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E2F5 Gene

protein-coding   GIFtS: 64
GCID: GC08P086089

E2F Transcription Factor 5, P130-Binding

  Search for E2F5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E2F Transcription Factor 5, P130-Binding1 2
E2F-52 3
Transcription Factor E2F52

External Ids:    HGNC: 31191   Entrez Gene: 18752   Ensembl: ENSG000001337407   OMIM: 6009675   UniProtKB: Q153293   

Export aliases for E2F5 gene to outside databases

Previous GC identifers: GC08P084913 GC08P086046 GC08P085869 GC08P086164 GC08P086276 GC08P081583


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for E2F5 Gene:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a
crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the
transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved
domains that are present in most members of the family. These domains include a DNA binding domain, a
dimerization domain which determines interaction with the differentiation regulated transcription factor proteins
(DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain
which is embedded within the transactivation domain. This protein is differentially phosphorylated and is
expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both
this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative
splicing results in multiple variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for E2F5 Gene:
E2F5 (E2F transcription factor 5, p130-binding) is a protein-coding gene. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is E2F1.

UniProtKB/Swiss-Prot: E2F5_HUMAN, Q15329
Function: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes
whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is
likely involved in the early responses of resting cells to growth factor stimulation

Gene Wiki entry for E2F5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the E2F5 gene promoter:
         HOXA9B   HOXA9   Meis-1a   Pax-4a   POU3F2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): E2F5 promoter sequence
   Search Chromatin IP Primers for E2F5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat E2F5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.2   Ensembl cytogenetic band:  8q21.2   HGNC cytogenetic band: 8q21.2

E2F5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E2F5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P086089:  view genomic region     (about GC identifiers)

Start:
86,089,460 bp from pter      End:
86,129,387 bp from pter
Size:
39,928 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: E2F5_HUMAN, Q15329 (See protein sequence)
Recommended Name: Transcription factor E2F5  
Size: 346 amino acids; 37610 Da
Subunit: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites.
Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52,
LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses
cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that
binds to MYBL2
Secondary accessions: E9PBN9 Q16601 Q92756
Alternative splicing: 3 isoforms:  Q15329-1   Q15329-2   Q15329-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for E2F5: NX_Q15329

Explore proteomics data for E2F5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys61
  • Modification sites at PhosphoSitePlus

  • See E2F5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001077057.1  NP_001077058.1  NP_001942.2  

    ENSEMBL proteins: 
     ENSP00000414312   ENSP00000398124   ENSP00000429120   ENSP00000428606   ENSP00000429669  
     ENSP00000430461   ENSP00000256117  
    Reactome Protein details: Q15329

    E2F5 Human Recombinant Protein Products:

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    Novus Biologicals E2F5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for E2F5

     
    Search eBioscience for Proteins for E2F5 

    E2F5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibodies for E2F5
    LSBio Antibodies in human, mouse, rat for E2F5

    E2F5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for E2F5
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    Cloud-Clone Corp. ELISAs for E2F5
    Cloud-Clone Corp. CLIAs for E2F5
    Search eBioscience for ELISAs for E2F5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR011991 WHTH_DNA-bd_dom
     IPR028316 E2F5
     IPR015633 E2F

    Graphical View of Domain Structure for InterPro Entry Q15329

    ProtoNet protein and cluster: Q15329

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: E2F5_HUMAN, Q15329
    Similarity: Belongs to the E2F/DP family


    Find genes that share domains with E2F5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: E2F5_HUMAN, Q15329
    Function: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes
    whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is
    likely involved in the early responses of resting cells to growth factor stimulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16360038
    GO:0008134transcription factor binding IPI16360038
         
    Find genes that share ontologies with E2F5           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for E2f5):
     behavior/neurological  cardiovascular system  cellular  craniofacial  homeostasis/metabolism 
     integument  mortality/aging  nervous system  skeleton 

    Find genes that share phenotypes with E2F5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out E2f5tm1Dli for E2F5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for E2F5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for E2F5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for E2F5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for E2F5

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for E2F5 (see all 833):
    A4GNT,  AACS,  ABCF2,  ABCF3,  ABI2,  ABTB1,  ACOT7,  ADAMTS12,  ADAMTS19,  ADAMTS4

    miRNA
    Products:
        
    miRTarBase miRNAs that target E2F5:
    hsa-mir-335-5p (MIRT017999), hsa-mir-378a-3p (MIRT043926), hsa-mir-124-3p (MIRT002917), hsa-mir-1 (MIRT023808), hsa-mir-34a-5p (MIRT000750), hsa-mir-205-5p (MIRT003321), hsa-mir-192-5p (MIRT004134), hsa-let-7b-5p (MIRT003833)

    Block miRNA regulation of human, mouse, rat E2F5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate E2F5 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-let-7g hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidE2F5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for E2F5
    Predesigned siRNA for gene silencing in human, mouse, rat E2F5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for E2F5

    Clone
    Products:
         
    OriGene clones in human, mouse for E2F5 (see all 17)
    OriGene ORF clones in mouse, rat for E2F5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): E2F5 (NM_001951)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for E2F5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat E2F5
    Addgene plasmids for E2F5 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for E2F5
    Browse ESI BIO Cell Lines and PureStem Progenitors for E2F5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    E2F5_HUMAN, Q15329: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with E2F5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for E2F5 About   (see all 23)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    Cell Cycle Control by BTG Proteins0.36
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    4Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with E2F5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for E2F5 (see all 14)
        ErbB2-ErbB3 Heterodimers
    Cell Cycle Control by BTG Proteins
    BRCA1 Pathway
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for E2F5
        Cell cycle Cell cycle (generic schema)

    5 BioSystems Pathways for E2F5
        Cell cycle
    G1 to S cell cycle control
    Spinal Cord Injury
    TGF-beta Receptor Signaling Pathway
    E2F transcription factor network

    3 Reactome Pathways for E2F5
        G0 and Early G1
    Cyclin D associated events in G1
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


    2 Kegg Pathways  (Kegg details for E2F5):
        Cell cycle
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including E2F5: 
              TGFB Signaling Targets in human mouse rat
              Stem Cell Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for E2F5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for E2F5 (Q153293 ENSP000003981244) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARID1AO144973, ENSP000003204854I2D: score=2 STRING: ENSP00000320485
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    KMT2DO146863, ENSP000003010674I2D: score=1 STRING: ENSP00000301067
    TFDP1Q141863, ENSP000003645194I2D: score=4 STRING: ENSP00000364519
    RBL2Q089993, ENSP000002621334I2D: score=5 STRING: ENSP00000262133
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    Find genes that share ontologies with E2F5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for E2F5

    1 Novoseek inferred chemical compound relationship for E2F5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrofolate 37.7 1 10823896 (1)



    Find genes that share compounds with E2F5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for E2F5 gene (3 alternative transcripts): 
    NM_001083588.1  NM_001083589.1  NM_001951.3  

    Unigene Cluster for E2F5:

    E2F transcription factor 5, p130-binding
    Hs.445758  [show with all ESTs]
    Unigene Representative Sequence: X86097
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418930(uc003yda.4) ENST00000416274 ENST00000519128(uc003ydc.1)
    ENST00000517476 ENST00000521429(uc010mab.3) ENST00000521234 ENST00000518234
    ENST00000520225 ENST00000256117(uc003ycz.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate E2F5 (see all 56):
    hsa-miR-520e hsa-miR-302d hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-let-7g hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidE2F5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): E2F5 (NM_001951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for E2F5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat E2F5
    Addgene plasmids for E2F5 
    Primer
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    OriGene qPCR primer pairs and template standards for E2F5
    OriGene qSTAR qPCR primer pairs in human, mouse for E2F5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat E2F5
      QuantiTect SYBR Green Assays in human, mouse, rat E2F5
      QuantiFast Probe-based Assays in human, mouse, rat E2F5

    Additional mRNA sequence: 

    U15642.1 U31556.1 X86097.1 Z78409.1 

    6 DOTS entries:

    DT.91767898  DT.305579  DT.95165122  DT.121478030  DT.86846772  DT.100813249 

    Selected AceView cDNA sequences (see all 91):

    CR605094 BX117249 BG282688 BM698762 AW589432 BX091085 BU735902 AA723164 
    CR599340 AA991290 AI740797 AW051475 AA455521 AA766588 BF116070 AA484938 
    AI066452 AA748780 N91476 AI827553 AL583354 AA743346 AA743197 BE858786 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for E2F5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            


    ECgene alternative splicing isoforms for E2F5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    E2F5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACTTGGG
    E2F5 Expression
    About this image


    E2F5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    E2F5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    E2F5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445758
        Pathway & Disease-focused RT2 Profiler PCR Arrays including E2F5: 
              TGFB Signaling Targets in human mouse rat
              Stem Cell Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for E2F5
    OriGene qSTAR qPCR primer pairs in human, mouse for E2F5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat E2F5
    QuantiTect SYBR Green Assays in human, mouse, rat E2F5
    QuantiFast Probe-based Assays in human, mouse, rat E2F5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for E2F5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E2f51 , 5 E2F transcription factor 51, 5 88.56(n)1
    88.96(a)1
      3 (3.10 cM)5
    135591  NM_007892.21  NP_031918.21 
     145786715 
    chicken
    (Gallus gallus)
    Aves E2F51 E2F transcription factor 5, p130-binding 75(n)
    80.3(a)
      420206  NM_001030942.1  NP_001026113.1 
    lizard
    (Anolis carolinensis)
    Reptilia E2F56
    E2F transcription factor 5, p130-binding
    63(a)
    1 ↔ 1
    4(23232818-23247809)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia e2f51 E2F transcription factor 5, p130-binding 72.48(n)
    81.21(a)
      100151699  NM_001127408.1  NP_001120880.1 
    zebrafish
    (Danio rerio)
    Actinopterygii e2f51 E2F transcription factor 5 64.99(n)
    66.89(a)
      402908  NM_001197300.1  NP_001184229.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta E2f21 E2F transcription factor 2 46.48(n)
    35.13(a)
      35381  NM_058007.5  NP_477355.1 
    worm
    (Caenorhabditis elegans)
    Secernentea efl-13   -- 41(a)   V(16961540-16968261)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons E2F11 E2F1 51.85(n)
    43.25(a)
      832283  NM_001036844.3  NP_001031921.3 


    ENSEMBL Gene Tree for E2F5 (if available)
    TreeFam Gene Tree for E2F5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for E2F5 gene
    E2F12  E2F32  E2F22  E2F42  E2F62  
    3 SIMAP similar genes for E2F5 using alignment to 5 protein entries:     E2F5_HUMAN (see all proteins):
    E2F3    E2F6    E2F4

    Find genes that share paralogs with E2F5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for E2F5 (see all 770)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899958771,2
    --86087681(+) AGACAC/TCATAG 2 -- us2k10--------
    rs1508130521,2
    --86087741(+) CCCTGC/TACATA 2 -- us2k10--------
    rs1398752531,2
    --86087744(+) TGCACA/CTATAA 2 -- us2k10--------
    rs1926459521,2
    --86087765(+) TGTTAC/TAAAGT 2 -- us2k10--------
    rs1452811791,2
    C--86087820(+) TACTAC/TTTGAC 2 -- us2k10--------
    rs1846309661,2
    --86088065(+) AATGGA/TGTGTT 2 -- us2k10--------
    rs101004421,2
    C,F,A,H--86088106(+) ATGTCA/GCTTCA 2 -- us2k121Minor allele frequency- G:0.38NS EA NA WA CSA 2227
    rs1890445181,2
    --86088194(+) TGCCAC/TATAGA 2 -- us2k10--------
    rs78369381,2
    C--86088198(+) ATATAG/AAATTT 2 -- us2k1 tfbs31Minor allele frequency- A:0.00NA 2
    rs2010505991,2
    C--86088218(+) TAATC-/TTTTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for E2F5 (86089460 - 86129387 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for E2F5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing E2F5
    DNA2.0 Custom Variant and Variant Library Synthesis for E2F5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600967    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for E2F5:
    Retinoblastoma

    Find genes that share disorders with E2F5           About GenesLikeMe

    4 Novoseek inferred disease relationships for E2F5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 69.3 1 15548374 (1)
    tumors 22 11 10738311 (3), 12368233 (1), 16721044 (1)
    cancer 9.3 3 16721044 (1), 8622649 (1), 19014670 (1)
    breast cancer 0 1 10738311 (1)

    Genetic Association Database (GAD): E2F5
    Human Genome Epidemiology (HuGE) Navigator: E2F5 (3 documents)

    Export disorders for E2F5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for E2F5 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with E2F5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PubMed id 7892279)1, 2, 3, 9 Sardet C....Weinberg R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. The molecular and functional characterization of E2F-5 transcription factor. (PubMed id 9464260)1, 2, 9 Vaishnav Y.N.... Pant V. (Biochem. Biophys. Res. Commun. 1998)
    3. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. (PubMed id 8589754)1, 2, 9 Itoh A....Mitsialis S.A. (Cell. Mol. Biol. Res. 1995)
    4. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    6. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (Mol. Cell 2007)
    7. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. (PubMed id 16360038)1, 2 Rubin S.M.... Pavletich N.P. (Cell 2005)
    8. E2F-5, a new E2F family member that interacts with p130 in vivo. (PubMed id 7760804)1, 2 Hijmans E.M....Bernards R. (Mol. Cell. Biol. 1995)
    9. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators. (PubMed id 10783242)1, 9 Morris L....La Thangue N.B. (Nat. Cell Biol. 2000)
    10. E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. (PubMed id 20181230)1, 9 Kothandaraman N....Choolani M. (BMC Cancer 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1875 HGNC: 3119 AceView: E2F5 Ensembl:ENSG00000133740 euGenes: HUgn1875
    ECgene: E2F5 Kegg: 1875 H-InvDB: E2F5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for E2F5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for E2F5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/e2f5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for E2F5 gene:
    Search GeneIP for patents involving E2F5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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