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E2F6 Gene

protein-coding GIFtS: 59

GC02M011536

E2F transcription factor 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
E2F-6 ^¹, ², ³
MGC111545 ^²

Descriptions
E2F transcription factor 6 ^²
E2F transcription factor 6, isoform 1 ^²

External Ids
HGNC: 3120¹
Entrez Gene: 1876²
UniProtKB: O75461³
Ensembl: ENSG00000169016⁷

Search outside databases for aliases for E2F6 gene

Previous GC identifers: GC02M011370 GC02M011636 GC02M011607

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for E2F6:

This gene encodes a member of the E2F transcription factor protein family. E2F family members play

a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They

are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins

contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain

which determines interaction with the differentiation regulated transcription factor proteins

(DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein

association domain which is embedded within the transactivation domain. The encoded protein of

this gene is atypical because it lacks the transactivation and tumor suppressor protein

association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent

transcription. The protein is part of a multimeric protein complex that contains a histone

methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have

been reported for this gene, but it has not been clearly demonstrated that they encode valid

isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: E2F6_HUMAN, O75461

Function: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins

through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F

recognition site. E2F-6 lacks the transcriptional activation and pocket protein binding domains.

Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the

cell cycle but not for normal cell cycle progression. May silence expression via the recruitment

of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity.

Overexpression delays the exit of cells from the S-phase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the E2F6 gene

Entrez Gene cytogenetic band: 2p25.1 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25.1

E2F6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M011536: (about GC identifiers)

Start:	11,501,952 bp from pter
End:	11,523,748 bp from pter
Size:	21,797 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005334.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: E2F6_HUMAN, O75461 (See protein sequence)

Recommended Name: Transcription factor E2F6

Size: 281 amino acids; 31844 Da

Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family

members. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8,

EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2

Subcellular location: Nucleus

Secondary accessions: A8K2Z8 O60544 Q53QY9 Q7Z2H6

Alternative splicing: 2 isoforms: O75461-1 O75461-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_937987.2

ENSEMBL proteins:

ENSP00000355036 ENSP00000302159 ENSP00000370936

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (E2F6)
	Human Recombinant Proteins from Abnova (E2F6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005667	transcription factor complex	IEA	--

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Antibodies for E2F6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for E2F6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (E2F6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (E2F6)
	Novus Biologicals Antibodies for E2F6

Assays for E2F6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O75461

ProtoNet protein and cluster: O75461

1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

UniProtKB/Swiss-Prot: E2F6_HUMAN, O75461

Similarity: Belongs to the E2F/DP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E2F6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 10): NM_001952

Applied Biosystems Silencer® siRNAs for E2F6

Sigma-Aldrich siRNA for E2F6

Sigma-Aldrich shRNA Panels and shRNA for E2F6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for E2F6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_198256
Myc/DDK tagged cDNA clone in CMV expression vector: NM_198256
untagged cDNA clones in CMV expression vector (see all 6): NM_198256

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198256

UniProtKB/Swiss-Prot: E2F6_HUMAN, O75461

Function: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins

through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F

recognition site. E2F-6 lacks the transcriptional activation and pocket protein binding domains.

Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the

cell cycle but not for normal cell cycle progression. May silence expression via the recruitment

of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity.

Overexpression delays the exit of cells from the S-phase

12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for E2f6):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	hematopoietic system
immune system	lethality-postnatal	life span-post-weaning/aging	nervous system	normal
reproductive system	skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003714	transcription corepressor activity	TAS	9501179

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for E2F6 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Chronic Myeloid Leukemia Signaling
Molecular Mechanisms of Cancer
Cell Cycle Regulation by BTG Family Proteins
Role of CHK Proteins in Cell Cycle Checkpoint Control
Role of BRCA1 in DNA Damage Response

GeneDecks E2F6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for E2F6

5/23 Interacting proteins for E2F6 (ENSP00000302159³ O75461²) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMI1	P35226²	STRING (score=.974) MINT-19898
RYBP	Q8N488²	STRING (score=.95) MINT-19309
TFDP2	Q14188²	STRING (score=.969) MINT-68429
PCGF2	P35227²	MINT-19899
REEP5	Q00765²	MINT-14072

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000083	regulation of transcription of G1/S-phase of mitotic cell cycle	IEA	--
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	9501179
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007049	cell cycle	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for E2F6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E2F6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 10): NM_001952

Sigma-Aldrich siRNA for E2F6

Sigma-Aldrich shRNA Panels and shRNA for E2F6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_198256

REFSEQ mRNAs for E2F6 gene:

NM_198256.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_198256

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_198256
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_198256
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_198256

Additional cDNA sequence:

AF041381.1 AF059292.1 AF088059.1 AK096197.1 AK223159.1 AK223407.1 AK290413.1 AK293504.1

AY083996.1 AY551346.1 AY551347.1 AY551348.1 AY551349.1 AY551350.1 AY551351.1 BC008348.1

BC062610.1 BC107740.1 CR603243.1 CR607422.1 CR621731.1 DQ786210.1

16 DOTS entries:

DT.452737 DT.91728817 DT.101982840 DT.91728798 DT.100799188 DT.100799187 DT.100804147 DT.120668502

DT.120999275 DT.100799184 DT.120999269 DT.91728816 DT.91902996 DT.100701172 DT.91728799 DT.95168245

24/171 AceView cDNA sequences (see all 171 ):

AU132447 NM_198257 AI334142 NM_198258 AY551351 BI768018 CR607422 BU076470

BI819207 NM_212540 AA770486 AI435088 CR621731 NM_198256 AI090043 BE257158

AF088059 AW025791 BF197262 BM972996 AI265956 BI772069 BU617283 AA724389

highest scoring ESTs for E2F6:

AF041381 AA127210 AF059292 AK096197 AU131585 AU132447 AY083996 AY551347 AY551348 AY551349

Unigene Cluster for E2F6:

E2F transcription factor 6

Hs.603093 [show with all ESTs]

Unigene Representative Sequence: NM_198256

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for E2F6 (see all 15 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c
SP1:											-																-		-
SP2:											-		-		-		-										-		-
SP3:							-				-																-		-
SP4:							-				-		-		-		-										-		-
SP5:							-				-		-		-		-		-								-		-

About this scheme

ECgene alternative splicing isoforms for E2F6

3 Ensembl transcripts including schematic representations:

ENST00000362009 ENST00000307236 ENST00000381525

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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E2F6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for E2F6

¹ / ² / ³

4 probe-sets matching E2F6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50412_at²^{, 3}	U95-C	1	1.00	1.00	0.90	1.01	AI082612	0.60	1.00	0.82	1
35984_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.99	AF041381	1.00	1.00	1.00	1
203957_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001952	0.40	1.00	0.76	1
203957_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks E2F6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGGCCCTT

SOURCE GeneReport for Unigene cluster: Hs.603093
Expression variation in blood from EXPOLDB for E2F6
UniProtKB/Swiss-Prot: E2F6_HUMAN, O75461
Tissue specificity: Expressed in all tissues examined. Highest levels in placenta, skeletal muscle,
heart, ovary, kidney, small intestine and spleen

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for E2F6 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	E2F6¹	--	E2F transcription factor 6	91.46(n) 95.37(a)	609996 XM_847370.1 XP_852463.1
chimpanzee (Pan troglodytes)	E2F6¹	--	E2F transcription factor 6	99.88(n) 100(a)	470148 XM_001159489.1 XP_001159489.1
cow (Bos taurus)	E2F6¹	--	E2F transcription factor 6	89.21(n) 93.59(a)	514085 NM_001076848.1 NP_001070316.1
rat (Rattus norvegicus)	E2f6¹	--	E2F transcription factor 6	77.69(n) 80.08(a)	313978 XM_233986.4 XP_233986.2
mouse (Mus musculus)	E2f6^{1, 5}	12 (6.00 cM)⁵	E2F transcription factor 6^{1, 5}	82.72(n)¹ 86.76(a)¹	50496¹ NM_033270.1¹ NP_150373.1¹ AA759531⁵ AB221552⁵ (see all 29)

About this table Species with no ortholog for E2F6

ENSEMBL Gene Tree for E2F6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for E2F6 gene

E2F5² E2F4²

Pseudogenes

3 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/118 NCBI SNPs in E2F6 are shown (see all 118 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 34)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6432194^1,2	A,C,F,H	11501868(+)	`AAGGTT/CAGGGT`	1	--	ng5¹		7		EU EA WA NA	560
	rs11687178^1,2	A,C,F,H	11501648(+)	`AAAGGC/AAGGGA`	1	--	ng5¹		8		EU EA WA NA	754
	rs11693023^1,2	A,C,F,H	11501718(+)	`TCTGCA/GAGGCA`	1	--	ng5¹		5		EU EA NA	442
	rs6712902^1,2	C,F,H	11502102(+)	`AATGAT/CGGTAT`	1	--	ut3¹		4		EU EA WA	398
--	rs11685543^1,2	A,C	11524098(+)	`ttcccA/Gggctc`	1	--	ng3¹		0	--	--	--	--
--	rs12165209^1,2	A,H	11503041(+)	`AGAAAT/CAGCTA`	1	--	ut3¹		1		EU	120
--	rs10929745^1,2	A,C	11524649(+)	`TGGCTC/GCCTCT`	1	--	ng3¹		0	--	--	--	--
--	rs11683124^1,2	C	11524793(+)	`acaggA/Ttgctg`	1	--	ng3¹		0	--	--	--	--
	rs6709507^1,2	A,C,F,H	11518655(+)	`tgtccG/Aggaac`	1	--	int¹		8		EU EA WA	836
	rs6751915^1,2	A,C,F,H	11509745(+)	`TAATCG/TTACAG`	1	--	int¹		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for E2F6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602944

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/27 PubMed articles for E2F6 gene (see all 27 ):

E2F-6, a member of the E2F family that can behave as a transcriptional repressor. (PubMed id 9501179)^{2, 3, 4} Trimarchi J.M....Lees J.A. (1998)
E2F-6: a novel member of the E2F family is an inhibitor of E2F- dependent transcription. (PubMed id 9704927)^{1, 3, 4} Cartwright P.... Helin K. (1998)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. (PubMed id 12004135)^{3, 4} Ogawa H....Nakatani Y. (2002)
Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. (PubMed id 9689056)^{3, 4} Gaubatz S.... Livingston D.M. (1998)
E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9. (PubMed id 12909625)^{1, 3} Oberley M.J....Farnham P.J. (2003)
A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. (PubMed id 15574595)^{1, 3} Giangrande P.H....Nevins J.R. (2004)
Human E2F6 is alternatively spliced to generate multiple protein isoforms. (PubMed id 15081404)^{1, 3} Kherrouche Z.... Monte D. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1876	HGNC: 3120	AceView: E2F6	Ensembl:ENSG00000169016	euGenes: HUgn1876
ECgene: E2F6	H-InvDB: E2F6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for E2F6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for E2F6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for E2F6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for E2F6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for E2F6		Antibodies for E2F6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for E2F6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for E2F6

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E2F6 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for E2F6

Summaries
for E2F6

Genomic Location
for E2F6

Proteins
for E2F6

Protein Domains/
Families
for E2F6

Gene Function
for E2F6

Pathways & Interactions
for E2F6

Drugs & Compounds
for E2F6

Transcripts
for E2F6

Expression
for E2F6

Orthologs
for E2F6

Paralogs
for E2F6

SNPs/Variants
for E2F6

Disorders & Mutations
for E2F6

Medical News
for E2F6

Publications
for E2F6

Search for E2F6

Genome Databases showing E2F6

Other Databases showing E2F6

Specialized Databases showing E2F6

Licensable Technologies
for E2F6

Services
for E2F6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

E2F6 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor E2F6

Summariesfor E2F6

Genomic Locationfor E2F6

Proteinsfor E2F6

Protein Domains/Familiesfor E2F6

Gene Functionfor E2F6

Pathways & Interactionsfor E2F6

Drugs & Compoundsfor E2F6

Transcriptsfor E2F6

Expression for E2F6

Orthologsfor E2F6

Paralogsfor E2F6

SNPs/Variantsfor E2F6

Disorders & Mutationsfor E2F6

Medical Newsfor E2F6

Publicationsfor E2F6

Search for E2F6

Genome Databases showing E2F6

Other Databases showing E2F6

Specialized Databases showing E2F6

Licensable Technologiesfor E2F6

Servicesfor E2F6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for E2F6

Summaries
for E2F6

Genomic Location
for E2F6

Proteins
for E2F6

Protein Domains/
Families
for E2F6

Gene Function
for E2F6

Pathways & Interactions
for E2F6

Drugs & Compounds
for E2F6

Transcripts
for E2F6

Expression
for E2F6

Orthologs
for E2F6

Paralogs
for E2F6

SNPs/Variants
for E2F6

Disorders & Mutations
for E2F6

Medical News
for E2F6

Publications
for E2F6

Licensable Technologies
for E2F6

Services
for E2F6