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E4F1 Gene

protein-coding   GIFtS: 57
GCID: GC16P002276

E4F Transcription Factor 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
E4F Transcription Factor 11 2 3     p120E4F2 3
E4F2 3 5     p50E4F2 3
Putative E3 Ubiquitin-Protein Ligase E4F12 3     Transcription Factor E4F12
Transcription Factor E4F2 3     EC 6.3.2.-3

External Ids:    HGNC: 31211   Entrez Gene: 18772   Ensembl: ENSG000001679677   OMIM: 6030225   UniProtKB: Q66K893   
ORGUL members:         

Export aliases for E4F1 gene to outside databases

Previous GC identifers: GC16M002500 GC16P002299 GC16P002213 GC16P002274 GC16P002199 GC16P002275


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for E4F1 Gene:
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding
activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from
the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced
phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A,
while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in
multiple transcripts encoding different proteins. (provided by RefSeq, Jan 2014)

GeneCards Summary for E4F1 Gene:
E4F1 (E4F transcription factor 1) is a protein-coding gene. Diseases associated with E4F1 include tuberous sclerosis, type 2, and polycystic kidney disease, type 1. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89
Function: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating
ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the
cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription
Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both
transcriptional activation and repression of viral genes

Gene Wiki entry for E4F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the E4F1 gene promoter:
         GR   NF-1/L   NF-1   p53   NF-kappaB   GATA-2   IRF-7A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidE4F1 promoter sequence
   Search Chromatin IP Primers for E4F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat E4F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

E4F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E4F1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002276:  view genomic region     (about GC identifiers)

Start:
2,273,567 bp from pter      End:
2,285,743 bp from pter
Size:
12,177 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89 (See protein sequence)
Recommended Name: Transcription factor E4F1  
Size: 784 amino acids; 83496 Da
Subunit: Homodimer; binds DNA as a dimer. Forms a complex with CDKN2A and TP53. Interactions with TP53, RB1,
ANP32A, BMI1 and FHL2 regulate E4F1 activity. Interacts with HDAC1, HMGA2 and RASSF1. Interacts with HBV protein
X
Developmental stage: Expressed in a variety of fetal tissues
Secondary accessions: A8K2R4 O00146

Explore the universe of human proteins at neXtProt for E4F1: NX_Q66K89

Explore proteomics data for E4F1 at MOPED

Post-translational modifications: 

  • Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity and activates
    transcription in presence of the adenoviral E1A protein. The major full length protein (p120E4F) functions as a
    repressor of transcription1
  • Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent and
    differentially regulates DNA-binding activity and function of both forms1
  • May be sumoylated by UBE2I upon interaction with CDKN2A1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See E4F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001275705.1  NP_001275707.1  NP_004415.3  

    ENSEMBL proteins: 
     ENSP00000301727   ENSP00000456760   ENSP00000457672   ENSP00000456005   ENSP00000454652  

    E4F1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q66K89

    ProtoNet protein and cluster: Q66K89

    UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89
    Similarity: Contains 9 C2H2-type zinc fingers


    E4F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: E4F1_HUMAN, Q66K89
    Function: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating
    ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the
    cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription
    Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both
    transcriptional activation and repression of viral genes
    Induction: Up-regulated by estrogen

         Genatlas biochemistry entry for E4F1:
    transcription factor E4F1,adenovirus EIA regulated,with low spliced isoforms,one 120kDa)
    upregulated,50kDa,down-regulated

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding TAS10869426
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10869426
    GO:0003713transcription coactivator activity TAS9121437
    GO:0003714transcription corepressor activity TAS10869426
         
    E4F1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for E4F1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Wnt reporter downregulated 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for E4f1):
     cellular  embryogenesis  growth/size/body  homeostasis/metabolism  integument 
     mortality/aging 

    E4F1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out E4f1tm1Pisc for E4F1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for E4F1
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    miRNA
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    hsa-mir-99a-5p (MIRT048699), hsa-mir-92a-3p (MIRT049823)

    Block miRNA regulation of human, mouse, rat E4F1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate E4F1:
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    SwitchGear 3'UTR luciferase reporter plasmidE4F1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: E4F1 (NM_004424)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    E4F1_HUMAN, Q66K89: Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm.
    Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle
    during embryogenesis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005819spindle IEA--

    E4F1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for E4F1 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 pathway
    p53 pathway


    1 BioSystems Pathway for E4F1
        p53 pathway


    UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for E4F1
    Interactions:

        GeneGlobe Interaction Network for E4F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for E4F1 (Q66K891, 2, 3 ENSP000003017274) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANP32AP396871, 2, 3, ENSP000004178644EBI-1227043,EBI-359234 MINT-4968493 MINT-4975442 MINT-4979091 I2D: score=3 STRING: ENSP00000417864
    ENSG00000206376Q96KQ72, 3MINT-67755 I2D: score=4 
    ENSG00000232045Q96KQ72, 3MINT-67755 I2D: score=4 
    ENSG00000236759Q96KQ72, 3MINT-67755 I2D: score=4 
    ENSG00000238134Q96KQ72, 3MINT-67755 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA14645522
    GO:0006260DNA replication IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007067mitosis IEA--
    GO:0008283cell proliferation TAS10869426

    E4F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for E4F1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for E4F1 gene (3 alternative transcripts): 
    NM_001288776.1  NM_001288778.1  NM_004424.4  

    Unigene Clusters for E4F1:

    E4F transcription factor 1
    Hs.513268  [show with all ESTs], Hs.615283
    Unigene Representative Sequences: AB209008, BC001713
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301727(uc002cpm.3 uc010bsi.3 uc010bsj.3) ENST00000565090
    ENST00000564139 ENST00000562589 ENST00000565413 ENST00000569796 ENST00000563643
    ENST00000564930 ENST00000567111
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate E4F1:
    hsa-miR-4307
    SwitchGear 3'UTR luciferase reporter plasmidE4F1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat E4F1

    Additional mRNA sequence: BC001713.1 

    9 DOTS entries:

    DT.100778478  DT.97815181  DT.113646  DT.120702796  DT.99967923  DT.120702790  DT.92430065  DT.100778477 
    DT.431106 

    Selected AceView cDNA sequences (see all 153):

    NM_001374 BI223566 Z38690 BC014068 BC063710 AW515664 CA488104 AK098028 
    BC080524 BM796095 CA405900 CA422408 BM676507 BU539326 AI675620 BM713890 
    BX284025 BX283985 AI420452 BC035205 AY298957 BU957083 BU501086 BF974953 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for E4F1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:              -                                                                                                   
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for E4F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    E4F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACCTGCA
    E4F1 Expression
    About this image


    E4F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Bone (Muscoskeletal System)
             Mandibular Fossa
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Neural Tube (Nervous System)
             Metencephalon
    E4F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    E4F1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.513268 Hs.615283

    UniProtKB/Swiss-Prot: E4F1_HUMAN, Q66K89
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E4F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for E4F1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E4f11 , 5 E4F transcription factor 11, 5 85.73(n)1
    88.46(a)1
      17 (12.39 cM)5
    135601  NM_007893.31  NP_031919.21 
     244437925 
    chicken
    (Gallus gallus)
    Aves E4F11 E4F transcription factor 1 68.82(n)
    71.25(a)
      416560  XM_414860.4  XP_414860.4 
    lizard
    (Anolis carolinensis)
    Reptilia E4F16
    E4F transcription factor 1
    62(a)
    1 ↔ 1
    GL343827.1(50693-66686)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.84172 Transcribed sequence with weak similarity to protein more 77.14(n)    142013035 
    zebrafish
    (Danio rerio)
    Actinopterygii e4f11 E4F transcription factor 1 58.26(n)
    52.2(a)
      561158  NM_001025513.1  NP_001020684.1 


    ENSEMBL Gene Tree for E4F1 (if available)
    TreeFam Gene Tree for E4F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for E4F1 gene
    Selected SIMAP similar genes for E4F1 using alignment to 6 protein entries:     E4F1_HUMAN (see all proteins) (see all similar genes):
    ZNF124    ZNF672    ZNF737    ZNF78L1    ZNF    ZNF345
    ZNF566    ZNF589    ZNF83    DKFZp434J0650    ZNF146    ZNF22
    ZNF500    ZNF501    ZNF56    ZNF625    ZNF660    ZNF876P

    E4F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for E4F1 (see all 340)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132689921,2
    C,F--2271578(+) TTAGTG/AAAGAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs309891,2
    C,F,H--2271606(-) accaaC/Gcaggc 1 -- us2k111Minor allele frequency- G:0.18NA WA CSA EA 373
    rs116410961,2
    C,F,H--2271671(+) attacG/Aggagt 1 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs1830587231,2
    --2271826(+) TGGGCA/GCCTGT 1 -- us2k10--------
    rs1463071621,2
    --2271935(+) AAAAAA/GTCTGG 1 -- us2k10--------
    rs1873506101,2
    --2272229(+) AAAAAC/TAAAAA 1 -- us2k10--------
    rs1394645301,2
    --2272290(+) GAGGCA/GGGCAG 1 -- us2k10--------
    rs1921155901,2
    --2272488(+) GCCTAA/GGTGAT 1 -- us2k10--------
    rs1443453751,2
    --2272627(+) GAGGCC/TGAAAT 1 -- us2k10--------
    rs80577311,2
    C,F--2272655(+) ctaggA/Ggtttg 1 -- us2k12Minor allele frequency- G:0.04NA EA 240

    HapMap Linkage Disequilibrium report for E4F1 (2273567 - 2285743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for E4F1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673834CNV Deletion23128226
    esv2750378CNV Deletion23290073
    esv2422427CNV Duplication17116639
    nsv1711CNV Insertion18451855
    dgv2562n71CNV Loss21882294
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv457351CNV Loss19166990
    nsv905139CNV Loss21882294
    dgv2540n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing E4F1
    DNA2.0 Custom Variant and Variant Library Synthesis for E4F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603022    OMIM disorders: --

    7 diseases for E4F1:    
    About MalaCards
    tuberous sclerosis, type 2    polycystic kidney disease, type 1    polycystic kidney disease    kidney disease
    tuberous sclerosis    hepatitis b    hepatitis


    E4F1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for E4F1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 14729613 (1), 12446718 (1)


    Export disorders for E4F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for E4F1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with E4F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. (PubMed id 15579445)1, 2, 9 Nakamura Y.... Sasano H. (Am. J. Pathol. 2004)
    2. Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (PubMed id 14729613)1, 2, 9 Fenton S.L.... Latif F. (Cancer Res. 2004)
    3. The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. (PubMed id 9121437)1, 2, 9 Fernandes E.R. and Rooney R.J. (Mol. Cell. Biol. 1997)
    4. Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. (PubMed id 12446718)1, 2, 9 Rizos H.... Kefford R.F. (J. Biol. Chem. 2003)
    5. Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. (PubMed id 9763670)1, 3, 9 Saccone S....Del Sal G. (Cytogenet. Cell Genet. 1998)
    6. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. (PubMed id 17557114)1, 2 Cvetanovic M....Opal P. (EMBO Rep. 2007)
    7. The LIM-only protein FHL2 is a negative regulator of E4F1. (PubMed id 16652157)1, 2 Paul C.... Sardet C. (Oncogene 2006)
    8. E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. (PubMed id 17110336)1, 2 Le Cam L....Sardet C. (Cell 2006)
    9. p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners. (PubMed id 15876874)1, 2 Rizos H.... Kefford R.F. (Cell Cycle 2005)
    10. Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. (PubMed id 12730668)1, 2 Colombo R.... Chiocca S. (Oncogene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1877 HGNC: 3121 AceView: DNASE1L2andE4F1 Ensembl:ENSG00000167967 euGenes: HUgn1877
    ECgene: E4F1 H-InvDB: E4F1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for E4F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for E4F1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for E4F1 gene:
    Search GeneIP for patents involving E4F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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