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Aliases for E2F6 Gene

Aliases for E2F6 Gene

  • E2F Transcription Factor 6 2 3
  • E2F-6 3 4

External Ids for E2F6 Gene

Previous GeneCards Identifiers for E2F6 Gene

  • GC02M011370
  • GC02M011636
  • GC02M011607
  • GC02M011536
  • GC02M011501
  • GC02M011584

Summaries for E2F6 Gene

Entrez Gene Summary for E2F6 Gene

  • This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for E2F6 Gene

E2F6 (E2F Transcription Factor 6) is a Protein Coding gene. Among its related pathways are Cell cycle and E2F transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is E2F5.

UniProtKB/Swiss-Prot for E2F6 Gene

  • Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3. Has a preference for the 5-TTTCCCGC-3 E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F6 Gene

Genomics for E2F6 Gene

Regulatory Elements for E2F6 Gene

Genomic Location for E2F6 Gene

Chromosome:
2
Start:
11,444,375 bp from pter
End:
11,466,177 bp from pter
Size:
21,803 bases
Orientation:
Minus strand

Genomic View for E2F6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for E2F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F6 Gene

Proteins for E2F6 Gene

  • Protein details for E2F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75461-E2F6_HUMAN
    Recommended name:
    Transcription factor E2F6
    Protein Accession:
    O75461
    Secondary Accessions:
    • A8K2Z8
    • G5E936
    • O60544
    • Q53QY9
    • Q6Q9Z6
    • Q7Z2H6

    Protein attributes for E2F6 Gene

    Size:
    281 amino acids
    Molecular mass:
    31844 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

    Alternative splice isoforms for E2F6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for E2F6 Gene

Proteomics data for E2F6 Gene at MOPED

Post-translational modifications for E2F6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for E2F6 Gene

Domains & Families for E2F6 Gene

Gene Families for E2F6 Gene

Graphical View of Domain Structure for InterPro Entry

O75461

UniProtKB/Swiss-Prot:

E2F6_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F6: view

Function for E2F6 Gene

Molecular function for E2F6 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3. Has a preference for the 5-TTTCCCGC-3 E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase

Gene Ontology (GO) - Molecular Function for E2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0003714 transcription corepressor activity TAS 9501179
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with E2F6: view
genes like me logo Genes that share phenotypes with E2F6: view

Animal Models for E2F6 Gene

MGI Knock Outs for E2F6:

Animal Model Products

Targeted motifs for E2F6 Gene
HOMER Transcription Factor Regulatory Elements motif E2F6
  • Consensus sequence: GGCGGGAARN Submotif: canonical Cell Type: Hela GEO ID: GSE31477

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for E2F6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for E2F6 Gene

Localization for E2F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F6 Gene COMPARTMENTS Subcellular localization image for E2F6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for E2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17001316
GO:0005667 transcription factor complex IEA --
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with E2F6: view

Pathways & Interactions for E2F6 Gene

genes like me logo Genes that share pathways with E2F6: view

Pathways by source for E2F6 Gene

1 GeneGo (Thomson Reuters) pathway for E2F6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for E2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9501179
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with E2F6: view

No data available for SIGNOR curated interactions for E2F6 Gene

Drugs & Compounds for E2F6 Gene

No Compound Related Data Available

Transcripts for E2F6 Gene

Unigene Clusters for E2F6 Gene

E2F transcription factor 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for E2F6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8: -
SP9: - - - - -
SP10: - -
SP11: - -
SP12: - - - - - - -
SP13: - - - - - -
SP14: - -
SP15: -

Relevant External Links for E2F6 Gene

GeneLoc Exon Structure for
E2F6
ECgene alternative splicing isoforms for
E2F6

Expression for E2F6 Gene

mRNA expression in normal human tissues for E2F6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F6 Gene

This gene is overexpressed in Urine (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for E2F6 Gene



SOURCE GeneReport for Unigene cluster for E2F6 Gene Hs.603093

mRNA Expression by UniProt/SwissProt for E2F6 Gene

O75461-E2F6_HUMAN
Tissue specificity: Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen
genes like me logo Genes that share expression patterns with E2F6: view

Protein tissue co-expression partners for E2F6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for E2F6 Gene

Orthologs for E2F6 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia E2F6 35
  • 90.6 (n)
  • 95 (a)
E2F6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia E2F6 35
  • 91.46 (n)
  • 95.37 (a)
E2F6 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E2f6 35
  • 83.21 (n)
  • 88.85 (a)
E2f6 16
E2f6 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia E2F6 35
  • 99.88 (n)
  • 100 (a)
E2F6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f6 35
  • 83.46 (n)
  • 90 (a)
oppossum
(Monodelphis domestica)
Mammalia E2F6 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F6 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F6 35
  • 73.18 (n)
  • 69.3 (a)
E2F6 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F6 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f6 35
  • 67.85 (n)
  • 67.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22662 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-195d17.2 35
  • 54.88 (n)
  • 50.7 (a)
E2F6 36
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta E2f 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-2 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for E2F6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F6 Gene

ENSEMBL:
Gene Tree for E2F6 (if available)
TreeFam:
Gene Tree for E2F6 (if available)

Paralogs for E2F6 Gene

Paralogs for E2F6 Gene

Pseudogenes.org Pseudogenes for E2F6 Gene

genes like me logo Genes that share paralogs with E2F6: view

Variants for E2F6 Gene

Sequence variations from dbSNP and Humsavar for E2F6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11203 -- 11,445,909(-) TGGTA(C/T)CTATA utr-variant-3-prime, nc-transcript-variant
rs1047392 -- 11,446,093(-) GTTCA(C/T)GTTTG utr-variant-3-prime, nc-transcript-variant
rs2884362 -- 11,466,858(+) ctgcc(C/T)tcctt upstream-variant-2KB
rs4292073 -- 11,449,236(+) CCTTA(A/C)CCCAT intron-variant
rs4408699 -- 11,449,303(+) AAAAC(A/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E2F6 Gene

Variant ID Type Subtype PubMed ID
esv27377 CNV Gain 19812545

Variation tolerance for E2F6 Gene

Residual Variation Intolerance Score: 57.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for E2F6 Gene

HapMap Linkage Disequilibrium report
E2F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F6 Gene

Disorders for E2F6 Gene

Relevant External Links for E2F6

Genetic Association Database (GAD)
E2F6
Human Genome Epidemiology (HuGE) Navigator
E2F6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
E2F6
genes like me logo Genes that share disorders with E2F6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for E2F6 Gene

Publications for E2F6 Gene

  1. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. (PMID: 18381414) Kozaki K. … Inazawa J. (Cancer Res. 2008) 23 67
  2. PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. (PMID: 17001316) Deshpande A.M. … Hansen M.F. (Oncogene 2007) 23 67
  3. New insights into BS69 functions. (PMID: 16565076) Velasco G. … Ansieau S. (J. Biol. Chem. 2006) 23 67
  4. A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. (PMID: 15536069) Attwooll C. … Helin K. (J. Biol. Chem. 2005) 23 67
  5. A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. (PMID: 15574595) Giangrande P.H. … Nevins J.R. (Genes Dev. 2004) 23 67

Products for E2F6 Gene

Sources for E2F6 Gene

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