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Aliases for E2F4 Gene

Aliases for E2F4 Gene

  • E2F Transcription Factor 4 2 3
  • E2F Transcription Factor 4, P107/P130-Binding 2 3 5
  • E2F-4 3 4
  • P107/P130-Binding Protein 3

External Ids for E2F4 Gene

Previous GeneCards Identifiers for E2F4 Gene

  • GC16P057920
  • GC16P067603
  • GC16P066962
  • GC16P067002
  • GC16P065783
  • GC16P053100

Summaries for E2F4 Gene

Entrez Gene Summary for E2F4 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F4 Gene

E2F4 (E2F Transcription Factor 4) is a Protein Coding gene. Diseases associated with E2F4 include retinoblastoma and retinal cancer. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is E2F1.

UniProtKB/Swiss-Prot for E2F4 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Wiki entry for E2F4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F4 Gene

Genomics for E2F4 Gene

Regulatory Elements for E2F4 Gene

Promoters for E2F4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around E2F4 on UCSC Golden Path with GeneCards custom track

Genomic Location for E2F4 Gene

Chromosome:
16
Start:
67,192,165 bp from pter
End:
67,198,918 bp from pter
Size:
6,754 bases
Orientation:
Plus strand

Genomic View for E2F4 Gene

Genes around E2F4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F4 Gene

Proteins for E2F4 Gene

  • Protein details for E2F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16254-E2F4_HUMAN
    Recommended name:
    Transcription factor E2F4
    Protein Accession:
    Q16254
    Secondary Accessions:
    • A6NGR8
    • B5BU56
    • Q12991
    • Q15328

    Protein attributes for E2F4 Gene

    Size:
    413 amino acids
    Molecular mass:
    43960 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. The E2F4/TFDP1 dimer interacts preferentially with pocket protein RBL1, which inhibits the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5). Interacts with CEBPA (when phosphorylated) (PubMed:15107404).

    Three dimensional structures from OCA and Proteopedia for E2F4 Gene

neXtProt entry for E2F4 Gene

Proteomics data for E2F4 Gene at MOPED

Post-translational modifications for E2F4 Gene

Other Protein References for E2F4 Gene

No data available for DME Specific Peptides for E2F4 Gene

Domains & Families for E2F4 Gene

Gene Families for E2F4 Gene

Suggested Antigen Peptide Sequences for E2F4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16254

UniProtKB/Swiss-Prot:

E2F4_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F4: view

Function for E2F4 Gene

Molecular function for E2F4 Gene

GENATLAS Biochemistry:
transcription factor E2F4,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis
UniProtKB/Swiss-Prot Function:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Ontology (GO) - Molecular Function for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 16360038
genes like me logo Genes that share ontologies with E2F4: view
genes like me logo Genes that share phenotypes with E2F4: view

Animal Models for E2F4 Gene

MGI Knock Outs for E2F4:

Animal Model Products

  • Taconic Biosciences Mouse Models for E2F4

Transcription Factor Targets for E2F4 Gene

Selected GeneGlobe predicted Target genes for E2F4
Targeted motifs for E2F4 Gene
HOMER Transcription Factor Regulatory Elements motif E2F4
  • Consensus sequence: GGCGGGAAAH Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for E2F4 Gene

Localization for E2F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F4 Gene COMPARTMENTS Subcellular localization image for E2F4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for E2F4 Gene

Pathways & Interactions for E2F4 Gene

genes like me logo Genes that share pathways with E2F4: view

SIGNOR curated interactions for E2F4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0002064 epithelial cell development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006884 cell volume homeostasis IEA --
genes like me logo Genes that share ontologies with E2F4: view

Drugs & Compounds for E2F4 Gene

(5) Drugs for E2F4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for E2F4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with E2F4: view

Transcripts for E2F4 Gene

Unigene Clusters for E2F4 Gene

E2F transcription factor 4, p107/p130-binding:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F4 Gene

No ASD Table

Relevant External Links for E2F4 Gene

GeneLoc Exon Structure for
E2F4
ECgene alternative splicing isoforms for
E2F4

Expression for E2F4 Gene

mRNA expression in normal human tissues for E2F4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F4 Gene

This gene is overexpressed in Fetal Liver (14.1), Pancreas (13.0), Peripheral blood mononuclear cells (8.5), and Colon (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for E2F4 Gene



SOURCE GeneReport for Unigene cluster for E2F4 Gene Hs.108371

mRNA Expression by UniProt/SwissProt for E2F4 Gene

Q16254-E2F4_HUMAN
Tissue specificity: Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with E2F4: view

Protein tissue co-expression partners for E2F4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for E2F4 Gene

Orthologs for E2F4 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F4 36
  • 100 (a)
OneToOne
E2F4 35
  • 97.79 (n)
  • 97.05 (a)
cow
(Bos Taurus)
Mammalia E2F4 36
  • 95 (a)
OneToOne
E2F4 35
  • 89.5 (n)
  • 93.55 (a)
dog
(Canis familiaris)
Mammalia E2F4 35
  • 90.16 (n)
  • 92.62 (a)
E2F4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E2f4 16
E2f4 35
  • 88.1 (n)
  • 92.91 (a)
E2f4 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia E2F4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f4 35
  • 89.38 (n)
  • 93.19 (a)
chicken
(Gallus gallus)
Aves E2F4 35
  • 73.23 (n)
  • 77.66 (a)
E2F4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F4 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24786 35
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f4 35
  • 68.14 (n)
  • 73.41 (a)
Str.4585 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6688 35
zebrafish
(Danio rerio)
Actinopterygii e2f4 36
  • 64 (a)
OneToOne
e2f4 35
  • 65.4 (n)
  • 70.19 (a)
wufb72f07 35
fruit fly
(Drosophila melanogaster)
Insecta E2f2 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-1 36
  • 30 (a)
OneToMany
efl-1 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1239 36
  • 65 (a)
OneToOne
Species with no ortholog for E2F4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F4 Gene

ENSEMBL:
Gene Tree for E2F4 (if available)
TreeFam:
Gene Tree for E2F4 (if available)

Paralogs for E2F4 Gene

Paralogs for E2F4 Gene

(3) SIMAP similar genes for E2F4 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for E2F4 Gene

genes like me logo Genes that share paralogs with E2F4: view

Variants for E2F4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for E2F4 Gene

Q16254-E2F4_HUMAN
The poly-Ser region of E2F4 is polymorphic and the number of Ser varies in the population (from 8 to 17). The variation might be associated with tumorigenesis.

Sequence variations from dbSNP and Humsavar for E2F4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3730398 -- 67,194,552(+) GAGGC(C/T)TGGAG intron-variant
rs3730399 -- 67,195,116(+) TTGCT(A/G)TGGTA intron-variant
rs3730400 -- 67,195,173(+) tgtcc(C/G)ccagg intron-variant
rs3730401 -- 67,195,304(+) ttctc(A/G)tactt intron-variant
rs3730407 -- 67,196,665(+) TCCCA(A/G)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E2F4 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990
dgv2889n71 CNV Loss 21882294

Variation tolerance for E2F4 Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for E2F4 Gene

HapMap Linkage Disequilibrium report
E2F4
Human Gene Mutation Database (HGMD)
E2F4

Disorders for E2F4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for E2F4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
retinal cancer
  • malignant neoplasm of retina
sensory system cancer
ocular cancer
  • eye neoplasm
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search E2F4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for E2F4

Genetic Association Database (GAD)
E2F4
Human Genome Epidemiology (HuGE) Navigator
E2F4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
E2F4
genes like me logo Genes that share disorders with E2F4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F4 Gene

Publications for E2F4 Gene

  1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PMID: 7892279) Sardet C. … Weinberg R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23 67
  2. E2F-4, a new member of the E2F transcription factor family, interacts with p107. (PMID: 7958924) Ginsberg D. … Livingston D.M. (Genes Dev. 1994) 2 3 23
  3. E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. (PMID: 19562678) Garneau H. … Rivard N. (J. Cell. Physiol. 2009) 3 23
  4. An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. (PMID: 17121828) Yochum G.S. … Goodman R.H. (J. Biol. Chem. 2007) 3 23
  5. E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA. (PMID: 17507799) Plesca D. … Almasan A. (Cell Cycle 2007) 3 23

Products for E2F4 Gene

Sources for E2F4 Gene

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