Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EBF2 Gene

Aliases for EBF2 Gene

  • Early B-Cell Factor 2 2 3 4
  • EBF-2 3 4
  • COE2 3 4
  • Metencephalon-Mesencephalnon-Olfactory Transcription Factor 1 3
  • Transcription Factor COE2 3
  • Collier, Olf And EBF 2 3
  • OLF-1/EBF-LIKE 3 3
  • O/E-3 3
  • OE-3 3

External Ids for EBF2 Gene

Summaries for EBF2 Gene

Entrez Gene Summary for EBF2 Gene

  • The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]

GeneCards Summary for EBF2 Gene

EBF2 (Early B-Cell Factor 2) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is EBF4.

UniProtKB/Swiss-Prot for EBF2 Gene

  • Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBF2 Gene

Genomics for EBF2 Gene

Genomic Location for EBF2 Gene

Start:
25,841,730 bp from pter
End:
26,045,397 bp from pter
Size:
203,668 bases
Orientation:
Minus strand

Genomic View for EBF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EBF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBF2 Gene

Regulatory Elements for EBF2 Gene

Proteins for EBF2 Gene

  • Protein details for EBF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAK2-COE2_HUMAN
    Recommended name:
    Transcription factor COE2
    Protein Accession:
    Q9HAK2
    Secondary Accessions:
    • A0PJM4
    • A6NMF7
    • F5H645
    • Q66VZ3
    • Q6DK36
    • Q6IS86
    • Q6ISA4

    Protein attributes for EBF2 Gene

    Size:
    575 amino acids
    Molecular mass:
    62650 Da
    Quaternary structure:
    • Forms either a homodimer or a heterodimer with a related family member.
    SequenceCaution:
    • Sequence=BAB13843.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EBF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EBF2 Gene

Proteomics data for EBF2 Gene at MOPED

Post-translational modifications for EBF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EBF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBF2 Gene

Domains for EBF2 Gene

UniProtKB/Swiss-Prot:

COE2_HUMAN
Domain:
  • Contains 1 IPT/TIG domain.:
    • Q9HAK2
Family:
  • Belongs to the COE family.:
    • Q9HAK2
genes like me logo Genes that share domains with EBF2: view

No data available for Gene Families for EBF2 Gene

Function for EBF2 Gene

Molecular function for EBF2 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3 (By similarity).

Gene Ontology (GO) - Molecular Function for EBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with EBF2: view
genes like me logo Genes that share phenotypes with EBF2: view

Animal Models for EBF2 Gene

MGI Knock Outs for EBF2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for EBF2 Gene

Localization for EBF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EBF2 Gene COMPARTMENTS Subcellular localization image for EBF2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for EBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EBF2: view

Pathways for EBF2 Gene

SuperPathways for EBF2 Gene

No Data Available

Interacting Proteins for EBF2 Gene

Gene Ontology (GO) - Biological Process for EBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0035563 positive regulation of chromatin binding IEA --
GO:0045893 positive regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with EBF2: view

No data available for Pathways by source for EBF2 Gene

Transcripts for EBF2 Gene

Unigene Clusters for EBF2 Gene

Early B-cell factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EBF2 Gene

No ASD Table

Relevant External Links for EBF2 Gene

GeneLoc Exon Structure for
EBF2
ECgene alternative splicing isoforms for
EBF2

Expression for EBF2 Gene

mRNA expression in normal human tissues for EBF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EBF2 Gene

This gene is overexpressed in Nerve - Tibial (8.5), Adipose - Visceral (Omentum) (7.2), and Adipose - Subcutaneous (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EBF2 Gene

SOURCE GeneReport for Unigene cluster for EBF2 Gene Hs.491292

genes like me logo Genes that share expressions with EBF2: view

Orthologs for EBF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EBF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EBF2 36
  • 99.59 (n)
  • 99.65 (a)
EBF2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EBF2 36
  • 92.52 (n)
  • 99.65 (a)
EBF2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EBF2 36
  • 92.52 (n)
  • 99.48 (a)
EBF2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ebf2 36
  • 89.91 (n)
  • 99.48 (a)
Ebf2 16
Ebf2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EBF2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EBF2 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ebf2 36
  • 89.8 (n)
  • 99.65 (a)
chicken
(Gallus gallus)
Aves EBF2 36
  • 84.06 (n)
  • 98.43 (a)
EBF2 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EBF2 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ebf2 36
  • 78.22 (n)
  • 93.9 (a)
zebrafish
(Danio rerio)
Actinopterygii coe2 36
  • 70.77 (n)
  • 81.87 (a)
coe2 37
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kn 37
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-3 37
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToMany
Species with no ortholog for EBF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EBF2 Gene

ENSEMBL:
Gene Tree for EBF2 (if available)
TreeFam:
Gene Tree for EBF2 (if available)

Paralogs for EBF2 Gene

Paralogs for EBF2 Gene

Selected SIMAP similar genes for EBF2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EBF2: view

Variants for EBF2 Gene

Sequence variations from dbSNP and Humsavar for EBF2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1026976 -- 25,952,008(+) ACACA(A/G)AAGAC intron-variant
rs1077668 -- 26,046,123(-) AATAC(G/T)CCCCG upstream-variant-2KB
rs1077669 -- 26,045,937(-) CCTTC(A/T)TTCAT upstream-variant-2KB
rs1077670 -- 26,045,867(-) TCCAG(A/G)AGACC upstream-variant-2KB
rs1077671 -- 26,046,252(-) CAGCC(C/G)GCGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EBF2 Gene

Variant ID Type Subtype PubMed ID
nsv890689 CNV Gain 21882294
essv17389 CNV CNV 17122850
esv32961 CNV Gain 17666407
nsv831272 CNV Gain+Loss 17160897
esv1009767 CNV Insertion 20482838
nsv524032 CNV Loss 19592680
esv2672485 CNV Deletion 23128226
nsv6127 CNV Insertion 18451855
esv267421 CNV Insertion 20981092
esv2736785 CNV Deletion 23290073
esv2736786 CNV Deletion 23290073
esv1420594 CNV Insertion 17803354
esv1423053 CNV Insertion 17803354
esv2500463 CNV Insertion 19546169
esv1052787 CNV Insertion 17803354

Relevant External Links for EBF2 Gene

HapMap Linkage Disequilibrium report
EBF2

Disorders for EBF2 Gene

Relevant External Links for EBF2

Genetic Association Database (GAD)
EBF2
Human Genome Epidemiology (HuGE) Navigator
EBF2
genes like me logo Genes that share disorders with EBF2: view

No data available for UniProtKB/Swiss-Prot for EBF2 Gene

Publications for EBF2 Gene

  1. The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development. (PMID: 9151732) Wang S.S. … Reed R.R. (J. Neurosci. 1997) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for EBF2 Gene

Sources for EBF2 Gene

Back to Top

Content