 |
 | Services
| |
 |
Aliases & Descriptions for EBF2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| COE2 1, 2, 3 | | EBF-2 2, 3 | | FLJ11500 1, 2 | | O/E-3 2 | | OE-3 2 |
| | | Descriptions |
|---|
| Collier, Olf and EBF 2 2 | | OLF-1/EBF-LIKE 3 2 | | early B-cell factor 2 2, 3 | metencephalon-mesencephalnon-olfactory transcription factor 1 2 | | transcription factor COE2 2 |
|
| | Search outside databases for aliases for EBF2 genePrevious GC identifers: GC08M025474 GC08M026054 GC08M025723 |
Summaries for EBF2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for EBF2: EBF2 belongs to the conserved Olf/EBF family (see MIM 164343) of helix-loop-helix transcription factors (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM] UniProtKB/Swiss-Prot: COE2_HUMAN, Q9HAK2Function: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity) |
Genomic Location for EBF2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EBF2 gene 
Entrez Gene cytogenetic band: 8p21.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.1EBF2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M025757:
(about GC identifiers)
Start:
|
25,757,490 bp from pter |
End:
|
25,958,309 bp from pter |
Size:
|
200,820 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000008.9 NT_023666.17
| Proteins for EBF2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: COE2_HUMAN, Q9HAK2 (See
protein sequence)Recommended Name: Transcription factor COE2 Size: 575 amino acids; 62650 Da
Subunit: Forms either a homodimer or a heterodimer with a related family member (By similarity)
Subcellular location: Nucleus (Potential)
Secondary accessions: A0PJM4 A6NMF7 Q6DK36 Q6IS86 Q6ISA4REFSEQ proteins: NP_073150.2
ENSEMBL proteins: ENSP00000386178
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for EBF2: Assays for EBF2: | Protein
Domains/ Families for EBF2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9HAK2
ProtoNet protein and cluster: Q9HAK2 3 Blocks protein families: IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB002909 Cell surface receptor IPT/TIG IPB003523 Transcription factor COE
UniProtKB/Swiss-Prot: COE2_HUMAN, Q9HAK2Similarity: Belongs to the COE familySimilarity: Contains 1 IPT/TIG domain | Gene Function for EBF2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_931923
Applied Biosystems Silencer® siRNAs for EBF2
Sigma-Aldrich siRNA for EBF2  Sigma-Aldrich shRNA for EBF2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022659                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022659                                  untagged cDNA clones in CMV expression vector (see all 2): NM_022659 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_022659
UniProtKB/Swiss-Prot: COE2_HUMAN, Q9HAK2Function: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)12 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Ebf2):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for EBF2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0045941 | positive regulation of transcription |
IEA | -- | About this table
|
Drugs & Compounds for EBF2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EBF2
|
Transcripts for EBF2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_931923
Sigma-Aldrich siRNA for EBF2  Sigma-Aldrich shRNA for EBF2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_022659 REFSEQ mRNAs for EBF2 gene: NM_022659.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_022659               OriGene GFP tagged cDNA clone in CMV expression vector: NM_022659                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022659                                  untagged cDNA clones in CMV expression vector (see all 2): NM_022659  Additional cDNA sequence: AK001144.1 AK021562.1 AK304372.1 AY700779.1 BC069665.1 BC069726.1 BC069747.1 BC069768.1 BC074794.2 BC113478.1 BC113504.1 BC137106.1 BC137107.1 3 DOTS entries: DT.75105086 DT.99941220 DT.70102522 24/30 AceView cDNA sequences (see all 30
):AU117744 BC069768 AI457889 BC069726 AK021562 NM_022659 BX282733 BQ878633 BC074794 BI488508 BC069747 AI200996 AK093878 BQ889735 BC069665 AL706446 AA911958 AY700779 AA311763 AI016316 AI744592 AW962848 AU144494 W92336
highest scoring ESTs for EBF2:AI744592 AK021562 AU117744 BC069665 BC069726 BC069747 BC069768 AK001144 AL701879 AL706446 Unigene Cluster for EBF2: Early B-cell factor 2 Hs.710674 [show with all ESTs]Unigene Representative Sequence: AK001144
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000408929
|
Expression for EBF2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EBF2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EBF2
1 / 2 / 3 4 probe-sets matching EBF2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.710674
|
Orthologs for EBF2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EBF2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for EBF2
ENSEMBL Gene Tree for EBF2 | Paralogs for EBF2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for EBF2 gene
- EBF32 EBF42 EBF12
|
SNPs/Variants for EBF2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EBF2 (up to first 250kb)
|
Disorders & Mutations for EBF2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609934
|
Medical News for EBF2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EBF2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for EBF2 gene:- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)3, 4 Nusbaum C....Lander E.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development. (PubMed id 9151732)2, 3 Wang S.S....Reed R.R. (1997)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection. (PubMed id 12139918)3 Wang S.S....Reed R.R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. (PubMed id 9151733)3 Tsai R.Y. and Reed R.R. (1997)
- Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. (PubMed id 17060461)1 Jimenez M.A....Rosen E.D. (2007)
- Molecular analysis of KAL-1, GnRH-R, NELF and EBF2 genes in a series of Kallmann syndrome and normosmic hypogonadotropic hypogonadism patients. (PubMed id 16423815)1 Trarbach E.B....Hackel C. (2005)
|
Search for EBF2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EBF2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EBF2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EBF2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EBF2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EBF2:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (EBF2) | | Antibodies (EBF2) |
| | | Search Tocris compounds for EBF2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|