBF3:
3MUJ (3D)        3N50 (3D)    
Secondary accessions: A0AUY1 Q5T6H9 Q9H4W5
Alternative splicing: 2 isoforms:  Q9H4W6-1   Q9H4W6-2   

Explore the universe of human proteins at neXtProt for EBF3: NX_Q9H4W6

Explore proteomics data for EBF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EBF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005463.1  
    ENSEMBL proteins: 
     ENSP00000357637   ENSP00000347463   ENSP00000387543  

    EBF3 Human Recombinant Protein Products:

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    Novus Biologicals EBF3 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EBF3

     
    Search eBioscience for Proteins for EBF3 

     
    antibodies-online proteins for EBF3 (4 products) 

     
    antibodies-online peptides for EBF3

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    antibodies-online antibodies for EBF3 (27 products) 

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    antibodies-online kits for EBF3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR011598 bHLH_dom
     IPR002909 IPT
     IPR018350 Transcription_factor_COE_CS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9H4W6

    ProtoNet protein and cluster: Q9H4W6

    3 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002909 Cell surface receptor IPT/TIG
    IPB003523 Transcription factor COE


    UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
    Similarity: Belongs to the COE family
    Similarity: Contains 1 IPT/TIG domain


    Find genes that share domains with EBF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COE3_HUMAN, Q9H4W6
    Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'
    (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with EBF3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EBF3:
     Decreased number of cells in m 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ebf3):
     mortality/aging  nervous system 

    Find genes that share phenotypes with EBF3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EBF3
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EBF3 (see all 113):
    hsa-miR-300 hsa-miR-128 hsa-miR-4305 hsa-miR-30d hsa-miR-374a hsa-miR-3162-5p hsa-miR-3142 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEBF3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EBF3
    Predesigned siRNA for gene silencing in human, mouse, rat EBF3

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EBF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EBF3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EBF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COE3_HUMAN, Q9H4W6: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with EBF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EBF3
    Interactions:

        Search GeneGlobe Interaction Network for EBF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EBF3 (Q9H4W61, 3 ENSP000003576374) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEN1O002551, 3, ENSP000003370884EBI-2111898,EBI-592789 I2D: score=1 STRING: ENSP00000337088
    EBF4Q9BQW33, ENSP000003700224I2D: score=2 STRING: ENSP00000370022
    PTCH1Q136353, ENSP000003323534I2D: score=1 STRING: ENSP00000332353
    ZNF423Q2M1K93, ENSP000002623834I2D: score=1 STRING: ENSP00000262383
    GLI2P100703, ENSP000003545864I2D: score=1 STRING: ENSP00000354586
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0045893positive regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with EBF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EBF3 (COE3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EBF3 gene: 
    NM_001005463.2  

    Unigene Cluster for EBF3:

    Early B-cell factor 3
    Hs.591374  [show with all ESTs]
    Unigene Representative Sequence: NM_001005463
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368648(uc001lki.2) ENST00000355311(uc021qav.1) ENST00000440978

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EBF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EBF3 (see all 113):
    hsa-miR-300 hsa-miR-128 hsa-miR-4305 hsa-miR-30d hsa-miR-374a hsa-miR-3162-5p hsa-miR-3142 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEBF3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EBF3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EBF3 (NM_001005463)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EBF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EBF3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EBF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EBF3
      QuantiTect SYBR Green Assays in human, mouse, rat EBF3
      QuantiFast Probe-based Assays in human, mouse, rat EBF3

    Additional mRNA sequence: 

    AK055710.1 AK097335.1 AK098025.1 AL713797.1 AL832828.1 BC126130.1 BC130479.1 

    5 DOTS entries:

    DT.453113  DT.97843441  DT.100009068  DT.65287643  DT.87046887 

    Selected AceView cDNA sequences (see all 72):

    BQ188129 BQ009895 BQ446939 AL832828 BI916246 BM722813 BM713178 BQ002251 
    BM681085 AA424135 AK098025 CB994928 W31642 BF592034 AI018329 AI240363 
    BX097567 AA424322 AI367877 AI828848 AW118684 BM716978 AI015088 BM673851 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EBF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCACTTG
    EBF3 Expression
    About this image


    EBF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 7 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
    EBF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EBF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591374

    UniProtKB/Swiss-Prot: COE3_HUMAN, Q9H4W6
    Tissue specificity: Expressed in brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EBF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EBF3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ebf31 , 5 early B cell factor 31, 5 94.25(n)1
    99.46(a)1
      7 (82.26 cM)5
    135931  NM_001113415.11  NP_001106886.11 
     1371936735 
    chicken
    (Gallus gallus)
    Aves EBF36
    early B-cell factor 3
    84(a)
    1 ↔ 1
    6(33682903-33790682)
    lizard
    (Anolis carolinensis)
    Reptilia EBF36
    early B-cell factor 3
    95(a)
    1 ↔ 1
    3(55729466-55929656)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6322 Xenopus laevis XEBF-3 protein (Xebf-3) mRNA, complete more 84.65(n)    AF040994.3 
    zebrafish
    (Danio rerio)
    Actinopterygii ebf31 early B-cell factor 3 81.6(n)
    96.89(a)
      567751  NM_001080602.1  NP_001074071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kn1 knot 68.43(n)
    79.13(a)
      45318  NM_137146.2  NP_610990.2 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-36
    Protein UNC-3 (unc-3) mRNA, complete cds
    55(a)
    1 → many
    X(14773538-14783564) WBGene00006743


    ENSEMBL Gene Tree for EBF3 (if available)
    TreeFam Gene Tree for EBF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EBF3 gene
    EBF22  EBF42  EBF12  
    4 SIMAP similar genes for EBF3 using alignment to 2 protein entries:     COE3_HUMAN (see all proteins):
    EBF2    EBF1    DKFZp667I0324    EBF4

    Find genes that share paralogs with EBF3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EBF3 (see all 2741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114525111,2
    C--125222841(+) TTTTT-/T/TT  
            
    ACTAT
    1 -- int11NA 2
    rs780442001,2
    --125223760(+) TATGGA/GAAAAA 1 -- int10--------
    rs46175031,2
    C,F,A,H--125255585(+) CTTAAA/GAAGCA 1 -- int111Minor allele frequency- G:0.29NS EA WA NA CSA 784
    rs761185981,2
    C--125255617(+) ATCACG/TTGAAC 1 -- int10--------
    rs1855557091,2
    C--125255627(+) CCCAGC/GAGGTG 1 -- int10--------
    rs792847761,2
    C--125255683(+) CAACAC/GAGTGA 1 -- int10--------
    rs751668681,2
    C--125255690(+) GTGAAA/GATCGG 1 -- int10--------
    rs741625201,2
    C--125256043(+) TACCAT/CTACCC 1 -- int11Minor allele frequency- C:0.00WA 2
    rs110169991,2
    C,A--125256044(+) ACCACC/TACCCA 1 -- int11Minor allele frequency- T:0.00WA 2
    rs1496109181,2
    C--125337581(+) TTTCC-/TTTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for EBF3 (131633547 - 131762105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for EBF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1978602CNV Deletion18987734
    nsv7618CNV Insertion18451855
    nsv896103CNV Loss21882294
    nsv896105CNV Loss21882294
    nsv825626CNV Loss20364138
    nsv832024CNV Loss17160897
    nsv896104CNV Loss21882294
    nsv825621CNV Gain20364138
    dgv181n67CNV Gain20364138
    nsv832023CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EBF3
    DNA2.0 Custom Variant and Variant Library Synthesis for EBF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607407    OMIM disorders: --

    2 diseases for EBF3:    
    About MalaCards
    glioblastoma multiforme    thyroid lymphoma

    1 disease from the University of Copenhagen DISEASES database for EBF3:
    Thyroid lymphoma

    Find genes that share disorders with EBF3           About GenesLikeMe

    Genetic Association Database (GAD): EBF3
    Human Genome Epidemiology (HuGE) Navigator: EBF3 (2 documents)

    Export disorders for EBF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EBF3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with EBF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. (PubMed id 12355068)1, 2, 3 Zardo G.... Costello J.F. (Nat. Genet. 2002)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    3. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. (PubMed id 18559491)1, 9 Bennett K.L....Plass C. (Cancer Res. 2008)
    4. A genome-wide association study of sleep habits and insomnia. (PubMed id 23728906)1 Byrne E.M....Wray N.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013)
    5. Aberrant DNA methylation and tumor suppressive activity of the EBF3 gene in gastric carcinoma. (PubMed id 21387304)1 Kim J....Kim W.H. (Int. J. Cancer 2012)
    6. Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA- binding proteins and a novel dimerization motif. (PubMed id 20592035)2 Siponen M.I.... Berglund H. (J. Biol. Chem. 2010)
    7. HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. (PubMed id 20029986)1 Bennett K.L....Eng C. (amp 2010)
    8. Emerging roles of the EBF family of transcription factors in tumor suppression. (PubMed id 19996307)1 Liao D. (Mol. Cancer Res. 2009)
    9. Association studies of 22 candidate SNPs with late-onset Alzheimer's disease. (PubMed id 18780302)4 Figgins J.A....Kamboh M.I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. [Construction of eukaryotic expression vector for EBF3 and EGFP fusion protein and its expression in HepG2 cells]. (PubMed id 18845077)1 Mao L.P....Wang X.Y. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253738 HGNC: 19087 AceView: DKFZp667B0210 Ensembl:ENSG00000108001 euGenes: HUgn253738
    ECgene: EBF3 H-InvDB: EBF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EBF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EBF3 gene:
    Search GeneIP for patents involving EBF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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