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Aliases for E2F2 Gene

Aliases for E2F2 Gene

  • E2F Transcription Factor 2 2 3 5
  • E2F-2 3 4
  • Transcription Factor E2F2 3

External Ids for E2F2 Gene

Previous GeneCards Identifiers for E2F2 Gene

  • GC01M023394
  • GC01M022908
  • GC01M023302
  • GC01M023578
  • GC01M023705
  • GC01M023832
  • GC01M022083

Summaries for E2F2 Gene

Entrez Gene Summary for E2F2 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F2 Gene

E2F2 (E2F Transcription Factor 2) is a Protein Coding gene. Diseases associated with E2F2 include Retinoblastoma and Retinal Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Glioma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter binding. An important paralog of this gene is E2F3.

UniProtKB/Swiss-Prot for E2F2 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

Gene Wiki entry for E2F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F2 Gene

Genomics for E2F2 Gene

Regulatory Elements for E2F2 Gene

Enhancers for E2F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F023584 1.5 FANTOM5 Ensembl ENCODE 12.7 -63.0 -63035 18.7 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A ZNF766 ZNF143 FOS ZNF436-AS1 LINC01355 PNRC2 E2F2 ID3 ZNF436 ASAP3 ENSG00000201405 STPG1 RPL11
GH01F023506 0.4 ENCODE 12.5 +24.3 24327 0.2 E2F2 ID3 PIR36355 ASAP3
GH01F023497 1.1 Ensembl ENCODE 12.2 +33.7 33666 0.8 HDGF ELF3 CBX3 ARID4B ZNF48 ZBTB40 ZNF2 RAD21 SLC30A9 ZNF143 TCEA3 E2F2 ID3 MDS2 PIR36355 ASAP3
GH01F023553 1.4 FANTOM5 ENCODE 12 -28.0 -27971 12.2 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC TBX21 ZNF436-AS1 LINC01355 MDS2 E2F2 ASAP3 ID3 ZNF436 TCEA3 GC01M023560 LOC105376859
GH01F023634 1.4 FANTOM5 Ensembl ENCODE 11.4 -104.0 -103958 2.0 HDGF ARNT WRNIP1 ARID4B SIN3A ZNF2 ZNF121 GLIS2 ZNF143 KLF7 ID3 MDS2 E2F2 ASAP3 GC01P023610 LOC729856
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around E2F2 on UCSC Golden Path with GeneCards custom track

Promoters for E2F2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001742676 250 1601 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CBX5 SP3 NFYC
ENSR00001518311 1550 201 NR4A1 ZFP37 ZBTB7A ARID1B ZFHX2 POLR2A NCOR1 ADNP IKZF1 ZNF341

Genomic Location for E2F2 Gene

Chromosome:
1
Start:
23,505,974 bp from pter
End:
23,531,250 bp from pter
Size:
25,277 bases
Orientation:
Minus strand

Genomic View for E2F2 Gene

Genes around E2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F2 Gene

Proteins for E2F2 Gene

  • Protein details for E2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14209-E2F2_HUMAN
    Recommended name:
    Transcription factor E2F2
    Protein Accession:
    Q14209
    Secondary Accessions:
    • B2R9W1
    • Q7Z6H1

    Protein attributes for E2F2 Gene

    Size:
    437 amino acids
    Molecular mass:
    47506 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active complex. Binds EAPP.

    Three dimensional structures from OCA and Proteopedia for E2F2 Gene

neXtProt entry for E2F2 Gene

Post-translational modifications for E2F2 Gene

  • Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for E2F2 Gene

No data available for DME Specific Peptides for E2F2 Gene

Domains & Families for E2F2 Gene

Gene Families for E2F2 Gene

Suggested Antigen Peptide Sequences for E2F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14209

UniProtKB/Swiss-Prot:

E2F2_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F2: view

Function for E2F2 Gene

Molecular function for E2F2 Gene

GENATLAS Biochemistry:
transcription factor E2F-like 2,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis
UniProtKB/Swiss-Prot Function:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

Gene Ontology (GO) - Molecular Function for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 15735762
GO:0003677 DNA binding TAS 8246995
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,NAS --
GO:0005515 protein binding IPI 16360038
GO:0008134 transcription factor binding IPI 16360038
genes like me logo Genes that share ontologies with E2F2: view
genes like me logo Genes that share phenotypes with E2F2: view

Animal Models for E2F2 Gene

MGI Knock Outs for E2F2:

Animal Model Products

miRNA for E2F2 Gene

miRTarBase miRNAs that target E2F2

Transcription Factor Targets for E2F2 Gene

Selected GeneGlobe predicted Target genes for E2F2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for E2F2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for E2F2 Gene

Localization for E2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F2 Gene COMPARTMENTS Subcellular localization image for E2F2 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with E2F2: view

Pathways & Interactions for E2F2 Gene

genes like me logo Genes that share pathways with E2F2: view

SIGNOR curated interactions for E2F2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS 8246996
GO:0007049 cell cycle IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with E2F2: view

Drugs & Compounds for E2F2 Gene

(1) Drugs for E2F2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HLM006474 Pharma E2F inhibitor 0

(2) Additional Compounds for E2F2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for E2F2 Gene

Compound Action Cas Number
HLM006474 E2F inhibitor 353519-63-8
genes like me logo Genes that share compounds with E2F2: view

Transcripts for E2F2 Gene

Unigene Clusters for E2F2 Gene

E2F transcription factor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for E2F2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1:
SP2: -
SP3: -

Relevant External Links for E2F2 Gene

GeneLoc Exon Structure for
E2F2
ECgene alternative splicing isoforms for
E2F2

Expression for E2F2 Gene

mRNA expression in normal human tissues for E2F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for E2F2 Gene

This gene is overexpressed in Whole Blood (x14.8), Esophagus - Mucosa (x7.1), and Colon - Transverse (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of E2F2 Gene:

E2F2

SOURCE GeneReport for Unigene cluster for E2F2 Gene:

Hs.194333

mRNA Expression by UniProt/SwissProt for E2F2 Gene:

Q14209-E2F2_HUMAN
Tissue specificity: Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
genes like me logo Genes that share expression patterns with E2F2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for E2F2 Gene

Orthologs for E2F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F2 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia E2F2 34 35
  • 88.84 (n)
cow
(Bos Taurus)
Mammalia E2F2 34 35
  • 88.01 (n)
rat
(Rattus norvegicus)
Mammalia E2f2 34
  • 84.36 (n)
mouse
(Mus musculus)
Mammalia E2f2 34 16 35
  • 84.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia E2F2 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F2 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F2 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC568846 34
  • 59.01 (n)
E2F2 35
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta E2f 36 35
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea efl-2 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for E2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for E2F2 Gene

ENSEMBL:
Gene Tree for E2F2 (if available)
TreeFam:
Gene Tree for E2F2 (if available)

Paralogs for E2F2 Gene

Paralogs for E2F2 Gene

(3) SIMAP similar genes for E2F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with E2F2: view

Variants for E2F2 Gene

Sequence variations from dbSNP and Humsavar for E2F2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1057480 -- 23,509,560(-) ACCTC(A/C)TTTGA intron-variant, utr-variant-3-prime
rs10917394 -- 23,506,647(+) CAGGC(A/G)TGTGG intron-variant, utr-variant-3-prime
rs1107081 -- 23,528,396(-) AAGGG(C/T)GTGAC intron-variant, nc-transcript-variant
rs111243020 -- 23,530,136(+) AAAGT(A/C)CCACA intron-variant
rs111334188 -- 23,519,764(+) ATCTC(C/T)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E2F2 Gene

Variant ID Type Subtype PubMed ID
esv3417141 CNV insertion 20981092
nsv834435 CNV loss 17160897

Variation tolerance for E2F2 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.98; 93.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for E2F2 Gene

Human Gene Mutation Database (HGMD)
E2F2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
E2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F2 Gene

Disorders for E2F2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for E2F2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
retinal cancer
  • malignant neoplasm of retina
sensory system cancer
- elite association - COSMIC cancer census association via MalaCards
Search E2F2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for E2F2

Genetic Association Database (GAD)
E2F2
Human Genome Epidemiology (HuGE) Navigator
E2F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
E2F2
genes like me logo Genes that share disorders with E2F2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F2 Gene

Publications for E2F2 Gene

  1. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham J.M. … Goode E.L. (Br. J. Cancer 2009) 3 22 46 64
  2. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. (PMID: 8246995) Ivey-Hoyle M. … Heimbrook D.C. (Mol. Cell. Biol. 1993) 2 3 4 64
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 64
  4. Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors. (PMID: 19142864) Justenhoven C. … Brauch H. (Int. J. Cancer 2009) 3 46 64
  5. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. (PMID: 19690970) Chen J. … Frazier M.L. (Cancer Causes Control 2009) 3 46 64

Products for E2F2 Gene

Sources for E2F2 Gene

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