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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

E4F1 Gene

protein-coding GIFtS: 54
GCID: GC16P002276

E4F transcription factor 1

Explore 6 diseases affiliated with
E4F1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
E4F Transcription Factor 1¹ ² ³		P120E4F¹
E4F¹ ² ³ ⁵		P50E4F¹
Putative E3 Ubiquitin-Protein Ligase E4F1² ³		Transcription Factor E4F1²
Transcription Factor E4F² ³		EC 6.3.2.-³

External Ids:	HGNC: 3121¹	Entrez Gene: 1877²	Ensembl: ENSG00000167967⁷	OMIM: 603022⁵	UniProtKB: Q66K89³

Export aliases for E4F1 gene to outside databases

Previous GC identifers: GC16M002500 GC16P002299 GC16P002213 GC16P002274 GC16P002199 GC16P002275

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for E4F1:

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding

activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the

full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced

phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A,

while the 50-kDa form acts as a transcriptional activator in its presence. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Function: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination

of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle.

Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription

Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional

activation and repression of viral genes

Gene Wiki entry for E4F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the E4F1 gene promoter:
GR NF-1/L NF-1 p53 NF-kappaB GATA-2 IRF-7A GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: E4F1 promoter sequence

Search SABiosciences Chromatin IP Primers for E4F1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat E4F1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

E4F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E4F1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P002276: view genomic region (about GC identifiers)

Start:	2,273,560 bp from pter	End:	2,285,743 bp from pter
Size:	12,184 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89 (See protein sequence)

Recommended Name: Transcription factor E4F1

Size: 784 amino acids; 83496 Da

Subunit: Homodimer; binds DNA as a dimer. Forms a complex with CDKN2A and TP53. Interactions with TP53, RB1, ANP32A,

BMI1 and FHL2 regulate E4F1 activity. Interacts with HDAC1, HMGA2 and RASSF1. Interacts with HBV protein X

Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded

from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during

embryogenesis (By similarity)

Developmental stage: Expressed in a variety of fetal tissues

Secondary accessions: A8K2R4 O00146

Explore the universe of human proteins at neXtProt for E4F1: NX_Q66K89

Post-translational modifications:

Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity and activates

transcription in presence of the adenoviral E1A protein. The major full length protein (p120E4F) functions as a

repressor of transcription¹

Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent and differentially

regulates DNA-binding activity and function of both forms¹

May be sumoylated by UBE2I upon interaction with CDKN2A¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q66K89

E4F1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004415.2

ENSEMBL proteins:

ENSP00000454643 ENSP00000301727 ENSP00000456760 ENSP00000456766 ENSP00000457672

ENSP00000456005 ENSP00000454652

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	Uscn Proteins for E4F1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005819	spindle	IEA	--

E4F1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

E4F1 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q66K89

ProtoNet protein and cluster: Q66K89

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Similarity: Contains 9 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Function: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination

of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle.

Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription

Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional

activation and repression of viral genes

Induction: Up-regulated by estrogen

Genatlas biochemistry entry for E4F1:

transcription factor E4F1,adenovirus EIA regulated,with low spliced isoforms,one 120kDa)

upregulated,50kDa,down-regulated

Enzyme Number (IUBMB): EC 6.3.2.-¹

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		hsa-miR-4307
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E4F1

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	TAS	10869426
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	9121437
GO:0003713	transcription coactivator activity	TAS	9121437
GO:0003714	transcription corepressor activity	TAS	10869426

E4F1 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for E4F1:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Wnt reporter downregulated

Animal Models:
Mouse knock-out E4f1^tm1Pisc for E4F1
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for E4f1):

cellular	embryogenesis	growth/size	homeostasis/metabolism	integument
mortality/aging

E4F1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

p53 pathway

p53 pathway

1.00

1 BioSystems Pathway for E4F1

p53 pathway

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Pathway: Protein modification; protein ubiquitination

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for E4F1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/22 Interacting proteins for E4F1 (Q66K89^{1, 2, 3} ENSP00000301727⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANP32A	P39687²^,³, ENSP00000417864⁴	MINT-4968493 MINT-4975442 MINT-4979091 I2D: score=3 STRING: ENSP00000417864
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-8207347 I2D: score=1 STRING: ENSP00000263925
LNX2	Q8N448²^,³, ENSP00000325929⁴	MINT-8207368 I2D: score=1 STRING: ENSP00000325929
SMAD9	O15198²^,³	MINT-62086 I2D: score=2
HDAC1	Q13547²^,³, ENSP00000362649⁴	MINT-6628981 MINT-6628988 MINT-6628993 I2D: score=2 STRING: ENSP00000362649

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	14645522
GO:0006260	DNA replication	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007067	mitosis	IEA	--

E4F1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for E4F1
Search CenterWatch for drugs/clinical trials and news about E4F1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for E4F1 gene:

NM_004424.3

Unigene Clusters for E4F1:

E4F transcription factor 1

Hs.513268 [show with all ESTs], Hs.615283

Unigene Representative Sequences: AB209008, BC001713

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000567577 ENST00000301727(uc002cpm.3 uc010bsi.3 uc010bsj.3)

ENST00000565090 ENST00000566142 ENST00000564139 ENST00000562589 ENST00000565413

ENST00000569796 ENST00000563643 ENST00000564930 ENST00000567111

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		hsa-miR-4307
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Additional cDNA sequence: BC001713.1

9 DOTS entries:

DT.100778478 DT.97815181 DT.113646 DT.120702796 DT.99967923 DT.120702790 DT.92430065 DT.100778477

DT.431106

24/153 AceView cDNA sequences (see all 153):

CA488104 AK098028 CA422408 BC035205 AI675620 BM713890 BC063710 AI420452

AY298957 Z38690 BX284025 BI223566 BM676507 BU501086 BU539326 BC014068

NM_001374 CA405900 BX283985 BC080524 BM796095 AW515664 BU957083 BE746628

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for E4F1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12
SP1:
SP2:
SP3:					-
SP4:
SP5:

ECgene alternative splicing isoforms for E4F1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

E4F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAACCTGCA

About this image

E4F1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See E4F1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for E4F1

SOURCE GeneReport for Unigene clusters: Hs.513268 Hs.615283

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Tissue specificity: Ubiquitously expressed

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for E4F1 gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	E4f1^{1 , 5}	E4F transcription factor 1^{1, 5}	85.85(n)¹ 88.72(a)¹		17 (12.39 cM)⁵ 13560¹ NM_007893.3¹ NP_031919.2¹ 24443792⁵
chicken (Gallus gallus)	Aves	E4F1¹	E4F transcription factor 1	68.08(n) 72.31(a)		416560 XM_414860.3 XP_414860.3
lizard (Anolis carolinensis)	Reptilia	E4F1⁶	--	64(a)	1 ↔ 1	GL343827.1(53809-63900)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.8417²	Transcribed sequence with weak similarity to protein more	77.14(n)		142013035
zebrafish (Danio rerio)	Actinopterygii	e4f1¹	E4F transcription factor 1	58.02(n) 51.29(a)		561158 NM_001025513.1 NP_001020684.1

ENSEMBL Gene Tree for E4F1 (if available)
TreeFam Gene Tree for E4F1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113268992^1,2		--	2271578(+)	`TTAGTG/AAAGAC`	1	--	us2k¹		1		CSA	2
rs30989^1,2	C,F,H,	--	2271606(-)	`ACCAAC/GCAGGC`	1	--	us2k¹		9		NA WA CSA EA	369
rs150283454^1,2	C,	--	2271664(+)	`GCTGG-/GAGATTA`	1	--	us2k¹		0	--	--	--	--
rs11641096^1,2	C,F,H,	--	2271671(+)	`ATTACG/AGGAGT`	1	--	us2k¹		2		NA WA	4
rs183058723^1,2		--	2271826(+)	`TGGGCA/GCCTGT`	1	--	us2k¹		0	--	--	--	--
rs146307162^1,2		--	2271935(+)	`AAAAAA/GTCTGG`	1	--	us2k¹		0	--	--	--	--
rs187350610^1,2		--	2272229(+)	`AAAAAC/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs139464530^1,2		--	2272290(+)	`GAGGCA/GGGCAG`	1	--	us2k¹		0	--	--	--	--
rs192115590^1,2		--	2272488(+)	`GCCTAA/GGTGAT`	1	--	us2k¹		0	--	--	--	--
rs144345375^1,2		--	2272627(+)	`GAGGCC/TGAAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for E4F1 (2273560 - 2285743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for E4F1
2 CNVs: 30002 5329

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing E4F1

DNA2.0 Custom Variant and Variant Library Synthesis for E4F1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

E4F1 for disorders           About GeneDecksing

OMIM gene information: 603022    OMIM disorders: --

6 diseases for E4F1:    About MalaCards

tuberous sclerosis, type 2 tuberous sclerosis polycystic kidney disease kidney disease

hepatitis b hepatitis

1 Novoseek disease relationship for E4F1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	14729613 (1), 12446718 (1)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for E4F1 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with E4F1)

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E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. (PubMed id 15579445)^{1, 2, 9} Nakamura Y.... Sasano H. (2004)
Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (PubMed id 14729613)^{1, 2, 9} Fenton S.L....Latif F. (2004)
The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. (PubMed id 9121437)^{1, 2, 9} Fernandes E.R. and Rooney R.J. (1997)
Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. (PubMed id 12446718)^{1, 2, 9} Rizos H.... Kefford R.F. (2003)
Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. (PubMed id 9763670)^{1, 3, 9} Saccone S....Del Sal G. (1998)
The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. (PubMed id 17557114)^{1, 2} Cvetanovic M....Opal P. (2007)
The LIM-only protein FHL2 is a negative regulator of E4F1. (PubMed id 16652157)^{1, 2} Paul C.... Sardet C. (2006)
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. (PubMed id 17110336)^{1, 2} Le Cam L....Sardet C. (2006)
p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners. (PubMed id 15876874)^{1, 2} Rizos H.... Kefford R.F. (2005)
Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. (PubMed id 12730668)^{1, 2} Colombo R.... Chiocca S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1877	HGNC: 3121	AceView: DNASE1L2andE4F1	Ensembl:ENSG00000167967	euGenes: HUgn1877
ECgene: E4F1	H-InvDB: E4F1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for E4F1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for E4F1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for E4F1 gene
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