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E2F2 Gene

protein-coding GIFtS: 68

GC01M023705

E2F transcription factor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
E2F-2 ^¹, ², ³
OTTHUMP00000003257 ^²

Descriptions
E2F transcription factor 2 ^²

External Ids
HGNC: 3114¹
Entrez Gene: 1870²
UniProtKB: Q14209³
Ensembl: ENSG00000007968⁷

Search outside databases for aliases for E2F2 gene

Previous GC identifers: GC01M023394 GC01M022908 GC01M023302 GC01M023578

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for E2F2:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F

family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins

and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins

contain several evolutionally conserved domains found in most members of the family. These domains

include a DNA binding domain, a dimerization domain which determines interaction with the

differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in

acidic amino acids, and a tumor suppressor protein association domain which is embedded within the

transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional

cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a

cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by

RefSeq]

UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to

RB1 protein, in a cell-cycle dependent manner

Gene Wiki entry for E2F2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the E2F2 gene

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36

E2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M023705: (about GC identifiers)

Start:	23,705,509 bp from pter
End:	23,730,300 bp from pter
Size:	24,792 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209 (See protein sequence)

Recommended Name: Transcription factor E2F2

Size: 437 amino acids; 47506 Da

Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family

members. The E2F-2 complex binds specifically hypophosphorylated retinoblastoma protein RB1.

During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the

DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A,

T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex.

Binds EAPP

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1N4M (3D)

Secondary accessions: B2R9W1 Q7Z6H1

Post-translational modifications:

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004082.1

ENSEMBL proteins:

ENSP00000355249

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (E2F2)
	Human Recombinant Proteins from Abnova (E2F2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	9190208
GO:0005667	transcription factor complex	IEA	--

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Antibodies for E2F2:

	Invitrogen Antibodies for E2F2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for E2F2
	R&D Systems Antibodies for E2F2 (E2F-2)
	Antibodies from Abcam (E2F2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (E2F2)
	Novus Biologicals Antibodies for E2F2

Assays for E2F2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14209

ProtoNet protein and cluster: Q14209

1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209

Similarity: Belongs to the E2F/DP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E2F2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004091

Applied Biosystems Silencer® siRNAs for E2F2

Sigma-Aldrich siRNA for E2F2

Sigma-Aldrich shRNA for E2F2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for E2F2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004091
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004091
untagged cDNA clones in CMV expression vector (see all 2): BC007609

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004091

UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to

RB1 protein, in a cell-cycle dependent manner

Genatlas biochemistry entry for E2F2:

transcription factor E2F-like 2,involved in cell proliferation,controlling genes regulating S phase

entry and DNA synthesis

13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for E2f2):

cellular	growth/size	hematopoietic system	immune system	lethality-prenatal/perinatal
life span-post-weaning/aging	liver/biliary system	nervous system	normal	renal/urinary system
respiratory system	skin/coat/nails	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	8246995
GO:0003702	RNA polymerase II transcription factor activity	TAS	8246996
GO:0005515	protein binding	IPI	8657141

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for E2F2 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Cell Cycle: G1/S Checkpoint Regulation
Role of CHK Proteins in Cell Cycle Checkpoint Control
Cell Cycle Regulation by BTG Family Proteins
Molecular Mechanisms of Cancer
Chronic Myeloid Leukemia Signaling

GeneDecks E2F2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for E2F2

5/57 Interacting proteins for E2F2 (ENSP00000355249³ Q14209^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RB1	P06400²	STRING (score=.999) MINT-4793621 MINT-4793646
Sp1 Sp1 (xeno)	O89090¹	EBI-718476, EBI-645192
MCPH1	Q8NEM0²	MINT-6804894
TFDP1	ENSP00000364519³	STRING (score=.996)
RBL1	ENSP00000362768³	STRING (score=.98)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	8246996
GO:0006915	apoptosis	IEA	--
GO:0051726	regulation of cell cycle	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for E2F2
2 Novoseek chemical compound relationships for E2F2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dihydrofolate	45.77	1	9671466 (1)
oligonucleotide	0.19	1	11159908 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (E2F2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004091

Sigma-Aldrich siRNA for E2F2

Sigma-Aldrich shRNA for E2F2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004091

REFSEQ mRNAs for E2F2 gene:

NM_004091.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004091

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004091
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004091
                                 untagged cDNA clones in CMV expression vector (see all 2): BC007609

Additional cDNA sequence:

AF086395.1 AK092799.1 AK313939.1 BC007609.1 BC053676.1 BT019523.1 L22846.1

5 DOTS entries:

DT.409341 DT.97806337 DT.95165608 DT.95165607 DT.121371445

24/86 AceView cDNA sequences (see all 86 ):

AW474186 AF086395 BU184108 BC007609 AA380435 BQ059687 CN481365 AI494253

L22846 BE257610 AI362968 BU167730 BQ059440 AW137640 NM_004091 BE221639

BM476248 AW673479 BM832308 BQ435306 BM916950 BE513711 BX097125 AW248585

highest scoring ESTs for E2F2:

L22846 AI082535 AI419844 BU184108 AA380435 AA677720 AA779186 AF086395 AI140298 AI141221

Unigene Cluster for E2F2:

E2F transcription factor 2

Hs.194333 [show with all ESTs]

Unigene Representative Sequence: NM_004091

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for E2F2

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8
SP1:
SP2:					-
SP3:							-

About this scheme

ECgene alternative splicing isoforms for E2F2

1 Ensembl transcript including schematic representation:

ENST00000361729

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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E2F2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for E2F2

¹ / ² / ³

10 probe-sets matching E2F2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2068_s_at²^{, 3}	U95-A	1	1.00	1.00	0.36	0.30	L22846	1.00	0.87	0.94	1
73591_at²^{, 3}	U95-D	1	1.00	1.00	0.73	1.21	AI869671	0.40	1.00	0.76	1
84129_at²^{, 3}	U95-D	1	1.00	1.00	0.52	0.86	AI419844	0.80	1.00	0.91	1
53663_at²^{, 3}	U95-B	1	0.94	1.00	0.92	0.96	AI082535	0.80	1.00	0.91	1
228361_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL561296	0.40	1.00	0.76	1
207042_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004091	0.60	1.00	0.82	1
235582_at²^{, 3}	U133-B	1	0.64	1.00	--	--	BG388715	0.40	1.00	0.76	1
228361_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207042_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235582_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

GeneDecks E2F2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAGCCTCCT

SOURCE GeneReport for Unigene cluster: Hs.194333
Expression variation in blood from EXPOLDB for E2F2
UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209
Tissue specificity: Highest level of expression is found in placenta, low levels are found in lung.
Found as well in many immortalized cell lines derived from tumor samples

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for E2F2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	E2F2¹	--	E2F transcription factor 2	99.62(n) 99.54(a)	469153 XM_524538.2 XP_524538.2
cow (Bos taurus)	E2F2¹	--	E2F transcription factor 2	87.07(n) 88.09(a)	617024 XM_869196.1 XP_874289.1
mouse (Mus musculus)	E2f2^{1, 5}	4⁵	E2F transcription factor 2^{1, 5}	84.44(n)¹ 83.98(a)¹	242705¹ NM_177733.3¹ NP_808401.1¹ AI048712⁵ AI553619⁵ (see all 12)
fruit fly (Drosophila melanogaster)	E2f³	93E6--7	positive regulation of nurse cell apoptosis DNA more	43(a)	--
rice (Oryza sativa)	AB041725.1²	--	--	72.52(n)	AB041725.1

About this table Species with no ortholog for E2F2

ENSEMBL Gene Tree for E2F2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for E2F2 gene

E2F1² E2F3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/228 NCBI SNPs in E2F2 are shown (see all 228 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 84)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6667575^1,2	A,C,F,H	23732108(+)	`TCTACG/ATATCT`	1	--	ng3¹		12		EU EA WA NA	1036
	rs2075993^1,2	A,C,F,H	23708951(+)	`CAGGCA/GGGGCC`	1	--	ut3¹		8		NS NA EU EA WA	732
	rs2742976^1,2	A,C,F,H	23730589(+)	`GGGATG/TCACAG`	1	--	ng3¹		6		NS EA EU WA	2094
	rs2742971^1,2	A,C,F	23708305(+)	`GGCCAA/GGAACA`	1	--	ut3¹		1		NS	176
	rs3820028^1,2	C,F,H	23707073(-)	`GATCTC/TGTTTG`	1	--	ut3¹ ese³		8		EU EA WA NA	780
	rs2075995^1,2	C,F,H	23720051(+)	`ATGAGC/ATGGTC`	1	H/Q	mis¹		11		MN NS EU EA WA NA	1132
	rs2229297^1,2	C,F,H	23720116(-)	`GACCTG/AGGAAG`	1	R/G	mis¹		10		MN NS EU EA WA	1062
	rs3218121^1,2	C,F,H	23730904(-)	`ggtgcC/Ttggca`	1	--	ng3¹		5		NS EU EA WA	594
	rs3218208^1,2	F,H	23708817(-)	`CCAGCC/TGGCAG`	1	--	ut3¹ ese³		5		NS EU EA WA	596
	rs2811970^1,2	A,C	23707225(+)	`GCTGAC/TCACTC`	1	--	ut3¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for E2F2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600426

2 Novoseek disease relationships for E2F2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	23.79	3	11883935 (1), 18316477 (1), 17200349 (1)
ovarian cancer	18.72	1	16721044 (1)

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Human Genome Epidemiology Navigator: E2F2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/92 PubMed articles for E2F2 gene (see all 92 ):

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. (PubMed id 8246995)^{2, 3, 4} Ivey-Hoyle M....Heimbrook D.C. (1993)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. (PubMed id 15716352)^{3, 4} Novy M.... Rotheneder H. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. (PubMed id 12502741)^{3, 4} Lee C.... Cho Y. (2002)
The retinoblastoma protein binds to a family of E2F transcription factors. (PubMed id 8246996)^{2, 3} Lees J.A....Helin K. (1993)
HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs. (PubMed id 15861133)^{1, 3} Longworth M.S....Laimins L.A. (2005)
Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. (PubMed id 12411495)^{1, 3} Schlisio S....Nevins J.R. (2002)
An E2F/miR-20a autoregulatory feedback loop. (PubMed id 17135249)^{1, 3} Sylvestre Y....Chartrand P. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1870	HGNC: 3114	AceView: E2F2	Ensembl:ENSG00000007968	euGenes: HUgn1870
ECgene: E2F2	H-InvDB: E2F2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for E2F2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/e2f2/

Licensable Technologies for E2F2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for E2F2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for E2F2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for E2F2		Antibodies for E2F2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for E2F2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
E2F2 Gene at Home site.
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E2F2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for E2F2

Summaries
for E2F2

Genomic Location
for E2F2

Proteins
for E2F2

Protein Domains/
Families
for E2F2

Gene Function
for E2F2

Pathways & Interactions
for E2F2

Drugs & Compounds
for E2F2

Transcripts
for E2F2

Expression
for E2F2

Orthologs
for E2F2

Paralogs
for E2F2

SNPs/Variants
for E2F2

Disorders & Mutations
for E2F2

Medical News
for E2F2

Publications
for E2F2

Search for E2F2

Genome Databases showing E2F2

Other Databases showing E2F2

Specialized Databases showing E2F2

Licensable Technologies
for E2F2

Services
for E2F2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

E2F2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor E2F2

Summariesfor E2F2

Genomic Locationfor E2F2

Proteinsfor E2F2

Protein Domains/Familiesfor E2F2

Gene Functionfor E2F2

Pathways & Interactionsfor E2F2

Drugs & Compoundsfor E2F2

Transcriptsfor E2F2

Expression for E2F2

Orthologsfor E2F2

Paralogsfor E2F2

SNPs/Variantsfor E2F2

Disorders & Mutationsfor E2F2

Medical Newsfor E2F2

Publicationsfor E2F2

Search for E2F2

Genome Databases showing E2F2

Other Databases showing E2F2

Specialized Databases showing E2F2

Licensable Technologiesfor E2F2

Servicesfor E2F2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for E2F2

Summaries
for E2F2

Genomic Location
for E2F2

Proteins
for E2F2

Protein Domains/
Families
for E2F2

Gene Function
for E2F2

Pathways & Interactions
for E2F2

Drugs & Compounds
for E2F2

Transcripts
for E2F2

Expression
for E2F2

Orthologs
for E2F2

Paralogs
for E2F2

SNPs/Variants
for E2F2

Disorders & Mutations
for E2F2

Medical News
for E2F2

Publications
for E2F2

Licensable Technologies
for E2F2

Services
for E2F2