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Aliases for E2F4 Gene

Aliases for E2F4 Gene

  • E2F Transcription Factor 4 2 3 5
  • E2F Transcription Factor 4, P107/P130-Binding 2 3
  • E2F-4 3 4
  • P107/P130-Binding Protein 3
  • Transcription Factor E2F4 3

External Ids for E2F4 Gene

Previous GeneCards Identifiers for E2F4 Gene

  • GC16P057920
  • GC16P067603
  • GC16P066962
  • GC16P067002
  • GC16P065783
  • GC16P053100

Summaries for E2F4 Gene

Entrez Gene Summary for E2F4 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F4 Gene

E2F4 (E2F Transcription Factor 4) is a Protein Coding gene. Diseases associated with E2F4 include Retinoblastoma and Erythema Infectiosum. Among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is E2F5.

UniProtKB/Swiss-Prot for E2F4 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Wiki entry for E2F4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F4 Gene

Genomics for E2F4 Gene

Regulatory Elements for E2F4 Gene

Enhancers for E2F4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G066515 2.1 FANTOM5 Ensembl ENCODE dbSUPER 23 -670.9 -670942 12.4 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 TK2 CKLF E2F4 KIAA0895L BEAN1 ZDHHC1 CKLF-CMTM1 ENSG00000260465 CMTM2 PLEKHG4
GH16G066902 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20.3 -287.6 -287625 4.1 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 YY1 FOS CES2 KIAA0895L E2F4 RRAD FAM96B CENPT EXOC3L1 C16orf70 CES3 LINC00920
GH16G067239 1.8 FANTOM5 ENCODE dbSUPER 24.5 +52.6 52570 10.3 MLX CREB3L1 AGO1 ZFP64 DMAP1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 CENPT E2F4 ATP6V0D1 ACD FHOD1 ELMO3 RANBP10 ENSG00000270165 ZDHHC1 THAP11
GH16G066871 1.6 FANTOM5 ENCODE 25.3 -318.3 -318325 5.1 CREB3L1 MLX FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 E2F4 CES2 CA7 PLEKHG4 ZDHHC1 KIAA0895L CENPT ENSG00000260465 FAM96B FBXL8
GH16G067556 1.5 Ensembl ENCODE dbSUPER 24.9 +364.1 364144 2.0 ZNF493 ZFP64 ZNF121 KLF7 FOS ZNF202 REST ZNF623 ZNF518A ZNF292 ZDHHC1 ENSG00000260465 CENPT ACD ENKD1 E2F4 KIAA0895L ENSG00000263276 FBXL8 ENSG00000270165
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around E2F4 on UCSC Golden Path with GeneCards custom track

Promoters for E2F4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087081 335 1001 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for E2F4 Gene

Chromosome:
16
Start:
67,192,165 bp from pter
End:
67,198,918 bp from pter
Size:
6,754 bases
Orientation:
Plus strand

Genomic View for E2F4 Gene

Genes around E2F4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F4 Gene

Proteins for E2F4 Gene

  • Protein details for E2F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16254-E2F4_HUMAN
    Recommended name:
    Transcription factor E2F4
    Protein Accession:
    Q16254
    Secondary Accessions:
    • A6NGR8
    • B5BU56
    • Q12991
    • Q15328

    Protein attributes for E2F4 Gene

    Size:
    413 amino acids
    Molecular mass:
    43960 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. The E2F4/TFDP1 dimer interacts preferentially with pocket protein RBL1, which inhibits the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5). Interacts with CEBPA (when phosphorylated) (PubMed:15107404).

    Three dimensional structures from OCA and Proteopedia for E2F4 Gene

neXtProt entry for E2F4 Gene

Post-translational modifications for E2F4 Gene

Other Protein References for E2F4 Gene

No data available for DME Specific Peptides for E2F4 Gene

Domains & Families for E2F4 Gene

Gene Families for E2F4 Gene

Suggested Antigen Peptide Sequences for E2F4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16254

UniProtKB/Swiss-Prot:

E2F4_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F4: view

Function for E2F4 Gene

Molecular function for E2F4 Gene

GENATLAS Biochemistry:
transcription factor E2F4,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis
UniProtKB/Swiss-Prot Function:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Ontology (GO) - Molecular Function for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10488129
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IC --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IMP,IEA 11418595
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IDA 11418595
genes like me logo Genes that share ontologies with E2F4: view
genes like me logo Genes that share phenotypes with E2F4: view

Animal Models for E2F4 Gene

MGI Knock Outs for E2F4:

Animal Model Products

Transcription Factor Targets for E2F4 Gene

Selected GeneGlobe predicted Target genes for E2F4
Targeted motifs for E2F4 Gene
HOMER Transcription Factor Regulatory Elements motif E2F4
  • Consensus sequence: GGCGGGAAAH Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for E2F4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for E2F4 Gene

Localization for E2F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for E2F4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 21454377
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with E2F4: view

Pathways & Interactions for E2F4 Gene

genes like me logo Genes that share pathways with E2F4: view

SIGNOR curated interactions for E2F4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA --
GO:0000278 mitotic cell cycle IEA --
GO:0002064 epithelial cell development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with E2F4: view

Drugs & Compounds for E2F4 Gene

(6) Drugs for E2F4 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HLM006474 Pharma E2F inhibitor 0

(1) Additional Compounds for E2F4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for E2F4 Gene

Compound Action Cas Number
HLM006474 E2F inhibitor 353519-63-8
genes like me logo Genes that share compounds with E2F4: view

Transcripts for E2F4 Gene

Unigene Clusters for E2F4 Gene

E2F transcription factor 4, p107/p130-binding:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for E2F4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F4 Gene

No ASD Table

Relevant External Links for E2F4 Gene

GeneLoc Exon Structure for
E2F4
ECgene alternative splicing isoforms for
E2F4

Expression for E2F4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for E2F4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F4 Gene

This gene is overexpressed in Fetal Liver (14.1), Pancreas (13.0), Peripheral blood mononuclear cells (8.5), and Colon (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for E2F4 Gene



Protein tissue co-expression partners for E2F4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of E2F4 Gene:

E2F4

SOURCE GeneReport for Unigene cluster for E2F4 Gene:

Hs.108371

mRNA Expression by UniProt/SwissProt for E2F4 Gene:

Q16254-E2F4_HUMAN
Tissue specificity: Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for E2F4 Gene

  • Liver(4.4)
  • Kidney(4.2)
  • Nervous system(3.1)
  • Intestine(2.4)
  • Skin(2.3)
  • Lung(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with E2F4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for E2F4 Gene

Orthologs for E2F4 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F4 34 35
  • 97.79 (n)
dog
(Canis familiaris)
Mammalia E2F4 34 35
  • 90.16 (n)
cow
(Bos Taurus)
Mammalia E2F4 34 35
  • 89.5 (n)
rat
(Rattus norvegicus)
Mammalia E2f4 34
  • 89.38 (n)
mouse
(Mus musculus)
Mammalia E2f4 34 16 35
  • 88.1 (n)
oppossum
(Monodelphis domestica)
Mammalia E2F4 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F4 34 35
  • 73.23 (n)
lizard
(Anolis carolinensis)
Reptilia E2F4 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f4 34
  • 68.14 (n)
Str.4585 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24786 34
zebrafish
(Danio rerio)
Actinopterygii e2f4 34 35
  • 65.4 (n)
wufb72f07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6688 34
fruit fly
(Drosophila melanogaster)
Insecta E2f2 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-1 36 35
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1239 35
  • 65 (a)
OneToOne
Species where no ortholog for E2F4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F4 Gene

ENSEMBL:
Gene Tree for E2F4 (if available)
TreeFam:
Gene Tree for E2F4 (if available)

Paralogs for E2F4 Gene

Paralogs for E2F4 Gene

(3) SIMAP similar genes for E2F4 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for E2F4 Gene

genes like me logo Genes that share paralogs with E2F4: view

Variants for E2F4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for E2F4 Gene

E2F4_HUMAN-Q16254
The poly-Ser region of E2F4 is polymorphic and the number of Ser varies in the population (from 8 to 17). The variation might be associated with tumorigenesis.

Sequence variations from dbSNP and Humsavar for E2F4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000042920 -- 67,198,827(+) GATTC(C/T)TATAT upstream-variant-2KB, utr-variant-3-prime
rs1000155738 -- 67,198,591(+) TCCTC(C/T)TGGCC upstream-variant-2KB, utr-variant-3-prime
rs1000421645 -- 67,192,500(+) GCCGG(A/G)GGATG intron-variant
rs1000495378 -- 67,197,142(+) TCTGG(G/T)TGCAT intron-variant, upstream-variant-2KB
rs1000694177 -- 67,194,487(+) CGGGG(G/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E2F4 Gene

Variant ID Type Subtype PubMed ID
nsv1160429 CNV deletion 26073780
nsv457513 CNV loss 19166990
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv524492 CNV loss 19592680
nsv572905 CNV loss 21841781
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for E2F4 Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for E2F4 Gene

Human Gene Mutation Database (HGMD)
E2F4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
E2F4

Disorders for E2F4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for E2F4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
erythema infectiosum
  • fifth disease
viral exanthem
sensory system cancer
retinal cancer
  • malignant neoplasm of retina
- elite association - COSMIC cancer census association via MalaCards
Search E2F4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for E2F4

Genetic Association Database (GAD)
E2F4
Human Genome Epidemiology (HuGE) Navigator
E2F4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
E2F4
genes like me logo Genes that share disorders with E2F4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F4 Gene

Publications for E2F4 Gene

  1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PMID: 7892279) Sardet C. … Weinberg R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
  2. E2F-4, a new member of the E2F transcription factor family, interacts with p107. (PMID: 7958924) Ginsberg D. … Livingston D.M. (Genes Dev. 1994) 2 3 4 22 64
  3. E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PMID: 11418595) Lang S.E. … Hearing P. (J. Biol. Chem. 2001) 3 4 22 64
  4. Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4. (PMID: 10679953) Zhong X. … Shimatake H. (Hum. Mutat. 2000) 3 4 22 64
  5. Genomic structure and mutation screening of the E2F4 gene in human tumors. (PMID: 10797289) Schwemmle S. … Pfeifer G.P. (Int. J. Cancer 2000) 3 4 22 64

Products for E2F4 Gene

Sources for E2F4 Gene

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