Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EBAG9 Gene

Aliases for EBAG9 Gene

  • Estrogen Receptor Binding Site Associated, Antigen, 9 2 3 5
  • Estrogen Receptor-Binding Fragment-Associated Gene 9 Protein 3 4
  • Cancer-Associated Surface Antigen RCAS1 3 4
  • RCAS1 4
  • PDAF 3
  • EB9 3

External Ids for EBAG9 Gene

Previous GeneCards Identifiers for EBAG9 Gene

  • GC08P110619
  • GC08P110220
  • GC08P110508
  • GC08P110621
  • GC08P105873

Summaries for EBAG9 Gene

Entrez Gene Summary for EBAG9 Gene

  • This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. [provided by RefSeq, Jul 2013]

GeneCards Summary for EBAG9 Gene

EBAG9 (Estrogen Receptor Binding Site Associated, Antigen, 9) is a Protein Coding gene. Diseases associated with EBAG9 include Placental Abruption and Bile Duct Carcinoma. Among its related pathways are Translational Control. GO annotations related to this gene include peptidase activator activity involved in apoptotic process.

UniProtKB/Swiss-Prot for EBAG9 Gene

  • May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

Gene Wiki entry for EBAG9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBAG9 Gene

Genomics for EBAG9 Gene

Regulatory Elements for EBAG9 Gene

Enhancers for EBAG9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EBAG9 on UCSC Golden Path with GeneCards custom track

Promoters for EBAG9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EBAG9 on UCSC Golden Path with GeneCards custom track

Genomic Location for EBAG9 Gene

109,539,700 bp from pter
109,565,996 bp from pter
26,297 bases
Plus strand

Genomic View for EBAG9 Gene

Genes around EBAG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBAG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBAG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBAG9 Gene

Proteins for EBAG9 Gene

  • Protein details for EBAG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-binding cancer antigen expressed on SiSo cells
    Protein Accession:
    Secondary Accessions:
    • A8K3N6
    • Q5Y8C7
    • Q6IB20
    • Q9BS76

    Protein attributes for EBAG9 Gene

    213 amino acids
    Molecular mass:
    24377 Da
    Quaternary structure:
    • Homodimer.
    • May serve as a prognostic marker for cancers such as adenocarcinomas of the lung and breast cancers. It is present and overexpressed in many patients suffering from breast carcinomas, its level of expression correlates with tumor grade, suggesting that it may be involved in cancer immune escape. According to PubMed:12672804, it is however not directly a tumor-associated antigen, but it rather modulates surface expression of tumor-associated O-linked glycan Tn when it is overexpressed, suggesting that it contributes indirectly to the antigenicity of tumor cells.

    Alternative splice isoforms for EBAG9 Gene


neXtProt entry for EBAG9 Gene

Proteomics data for EBAG9 Gene at MOPED

Post-translational modifications for EBAG9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EBAG9 (RCAS1)

No data available for DME Specific Peptides for EBAG9 Gene

Domains & Families for EBAG9 Gene

Protein Domains for EBAG9 Gene


Suggested Antigen Peptide Sequences for EBAG9 Gene

Graphical View of Domain Structure for InterPro Entry



  • The coiled coil domain is necessary for the homodimerization.
  • The coiled coil domain is necessary for the homodimerization.
genes like me logo Genes that share domains with EBAG9: view

No data available for Gene Families for EBAG9 Gene

Function for EBAG9 Gene

Molecular function for EBAG9 Gene

UniProtKB/Swiss-Prot Function:
May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
UniProtKB/Swiss-Prot Induction:
By estrogen.
genes like me logo Genes that share phenotypes with EBAG9: view

Animal Models for EBAG9 Gene

MGI Knock Outs for EBAG9:

Animal Model Products

  • Taconic Biosciences Mouse Models for EBAG9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EBAG9 Gene

Localization for EBAG9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBAG9 Gene

Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.

Subcellular locations from

Jensen Localization Image for EBAG9 Gene COMPARTMENTS Subcellular localization image for EBAG9 gene
Compartment Confidence
golgi apparatus 4
mitochondrion 3
plasma membrane 3
cytoskeleton 1
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for EBAG9 Gene

Pathways & Interactions for EBAG9 Gene

SuperPathways for EBAG9 Gene

Superpath Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with EBAG9: view

Pathways by source for EBAG9 Gene

1 Cell Signaling Technology pathway for EBAG9 Gene

Gene Ontology (GO) - Biological Process for EBAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10426319
genes like me logo Genes that share ontologies with EBAG9: view

No data available for SIGNOR curated interactions for EBAG9 Gene

Drugs & Compounds for EBAG9 Gene

(1) Drugs for EBAG9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EBAG9: view

Transcripts for EBAG9 Gene

Unigene Clusters for EBAG9 Gene

Estrogen receptor binding site associated, antigen, 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EBAG9 Gene

No ASD Table

Relevant External Links for EBAG9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EBAG9 Gene

mRNA expression in normal human tissues for EBAG9 Gene

Protein differential expression in normal tissues from HIPED for EBAG9 Gene

This gene is overexpressed in Plasma (17.2), Pancreas (14.1), Testis (9.8), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EBAG9 Gene

SOURCE GeneReport for Unigene cluster for EBAG9 Gene Hs.409368

mRNA Expression by UniProt/SwissProt for EBAG9 Gene

Tissue specificity: Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
genes like me logo Genes that share expression patterns with EBAG9: view

Protein tissue co-expression partners for EBAG9 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EBAG9 Gene

Orthologs for EBAG9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EBAG9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EBAG9 35
  • 93.11 (n)
  • 97.18 (a)
EBAG9 36
  • 97 (a)
(Canis familiaris)
Mammalia EBAG9 35
  • 94.05 (n)
  • 96.24 (a)
EBAG9 36
  • 97 (a)
(Mus musculus)
Mammalia Ebag9 35
  • 91.08 (n)
  • 97.65 (a)
Ebag9 16
Ebag9 36
  • 97 (a)
(Pan troglodytes)
Mammalia EBAG9 35
  • 99.69 (n)
  • 100 (a)
EBAG9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ebag9 35
  • 91.08 (n)
  • 94.37 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
-- 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
-- 36
  • 77 (a)
(Gallus gallus)
Aves EBAG9 35
  • 82.94 (n)
  • 90.61 (a)
EBAG9 36
  • 90 (a)
(Anolis carolinensis)
Reptilia EBAG9 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ebag9 35
  • 76.51 (n)
  • 82.38 (a)
Str.2052 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24520 35
(Danio rerio)
Actinopterygii ebag9 35
  • 70.91 (n)
  • 78.77 (a)
zgc56608 35
ebag9 36
  • 77 (a)
Species with no ortholog for EBAG9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EBAG9 Gene

Gene Tree for EBAG9 (if available)
Gene Tree for EBAG9 (if available)

Paralogs for EBAG9 Gene

(2) SIMAP similar genes for EBAG9 Gene using alignment to 5 proteins: Pseudogenes for EBAG9 Gene

genes like me logo Genes that share paralogs with EBAG9: view

No data available for Paralogs for EBAG9 Gene

Variants for EBAG9 Gene

Sequence variations from dbSNP and Humsavar for EBAG9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2022934 -- 109,555,545(-) AGAGA(C/T)TGGAG intron-variant
rs7838445 -- 109,548,065(+) cctaa(C/T)ccagg intron-variant
rs7839394 -- 109,541,365(+) AAGTA(A/G)GATAT intron-variant
rs7839449 -- 109,541,533(+) GCGTT(C/T)AAGTG intron-variant
rs2703377 -- 109,553,955(-) ACACA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EBAG9 Gene

Variant ID Type Subtype PubMed ID
nsv891281 CNV Loss 21882294

Variation tolerance for EBAG9 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EBAG9 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBAG9 Gene

Disorders for EBAG9 Gene

MalaCards: The human disease database

(6) MalaCards diseases for EBAG9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
placental abruption
  • abruptio placenta
bile duct carcinoma
  • carcinoma of extrahepatic bile duct
cervical adenocarcinoma
  • adenocarcinoma cervix uteri
  • acute adenitis
endometrial cancer
  • endometrial cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search EBAG9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EBAG9

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EBAG9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EBAG9 Gene

Publications for EBAG9 Gene

  1. Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers. (PMID: 11705872) Tsuneizumi M. … Nakamura Y. (Clin. Cancer Res. 2001) 3 23 48 67
  2. Analysis of the expression of human tumor antigens in ovarian cancer tissues. (PMID: 20164540) Ali-Fehmi R. … Tainsky M.A. (Cancer Biomark 2010) 3 23
  3. The level of RCAS1 expression is inversely correlated with the number of vimentin-positive stromal cells in epithelial ovarian cancer. (PMID: 19574770) Sonoda K. … Wake N. (Int. J. Gynecol. Cancer 2009) 3 23
  4. Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study. (PMID: 19813143) Adamek D. … Gajda M. (Folia Neuropathol 2009) 3 23
  5. [Evaluation of RCAS1 as serum tumor marker for pancreatic cancer]. (PMID: 19957811) Yang Y.C. … Dai M.H. (Zhonghua Wai Ke Za Zhi 2009) 3 23

Products for EBAG9 Gene

Sources for EBAG9 Gene