Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EAPP Gene

Aliases for EAPP Gene

  • E2F Associated Phosphoprotein 2 3 5
  • C14orf11 3 4
  • Chromosome 14 Open Reading Frame 11 2
  • E2F-Associated Phosphoprotein 3
  • BM036 3

External Ids for EAPP Gene

Previous HGNC Symbols for EAPP Gene

  • C14orf11

Previous GeneCards Identifiers for EAPP Gene

  • GC14M034055
  • GC14M034985
  • GC14M015103

Summaries for EAPP Gene

Entrez Gene Summary for EAPP Gene

  • This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for EAPP Gene

EAPP (E2F Associated Phosphoprotein) is a Protein Coding gene. Among its related pathways are DNA Damage.

UniProtKB/Swiss-Prot for EAPP Gene

  • May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.

Gene Wiki entry for EAPP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EAPP Gene

Genomics for EAPP Gene

Regulatory Elements for EAPP Gene

Enhancers for EAPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G035330 2.1 FANTOM5 Ensembl ENCODE dbSUPER 25.1 -797.2 -797204 12.3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 PSMA6 NFKBIA EAPP RPS19P3 PPP2R3C BAZ1A FAM177A1 SRP54 QRSL1P3 LOC644584
GH14G035364 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19.5 -827.7 -827747 6.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 SLC30A9 ZNF766 FOS SP5 NFKBIA PSMA6 BAZ1A EAPP PPP2R3C RPS19P3 FAM177A1 RALGAPA1 SRP54 ENSG00000258860
GH14G035120 1.4 ENCODE dbSUPER 28.3 -582.7 -582706 3.8 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D PPP2R3C EAPP RPS19P3 KIAA0391 NFKBIA FAM177A1 BAZ1A
GH14G035383 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.5 -845.5 -845503 3.9 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF121 FOS EAPP NFKBIA FAM177A1 PSMA6 RPS19P3 PPP2R3C RALGAPA1 RPLP0P3 ENSG00000258860
GH14G035412 1.4 Ensembl ENCODE dbSUPER 20.5 -873.6 -873589 1.0 ELF3 ARID4B ZNF2 THRB RAD21 RARA ZNF143 RELB CREM MIXL1 EAPP RPS19P3 CFL2 RNU1-27P NFKBIA DNAJC8P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EAPP on UCSC Golden Path with GeneCards custom track

Promoters for EAPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067564 437 1801 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for EAPP Gene

Chromosome:
14
Start:
34,515,929 bp from pter
End:
34,539,737 bp from pter
Size:
23,809 bases
Orientation:
Minus strand

Genomic View for EAPP Gene

Genes around EAPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EAPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EAPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EAPP Gene

Proteins for EAPP Gene

  • Protein details for EAPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q56P03-EAPP_HUMAN
    Recommended name:
    E2F-associated phosphoprotein
    Protein Accession:
    Q56P03
    Secondary Accessions:
    • Q9BVF4
    • Q9NWV5
    • Q9NZ86

    Protein attributes for EAPP Gene

    Size:
    285 amino acids
    Molecular mass:
    32762 Da
    Quaternary structure:
    • Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4.
    SequenceCaution:
    • Sequence=AAF67623.1; Type=Frameshift; Positions=178, 189, 198, 226; Evidence={ECO:0000305}; Sequence=AAO17041.1; Type=Frameshift; Positions=178, 189, 198, 226; Evidence={ECO:0000305}; Sequence=AAO17042.1; Type=Frameshift; Positions=178, 189, 198, 226; Evidence={ECO:0000305};

neXtProt entry for EAPP Gene

Post-translational modifications for EAPP Gene

  • Ubiquitination at isoforms=93
  • Modification sites at PhosphoSitePlus

Other Protein References for EAPP Gene

No data available for DME Specific Peptides for EAPP Gene

Domains & Families for EAPP Gene

Protein Domains for EAPP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EAPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EAPP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for EAPP Gene

Function for EAPP Gene

Molecular function for EAPP Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.
genes like me logo Genes that share phenotypes with EAPP: view

Animal Model Products

CRISPR Products

miRNA for EAPP Gene

miRTarBase miRNAs that target EAPP

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EAPP Gene

Localization for EAPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for EAPP Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EAPP gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for EAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15716352
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with EAPP: view

Pathways & Interactions for EAPP Gene

SuperPathway Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with EAPP: view

Pathways by source for EAPP Gene

1 Cell Signaling Technology pathway for EAPP Gene

Gene Ontology (GO) - Biological Process for EAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 15716352
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA 15716352
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IDA 15716352
genes like me logo Genes that share ontologies with EAPP: view

No data available for SIGNOR curated interactions for EAPP Gene

Drugs & Compounds for EAPP Gene

No Compound Related Data Available

Transcripts for EAPP Gene

Unigene Clusters for EAPP Gene

E2F-associated phosphoprotein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EAPP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for EAPP Gene

GeneLoc Exon Structure for
EAPP
ECgene alternative splicing isoforms for
EAPP

Expression for EAPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EAPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EAPP Gene

This gene is overexpressed in Lung (30.9), Prostate (13.5), Testis (9.2), and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EAPP Gene



Protein tissue co-expression partners for EAPP Gene

NURSA nuclear receptor signaling pathways regulating expression of EAPP Gene:

EAPP

SOURCE GeneReport for Unigene cluster for EAPP Gene:

Hs.433269

mRNA Expression by UniProt/SwissProt for EAPP Gene:

Q56P03-EAPP_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.

Evidence on tissue expression from TISSUES for EAPP Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Bone marrow(4.3)
genes like me logo Genes that share expression patterns with EAPP: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EAPP Gene

Orthologs for EAPP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EAPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EAPP 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia EAPP 34
  • 90.18 (n)
-- 35
  • 87 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EAPP 34 35
  • 89.91 (n)
mouse
(Mus musculus)
Mammalia Eapp 34 16 35
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Eapp 34
  • 83.39 (n)
oppossum
(Monodelphis domestica)
Mammalia EAPP 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EAPP 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves EAPP 34 35
  • 70.24 (n)
lizard
(Anolis carolinensis)
Reptilia EAPP 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eapp 34
  • 66.9 (n)
zebrafish
(Danio rerio)
Actinopterygii eapp 34 35
  • 64.18 (n)
wufd21g02 34
worm
(Caenorhabditis elegans)
Secernentea F48E8.2 35
  • 15 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G08320 34
  • 56.72 (n)
rice
(Oryza sativa)
Liliopsida Os02g0635700 34
  • 54.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for EAPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EAPP Gene

ENSEMBL:
Gene Tree for EAPP (if available)
TreeFam:
Gene Tree for EAPP (if available)

Paralogs for EAPP Gene

No data available for Paralogs for EAPP Gene

Variants for EAPP Gene

Sequence variations from dbSNP and Humsavar for EAPP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000095890 -- 34,531,948(+) GCGGG(C/T)GCCTG intron-variant
rs1000098956 -- 34,539,276(+) TACTA(A/C)GGTGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000161824 -- 34,530,520(+) GAGAC(C/T)TATCT intron-variant
rs1000273717 -- 34,521,916(+) GGCGT(G/T)AGCCA intron-variant
rs1000287556 -- 34,519,341(+) ACCAG(C/G)CTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EAPP Gene

Variant ID Type Subtype PubMed ID
dgv1865n100 CNV loss 25217958
dgv3608n54 CNV gain 21841781
esv1007795 OTHER inversion 20482838
esv3634031 CNV loss 21293372
nsv1042294 CNV gain 25217958
nsv1049048 CNV gain 25217958
nsv528989 CNV gain 19592680
nsv564194 CNV loss 21841781
nsv7251 OTHER inversion 18451855
nsv9131 CNV loss 18304495
nsv92 OTHER inversion 15895083

Variation tolerance for EAPP Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EAPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EAPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EAPP Gene

Disorders for EAPP Gene

Relevant External Links for EAPP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EAPP

No disorders were found for EAPP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EAPP Gene

Publications for EAPP Gene

  1. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. (PMID: 15716352) Novy M. … Rotheneder H. (Mol. Biol. Cell 2005) 2 3 4 22 64
  2. Regulation of the E2F-associated phosphoprotein promoter by GC-box binding proteins. (PMID: 18588995) Schwarzmayr L. … Rotheneder H. (Int. J. Biochem. Cell Biol. 2008) 3 22 64
  3. Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes. (PMID: 15820313) Kamnasaran D. … Cox D.W. (Genomics 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for EAPP Gene

Sources for EAPP Gene

Content
Loading form....