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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EBF2 Gene

protein-coding GIFtS: 46
GCID: GC08M025757

early B-cell factor 2

Explore 6 diseases affiliated with
EBF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Early B-Cell Factor 2¹ ² ³		OE-3²
COE2¹ ² ³		Collier, Olf And EBF 2²
EBF-2² ³		Metencephalon-Mesencephalnon-Olfactory Transcription Factor 1²
FLJ11500¹		OLF-1/EBF-LIKE 3²
O/E-3²		Transcription Factor COE2²

External Ids:	HGNC: 19090¹	Entrez Gene: 64641²	Ensembl: ENSG00000221818⁷	OMIM: 609934⁵	UniProtKB: Q9HAK2³

Export aliases for EBF2 gene to outside databases

Previous GC identifers: GC08M025474 GC08M026054 GC08M025723 GC08M024246

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EBF2:

The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix

transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in

variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of

osteoblasts. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: COE2_HUMAN, Q9HAK2

Function: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn

regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes

variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EBF2 gene promoter:
NF-YA FOXO3 NF-YB CBF-A CBF-B FOXO3a CP1A MRF-2 NF-Y CBF(2)
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for EBF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EBF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.1

EBF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EBF2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M025757: view genomic region (about GC identifiers)

Start:	25,699,246 bp from pter	End:	25,902,913 bp from pter
Size:	203,668 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COE2_HUMAN, Q9HAK2 (See protein sequence)

Recommended Name: Transcription factor COE2

Size: 575 amino acids; 62650 Da

Subunit: Forms either a homodimer or a heterodimer with a related family member (By similarity)

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=BAB13843.1; Type=Erroneous initiation;

Secondary accessions: A0PJM4 A6NMF7 Q6DK36 Q6IS86 Q6ISA4

Explore the universe of human proteins at neXtProt for EBF2: NX_Q9HAK2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HAK2

EBF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_073150.2

ENSEMBL proteins:

ENSP00000430241 ENSP00000386178 ENSP00000437909

Human Recombinant Protein Products for EBF2:

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	Uscn Proteins for EBF2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

EBF2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EBF2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR014756 Ig_E-set

IPR011598 HLH_dom

IPR002909 IPT_TIG_rcpt

IPR018350 Transcription_factor_COE_CS

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q9HAK2

ProtoNet protein and cluster: Q9HAK2

3 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB002909 Cell surface receptor IPT/TIG

IPB003523 Transcription factor COE

UniProtKB/Swiss-Prot: COE2_HUMAN, Q9HAK2

Similarity: Belongs to the COE family

Similarity: Contains 1 IPT/TIG domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COE2_HUMAN, Q9HAK2

Function: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn

regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes

variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	--	--
GO:0046872	metal ion binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

EBF2 for ontologies About GeneDecksing

Phenotypes:
14 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ebf2):

adipose tissue	behavior/neurological	cellular	craniofacial	endocrine/exocrine gland
growth/size	limbs/digits/tail	mortality/aging	nervous system	normal
reproductive system	respiratory system	skeleton	taste/olfaction

EBF2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for EBF2: Ebf2^tm1Ddr Ebf2^tm1Ggc

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for EBF2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EBF2
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate EBF2 (see all 24):
		hsa-miR-3685 hsa-miR-3200-5p hsa-miR-520f hsa-miR-1263 hsa-miR-376b hsa-miR-520d-5p hsa-miR-10b hsa-miR-488

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EBF2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for EBF2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for EBF2 (Q9HAK2³ ENSP00000386178⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZNF423	Q2M1K9³, ENSP00000262383⁴	I2D: score=1 STRING: ENSP00000262383
EBF4	Q9BQW3³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007275	multicellular organismal development	IEA	--
GO:0045893	positive regulation of transcription, DNA-dependent	IEA	--

EBF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EBF2
Search CenterWatch for drugs/clinical trials and news about EBF2 / COE2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EBF2 gene:

NM_022659.3

Unigene Cluster for EBF2:

Early B-cell factor 2

Hs.491292 [show with all ESTs]

Unigene Representative Sequence: NM_022659

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000520164(uc010lug.2 uc003xes.2) ENST00000408929 ENST00000517825(uc003xet.2)

ENST00000535548

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EBF2
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate EBF2 (see all 24):
		hsa-miR-3685 hsa-miR-3200-5p hsa-miR-520f hsa-miR-1263 hsa-miR-376b hsa-miR-520d-5p hsa-miR-10b hsa-miR-488

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EBF2
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Additional cDNA sequence:

AK001144.1 AK021562.1 AK093878.1 AK304372.1 BC069665.1 BC069726.1 BC069747.1 BC069768.1

BC074794.2 BC113478.1 BC113504.1 BC137106.1 BC137107.1

3 DOTS entries:

DT.75105086 DT.99941220 DT.70102522

24/30 AceView cDNA sequences (see all 30):

BC069726 AK021562 AI457889 BC074794 BX282733 AU117744 BC069768 NM_022659

BQ878633 AY700779 BI488508 AI016316 BC069747 AA911958 AI200996 AL706446

BC069665 BQ889735 AK093878 AA311763 W92336 D62112 AI744592 AU144494

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EBF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTAAAAAC

About this image

EBF2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Ganglion Cell Layer

Immature Ganglion Cells

Ganglion, Retina

Eye

Inner Nuclear Layer

Cone Bipolar Precursor Cells

Bipolar, Retina

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

See EBF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EBF2

SOURCE GeneReport for Unigene cluster: Hs.491292

SABiosciences Custom PCR Arrays for EBF2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for EBF2 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EBF2¹	early B-cell factor 2	84.06(n) 98.43(a)		395176 NM_001164536.1 NP_001158008.1
lizard (Anolis carolinensis)	Reptilia	EBF2⁶ EBF4⁶ (see all 4)	--	96(a) 92(a) (see all 4)	1 ↔ many possible ortholog (see all 4)	GL343445.1(672334-701738) GL344110.1(4004-42082)
zebrafish (Danio rerio)	Actinopterygii	coe2¹	coe2	71.01(n) 82.22(a)		30692 NM_131418.1 NP_571493.1
fruit fly (Drosophila melanogaster)	Insecta	kn⁶	knot	49(a)	1 → many	2R(10660152-10694566)
worm (Caenorhabditis elegans)	Secernentea	unc-3⁶	Transcription factor unc-3	48(a)	1 → many	X(14773297-14783495)

ENSEMBL Gene Tree for EBF2 (if available)
TreeFam Gene Tree for EBF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EBF2 gene

EBF3² EBF4² EBF1²

4 SIMAP similar genes for EBF2 using alignment to 5 protein entries: COE2_HUMAN (see all proteins):

DKFZp667I0324 EBF3 EBF1 EBF4

EBF2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17054425^1,2	C,F,H	--	24243504(+)	`CTATCG/ATCTGC`	1	--	ds500¹		9		NA NS EA CSA WA	680
rs35717640^1,2	C	--	24243768(+)	`ATGGAA/-TATAT`	1	--	ds500¹		1		NA	2
rs11784745^1,2	H	--	24243953(+)	`AAAAAA/TAAAAA`	1	--	ds500¹		0	--	--	--	--
rs11784013^1,2	H	--	24243954(+)	`AAAATA/TAAAAA`	1	--	ds500¹		0	--	--	--	--
rs28684524^1,2	C	--	24243962(+)	`AAATAA/GAAAGC`	1	--	ds500¹		2		WA	120
rs112861105^1,2		--	24244695(+)	`TAAAAG/ACAATG`	1	--	ut3¹		2		CSA WA	120
rs78918703^1,2	C,F	--	24244882(+)	`TTGGCG/ACTTTA`	1	--	ut3¹		1		EA	120
rs57205770^1,2	C	--	24245640(+)	`TCTAAA/CGAGTC`	1	--	ut3¹		2		WA	120
rs10091765^1,2	C,F	--	24245869(+)	`ACATGG/AGAATT`	1	--	ut3¹		1		WA	118
rs10107574^1,2	C,F	--	24246262(+)	`TACACA/Ctttat`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for EBF2 (25699246 - 25902913 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for EBF2
3 CNVs: 100301 7679 2748

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EBF2

DNA2.0 Custom Variant and Variant Library Synthesis for EBF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EBF2 for disorders           About GeneDecksing

OMIM gene information: 609934    OMIM disorders: --

6 diseases for EBF2:    About MalaCards

motor neuritis kallmann syndrome hypogonadotropism hypogonadism

osteosarcoma neuronitis

Human Genome Epidemiology (HuGE) Navigator: EBF2 (5 documents)

Export disorders for EBF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for EBF2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with EBF2)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)^{1, 2} Nusbaum C....Lander E.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development. (PubMed id 9151732)^{1, 3} Wang S.S....Reed R.R. (1997)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)¹ He C....Hunter D.J. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Profiling of chemonaive osteosarcoma and paired-norma l cells identifies EBF2 as a mediator of osteoprotegerin inhibition to tumor ne crosis factor-related apoptosis-inducing ligand-induced apoptosis. (PubMed id 19671856)¹ PatiA+o-GarcA-a A....Lecanda F. (2009)
Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)¹ Choy K.W....Pang C.P. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64641	HGNC: 19090	AceView: EBF2	Ensembl:ENSG00000221818	euGenes: HUgn64641
ECgene: EBF2	H-InvDB: EBF2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for EBF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for EBF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for EBF2 gene:
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GeneCards and IP:
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early B-cell factor 2

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