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Aliases & Descriptions for EARS2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.17 3 | | GluRS 3 | | KIAA1970 1, 2, 3 | | MSE1 1, 2 |
| | | Descriptions |
|---|
| Glutamate--tRNA ligase 3 | | glutamate tRNA ligase 2, mitochondrial 2 | | glutamyl-tRNA synthetase 2 2 | | glutamyl-tRNA synthetase 2, mitochondrial (putative) 2 |
|
| | Search outside databases for aliases for EARS2 gene |
Summaries for EARS2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SYEM_HUMAN, Q5JPH6Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) |
Genomic Location for EARS2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EARS2 gene 
Entrez Gene cytogenetic band: 16p12.1 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p12.3EARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M023440:
(about GC identifiers)
Start:
|
23,440,835 bp from pter |
End:
|
23,476,197 bp from pter |
Size:
|
35,363 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010393.15
| Proteins for EARS2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYEM_HUMAN, Q5JPH6 (See
protein sequence)Recommended Name: Probable glutamyl-tRNA synthetase, mitochondrial precursor Size: 523 amino acids; 58689 Da
Subcellular location: Mitochondrion matrix (By similarity)
Secondary accessions: B3KTT2 Q8TF31REFSEQ proteins: NP_001077083.1
ENSEMBL proteins: ENSP00000343488
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for EARS2: Assays for EARS2: | Protein
Domains/ Families for EARS2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q5JPH6
ProtoNet protein and cluster: Q5JPH6 1 Blocks protein family: IPB000924 Glutamyl-tRNA synthetase signature
UniProtKB/Swiss-Prot: SYEM_HUMAN, Q5JPH6Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family | Gene Function for EARS2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NR_003501
Applied Biosystems Silencer® siRNAs for EARS2
Sigma-Aldrich siRNA for EARS2  Sigma-Aldrich shRNA for EARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001083614                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001083614                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001083614 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001083614
UniProtKB/Swiss-Prot: SYEM_HUMAN, Q5JPH6Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)Catalytic activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)Enzyme Number (IUBMB): EC 6.1.1.17 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for EARS2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for EARS2 (Your Favorite Gene powered by Ingenuity) 
5/37 Interacting proteins for EARS2 (ENSP000003434883) via UniProtKB, MINT, and/or STRING (see all 37
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006424 | glutamyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for EARS2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EARS2
|
Transcripts for EARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NR_003501
Sigma-Aldrich siRNA for EARS2  Sigma-Aldrich shRNA for EARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001083614 REFSEQ mRNAs for EARS2 gene: NM_001083614.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001083614               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001083614                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001083614                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001083614  Additional cDNA sequence: AB075850.1 AF088053.1 AK095998.1 AL832489.1 BC020592.1 BC040013.1 BX648129.1 CR613598.1 18 DOTS entries: DT.100844821 DT.448238 DT.100781219 DT.120691069 DT.100008435 DT.100027545 DT.95275717 DT.95099257 DT.120691009 DT.120691084 DT.91713220 DT.95199993 DT.95218806 DT.100781217 DT.120690960 DT.120690994 DT.120691020 DT.97784815
highest scoring ESTs for EARS2:AB075850 AI547137 AI929390 AK095998 AL520724 AL559488 AL832489 BC040013 BE242636 BE612832 Unigene Cluster for EARS2: Glutamyl-tRNA synthetase 2, mitochondrial (putative) Hs.620541 [show with all ESTs]Unigene Representative Sequence: NM_001083614
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for EARS2
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for EARS2
1 Ensembl transcript including schematic representation: ENST00000341597
|
Expression for EARS2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EARS2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EARS2
1 / 2 / 3 7 probe-sets matching EARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.620541
|
Orthologs for EARS2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EARS2 gene from 5/18 species (see all 18
)
About this table Species with no ortholog for EARS2
ENSEMBL Gene Tree for EARS2 | Paralogs for EARS2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for EARS2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EARS2 (up to first 250kb)
|
Disorders & Mutations for EARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612799
|
Medical News for EARS2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EARS2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for EARS2 gene: |
Search for EARS2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EARS2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EARS2
(According to HUGE)
About This Section
| |
Specialized Databases showing EARS2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EARS2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EARS2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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