Aliases for EBF2 Gene
External Ids for EBF2 Gene
The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]
GeneCards Summary for EBF2 Gene
EBF2 (Early B-Cell Factor 2) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is EBF4.
UniProtKB/Swiss-Prot for EBF2 Gene
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3 (By similarity).