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Aliases & Descriptions for EBF1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| COE1 2, 3 | | EBF 2, 3 | | FLJ39389 2 | | FLJ41763 2 | | O/E-1 2, 3 | | OE-1 3 | | OLF1 1, 2 |
| | | Descriptions |
|---|
| Collier, Olf and EBF transcription factor 1 2 | | Early B-cell factor 1, 2, 3 | | early B-cell factor 1 2 | | olfactory neuronal transcription factor 1 2 |
|
| | Search outside databases for aliases for EBF1 gene |
Summaries for EBF1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: COE1_HUMAN, Q9UH73Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)Gene Wiki entry for EBF1 |
Genomic Location for EBF1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q34EBF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M158059:
(about GC identifiers)
Start:
|
158,058,006 bp from pter |
End:
|
158,459,347 bp from pter |
Size:
|
401,342 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000005.8 NT_023133.12
| Proteins for EBF1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: COE1_HUMAN, Q9UH73 (See
protein sequence)Recommended Name: Transcription factor COE1 Size: 591 amino acids; 64464 Da
Subunit: Forms either a homodimer or a heterodimer with a related family member (By similarity). Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8IW11Alternative splicing: 2 isoforms: Q9UH73-1 Q9UH73-2 REFSEQ proteins: NP_076870.1
ENSEMBL proteins: ENSP00000322898 ENSP00000370029 ENSP00000337140
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: EBF1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for EBF1: Assays for EBF1: | Protein
Domains/ Families for EBF1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UH73
ProtoNet protein and cluster: Q9UH73 3 Blocks protein families: IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB002909 Cell surface receptor IPT/TIG IPB003523 Transcription factor COE
UniProtKB/Swiss-Prot: COE1_HUMAN, Q9UH73Similarity: Belongs to the COE familySimilarity: Contains 1 IPT/TIG domain | Gene Function for EBF1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024007
Applied Biosystems Silencer® siRNAs for EBF1
Sigma-Aldrich siRNA for EBF1  Sigma-Aldrich shRNA for EBF1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024007                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024007                                  untagged cDNA clones in CMV expression vector (see all 2): NM_024007 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024007
UniProtKB/Swiss-Prot: COE1_HUMAN, Q9UH73Function: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ebf1):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for EBF1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for EBF1 
5/23 Interacting proteins for EBF1 (ENSP000003228983) via UniProtKB, MINT, and/or STRING (see all 23
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | About this table
|
Drugs & Compounds for EBF1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EBF1
|
Transcripts for EBF1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024007
Sigma-Aldrich siRNA for EBF1  Sigma-Aldrich shRNA for EBF1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024007 REFSEQ mRNAs for EBF1 gene: NM_024007.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024007               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024007                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024007                                  untagged cDNA clones in CMV expression vector (see all 2): NM_024007  Additional cDNA sequence: AF208502.1 AK021803.1 AK096708.1 AK123757.1 AK289712.1 AK303698.1 AK304438.1 BC019927.1 BC038805.1 BC041178.1 10 DOTS entries: DT.97839542 DT.309797 DT.206057 DT.40198193 DT.97839541 DT.101957176 DT.100683327 DT.120818321 DT.95069897 DT.95356530 24/105 AceView cDNA sequences (see all 105
):AA910081 BM932023 AK021803 BX282724 BM802733 AA746092 AA427900 AI478562 AA904035 AI493206 AA669979 H88863 AU145682 BM685055 BQ423155 AA761874 BQ430921 AA814680 AI458258 AI472207 CB990370 AW303324 AA743152 AU119304
highest scoring ESTs for EBF1:AF208502 AI381930 BC038805 BC041178 BQ227494 BQ430921 BQ438923 BU597395 BX282724 CB989550 Unigene Cluster for EBF1: Early B-cell factor 1 Hs.573143 [show with all ESTs]Unigene Representative Sequence: NM_024007
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000313708
ENST00000380654
ENST00000336546
|
Expression for EBF1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EBF1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EBF1
1 / 2 / 3 11 probe-sets matching EBF1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCAGTGGTT
SOURCE GeneReport for Unigene cluster: Hs.573143
|
Orthologs for EBF1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EBF1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for EBF1
ENSEMBL Gene Tree for EBF1 | Paralogs for EBF1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for EBF1 gene
- EBF32 EBF22 EBF42
|
SNPs/Variants for EBF1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EBF1 (up to first 250kb)
|
Disorders & Mutations for EBF1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 164343
1 Novoseek disease relationship for EBF1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| plasmacytoma |
62.36 |
1 |
8693297 (1) |
About this table
Human Genome Epidemiology Navigator: EBF1 (1 document)
|
Medical News for EBF1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EBF1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/59 PubMed articles for EBF1 gene (see all 59
):- Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11. (PubMed id 8012110)1, 2, 3 Milatovich A....Francke U. (1994)
- Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse. (PubMed id 10942392)1, 3, 4 Gisler R.... Sigvardsson M. (2000)
- Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. (PubMed id 14630787)1, 3, 4 Bond H.M....Venuta S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Inhibition of p300/CBP by early B-cell factor. (PubMed id 12748286)1, 3 Zhao F....Kadesch T. (2003)
- Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. (PubMed id 15920012)1, 3 Smith E.M....Sigvardsson M. (2005)
- Early B-cell Factor gene association with multiple sclerosis in the Spanish population. (PubMed id 16255771)1, 3 Martinez A....Urcelay E. (2005)
- The human V-preB promoter is a target for coordinated activation by early B cell factor and E47. (PubMed id 11994467)1, 3 Gisler R. and Sigvardsson M. (2002)
- Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. (PubMed id 8491377)1, 3 Hagman J....Grosschedl R. (1993)
- Purification of early-B-cell factor and characterization of its DNA-binding specificity. (PubMed id 8497258)1, 3 Travis A....Grosschedl R. (1993)
|
Search for EBF1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EBF1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EBF1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EBF1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EBF1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EBF1:

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| | Recombinant Proteins (EBF1) | | Antibodies (EBF1) |
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Incremental update: 13 Oct 2009
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