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Aliases for E2F7 Gene

Aliases for E2F7 Gene

  • E2F Transcription Factor 7 2 3 5
  • E2F-7 3 4

External Ids for E2F7 Gene

Previous GeneCards Identifiers for E2F7 Gene

  • GC12M075917
  • GC12M077415
  • GC12M074467

Summaries for E2F7 Gene

Entrez Gene Summary for E2F7 Gene

  • E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]

GeneCards Summary for E2F7 Gene

E2F7 (E2F Transcription Factor 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Gastric cancer network 1. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is E2F8.

UniProtKB/Swiss-Prot for E2F7 Gene

  • Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5-TTTC[CG]CGC-3. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5-TTCCCGCC-3 and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.

Gene Wiki entry for E2F7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F7 Gene

Genomics for E2F7 Gene

Regulatory Elements for E2F7 Gene

Promoters for E2F7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around E2F7 on UCSC Golden Path with GeneCards custom track

Genomic Location for E2F7 Gene

Chromosome:
12
Start:
77,021,246 bp from pter
End:
77,065,580 bp from pter
Size:
44,335 bases
Orientation:
Minus strand

Genomic View for E2F7 Gene

Genes around E2F7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F7 Gene

Proteins for E2F7 Gene

  • Protein details for E2F7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AV8-E2F7_HUMAN
    Recommended name:
    Transcription factor E2F7
    Protein Accession:
    Q96AV8
    Secondary Accessions:
    • A6NC74
    • B2RMR7
    • B3KTZ5
    • B3KUP8
    • B5MED9

    Protein attributes for E2F7 Gene

    Size:
    911 amino acids
    Molecular mass:
    99888 Da
    Quaternary structure:
    • Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Interacts with HIF1A.
    SequenceCaution:
    • Sequence=BAG53257.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG53510.1; Type=Frameshift; Positions=229; Evidence={ECO:0000305};

    Alternative splice isoforms for E2F7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for E2F7 Gene

Proteomics data for E2F7 Gene at MOPED

Post-translational modifications for E2F7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for E2F7 Gene

No data available for DME Specific Peptides for E2F7 Gene

Domains & Families for E2F7 Gene

Gene Families for E2F7 Gene

Protein Domains for E2F7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AV8

UniProtKB/Swiss-Prot:

E2F7_HUMAN :
  • In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (PubMed:14633988).
  • Belongs to the E2F/DP family.
Domain:
  • In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (PubMed:14633988).
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F7: view

Function for E2F7 Gene

Molecular function for E2F7 Gene

UniProtKB/Swiss-Prot Function:
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5-TTTC[CG]CGC-3. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5-TTCCCGCC-3 and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.
UniProtKB/Swiss-Prot Induction:
By p53/TP53 following DNA damage: expression is directly activated by p53/TP53 (at protein level).

Gene Ontology (GO) - Molecular Function for E2F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with E2F7: view
genes like me logo Genes that share phenotypes with E2F7: view

Animal Models for E2F7 Gene

MGI Knock Outs for E2F7:

Animal Model Products

Targeted motifs for E2F7 Gene
HOMER Transcription Factor Regulatory Elements motif E2F7
  • Consensus sequence: VDTTTCCCGCCA Submotif: canonical Cell Type: Hela GEO ID: GSE32673

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for E2F7 Gene

Localization for E2F7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F7 Gene COMPARTMENTS Subcellular localization image for E2F7 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for E2F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with E2F7: view

Pathways & Interactions for E2F7 Gene

genes like me logo Genes that share pathways with E2F7: view

Gene Ontology (GO) - Biological Process for E2F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 22802528
GO:0001890 placenta development ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with E2F7: view

No data available for SIGNOR curated interactions for E2F7 Gene

Drugs & Compounds for E2F7 Gene

(1) Drugs for E2F7 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 350
genes like me logo Genes that share compounds with E2F7: view

Transcripts for E2F7 Gene

Unigene Clusters for E2F7 Gene

E2F transcription factor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for E2F7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for E2F7 Gene

GeneLoc Exon Structure for
E2F7
ECgene alternative splicing isoforms for
E2F7

Expression for E2F7 Gene

mRNA expression in normal human tissues for E2F7 Gene

mRNA differential expression in normal tissues according to GTEx for E2F7 Gene

This gene is overexpressed in Testis (x4.3).

Protein differential expression in normal tissues from HIPED for E2F7 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for E2F7 Gene



SOURCE GeneReport for Unigene cluster for E2F7 Gene Hs.416375

genes like me logo Genes that share expression patterns with E2F7: view

Protein tissue co-expression partners for E2F7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for E2F7 Gene

Orthologs for E2F7 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia E2F7 35
  • 81.08 (n)
  • 78 (a)
E2F7 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia E2F7 35
  • 83.74 (n)
  • 82.77 (a)
E2F7 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E2f7 35
  • 80.75 (n)
  • 80.04 (a)
E2f7 16
E2f7 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia E2F7 35
  • 99.6 (n)
  • 99.56 (a)
E2F7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f7 35
  • 85.26 (n)
  • 87.65 (a)
oppossum
(Monodelphis domestica)
Mammalia E2F7 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F7 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F7 35
  • 64.14 (n)
  • 56.03 (a)
E2F7 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F7 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f7 35
  • 60.32 (n)
  • 51.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16369 35
zebrafish
(Danio rerio)
Actinopterygii e2f7 35
  • 55.73 (n)
  • 53.16 (a)
e2f7 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea efl-3 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for E2F7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F7 Gene

ENSEMBL:
Gene Tree for E2F7 (if available)
TreeFam:
Gene Tree for E2F7 (if available)

Paralogs for E2F7 Gene

Paralogs for E2F7 Gene

(1) SIMAP similar genes for E2F7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with E2F7: view

Variants for E2F7 Gene

Sequence variations from dbSNP and Humsavar for E2F7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs310791 - 77,056,010(+) AACAA(A/G)CTTAA intron-variant, upstream-variant-2KB, reference, missense
rs3829295 - 77,029,839(+) GGGCA(C/T)GACAA reference, missense
rs310831 - 77,025,561(+) ACCTG(A/T)TGTAA reference, missense
rs184304 -- 77,043,495(+) GGGAA(C/T)GGGCT intron-variant
rs188707 -- 77,035,622(+) ccaga(A/G)caaag intron-variant

Variation tolerance for E2F7 Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for E2F7 Gene

HapMap Linkage Disequilibrium report
E2F7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for E2F7 Gene

Disorders for E2F7 Gene

Relevant External Links for E2F7

Genetic Association Database (GAD)
E2F7
Human Genome Epidemiology (HuGE) Navigator
E2F7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
E2F7

No disorders were found for E2F7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for E2F7 Gene

Publications for E2F7 Gene

  1. E2F7, a novel target, is up-regulated by p53 and mediates DNA damage- dependent transcriptional repression. (PMID: 22802528) Carvajal L.A. … Manfredi J.J. (Genes Dev. 2012) 3 4 67
  2. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. (PMID: 12893818) de Bruin A. … Leone G. (J. Biol. Chem. 2003) 2 3
  3. A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma. (PMID: 25411162) Hazar-Rethinam M. … Saunders N.A. (Clin. Cancer Res. 2015) 3
  4. MicroRNA-424 may function as a tumor suppressor in endometrial carcinoma cells by targeting E2F7. (PMID: 25708247) Li Q. … Xiao Y.B. (Oncol. Rep. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for E2F7 Gene

Sources for E2F7 Gene

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