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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

E2F5 Gene

protein-coding   GIFtS: 62
GCID: GC08P086089

E2F transcription factor 5, p130-binding
 Explore 19 diseases affiliated with
E2F5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for E2F5    

Aliases
for E2F5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
E2F Transcription Factor 5, P130-Binding1 2
E2F-52 3
Transcription Factor E2F52

External Ids:    HGNC: 31191   Entrez Gene: 18752   Ensembl: ENSG000001337407   OMIM: 6009675   UniProtKB: Q153293   

Export aliases for E2F5 gene to outside databases

Previous GC identifers: GC08P084913 GC08P086046 GC08P085869 GC08P086164 GC08P086276 GC08P081583


Summaries
for E2F5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for E2F5:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial
role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming
proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are
present in most members of the family. These domains include a DNA binding domain, a dimerization domain which
determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain
enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the
transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human
tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor
suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: E2F5_HUMAN, Q15329
Function: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes
whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is
likely involved in the early responses of resting cells to growth factor stimulation

Gene Wiki entry for E2F5


Genomic Views
for E2F5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the E2F5 gene promoter:
         HOXA9B   HOXA9   Meis-1a   Pax-4a   POU3F2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): E2F5 promoter sequence
   Search SABiosciences Chromatin IP Primers for E2F5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat E2F5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.2   Ensembl cytogenetic band:  8q21.2   HGNC cytogenetic band: 8q21.2

E2F5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E2F5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P086089:  view genomic region     (about GC identifiers)

Start:
 86,089,460 bp from pter      End:
 86,129,387 bp from pter
Size:
 39,928 bases      Orientation:
 plus strand

Proteins
for E2F5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: E2F5_HUMAN, Q15329 (See protein sequence)
Recommended Name: Transcription factor E2F5  
Size: 346 amino acids; 37610 Da
Subunit: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites.
Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54,
MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell
cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to
MYBL2
Subcellular location: Nucleus
Secondary accessions: E9PBN9 Q16601 Q92756
Alternative splicing: 3 isoforms:  Q15329-1   Q15329-2   Q15329-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for E2F5: NX_Q15329

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15329

    • E2F5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001077057.1  NP_001077058.1  NP_001942.2  

    ENSEMBL proteins: 
     ENSP00000414312   ENSP00000398124   ENSP00000429120   ENSP00000428606   ENSP00000429669  
     ENSP00000430461   ENSP00000256117  
    Reactome Protein details: Q15329
    Human Recombinant Protein Products: 
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    Novus Biologicals E2F5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for E2F5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--


    E2F5 for ontologies           About GeneDecksing



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    Uscn Antibodies for E2F5
    ThermoFisher Antibodies for E2F5

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    Uscn ELISAs and CLIAs for E2F5

    Protein Domains /
    Families
    for E2F5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    E2F5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003316 E2F_TDP
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR015633 E2F

    Graphical View of Domain Structure for InterPro Entry Q15329

    ProtoNet protein and cluster: Q15329

    1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: E2F5_HUMAN, Q15329
    Similarity: Belongs to the E2F/DP family


    Function
    for E2F5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: E2F5_HUMAN, Q15329
    Function: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes
    whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is
    likely involved in the early responses of resting cells to growth factor stimulation

    10/862 SABiosciences Target genes for E2F5 (see all 862):
    A4GNT AACS ABCF2 ABCF3 ABI2 ABTB1 ACOT7 ADAMTS12 ADAMTS19 ADAMTS4

    miRNA
    Products:            		miRTarBase miRNAs that target E2F5:
    hsa-mir-34a (MIRT000750), hsa-mir-192 (MIRT004134), hsa-let-7b (MIRT003833)

    OriGene 3'-UTR Clone (see all 3): E2F5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat E2F5
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate E2F5 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-let-7g hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: E2F5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for E2F5 (see all 4)
    OriGene shRNA RFP: E2F5
    OriGene siRNA: E2F5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat E2F5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for E2F5

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for E2F5 (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat E2F5 

    Cell Line
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    Search LifeMap BioReagents cell lines for E2F5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F5

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16360038
    GO:0008134transcription factor binding IPI16360038


    E2F5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out E2f5tm1Dli for E2F5
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for E2f5):
     behavior/neurological  cardiovascular system  cellular  craniofacial  homeostasis/metabolism 
     integument  mortality/aging  nervous system  skeleton 

    E2F5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for E2F5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cyclins and Cell Cycle Regulation
    		Cyclins and Cell Cycle Regulation1.00
    		Cyclin D associated events in G10.32
    		G1-S Phase Transition0.67
    		G1 Phase0.32
    		Cell Cycle Control by BTG Proteins0.36
    2Cell cycle_Cell cycle (generic schema)
    		Cell cycle_Cell cycle (generic schema)1.00
    		G0 and Early G10.31
    		Cell cycle Cell cycle (generic schema)1.00
    3Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    		Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer1.00
    		Signaling by TGF-beta Receptor Complex0.61
    		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    4Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		p53 Signaling0.32
    		Estrogen-mediated S-Phase Entry0.55
    5Cell cycle
    		Cell cycle1.00
    		G1 to S cell cycle control0.38
    		Cell cycle0.57

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for E2F5
        Cell cycle Cell cycle (generic schema)

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for E2F5 (see all 14)
        ErbB2-ErbB3 Heterodimers
    Cell Cycle Control by BTG Proteins
    BRCA1 Pathway
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for E2F5
        Cell cycle Cell cycle (generic schema)

    4 BioSystems Pathways for E2F5 
        G1 to S cell cycle control
    Cell cycle
    TGF-beta Receptor Signaling Pathway
    E2F transcription factor network

    5/12        Reactome Pathways for E2F5 (see all 12)
        G1 Phase
    Generic Transcription Pathway
    Mitotic G1-G1/S phases
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    G0 and Early G1


    2         Kegg Pathways  (Kegg details for E2F5):
        Cell cycle
    TGF-beta signaling pathway


    E2F5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for E2F5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for E2F5 (Q153293 ENSP000003981244) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARID1AO144973, ENSP000003204854I2D: score=2 STRING: ENSP00000320485
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    MLL2O146863, ENSP000003010674I2D: score=1 STRING: ENSP00000301067
    TFDP1Q141863, ENSP000003645194I2D: score=4 STRING: ENSP00000364519
    RBL2Q089993, ENSP000002621334I2D: score=5 STRING: ENSP00000262133
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--


    E2F5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for E2F5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    E2F5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for E2F5
    1 Novoseek chemical compound relationship for E2F5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrofolate 37.7 1 10823896 (1)

    Search CenterWatch for drugs/clinical trials and news about E2F5 

    Transcripts
    for E2F5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for E2F5 gene (3 alternative transcripts): 
    NM_001083588.1  NM_001083589.1  NM_001951.3  

    Unigene Cluster for E2F5:

    E2F transcription factor 5, p130-binding
    Hs.445758  [show with all ESTs]
    Unigene Representative Sequence: X86097
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418930(uc003yda.4) ENST00000416274 ENST00000519128(uc003ydc.1)
    ENST00000517476 ENST00000521429(uc010mab.3) ENST00000521234 ENST00000518234
    ENST00000520225 ENST00000256117(uc003ycz.4)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): E2F5
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat E2F5
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate E2F5 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-let-7g hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: E2F5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for E2F5 (see all 4)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    U15642.1 U31556.1 X86097.1 Z78409.1 

    6 DOTS entries:

    DT.91767898  DT.305579  DT.95165122  DT.121478030  DT.86846772  DT.100813249 

    24/91 AceView cDNA sequences (see all 91):

    AA484938 AI740797 AA748780 BF116070 AA766588 AA455521 BX117249 BX091085 
    AW051475 BG282688 CR605094 AW589432 AI066452 CR599340 AA723164 BU735902 
    BM698762 AA991290 AI857267 AW303631 AI478923 AW139923 BE878145 BV167966 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for E2F5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            


    ECgene alternative splicing isoforms for E2F5

    Expression
    for E2F5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    E2F5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAACTTGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    E2F5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusChoroid Plexus Progenitor CellsChoroid Plexus
    BrainChoroid PlexusChoroid Plexus Progenitor CellsChoroid Plexus
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See E2F5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for E2F5

    SOURCE GeneReport for Unigene cluster: Hs.445758
        SABiosciences Expression via Pathway-Focused PCR Arrays including E2F5: 
              TGFB Signaling Targets in human mouse rat
              Stem Cell Signaling in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat E2F5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F5

    Orthologs
    for E2F5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for E2F5 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia E2f51 , 5 E2F transcription factor 51, 5 88.86(n)1
    90.75(a)1    		   3 (3.10 cM)5
    135591  NM_007892.21  NP_031918.21 
     145786715 
    chicken
    (Gallus gallus)    		 Aves E2F51 E2F transcription factor 5, p130-binding 74.13(n)
    78.7(a)    		   420206  NM_001030942.1  NP_001026113.1 
    lizard
    (Anolis carolinensis)    		 Reptilia E2F56
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(23236433-23249557)
    zebrafish
    (Danio rerio)    		 Actinopterygii e2f51 E2F transcription factor 5 65(n)
    67(a)    		   402908  NM_001197300.1  NP_001184229.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta E2f21 E2F transcription factor 2 46.55(n)
    35.59(a)    		   35381  NM_058007.4  NP_477355.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea efl-13   -- 41(a)   V(16961540-16968261)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons E2F11 E2F transcription factor 1 52.14(n)
    43.58(a)    		   832283  NM_122128.2  NP_568413.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 E2F family transcription factor protein, putative,...
    E2F family transcription factor protein, putative,...
    (see all 4)    		 27(a)
    25(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 4(20377617-20383348)
    12(2938686-2944066)


    ENSEMBL Gene Tree for E2F5 (if available)
    TreeFam Gene Tree for E2F5 (if available) 

    Paralogs
    for E2F5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for E2F5 gene
    E2F12  E2F32  E2F22  E2F42  E2F62  
    3 SIMAP similar genes for E2F5 using alignment to 5 protein entries:     E2F5_HUMAN (see all proteins):
    E2F3    E2F6    E2F4

    E2F5 for paralogs           About GeneDecksing



    Genomic Variants
    for E2F5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/684 NCBI SNPs in E2F5 are shown (see all 684)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs775779111,2
    		F,--81619843(+) AAAAAG/AAAAAA 4 -- ds50011Minor allele frequency- A:0.50NA 4
    rs2019581411,2
    		C--81620514(-) GGCAGG/TAAAAA 4 -- ut310--------
    rs1899958771,2
    		--86087681(+) AGACAC/TCATAG 2 -- us2k10--------
    rs1508130521,2
    		--86087741(+) CCCTGC/TACATA 2 -- us2k10--------
    rs1398752531,2
    		--86087744(+) TGCACA/CTATAA 2 -- us2k10--------
    rs1926459521,2
    		--86087765(+) TGTTAC/TAAAGT 2 -- us2k10--------
    rs1452811791,2
    		--86087820(+) TACTAC/TTTGAC 2 -- us2k10--------
    rs1846309661,2
    		--86088065(+) AATGGA/TGTGTT 2 -- us2k10--------
    rs101004421,2
    		C,F,A,H,--86088106(+) ATGTCA/GCTTCA 2 -- us2k121Minor allele frequency- G:0.38NS EA NA WA CSA 2227
    rs1890445181,2
    		--86088194(+) TGCCAC/TATAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for E2F5 (86089460 - 86129387 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for E2F5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing E2F5
    DNA2.0 Custom Variant and Variant Library Synthesis for E2F5

    Disorders / Diseases
    for E2F5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    E2F5 for disorders           About GeneDecksing

    OMIM gene information: 600967    OMIM disorders: --

    19 diseases for E2F5:    About MalaCards
    chronic lymphocytic leukemia    epithelial ovarian cancer    lymphocytic leukemia    ovarian cancer
    retinoblastoma    breast cancer    hepatocellular carcinoma    ovarian carcinoma
    choroiditis    pancreatic carcinoma    carcinoma    prostate carcinoma
    leukemia    pancreatitis    sarcoma    prostatitis
    thyroiditis    glioblastoma    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for E2F5:
    Retinoblastoma

    4 Novoseek disease relationships for E2F5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 69.3 1 15548374 (1)
    tumors 22 11 10738311 (3), 12368233 (1), 16721044 (1)
    cancer 9.3 3 16721044 (1), 8622649 (1), 19014670 (1)
    breast cancer 0 1 10738311 (1)

    Human Genome Epidemiology (HuGE) Navigator: E2F5 (3 documents)

    Export disorders for E2F5 gene to outside databases

    Publications
    for E2F5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for E2F5 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with E2F5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PubMed id 7892279)1, 2, 3, 9 Sardet C....Weinberg R.A. (1995)
    2. The molecular and functional characterization of E2F-5 transcription factor. (PubMed id 9464260)1, 2, 9 Vaishnav Y.N.... Pant V. (1998)
    3. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. (PubMed id 8589754)1, 2, 9 Itoh A....Mitsialis S.A. (1995)
    4. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (2007)
    5. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. (PubMed id 16360038)1, 2 Rubin S.M....Pavletich N.P. (2005)
    6. E2F-5, a new E2F family member that interacts with p130 in vivo. (PubMed id 7760804)1, 2 Hijmans E.M....Bernards R. (1995)
    7. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators. (PubMed id 10783242)1, 9 Morris L....La Thangue N.B. (2000)
    8. E2F5 status significantly improves malignancy diagnos is of epithelial ovarian cancer. (PubMed id 20181230)1, 9 Kothandaraman N....Choolani M. (2010)
    9. A potential oncogenic role of the commonly observed E 2F5 overexpression in hepatocellular carcinoma. (PubMed id 21274376)1 Jiang Y....Chung Y.J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for E2F5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing E2F5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1875 HGNC: 3119 AceView: E2F5 Ensembl:ENSG00000133740 euGenes: HUgn1875
    ECgene: E2F5 Kegg: 1875 H-InvDB: E2F5

    Other Databases showing E2F5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing E2F5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for E2F5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for E2F5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/e2f5/

    Intellectual Property
    for E2F5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for E2F5 gene:
    Search GeneIP for patents involving E2F5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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