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E2F4 Gene

protein-coding GIFtS: 66

GC16P065783

E2F transcription factor 4, p107/p130-binding
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2F-4 ^¹, ², ³

Descriptions
E2F transcription factor 4 ^²
E2F transcription factor 4, p107/p130-binding ^²
p107/p130-binding protein ^²

External Ids
HGNC: 3118¹
Entrez Gene: 1874²
UniProtKB: Q16254³
Ensembl: ENSG00000205250⁷

Search outside databases for aliases for E2F4 gene

Previous GC identifers: GC16P057920 GC16P067603 GC16P066962 GC16P067002

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for E2F4:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F

family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins

and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins

contain several evolutionally conserved domains found in most members of the family. These domains

include a DNA binding domain, a dimerization domain which determines interaction with the

differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in

acidic amino acids, and a tumor suppressor protein association domain which is embedded within the

transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107

and p130, but with higher affinity to the last two. It plays an important role in the suppression

of proliferation-associated genes, and its gene mutation and increased expression may be

associated with human cancer. [provided by RefSeq]

UniProtKB/Swiss-Prot: E2F4_HUMAN, Q16254

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from G1 to S phase. E2F-4 binds with high

affinity to RBL1 and RBL2. In some instances, can also bind RB protein

Gene Wiki entry for E2F4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the E2F4 gene

Entrez Gene cytogenetic band: 16q21-q22 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q21-q22

E2F4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P065783: (about GC identifiers)

Start:	65,783,569 bp from pter
End:	65,790,322 bp from pter
Size:	6,754 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: E2F4_HUMAN, Q16254 (See protein sequence)

Recommended Name: Transcription factor E2F4

Size: 413 amino acids; 43960 Da

Subunit: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to

E2F sites. The E2F4/DP-1 dimer interacts preferentially with pocket protein RBL1, which inhibits

the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma

protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone

acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component

of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37,

LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent

cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37,

LIN52 and LIN54 form a subcomplex that binds to MYBL2

Subcellular location: Nucleus

Developmental stage: Present in the growth-arrested state, its abundance does not change

significantly as cells move into and through the cell cycle

PDB structures from and Proteopedia :

1CF7 (3D)

Secondary accessions: A6NGR8 B5BU56 Q12991 Q15328

Post-translational modifications:

Differentially phosphorylated in vivo¹

REFSEQ proteins: NP_001941.2

ENSEMBL proteins:

ENSP00000368686

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (E2F4)
	Human Recombinant Proteins from Abnova (E2F4)

OriGene Purified Recombinant Human Protein: E2F4

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	9190208
GO:0005667	transcription factor complex	IEA	--

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Antibodies for E2F4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of E2F4
	Sigma-Aldrich Antibody Arrays and Antibodies for E2F4
	R&D Systems Antibodies for E2F4 (E2F-4)
	Antibodies from Abcam (E2F4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (E2F4)
	Novus Biologicals Antibodies for E2F4

Assays for E2F4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q16254

ProtoNet protein and cluster: Q16254

1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

UniProtKB/Swiss-Prot: E2F4_HUMAN, Q16254

Similarity: Belongs to the E2F/DP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E2F4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001950

Applied Biosystems Silencer® siRNAs for E2F4

Sigma-Aldrich siRNA for E2F4

Sigma-Aldrich shRNA Panels and shRNA for E2F4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for E2F4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001950
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001950
untagged cDNA clone in CMV expression vector: NM_001950

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001950

UniProtKB/Swiss-Prot: E2F4_HUMAN, Q16254

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from G1 to S phase. E2F-4 binds with high

affinity to RBL1 and RBL2. In some instances, can also bind RB protein

Genatlas biochemistry entry for E2F4:

transcription factor E2F4,involved in cell proliferation,controlling genes regulating S phase entry

and DNA synthesis

15/21 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for E2f4) (see all 21 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	11418595
GO:0005515	protein binding	IPI	11418595 14532282

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for E2F4 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Role of BRCA1 in DNA Damage Response
Cell Cycle Regulation by BTG Family Proteins
Molecular Mechanisms of Cancer
Chronic Myeloid Leukemia Signaling
Glioma Signaling

GeneDecks E2F4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for E2F4

5/67 Interacting proteins for E2F4 (Q16254^{1, 2} ENSP00000368686³) via UniProtKB, MINT, and/or STRING (see all 67 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TFDP2	Q14188², ENSP00000309622³	MINT-24872 STRING (score=.994)
MYBL2	P10244², ENSP00000217026³	MINT-4054181 STRING (score=.941)
LIN9	Q5TKA1², ENSP00000355772³	MINT-4054190 STRING (score=.883)
TRRAP	Q9Y4A5¹, ENSP00000352925³	EBI-448943, EBI-399128 STRING (score=.711)
DHX30	Q7L2E3²	MINT-4303945

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5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000083	regulation of transcription of G1/S-phase of mitotic cell cycle	IEA	--
GO:0002064	epithelial cell development	IEA	--
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006884	cell volume homeostasis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for E2F4
2 Novoseek chemical compound relationships for E2F4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	15.53	1	15040009 (1)
benzo(a)pyrene	13.41	5	16944783 (3), 16600106 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E2F4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001950

Sigma-Aldrich siRNA for E2F4

Sigma-Aldrich shRNA Panels and shRNA for E2F4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001950

REFSEQ mRNAs for E2F4 gene:

NM_001950.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001950

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001950
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001950
                                 untagged cDNA clone in CMV expression vector: NM_001950

Additional cDNA sequence:

AB451292.1 AB451425.1 BC021050.1 BC033180.1 CR609179.1 CR614512.1 S75174.1 U15641.1

X86096.1

15 DOTS entries:

DT.454769 DT.91753352 DT.100793333 DT.100793325 DT.91990113 DT.100764714 DT.120684194 DT.87006638

DT.95155691 DT.91753350 DT.97847998 DT.100793327 DT.100793336 DT.91753348 DT.120684199

24/304 AceView cDNA sequences (see all 304 ):

BM068744 BI261063 BC021050 Z41328 BI906524 BQ067481 BQ684920 BF984018

AI888615 BI907427 CF135053 BM547802 BX438889 BI911650 BM740399 CF132202

BX111165 AI475130 BM678392 BM721878 BQ932976 AA766116 BM739597 BM799271

highest scoring ESTs for E2F4:

AA552140 S75174 AA065319 AA065320 AA234038 AA258249 AA259094 AA282158 AA282207 AA283756

Unigene Cluster for E2F4:

E2F transcription factor 4, p107/p130-binding

Hs.108371 [show with all ESTs]

Unigene Representative Sequence: NM_001950

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000379378

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

E2F4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for E2F4

¹ / ² / ³

8 probe-sets matching E2F4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38707_r_at²^{, 3}	U133-A	1	1.00	1.00	0.87	1.29	S75174	1.00	1.00	1.00	1
1724_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.90	S75174	1.00	1.00	1.00	1
1703_g_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.93	S75174	1.00	1.00	1.00	1
38706_at²^{, 3}	U95-A	1	0.88	1.00	0.87	0.88	AA552140	1.00	1.00	1.00	1
38707_r_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S75174	1.00	1.00	1.00	1
202248_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000110	0.20	1.00	0.72	1
38707_r_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202248_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks E2F4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTAAGGCTA

SOURCE GeneReport for Unigene cluster: Hs.108371
Expression variation in blood from EXPOLDB for E2F4
UniProtKB/Swiss-Prot: E2F4_HUMAN, Q16254
Tissue specificity: Found in all tissue examined including heart, brain, placenta, lung, liver,
skeletal muscle, kidney and pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for E2F4 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	E2F4¹	--	E2F transcription factor 4, p107/p130-binding	91.34(n) 94.36(a)	611243 XM_848882.1 XP_853975.1
chimpanzee (Pan troglodytes)	E2F4¹	--	E2F transcription factor 4, p107/p130-binding	99(n) 99(a)	454158 XM_511025.2 XP_511025.2
cow (Bos taurus)	E2F4¹	--	E2F transcription factor 4, p107/p130-binding	90.41(n) 94.29(a)	525428 NM_001075873.1 NP_001069341.1
mouse (Mus musculus)	E2f4^{1, 5}	8⁵	E2F transcription factor 4^{1, 5}	88.35(n)¹ 93.4(a)¹	104394¹ NM_148952.1¹ NP_683754.1¹ AA004023⁵ AI427446⁵ (see all 18)
chicken (Gallus gallus)	E2F4¹	--	E2F transcription factor 4, p107/p130-binding	73.2(n) 76.84(a)	769430 XM_001231947.1 XP_001231948.1

About this table Species with no ortholog for E2F4

ENSEMBL Gene Tree for E2F4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for E2F4 gene

E2F5² E2F6²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: E2F4_HUMAN, Q16254

Polymorphism: The poly-Ser region of E2F4 is polymorphic and the number of Ser varies in the

population (from 8 to 17). The variation might be associated with tumorigenesis

10/28 NCBI SNPs in E2F4 are shown (see all 28 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3730404^1,2	F	65787328(+)	`agcagC/Tagcag`	1	S/S	syn¹ ese³		1	NS	164
	rs3730407^1,2	A,C,F,H	65788069(+)	`TCCCAA/GTCTGC`	1	--	int¹		15	NS EU EA WA	1488
	rs3730405^1,2	C,F,H	65787891(+)	`TTCCTC/TCTTTG`	1	--	int¹ trp³		11	NS EU EA WA	1062
	rs3730403^1,2	C,F,H	65786987(+)	`GAGTCT/GTCTTC`	1	--	int¹		15	NS EU EA WA	1464
	rs3730406^1,2	C,F,H	65787923(+)	`GCTCTC/TCTATC`	1	--	int¹		9	NS EU EA WA	1014
	rs3730394^1,2	F,H	65784770(+)	`AGAACG/AGTCTC`	1	--	int¹		5	NS EU EA WA	598
--	rs3730399^1,2	C,F	65786520(+)	`TTGCTA/GTGGTA`	1	--	int¹		7	NS	656
--	rs3730402^1,2	F	65786762(+)	`aactcC/Atgacc`	1	--	int¹		1	NS	174
--	rs3730393^1,2	F	65783906(+)	`CGGGGG/AATGTT`	1	--	int¹		1	NS	168
--	rs3730397^1,2	F	65785629(+)	`CTGGGC/TTCTCA`	1	--	int¹		1	NS	172

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HapMap Linkage Disequilibrium images for E2F4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600659

10/14 Novoseek disease relationships for E2F4 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	79.62	4	9139687 (1), 15548374 (1), 12674332 (1), 12754095 (1)
microsatellite instability	58.99	1	10679953 (1)
tumors	35.16	19	10797289 (3), 9824204 (2), 12373148 (2), 15867222 (2) (see all 12)
cancer	24.24	8	10717241 (1), 9777938 (1), 9824204 (1), 15611646 (1) (see all 7)
prostate carcinoma	19.64	2	15231644 (2)
colorectal cancer	15.96	7	12148576 (5), 10679953 (1), 11706064 (1)
colon cancer	12.64	1	12373148 (1)
somatic mutations	12.43	2	9927063 (1), 10797289 (1)
ovarian cancer	12.34	3	16638845 (2)
breast carcinoma	6.85	2	11759817 (2)

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Human Genome Epidemiology Navigator: E2F4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/183 PubMed articles for E2F4 gene (see all 183 ):

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PubMed id 7892279)^{1, 2, 3, 4} Sardet C....Weinberg R.A. (1995)
E2F-4, a new member of the E2F transcription factor family, interacts with p107. (PubMed id 7958924)^{1, 2, 3, 4} Ginsberg D.... Livingston D.M. (1994)
Genomic structure and mutation screening of the E2F4 gene in human tumors. (PubMed id 10797289)^{1, 3, 4} Schwemmle S. and Pfeifer G.P. (2000)
Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4. (PubMed id 10679953)^{1, 3, 4} Zhong X.... Shimatake H. (2000)
E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595)^{1, 3, 4} Lang S.E.... Hearing P. (2001)
Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)^{3, 4} Litovchick L.... DeCaprio J.A. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
HCF-1 functions as a coactivator for the zinc finger protein Krox20. (PubMed id 14532282)^{3, 4} Luciano R.L. and Wilson A.C. (2003)
Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. (PubMed id 10090723)^{3, 4} Zheng N.... Pavletich N.P. (1999)
The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130. (PubMed id 9074408)^{3, 4} Williams C.D....Thomas N.S.B. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1874	HGNC: 3118	AceView: E2F4	Ensembl:ENSG00000205250	euGenes: HUgn1874
ECgene: E2F4	H-InvDB: E2F4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for E2F4	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/e2f4/

Licensable Technologies for E2F4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for E2F4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for E2F4-related products

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Antibodies for E2F4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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E2F4 Gene at Home site.
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E2F4 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for E2F4

Summaries
for E2F4

Genomic Location
for E2F4

Proteins
for E2F4

Protein Domains/
Families
for E2F4

Gene Function
for E2F4

Pathways & Interactions
for E2F4

Drugs & Compounds
for E2F4

Transcripts
for E2F4

Expression
for E2F4

Orthologs
for E2F4

Paralogs
for E2F4

SNPs/Variants
for E2F4

Disorders & Mutations
for E2F4

Medical News
for E2F4

Publications
for E2F4

Search for E2F4

Genome Databases showing E2F4

Other Databases showing E2F4

Specialized Databases showing E2F4

Licensable Technologies
for E2F4

Services
for E2F4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

E2F4 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor E2F4

Summariesfor E2F4

Genomic Locationfor E2F4

Proteinsfor E2F4

Protein Domains/Familiesfor E2F4

Gene Functionfor E2F4

Pathways & Interactionsfor E2F4

Drugs & Compoundsfor E2F4

Transcriptsfor E2F4

Expression for E2F4

Orthologsfor E2F4

Paralogsfor E2F4

SNPs/Variantsfor E2F4

Disorders & Mutationsfor E2F4

Medical Newsfor E2F4

Publicationsfor E2F4

Search for E2F4

Genome Databases showing E2F4

Other Databases showing E2F4

Specialized Databases showing E2F4

Licensable Technologiesfor E2F4

Servicesfor E2F4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for E2F4

Summaries
for E2F4

Genomic Location
for E2F4

Proteins
for E2F4

Protein Domains/
Families
for E2F4

Gene Function
for E2F4

Pathways & Interactions
for E2F4

Drugs & Compounds
for E2F4

Transcripts
for E2F4

Expression
for E2F4

Orthologs
for E2F4

Paralogs
for E2F4

SNPs/Variants
for E2F4

Disorders & Mutations
for E2F4

Medical News
for E2F4

Publications
for E2F4

Licensable Technologies
for E2F4

Services
for E2F4