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E4F1 Gene

protein-coding GIFtS: 57

GC16P002213

E4F transcription factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E4F ^¹, ², ³, ⁵
EC 6.3.2.- ^³
MGC99614 ^²
p120E4F ^², ³
p50E4F ^³

Descriptions
E4F transcription factor 1 ^², ³
Putative E3 ubiquitin-protein ligase E4F1 ^³
Transcription factor E4F ^³

External Ids
HGNC: 3121¹
Entrez Gene: 1877²
UniProtKB: Q66K89³
Ensembl: ENSG00000167967⁷

Search outside databases for aliases for E4F1 gene

Previous GC identifers: GC16M002500 GC16P002299

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for E4F1:

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose

DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal

product is generated from the full-length protein through proteolytic cleavage. The protein is

differentially regulated by E1A-induced phosphorylation. The full-length gene product represses

transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a

transcriptional activator in its presence. [provided by RefSeq]

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for

both transcriptional activation and repression of viral genes

Gene Wiki entry for E4F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the E4F1 gene

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

E4F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P002213: (about GC identifiers)

Start:	2,213,568 bp from pter
End:	2,225,744 bp from pter
Size:	12,177 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_037887.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89 (See protein sequence)

Recommended Name: Transcription factor E4F1

Size: 784 amino acids; 83477 Da

Subunit: Homodimer; binds DNA as a dimer. Forms a complex with CDKN2A and TP53. Interactions with

TP53, RB1, ANP32A, BMI1 and FHL2 regulate E4F1 activity. Interacts with HDAC1, HMGA2 and RASSF1.

Interacts with HBV protein X

Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the

cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes

to the mitotic spindle during embryogenesis (By similarity)

Developmental stage: Expressed in a variety of fetal tissues

Secondary accessions: A8K2R4 O00146

Post-translational modifications:

Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity

and activates transcription in presence of the adenoviral E1A protein. The major full length

protein (p120E4F) functions as a repressor of transcription¹

Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent

and differentially regulates DNA-binding activity and function of both forms¹

May be sumoylated by UBE2I upon interaction with CDKN2A¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004415.2

ENSEMBL proteins:

ENSP00000301727

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (E4F1)
	Human Recombinant Proteins from Abnova (E4F1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005819	spindle	IEA	--

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Antibodies for E4F1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for E4F1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (E4F1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (E4F1)
	Novus Biologicals Antibodies for E4F1

Assays for E4F1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q66K89

ProtoNet protein and cluster: Q66K89

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Similarity: Contains 9 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E4F1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E4F1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004424

Applied Biosystems Silencer® siRNAs for E4F1

Sigma-Aldrich siRNA for E4F1

Sigma-Aldrich shRNA for E4F1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for E4F1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004424
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004424
untagged cDNA clone in CMV expression vector: NM_004424

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004424

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Function: May function as a transcriptional repressor. May also function as a ubiquitin ligase

mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and

proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor

pathways and regulates the cyclin CCNA2 transcription

Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for

both transcriptional activation and repression of viral genes

Induction: Up-regulated by estrogen

Enzyme Number (IUBMB): EC 6.3.2.-

Genatlas biochemistry entry for E4F1:

transcription factor E4F1,adenovirus EIA regulated,with low spliced isoforms,one 120kDa)

upregulated,50kDa,down-regulated

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for E4f1):

cellular

embryogenesis

growth/size

lethality-prenatal/perinatal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	9121437 10869426
GO:0003713	transcription coactivator activity	TAS	9121437
GO:0003714	transcription corepressor activity	TAS	10869426
GO:0005515	protein binding	IPI	14729613
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for E4F1

5/13 Interacting proteins for E4F1 (Q66K89^{1, 2} ENSP00000301727³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANP32A	P39687², ENSP00000267918³	MINT-4968493 MINT-4975442 MINT-4979091 STRING (score=.963)
RASSF1	Q9NS23-2¹, ENSP00000352323³	EBI-1227043, EBI-438698 STRING (score=.953)
HDAC1	Q13547²	MINT-6628981 MINT-6628988 MINT-6628993
EHMT2	Q96KQ7²	MINT-67755
ENSG00000206376	Q96KQ7²	MINT-67755

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	IEA	--
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for E4F1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E4F1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E4F1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004424

Sigma-Aldrich siRNA for E4F1

Sigma-Aldrich shRNA for E4F1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004424

REFSEQ mRNAs for E4F1 gene:

NM_004424.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004424

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004424
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004424
                                 untagged cDNA clone in CMV expression vector: NM_004424

Additional cDNA sequence: BC001713.1

10 DOTS entries:

DT.100778478 DT.97815181 DT.113646 DT.120702796 DT.99967923 DT.120702790 DT.92430065 DT.100778477

DT.431106 DT.120702799

24/153 AceView cDNA sequences (see all 153 ):

CA405900 BM676507 NM_001374 BI223566 BC080524 AI675620 BC063710 CA422408

BU957083 Z38690 AK098028 BC014068 BM713890 BU501086 BC035205 BX283985

BU539326 AY298957 AW515664 BX284025 BM796095 AI420452 CA488104 BG028095

highest scoring ESTs for E4F1:

AI671641 AA146592 AA149892 AA149939 AA160732 AA191608 AA326866 AA548983 AA554733 AA600759

Unigene Clusters for E4F1:

E4F transcription factor 1

Hs.513268 [show with all ESTs], Hs.615283

Unigene Representative Sequences: AB209008, BC001713

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for E4F1 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12
SP1:
SP2:
SP3:					-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for E4F1

1 Ensembl transcript including schematic representation:

ENST00000301727

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

E4F1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for E4F1

¹ / ² / ³

3 probe-sets matching E4F1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
78541_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI671641	0.80	1.00	0.91	1
218524_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004424	0.60	0.83	0.73	1
218524_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTATTGTA

SOURCE GeneReport for Unigene clusters: Hs.513268 Hs.615283
UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for E4F1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	E4F1¹	--	E4F transcription factor 1	90.64(n) 87.63(a)	454356 XM_511205.2 XP_511205.2
cow (Bos taurus)	E4F1¹	--	E4F transcription factor 1	85.98(n) 86.72(a)	515997 XM_594119.3 XP_594119.3
rat (Rattus norvegicus)	E4f1¹	--	E4F transcription factor 1	82.38(n) 82.79(a)	681359 XM_001061399.1 XP_001061399.1
mouse (Mus musculus)	E4f1^{1, 5}	17 (12.00 cM)⁵	E4F transcription factor 1^{1, 5}	85.85(n)¹ 88.72(a)¹	13560¹ NM_007893.3¹ NP_031919.2¹ AF126967⁵ AK033285⁵ (see all 15)
chicken (Gallus gallus)	E4F1¹	--	E4F transcription factor 1	68.51(n) 70.17(a)	416560 XM_414860.2 XP_414860.2

About this table Species with no ortholog for E4F1

ENSEMBL Gene Tree for E4F1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/59 NCBI SNPs in E4F1 are shown (see all 59 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 40)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs26839^1,2	C	2222257(+)	`CCCCCA/GCCAGC`	1	R/H	mis¹ ese³		3		EA NA	58
--	rs11641096^1,2	C	2211672(+)	`attacA/Gggagt`	1	--	ng5¹		0	--	--	--	--
--	rs30989^1,2	C	2211607(-)	`accaaC/Gcaggc`	1	--	ng5¹		0	--	--	--	--
	rs2241070^1,2	C,F	2218510(+)	`ACAGCG/ATTGCT`	1	A/A	syn¹		5		EA NA	1840
	rs27382^1,2	A,C,F,H	2220278(+)	`TCCCTG/AATGTG`	1	--	int¹		8		MN NA EU EA WA	738
	rs30988^1,2	A,C,F,H	2214301(-)	`AAAGAG/ACTAGA`	1	--	int¹		8		EU EA WA	840
	rs26837^1,2	A,C,F	2220319(+)	`GGGCAA/GGCTCT`	1	--	int¹		1		MN	184
--	rs3096278^1,2	A,C	2216090(-)	`CAAGGC/TGGAGT`	1	--	int¹		0	--	--	--	--
	rs11648028^1,2	A,C	2221343(+)	`GGCCTC/TTGTCC`	1	--	int¹		0	--	--	--	--
	rs27709^1,2	F	2221830(+)	`CGGCTG/ATCTCT`	1	--	int¹		1		MN	184

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HapMap Linkage Disequilibrium images for E4F1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603022

1 Novoseek disease relationship for E4F1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	2	14729613 (1), 12446718 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/29 PubMed articles for E4F1 gene (see all 29 ):

E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. (PubMed id 15579445)^{1, 3, 4} Nakamura Y.... Sasano H. (2004)
Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (PubMed id 14729613)^{1, 3, 4} Fenton S.L....Latif F. (2004)
The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. (PubMed id 9121437)^{1, 3, 4} Fernandes E.R. and Rooney R.J. (1997)
Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. (PubMed id 12446718)^{1, 3, 4} Rizos H.... Kefford R.F. (2003)
Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. (PubMed id 9763670)^{1, 2, 3} Saccone S....Del Sal G. (1998)
The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. (PubMed id 17557114)^{3, 4} Cvetanovic M....Opal P. (2007)
The LIM-only protein FHL2 is a negative regulator of E4F1. (PubMed id 16652157)^{3, 4} Paul C....Sardet C. (2006)
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. (PubMed id 17110336)^{3, 4} Le Cam L....Sardet C. (2006)
p53 is involved in the p120E4F-mediated growth arrest. (PubMed id 10644996)^{3, 4} Sandy P....Del Sal G. (2000)
pRB binds to and modulates the transrepressing activity of the E1A- regulated transcription factor p120E4F. (PubMed id 10869426)^{3, 4} Fajas L.... Sardet C. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1877	HGNC: 3121	AceView: DNASE1L2andE4F1	Ensembl:ENSG00000167967	euGenes: HUgn1877
ECgene: E4F1	H-InvDB: E4F1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for E4F1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for E4F1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for E4F1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for E4F1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for E4F1		Antibodies for E4F1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for E4F1		Browse small molecules at Sigma-Aldrich
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E4F1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for E4F1

Summaries
for E4F1

Genomic Location
for E4F1

Proteins
for E4F1

Protein Domains/
Families
for E4F1

Gene Function
for E4F1

Pathways & Interactions
for E4F1

Drugs & Compounds
for E4F1

Transcripts
for E4F1

Expression
for E4F1

Orthologs
for E4F1

Paralogs
for E4F1

SNPs/Variants
for E4F1

Disorders & Mutations
for E4F1

Medical News
for E4F1

Publications
for E4F1

Search for E4F1

Genome Databases showing E4F1

Other Databases showing E4F1

Specialized Databases showing E4F1

Licensable Technologies
for E4F1

Services
for E4F1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

E4F1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor E4F1

Summariesfor E4F1

Genomic Locationfor E4F1

Proteinsfor E4F1

Protein Domains/Familiesfor E4F1

Gene Functionfor E4F1

Pathways & Interactionsfor E4F1

Drugs & Compoundsfor E4F1

Transcriptsfor E4F1

Expression for E4F1

Orthologsfor E4F1

Paralogsfor E4F1

SNPs/Variantsfor E4F1

Disorders & Mutationsfor E4F1

Medical Newsfor E4F1

Publicationsfor E4F1

Search for E4F1

Genome Databases showing E4F1

Other Databases showing E4F1

Specialized Databases showing E4F1

Licensable Technologiesfor E4F1

Servicesfor E4F1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for E4F1

Summaries
for E4F1

Genomic Location
for E4F1

Proteins
for E4F1

Protein Domains/
Families
for E4F1

Gene Function
for E4F1

Pathways & Interactions
for E4F1

Drugs & Compounds
for E4F1

Transcripts
for E4F1

Expression
for E4F1

Orthologs
for E4F1

Paralogs
for E4F1

SNPs/Variants
for E4F1

Disorders & Mutations
for E4F1

Medical News
for E4F1

Publications
for E4F1

Licensable Technologies
for E4F1

Services
for E4F1