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E2F3 Gene

protein-coding   GIFtS: 69
GCID: GC06P020402

E2F Transcription Factor 3

  See E2F3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E2F Transcription Factor 31 2
E2F-32 3
Transcription Factor E2F32
KIAA00753

External Ids:    HGNC: 31151   Entrez Gene: 18712   Ensembl: ENSG000001122427   OMIM: 6004275   UniProtKB: O007163   

Export aliases for E2F3 gene to outside databases

Previous GC identifers: GC06P020459 GC06P020510


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for E2F3 Gene:
This gene encodes a member of a small family of transcription factors that function through binding of DP
interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts
directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle.
Altered copy number and activity of this gene have been observed in a number of human cancers. There are
pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Mar 2013)

GeneCards Summary for E2F3 Gene:
E2F3 (E2F transcription factor 3) is a protein-coding gene. Diseases associated with E2F3 include retinoblastoma. GO annotations related to this gene include core promoter binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is E2F1.

UniProtKB/Swiss-Prot: E2F3_HUMAN, O00716
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner

Gene Wiki entry for E2F3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the E2F3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   p53   E2F-2   IRF-1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): E2F3 promoter sequence
   Search Chromatin IP Primers for E2F3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat E2F3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22

E2F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E2F3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P020402:  view genomic region     (about GC identifiers)

Start:
20,402,137 bp from pter      End:
20,493,945 bp from pter
Size:
91,809 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: E2F3_HUMAN, O00716 (See protein sequence)
Recommended Name: Transcription factor E2F3  
Size: 465 amino acids; 49162 Da
Subunit: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F
sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F
transactivation domain. Binds EAPP
Secondary accessions: Q15000 Q68DT0 Q9BZ44
Alternative splicing: 2 isoforms:  O00716-1   O00716-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for E2F3: NX_O00716

Explore proteomics data for E2F3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See E2F3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230005.1  NP_001940.1  

    ENSEMBL proteins: 
     ENSP00000262904   ENSP00000443418  
    Reactome Protein details: O00716

    E2F3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for E2F3

     
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    Search eBioscience for ELISAs for E2F3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR011991 WHTH_DNA-bd_dom
     IPR015633 E2F

    Graphical View of Domain Structure for InterPro Entry O00716

    ProtoNet protein and cluster: O00716

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: E2F3_HUMAN, O00716
    Similarity: Belongs to the E2F/DP family


    Find genes that share domains with E2F3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: E2F3_HUMAN, O00716
    Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
    5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
    regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
    G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner

         Genatlas biochemistry entry for E2F3:
    transcription factor E2F-like 3,involved in cell proliferation,controlling genes regulating S phase entry and DNA
    synthesis,involved in transcription repression in quiescent cell by interaction with histone deacetylase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding IDA15735762
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10779361
         
    Find genes that share ontologies with E2F3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for E2F3:
     Increased cell death in breast  Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for E2f3) (see all 19):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  no phenotypic analysis  normal 

    Find genes that share phenotypes with E2F3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for E2F3: E2f3tm3.1Gle E2f3tm1Lees E2f3tm1.2Gle E2f3tm2.1Gle

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    miRNA
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    miRTarBase miRNAs that target E2F3:
    hsa-mir-16-5p (MIRT051187), hsa-mir-149-5p (MIRT045547), hsa-mir-195-5p (MIRT000223), hsa-mir-34c-5p (MIRT000760), hsa-mir-24-3p (MIRT030551), hsa-mir-101-3p (MIRT027334), hsa-mir-203a (MIRT006268), hsa-mir-17-5p (MIRT005849), hsa-mir-20a-5p (MIRT005855), hsa-mir-200b-3p (MIRT006298), hsa-mir-128-3p (MIRT003734), hsa-mir-32-5p (MIRT028350), hsa-mir-30c-5p (MIRT047838), hsa-mir-141-3p (MIRT021649), hsa-mir-106b-5p (MIRT005863), hsa-let-7b-5p (MIRT051918), hsa-mir-34a-5p (MIRT001756), hsa-mir-210-3p (MIRT003184), hsa-mir-125b-5p (MIRT005503), hsa-mir-221-3p (MIRT024159)

    Block miRNA regulation of human, mouse, rat E2F3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate E2F3 (see all 171):
    hsa-miR-100* hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-3622b-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidE2F3 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for E2F3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    E2F3_HUMAN, O00716: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with E2F3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for E2F3 About   (see all 31)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    Cell Cycle Control by BTG Proteins0.36
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3Cell cycle Regulation of G1 S transition part 2
    Cell cycle Cell cycle generic schema 0.38
    G2 Phase0.00
    4E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    5CDK-mediated phosphorylation and removal of Cdc6
    Regulation of DNA replication0.93
    DNA Replication Pre-Initiation0.81
    DNA Replication0.92
    Association of licensing factors with the pre-replicative complex0.00
    Assembly of the pre-replicative complex0.89
    CDC6 association with the ORC-origin complex0.00
    M/G1 Transition0.81


    Find genes that share SuperPaths with E2F3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for E2F3 (see all 14)
        ErbB2-ErbB3 Heterodimers
    Cell Cycle Control by BTG Proteins
    BRCA1 Pathway
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for E2F3
        Cell cycle Cell cycle (generic schema)

    5 BioSystems Pathways for E2F3
        Cell cycle
    G1 to S cell cycle control
    RB in Cancer
    E2F transcription factor network
    Validated targets of C-MYC transcriptional activation


    Selected Reactome Pathways for E2F3 (see all 7)
        Oxidative Stress Induced Senescence
    CDC6 association with the ORC:origin complex
    Pre-NOTCH Transcription and Translation
    Oncogene Induced Senescence
    G2 Phase


    Selected Kegg Pathways  (Kegg details for E2F3) (see all 13):
        Cell cycle
    Hepatitis B
    HTLV-I infection
    Pathways in cancer
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including E2F3: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for E2F3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for E2F3 (O007161, 2, 3 ENSP000002629044) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RB1P064001, 2, 3, ENSP000002671634EBI-765551,EBI-491274 MINT-6628399 MINT-4793635 I2D: score=4 STRING: ENSP00000267163
    MYBL2P102442, 3, ENSP000002170264MINT-4053806 I2D: score=2 STRING: ENSP00000217026
    RYBPQ8N4883, ENSP000004194944I2D: score=4 STRING: ENSP00000419494
    CCNA2P202483, ENSP000002740264I2D: score=2 STRING: ENSP00000274026
    CDK3Q005263, ENSP000004000884I2D: score=2 STRING: ENSP00000400088
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000085mitotic G2 phase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS8246996
    GO:0007219Notch signaling pathway TAS--

    Find genes that share ontologies with E2F3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for E2F3

    2 Novoseek inferred chemical compound relationships for E2F3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    silymarin 45.5 3 12479270 (2), 12429923 (1)
    oligonucleotide 8.62 1 11159908 (1)



    Find genes that share compounds with E2F3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for E2F3 gene (2 alternative transcripts): 
    NM_001243076.2  NM_001949.4  

    Unigene Cluster for E2F3:

    E2F transcription factor 3
    Hs.269408  [show with all ESTs]
    Unigene Representative Sequence: NM_001949
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346618(uc003ncz.2 uc003nda.2 uc021ymj.1) ENST00000535432

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    hsa-miR-100* hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-3622b-3p hsa-miR-200b
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    Additional mRNA sequence: 

    BC016847.1 BC114554.1 CR749285.1 D38550.1 Y10479.1 

    7 DOTS entries:

    DT.316226  DT.95157544  DT.121337303  DT.100764715  DT.97799967  DT.99947754  DT.91876360 

    Selected AceView cDNA sequences (see all 147):

    BU633769 AA503807 AA418827 BX104959 AA362033 AA836886 AA552312 NM_001949 
    AU131847 BQ129958 AL120952 AA552313 AW518742 D38550 CK905775 AW043596 
    BM973662 AA649029 BX643551 AA730230 AI159954 AI803246 AA379060 AA190904 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for E2F3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:        -     -                                               -                           
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                          -           -     -     -     -     -     -     -               


    ECgene alternative splicing isoforms for E2F3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    E2F3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACTCGTG
    E2F3 Expression
    About this image


    E2F3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
    E2F3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    E2F3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.269408
        Pathway & Disease-focused RT2 Profiler PCR Arrays including E2F3: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for E2F3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E2f31 , 5 E2F transcription factor 31, 5 92.92(n)1
    95.62(a)1
      13 (13.09 cM)5
    135571  NM_010093.31  NP_034223.11 
     299065755 
    chicken
    (Gallus gallus)
    Aves E2F31 E2F transcription factor 3 81.25(n)
    88.69(a)
      420824  XM_418915.4  XP_418915.4 
    lizard
    (Anolis carolinensis)
    Reptilia E2F36
    E2F transcription factor 3
    77(a)
    1 ↔ 1
    4(55799949-55811716)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981592 transcription factor E2F 74.71(n)    AF078111.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570619962   -- 71.43(n)   325010  57061996 
    fruit fly
    (Drosophila melanogaster)
    Insecta E2f3 positive regulation of nurse cell
    apoptosis DNA more
    44(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea efl-26
    Protein EFL-2, isoform a
    20(a)
    1 → many
    II(13406160-13411280) WBGene00001162


    ENSEMBL Gene Tree for E2F3 (if available)
    TreeFam Gene Tree for E2F3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for E2F3 gene
    E2F12  E2F22  E2F52  E2F42  E2F62  
    5 SIMAP similar genes for E2F3 using alignment to 3 protein entries:     E2F3_HUMAN (see all proteins):
    E2F4    E2F6    E2F5    E2F2    E2F1

    Find genes that share paralogs with E2F3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for E2F3
    PGOHUM00000237365 PGOHUM00000259773


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for E2F3 (see all 1991)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507781871,2
    --20322395(+) AACATG/TGATGG 1 -- us2k10--------
    rs1827787281,2
    --20322408(+) CAAGAA/GCAGGG 1 -- us2k10--------
    rs780842441,2
    C,F--20322547(+) GGAGGC/TGGATC 1 -- us2k12Minor allele frequency- T:0.13WA 120
    rs126603541,2
    C,H--20322640(+) TGGTGG/ACACGT 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs94657291,2
    C,A,H--20322795(+) GTCACT/CTCTAC 1 -- us2k110Minor allele frequency- C:0.36WA NA CSA EA 369
    rs1871387561,2
    --20322877(+) TGGTGA/CAAGGT 1 -- us2k10--------
    rs1499665281,2
    --20322914(+) TCAGAA/GAAGGT 1 -- us2k10--------
    rs1927948081,2
    --20322917(+) GAAAAC/GGTAAC 1 -- us2k10--------
    rs795923801,2
    C,F--20323070(+) CTATGA/TGCACC 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1825902821,2
    --20323284(+) TTTTTA/TAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for E2F3 (20402137 - 20493945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for E2F3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673142CNV Deletion23128226
    nsv883468CNV Loss21882294
    nsv883467CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600427    OMIM disorders: --

    1 disease for E2F3:    
    About MalaCards
    retinoblastoma

    1 disease from the University of Copenhagen DISEASES database for E2F3:
    Retinoblastoma

    Find genes that share disorders with E2F3           About GenesLikeMe

    8 Novoseek inferred disease relationships for E2F3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 79.2 10 16180235 (3), 16007192 (2), 17251444 (1), 18541154 (1) (see all 5)
    bladder cancer 41.4 15 16909110 (3), 14716298 (3), 15122326 (2), 16938365 (1) (see all 5)
    aggressiveness 32.2 3 16938365 (1), 16909110 (1)
    tumors 32.1 20 15122326 (5), 16180235 (2), 16340309 (2), 11883935 (1) (see all 8)
    prostate cancer 30.1 15 15184867 (4), 16909110 (4), 16938365 (1), 16180235 (1)
    cancer 23.2 2 16938365 (2)
    ovarian cancer 22.3 1 19738611 (1)
    primary tumor 0 4 16180235 (1), 17099872 (1)

    Genetic Association Database (GAD): E2F3
    Human Genome Epidemiology (HuGE) Navigator: E2F3 (3 documents)

    Export disorders for E2F3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for E2F3 gene, integrated from 10 sources (see all 149):
    (articles sorted by number of sources associating them with E2F3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The retinoblastoma protein binds to a family of E2F transcription factors. (PubMed id 8246996)1, 2, 3 Lees J.A.... Helin K. (Mol. Cell. Biol. 1993)
    2. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4, 9 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    3. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. (PubMed id 15716352)1, 2 Novy M.... Rotheneder H. (Mol. Biol. Cell 2005)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    6. E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. (PubMed id 15122326)1, 9 Oeggerli M....Sauter G. (Oncogene 2004)
    7. Role of E2F3 expression in modulating cellular proliferation rate in human bladder and prostate cancer cells. (PubMed id 16909110)1, 9 Olsson A.Y....Cooper C.S. (Oncogene 2007)
    8. Nuclear overexpression of the E2F3 transcription factor in human lung cancer. (PubMed id 16938365)1, 9 Cooper C.S....Cheng S.J. (Lung Cancer 2006)
    9. Expression analysis of 6p22 genomic gain in retinoblastoma. (PubMed id 16180235)1, 9 Orlic M....Gallie B.L. (amp 2006)
    10. Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. (PubMed id 15184867)1, 9 Foster C.S....Cooper C.S. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1871 HGNC: 3115 AceView: E2F3 Ensembl:ENSG00000112242 euGenes: HUgn1871
    ECgene: E2F3 Kegg: 1871 H-InvDB: E2F3

    (According to HUGE)
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    HUGE: KIAA0075

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for E2F3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for E2F3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/e2f3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for E2F3 gene:
    Search GeneIP for patents involving E2F3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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