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EAPP Gene

protein-coding   GIFtS: 55
GCID: GC14M034985

E2F-Associated Phosphoprotein

(Previous name: chromosome 14 open reading frame 11)
(Previous symbol: C14orf11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E2F-Associated Phosphoprotein1 2
C14orf111 2 3
Chromosome 14 Open Reading Frame 111
BM0362

External Ids:    HGNC: 193121   Entrez Gene: 558372   Ensembl: ENSG000001295187   OMIM: 6094865   UniProtKB: Q56P033   

Export aliases for EAPP gene to outside databases

Previous GC identifers: GC14M034055 GC14M015103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EAPP Gene:
This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein
localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to
modulate E2F-regulated transcription and stimulate proliferation. (provided by RefSeq, Jul 2008)

GeneCards Summary for EAPP Gene:
EAPP (E2F-associated phosphoprotein) is a protein-coding gene. Diseases associated with EAPP include farmer's lung, and holoprosencephaly.

UniProtKB/Swiss-Prot: EAPP_HUMAN, Q56P03
Function: May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the
cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression

Gene Wiki entry for EAPP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EAPP gene promoter:
         FOXF2   FOXD1   IRF-1   RelA   LCR-F1   NF-kappaB   Arnt   FOXC1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEAPP promoter sequence
   Search Chromatin IP Primers for EAPP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EAPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.1   Ensembl cytogenetic band:  14q13.1   HGNC cytogenetic band: 14q13

EAPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EAPP gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M034985:  view genomic region     (about GC identifiers)

Start:
34,985,135 bp from pter      End:
35,008,943 bp from pter
Size:
23,809 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EAPP_HUMAN, Q56P03 (See protein sequence)
Recommended Name: E2F-associated phosphoprotein  
Size: 285 amino acids; 32762 Da
Subunit: Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3,
but not E2F4
Developmental stage: During the cell cycle, expression disappears during mitosis
Sequence caution: Sequence=AAF67623.1; Type=Frameshift; Positions=178, 189, 198, 226; Sequence=AAO17041.1;
Type=Frameshift; Positions=178, 189, 198, 226; Sequence=AAO17042.1; Type=Frameshift; Positions=178, 189, 198,
226;
Secondary accessions: Q9BVF4 Q9NWV5 Q9NZ86

Explore the universe of human proteins at neXtProt for EAPP: NX_Q56P03

Explore proteomics data for EAPP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys93
  • Modification sites at PhosphoSitePlus

  • See EAPP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060923.2  
    ENSEMBL proteins: 
     ENSP00000250454   ENSP00000450908   ENSP00000452439  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019370 E2F-assoc_phosphoprotein

    Graphical View of Domain Structure for InterPro Entry Q56P03

    ProtoNet protein and cluster: Q56P03


    EAPP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EAPP_HUMAN, Q56P03
    Function: May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the
    cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression

    Phenotypes:
         1 GenomeRNAi human phenotype for EAPP:

     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EAPP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EAPP
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    miRNA
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    miRTarBase miRNAs that target EAPP:
    hsa-mir-361-5p (MIRT020078), hsa-mir-93-5p (MIRT048911)

    Block miRNA regulation of human, mouse, rat EAPP using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate EAPP:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidEAPP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EAPP_HUMAN, Q56P03: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    EAPP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EAPP About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EAPP
        Cell Cycle / Checkpoint Control




    EAPP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EAPP
    Interactions:

        Search GeneGlobe Interaction Network for EAPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for EAPP (Q56P032, 3 ENSP000002504544) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE3AQ050862, 3, ENSP000003810454MINT-2874650 I2D: score=3 STRING: ENSP00000381045
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2874631 I2D: score=3 STRING: ENSP00000357292
    AAR2Q9Y3123, ENSP000003136744I2D: score=4 STRING: ENSP00000313674
    E2F1Q010943, ENSP000003455714I2D: score=2 STRING: ENSP00000345571
    E2F3O007163, ENSP000002629044I2D: score=2 STRING: ENSP00000262904
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IDA15716352
    GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter IDA15716352
    GO:0034244negative regulation of transcription elongation from RNA polymerase II promoter IDA15716352

    EAPP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EAPP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EAPP gene: 
    NM_018453.3  

    Unigene Cluster for EAPP:

    E2F-associated phosphoprotein
    Hs.433269  [show with all ESTs]
    Unigene Representative Sequence: NM_018453
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250454(uc001wsd.1) ENST00000554792 ENST00000555705 ENST00000555683

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate EAPP:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidEAPP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EAPP
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      QuantiTect SYBR Green Assays in human, mouse, rat EAPP
      QuantiFast Probe-based Assays in human, mouse, rat EAPP

    Additional mRNA sequence: 

    AF217512.1 AK000585.1 AK225467.1 AK225477.1 AK225991.1 AY157300.1 AY157301.1 AY869694.1 
    BC001245.1 

    10 DOTS entries:

    DT.448951  DT.99998772  DT.95086769  DT.100680953  DT.120790963  DT.97765627  DT.97800149  DT.100821684 
    DT.120790976  DT.92428950 

    Selected AceView cDNA sequences (see all 242):

    BQ648032 BQ651747 CA455313 T30278 D79510 BQ644142 CA444260 BU661711 
    BU171158 CB157729 BU856994 BQ029214 AI365641 AA046315 AI140095 BM682986 
    AA676250 CB107481 AI356848 CR609381 BM719002 BM479939 BG680985 AW015457 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EAPP (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                          -     -           -                                       
    SP2:                          -     -           -           -     -                     
    SP3:                          -     -           -                                       
    SP4:                                -           -                                       
    SP5:                                            -                                       


    ECgene alternative splicing isoforms for EAPP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EAPP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTGAAT
    EAPP Expression
    About this image


    EAPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    EAPP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EAPP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433269

    UniProtKB/Swiss-Prot: EAPP_HUMAN, Q56P03
    Tissue specificity: Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower
    levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and
    cerebral cortex. Expressed in COS1 and transformed skin fibroblasts

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EAPP gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eapp1 , 5 E2F-associated phosphoprotein1, 5 84.4(n)1
    88.57(a)1
      12 (23.46 cM)5
    662661  NM_025456.31  NP_079732.11 
     546703405 
    chicken
    (Gallus gallus)
    Aves EAPP1 E2F-associated phosphoprotein 70.24(n)
    70.36(a)
      423319  NM_001197245.1  NP_001184174.1 
    lizard
    (Anolis carolinensis)
    Reptilia EAPP6
    E2F-associated phosphoprotein
    67(a)
    1 ↔ 1
    2(54794734-54805912)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF547510.12   -- 77.34(n)    CF547510.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd21g022 wufd21g02 73.83(n)   327318  BC056728.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F48E8.26
    Protein F48E8.2 (F48E8.2) mRNA, complete cds
    15(a)
    1 ↔ 1
    III(5464398-5467972) WBGene00018609
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G083201 AT5G08320 56.72(n)
    48.39(a)
      830728  NM_120915.1  NP_196449.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06357001 Os02g0635700 54.59(n)
    55.12(a)
      4330079  NM_001054055.2  NP_001047520.2 


    ENSEMBL Gene Tree for EAPP (if available)
    TreeFam Gene Tree for EAPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EAPP (see all 528)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471765931,2
    --34984806(+) TGATCA/TCAGCT 1 -- ds50010--------
    rs1402920681,2
    --34984821(+) GCAACC/TTCAGC 1 -- ds50010--------
    rs118453811,2
    C,F,A,H--34984913(+) tttctA/Gttttt 1 -- ds50016Minor allele frequency- G:0.02NS EA NA WA 538
    rs1442027971,2
    C--34985236(+) GAACAG/TTTTAA 1 -- ut310--------
    rs1474202991,2
    C--34985258(+) TTTAAC/TAAAAA 1 -- ut310--------
    rs115518001,2
    C,H--34985335(+) TCAAAG/AAAAAA 1 -- ut312Minor allele frequency- A:0.01NS NA 174
    rs1911933821,2
    --34985419(+) GCTTCC/TTCAAT 1 -- ut310--------
    rs77661,2
    C,F,O,A,H--34985506(-) CCCAAC/GTGGCA 1 -- ut31 ese315Minor allele frequency- G:0.03MN NA EA NS WA CSA EU 2361
    rs2020446601,2
    --34985534(+) GCTAAA/CACATT 2 V syn10--------
    rs1499232741,2
    C--34985538(+) AAACAC/TTGAAA 2 N S mis10--------

    HapMap Linkage Disequilibrium report for EAPP (34985135 - 35008943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for EAPP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv9131CNV Loss18304495
    nsv901600CNV Gain21882294
    nsv528989CNV Gain19592680
    nsv92OTHER Inversion15895083
    nsv7251OTHER Inversion18451855
    esv1007795OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EAPP
    DNA2.0 Custom Variant and Variant Library Synthesis for EAPP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609486    OMIM disorders: --

    5 diseases for EAPP:    
    About MalaCards
    farmer's lung    holoprosencephaly    coloboma    cerebritis
    ataxia

    2 diseases from the University of Copenhagen DISEASES database for EAPP:
    farmer's lung     Holoprosencephaly

    EAPP for disorders           About GeneDecksing


    Export disorders for EAPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EAPP gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with EAPP)
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    1. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. (PubMed id 15716352)1, 2, 3, 9 Novy M.... Rotheneder H. (Mol. Biol. Cell 2005)
    2. Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes. (PubMed id 15820313)1, 2 Kamnasaran D.... Cox D.W. (Genomics 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Regulation of the E2F-associated phosphoprotein promoter by GC-box binding proteins. (PubMed id 18588995)1, 9 Schwarzmayr L....Rotheneder H. (amp 2008)
    7. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PubMed id 23936387)1 A9stensson M....Torinsson-Naluai A.8. (PLoS ONE 2013)
    8. Regulation of the MDR1 promoter by E2F1 and EAPP. (PubMed id 23542036)1 Andorfer P. and Rotheneder H. (FEBS Lett. 2013)
    9. EAPP: gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest. (PubMed id 21258403)1 Andorfer P. and Rotheneder H. (Oncogene 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55837 HGNC: 19312 AceView: C14orf11 Ensembl:ENSG00000129518 euGenes: HUgn55837
    ECgene: EAPP H-InvDB: EAPP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EAPP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EAPP gene:
    Search GeneIP for patents involving EAPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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