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Aliases for EAF2 Gene

Aliases for EAF2 Gene

  • ELL Associated Factor 2 2 3 5
  • Testosterone-Regulated Apoptosis Inducer And Tumor Suppressor Protein 3 4
  • TRAITS 3 4
  • ELL-Associated Factor 2 3
  • BM040 3
  • U19 3

External Ids for EAF2 Gene

Previous GeneCards Identifiers for EAF2 Gene

  • GC03P121194
  • GC03P122835
  • GC03P122874
  • GC03P123036
  • GC03P121555
  • GC03P118928

Summaries for EAF2 Gene

GeneCards Summary for EAF2 Gene

EAF2 (ELL Associated Factor 2) is a Protein Coding gene. Diseases associated with EAF2 include Eaf and Childhood Leukemia. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is EAF1.

UniProtKB/Swiss-Prot for EAF2 Gene

  • Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.

Gene Wiki entry for EAF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EAF2 Gene

Genomics for EAF2 Gene

Regulatory Elements for EAF2 Gene

Enhancers for EAF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around EAF2 on UCSC Golden Path with GeneCards custom track

Promoters for EAF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EAF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EAF2 Gene

Chromosome:
3
Start:
121,835,183 bp from pter
End:
121,886,526 bp from pter
Size:
51,344 bases
Orientation:
Plus strand

Genomic View for EAF2 Gene

Genes around EAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EAF2 Gene

Proteins for EAF2 Gene

  • Protein details for EAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CJ1-EAF2_HUMAN
    Recommended name:
    ELL-associated factor 2
    Protein Accession:
    Q96CJ1
    Secondary Accessions:
    • Q9NZ82

    Protein attributes for EAF2 Gene

    Size:
    260 amino acids
    Molecular mass:
    28792 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with TCEA1 (By similarity). Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL and ELL2.

    Alternative splice isoforms for EAF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EAF2 Gene

Post-translational modifications for EAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EAF2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EAF2 (EAF2)
  • Abcam antibodies for EAF2

No data available for DME Specific Peptides for EAF2 Gene

Domains & Families for EAF2 Gene

Protein Domains for EAF2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96CJ1

UniProtKB/Swiss-Prot:

EAF2_HUMAN :
  • Belongs to the EAF family.
Family:
  • Belongs to the EAF family.
genes like me logo Genes that share domains with EAF2: view

No data available for Gene Families for EAF2 Gene

Function for EAF2 Gene

Molecular function for EAF2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
UniProtKB/Swiss-Prot Induction:
By androgen.

Gene Ontology (GO) - Molecular Function for EAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16114057
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 16114057
GO:0005515 protein binding IEA,IPI 17395368
genes like me logo Genes that share ontologies with EAF2: view
genes like me logo Genes that share phenotypes with EAF2: view

Animal Models for EAF2 Gene

MGI Knock Outs for EAF2:

Animal Model Products

CRISPR Products

miRNA for EAF2 Gene

miRTarBase miRNAs that target EAF2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EAF2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EAF2 Gene

Localization for EAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EAF2 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EAF2 Gene COMPARTMENTS Subcellular localization image for EAF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for EAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA,IDA --
GO:0008023 transcription elongation factor complex IDA 22195968
GO:0016607 nuclear speck IEA --
GO:0032783 ELL-EAF complex IEA --
genes like me logo Genes that share ontologies with EAF2: view

Pathways & Interactions for EAF2 Gene

genes like me logo Genes that share pathways with EAF2: view

Pathways by source for EAF2 Gene

1 Cell Signaling Technology pathway for EAF2 Gene

SIGNOR curated interactions for EAF2 Gene

Activates:

Gene Ontology (GO) - Biological Process for EAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006915 apoptotic process IEA --
GO:0030308 negative regulation of cell growth IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16114057
genes like me logo Genes that share ontologies with EAF2: view

Drugs & Compounds for EAF2 Gene

No Compound Related Data Available

Transcripts for EAF2 Gene

Unigene Clusters for EAF2 Gene

ELL associated factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EAF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EAF2 Gene

No ASD Table

Relevant External Links for EAF2 Gene

GeneLoc Exon Structure for
EAF2
ECgene alternative splicing isoforms for
EAF2

Expression for EAF2 Gene

mRNA expression in normal human tissues for EAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EAF2 Gene

This gene is overexpressed in Pancreatic juice (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EAF2 Gene



Protein tissue co-expression partners for EAF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EAF2 Gene:

EAF2

SOURCE GeneReport for Unigene cluster for EAF2 Gene:

Hs.477325

mRNA Expression by UniProt/SwissProt for EAF2 Gene:

Q96CJ1-EAF2_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes.
genes like me logo Genes that share expression patterns with EAF2: view

Primer Products

No data available for mRNA differential expression in normal tissues for EAF2 Gene

Orthologs for EAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EAF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EAF2 34
  • 89.83 (n)
  • 88.42 (a)
EAF2 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EAF2 34
  • 89.49 (n)
  • 86.54 (a)
EAF2 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eaf2 34
  • 85.33 (n)
  • 81.08 (a)
Eaf2 16
Eaf2 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EAF2 34
  • 99.62 (n)
  • 98.85 (a)
EAF2 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eaf2 34
  • 84.68 (n)
  • 80.69 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EAF2 35
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves EAF2 34
  • 73.84 (n)
  • 74.1 (a)
EAF2 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EAF2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eaf2 34
  • 65.72 (n)
  • 71.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68453 34
zebrafish
(Danio rerio)
Actinopterygii eaf2 34
  • 58.73 (n)
  • 63.1 (a)
wufb76c01 34
eaf2 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eaf 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eaf-1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for EAF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EAF2 Gene

ENSEMBL:
Gene Tree for EAF2 (if available)
TreeFam:
Gene Tree for EAF2 (if available)

Paralogs for EAF2 Gene

Paralogs for EAF2 Gene

(1) SIMAP similar genes for EAF2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EAF2: view

Variants for EAF2 Gene

Sequence variations from dbSNP and Humsavar for EAF2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2332056 -- 121,879,450(-) gattt(C/T)tttgt intron-variant
rs4610269 -- 121,848,931(+) CATCT(A/G)TCAAA intron-variant
rs4642169 -- 121,841,376(+) ggcgc(A/G)cgctt intron-variant
rs4676758 -- 121,864,568(+) CCCAG(C/T)ACTTT intron-variant
rs4676760 -- 121,879,467(+) cagat(G/T)aatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EAF2 Gene

Variant ID Type Subtype PubMed ID
dgv8524n54 CNV gain 21841781
esv3305904 CNV mobile element insertion 20981092
esv33139 CNV loss 17666407
esv3361990 CNV insertion 20981092
esv3451038 OTHER inversion 20981092
nsv1141890 OTHER inversion 24896259
nsv516233 CNV gain+loss 19592680
nsv967053 CNV duplication 23825009

Variation tolerance for EAF2 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EAF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EAF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EAF2 Gene

Disorders for EAF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EAF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
eaf
  • eosinophilic angiocentric fibrosis
childhood leukemia
- elite association - COSMIC cancer census association via MalaCards
Search EAF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EAF2

Genetic Association Database (GAD)
EAF2
Human Genome Epidemiology (HuGE) Navigator
EAF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EAF2
genes like me logo Genes that share disorders with EAF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EAF2 Gene

Publications for EAF2 Gene

  1. ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. (PMID: 12446457) Simone F. … Thirman M.J. (Blood 2003) 2 3 4 22 65
  2. Suppression of prostate tumor growth by U19, a novel testosterone- regulated apoptosis inducer. (PMID: 12907652) Xiao W. … Wang Z. (Cancer Res. 2003) 2 3 4 22 65
  3. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. (PMID: 16006523) Kong S.E. … Conaway R.C. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 65
  4. The little elongation complex regulates small nuclear RNA transcription. (PMID: 22195968) Smith E.R. … Shilatifard A. (Mol. Cell 2011) 3 4 65
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65

Products for EAF2 Gene

Sources for EAF2 Gene

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