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E2F3 Gene

protein-coding GIFtS: 65

GC06P020510

E2F transcription factor 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp686C18211 ^²
E2F-3 ^², ³
KIAA0075 ^², ³
MGC104598 ^²
OTTHUMP00000018012 ^²

Descriptions
E2F transcription factor 3 ^²

External Ids
HGNC: 3115¹
Entrez Gene: 1871²
UniProtKB: O00716³
Ensembl: ENSG00000112242⁷

Search outside databases for aliases for E2F3 gene

Previous GC identifer: GC06P020459

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for E2F3:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F

family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins

and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins

contain several evolutionally conserved domains found in most members of the family. These domains

include a DNA binding domain, a dimerization domain which determines interaction with the

differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in

acidic amino acids, and a tumor suppressor protein association domain which is embedded within the

transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional

cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a

cell-cycle dependent manner. [provided by RefSeq]

UniProtKB/Swiss-Prot: E2F3_HUMAN, O00716

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to

RB1 protein, in a cell-cycle dependent manner

Gene Wiki entry for E2F3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the E2F3 gene

Entrez Gene cytogenetic band: 6p22 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22

E2F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P020510: (about GC identifiers)

Start:	20,510,377 bp from pter
End:	20,601,921 bp from pter
Size:	91,545 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: E2F3_HUMAN, O00716 (See protein sequence)

Recommended Name: Transcription factor E2F3

Size: 465 amino acids; 49162 Da

Subunit: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to

E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that

inhibit the E2F transactivation domain. Binds EAPP

Subcellular location: Nucleus

Secondary accessions: Q15000 Q9BZ44

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001940.1

ENSEMBL proteins:

ENSP00000262904 ENSP00000367914

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (E2F3)
	Human Recombinant Proteins from Abnova (E2F3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	9190208
GO:0005667	transcription factor complex	IEA	--

About this table

Antibodies for E2F3:

	Invitrogen Antibodies for E2F3
	Millipore Mono- and Polyclonal Antibodies for the study of E2F3
	Sigma-Aldrich Antibody Arrays and Antibodies for E2F3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (E2F3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (E2F3)
	Novus Biologicals Antibodies for E2F3

Assays for E2F3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O00716

ProtoNet protein and cluster: O00716

1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

UniProtKB/Swiss-Prot: E2F3_HUMAN, O00716

Similarity: Belongs to the E2F/DP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F3)
		Millipore RNAi Products for the Analysis of E2F3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (E2F3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001949

Applied Biosystems Silencer® siRNAs for E2F3

Sigma-Aldrich siRNA for E2F3

Sigma-Aldrich shRNA Panels and shRNA for E2F3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for E2F3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001949
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001949
untagged cDNA clone in CMV expression vector: NM_001949

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001949

UniProtKB/Swiss-Prot: E2F3_HUMAN, O00716

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to

RB1 protein, in a cell-cycle dependent manner

Genatlas biochemistry entry for E2F3:

transcription factor E2F-like 3,involved in cell proliferation,controlling genes regulating S phase

entry and DNA synthesis,involved in transcription repression in quiescent cell by interaction with

histone deacetylase

15/21 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for E2f3) (see all 21 ):

	adipose tissue	behavior/neurological	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	nervous system	no phenotypic analysis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	8246996
GO:0005515	protein binding	IPI	17438371

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for E2F3 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Cell Cycle Regulation by BTG Family Proteins
Chronic Myeloid Leukemia Signaling
Glioma Signaling
Cell Cycle: G1/S Checkpoint Regulation
Molecular Mechanisms of Cancer

GeneDecks E2F3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for E2F3

5 Interacting proteins for E2F3 (O00716^{1, 2}) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
E7 E7 (xeno) P06465¹ EBI-765551, EBI-963841
Sp1 Sp1 (xeno) O89090¹ EBI-765551, EBI-645192
RB1 P06400² MINT-6628399 MINT-4793635
MYBL2 P10244² MINT-4053806
-- P03129² MINT-73499
About this table
4 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006350 transcription IEA --
GO:0006355 regulation of transcription, DNA-dependent IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS 8246996
GO:0007049 cell cycle IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for E2F3
1 Novoseek chemical compound relationship for E2F3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	0.00	1	11159908 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F3)
		Millipore RNAi Products for the Analysis of E2F3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (E2F3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001949

Sigma-Aldrich siRNA for E2F3

Sigma-Aldrich shRNA Panels and shRNA for E2F3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001949

REFSEQ mRNAs for E2F3 gene:

NM_001949.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001949

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001949
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001949
                                 untagged cDNA clone in CMV expression vector: NM_001949

Additional cDNA sequence: BC099908.1

7 DOTS entries:

DT.95157544 DT.316226 DT.91876360 DT.121337303 DT.100764715 DT.97799967 DT.99947754

24/147 AceView cDNA sequences (see all 147 ):

CA414397 Y10479 BQ436237 AA190904 BX643551 BM802347 AI640363 BM973662

AW043596 NM_001949 AA418827 D38550 AA552312 AW135917 AI148191 AI700195

AU131847 CK905775 BU166423 BM699999 AW518742 AI159954 BM669957 BU633769

highest scoring ESTs for E2F3:

D38550 AA075300 AA146763 AA146764 AA146874 AA146875 AA190904 AA191311 AA337886 AA352328

Unigene Clusters for E2F3:

E2F transcription factor 3

Hs.269408 [show with all ESTs], Hs.703174 [show with all ESTs]

Unigene Representative Sequences: NM_001949, BC099908

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for E2F3

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b
SP1:			-		-																-
SP2:
SP3:
SP4:									-				-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for E2F3

2 Ensembl transcripts including schematic representations:

ENST00000346618 ENST00000378646

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

E2F3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for E2F3

¹ / ² / ³

5 probe-sets matching E2F3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41632_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D38550	1.00	1.00	1.00	1
203693_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001949	0.60	1.00	0.82	1
203692_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI640363	0.80	1.00	0.91	1
203693_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203692_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.269408 Hs.703174
Expression variation in blood from EXPOLDB for E2F3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for E2F3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	E2F3¹	--	E2F transcription factor 3	96.26(n) 97.84(a)	541184 XM_614932.3 XP_614932.2
rat (Rattus norvegicus)	E2f3¹	--	E2F transcription factor 3	94.62(n) 97.76(a)	291105 XM_214476.4 XP_214476.4
mouse (Mus musculus)	E2f3^{1, 5}	13⁵	E2F transcription factor 3^{1, 5}	93.14(n)¹ 95.84(a)¹	13557¹ NM_010093.2¹ NP_034223.1¹ AA866903⁵ AF015948⁵ (see all 18)
chicken (Gallus gallus)	E2F3¹	--	E2F transcription factor 3	75.18(n) 78.87(a)	420824 XM_418915.2 XP_418915.2
zebrafish (Danio rerio)	57061996²	--	--	71.43(n)	325010 57061996

About this table Species with no ortholog for E2F3

ENSEMBL Gene Tree for E2F3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for E2F3 gene

E2F1² E2F2²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/469 NCBI SNPs in E2F3 are shown (see all 469 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 157)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs749215^1,2	A,C,F,H	20509888(-)	`CATCAT/CGGTTA`	1	--	ng5¹		11		MN EU EA WA NA	1204
	rs4134990^1,2	C,F,H	20601966(+)	`TGCTCC/GTCTAT`	1	--	ng3¹		18		NS EU EA WA NA	1332
--	rs4134986^1,2	C,F,H	20600386(+)	`AACCAC/GAAGAG`	1	--	ut3¹ ese³		8		NS EU EA WA NA	724
--	rs1042317^1,2	A,C,F	20600974(+)	`CTGGGC/TTTAAC`	1	--	ut3¹		8		NS MN	1018
	rs4134982^1,2	C,F,H	20598407(+)	`ATAGCG/AATTGC`	1	N/D	mis¹		5		NS EU EA WA	584
--	rs2031109^1,2	C,F	20601988(-)	`GAAAAA/TGAAAA`	1	--	ng3¹		1		NS	160
--	rs9465729^1,2	A,C	20508517(+)	`GTCACC/TTCTAC`	1	--	ng5¹		0	--	--	--	--
--	rs4134984^1,2	F	20599372(+)	`TCCCCC/TGTCCC`	1	--	ut3¹ ese³		1		NS	176
	rs4134973^1,2	H	20596353(+)	`CCCAAG/AGGCCC`	1	R/G	mis¹		5		NS EU EA WA	586
--	rs4134991^1,2	F	20601980(+)	`TTGAAT/CTTTTT`	1	--	ng3¹		1		NS	172

About this table

HapMap Linkage Disequilibrium images for E2F3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600427

7 Novoseek disease relationships for E2F3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	79.02	10	16180235 (3), 16007192 (2), 17251444 (1), 18541154 (1) (see all 5)
bladder cancer	43.70	15	16909110 (3), 14716298 (3), 15122326 (2), 16938365 (1) (see all 5)
aggressiveness	34.97	3	16938365 (1), 16909110 (1)
prostate cancer	32.82	15	15184867 (4), 16909110 (4), 16938365 (1), 16180235 (1)
tumors	31.18	20	15122326 (5), 16180235 (2), 16340309 (2), 11883935 (1) (see all 8)
cancer	15.11	2	16938365 (2)
primary tumor	2.11	4	16180235 (1), 17099872 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/98 PubMed articles for E2F3 gene (see all 98 ):

The retinoblastoma protein binds to a family of E2F transcription factors. (PubMed id 8246996)^{2, 3, 4} Lees J.A....Helin K. (1993)
EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. (PubMed id 15716352)^{3, 4} Novy M.... Rotheneder H. (2005)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)^{3, 4} Nomura N....Tabata S. (1994)
E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. (PubMed id 15122326)^{1, 3} Oeggerli M....Sauter G. (2004)
Role of E2F3 expression in modulating cellular proliferation rate in human bladder and prostate cancer cells. (PubMed id 16909110)^{1, 3} Olsson A.Y....Cooper C.S. (2007)
Nuclear overexpression of the E2F3 transcription factor in human lung cancer. (PubMed id 16938365)^{1, 3} Cooper C.S....Cheng S.J. (2006)
Expression analysis of 6p22 genomic gain in retinoblastoma. (PubMed id 16180235)^{1, 3} Orlic M....Gallie B.L. (2006)
Amplification and overexpression of E2F3 in human bladder cancer. (PubMed id 14716298)^{1, 3} Feber A....Cooper C.S. (2004)
Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. (PubMed id 12748276)^{1, 3} Giangrande P.H....Nevins J.R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1871	HGNC: 3115	AceView: E2F3	Ensembl:ENSG00000112242	euGenes: HUgn1871
ECgene: E2F3	H-InvDB: E2F3

(According to HUGE)
About This Section

HUGE: KIAA0075

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for E2F3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/e2f3/

Licensable Technologies for E2F3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for E2F3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for E2F3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for E2F3		Antibodies for E2F3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for E2F3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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E2F3 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for E2F3

Summaries
for E2F3

Genomic Location
for E2F3

Proteins
for E2F3

Protein Domains/
Families
for E2F3

Gene Function
for E2F3

Pathways & Interactions
for E2F3

Drugs & Compounds
for E2F3

Transcripts
for E2F3

Expression
for E2F3

Orthologs
for E2F3

Paralogs
for E2F3

SNPs/Variants
for E2F3

Disorders & Mutations
for E2F3

Medical News
for E2F3

Publications
for E2F3

Search for E2F3

Genome Databases showing E2F3

Other Databases showing E2F3

Specialized Databases showing E2F3

Licensable Technologies
for E2F3

Services
for E2F3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

E2F3 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor E2F3

Summariesfor E2F3

Genomic Locationfor E2F3

Proteinsfor E2F3

Protein Domains/Familiesfor E2F3

Gene Functionfor E2F3

Pathways & Interactionsfor E2F3

Drugs & Compoundsfor E2F3

Transcriptsfor E2F3

Expression for E2F3

Orthologsfor E2F3

Paralogsfor E2F3

SNPs/Variantsfor E2F3

Disorders & Mutationsfor E2F3

Medical Newsfor E2F3

Publicationsfor E2F3

Search for E2F3

Genome Databases showing E2F3

Other Databases showing E2F3

Specialized Databases showing E2F3

Licensable Technologiesfor E2F3

Servicesfor E2F3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for E2F3

Summaries
for E2F3

Genomic Location
for E2F3

Proteins
for E2F3

Protein Domains/
Families
for E2F3

Gene Function
for E2F3

Pathways & Interactions
for E2F3

Drugs & Compounds
for E2F3

Transcripts
for E2F3

Expression
for E2F3

Orthologs
for E2F3

Paralogs
for E2F3

SNPs/Variants
for E2F3

Disorders & Mutations
for E2F3

Medical News
for E2F3

Publications
for E2F3

Licensable Technologies
for E2F3

Services
for E2F3