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E2F2 Gene

protein-coding   GIFtS: 65
GCID: GC01M023832

E2F Transcription Factor 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E2F Transcription Factor 21 2
E2F-22 3
Transcription Factor E2F22

External Ids:    HGNC: 31141   Entrez Gene: 18702   Ensembl: ENSG000000079687   OMIM: 6004265   UniProtKB: Q142093   

Export aliases for E2F2 gene to outside databases

Previous GC identifers: GC01M023394 GC01M022908 GC01M023302 GC01M023578 GC01M023705 GC01M022083


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for E2F2 Gene:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a
crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the
transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved
domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain
which determines interaction with the differentiation regulated transcription factor proteins (DP), a
transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is
embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional
cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent
manner, and it exhibits overall 46% amino acid identity to E2F1. (provided by RefSeq, Jul 2008)

GeneCards Summary for E2F2 Gene:
E2F2 (E2F transcription factor 2) is a protein-coding gene. GO annotations related to this gene include core promoter binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is E2F1.

UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner

Gene Wiki entry for E2F2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the E2F2 gene promoter:
         Max1   USF1   AML1a   USF-1   Sox9   c-Myb   Tal-1beta   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidE2F2 promoter sequence
   Search Chromatin IP Primers for E2F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat E2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36

E2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E2F2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023832:  view genomic region     (about GC identifiers)

Start:
23,832,920 bp from pter      End:
23,857,712 bp from pter
Size:
24,793 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209 (See protein sequence)
Recommended Name: Transcription factor E2F2  
Size: 437 amino acids; 47506 Da
Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The
E2F2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes
phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally
active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing
the active complex. Binds EAPP
1 PDB 3D structure from and Proteopedia for E2F2:
1N4M (3D)    
Secondary accessions: B2R9W1 Q7Z6H1

Explore the universe of human proteins at neXtProt for E2F2: NX_Q14209

Explore proteomics data for E2F2 at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See E2F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004082.1  
    ENSEMBL proteins: 
     ENSP00000355249  
    Reactome Protein details: Q14209

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR011991 WHTH_DNA-bd_dom
     IPR015633 E2F

    Graphical View of Domain Structure for InterPro Entry Q14209

    ProtoNet protein and cluster: Q14209

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209
    Similarity: Belongs to the E2F/DP family


    Find genes that share domains with E2F2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: E2F2_HUMAN, Q14209
    Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
    5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
    regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
    g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner

         Genatlas biochemistry entry for E2F2:
    transcription factor E2F-like 2,involved in cell proliferation,controlling genes regulating S phase entry and DNA
    synthesis

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding IDA15735762
    GO:0003677DNA binding TAS8246995
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16360038
    GO:0008134transcription factor binding IPI16360038
         
    Find genes that share ontologies with E2F2           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for E2f2):
     cellular  growth/size/body  hematopoietic system  immune system  integument 
     liver/biliary system  mortality/aging  nervous system  normal  renal/urinary system 
     respiratory system  vision/eye 

    Find genes that share phenotypes with E2F2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out E2f2tm1Zubi for E2F2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for E2F2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for E2F2

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for E2F2 (see all 1003):
    A4GNT,  AACS,  ABCE1,  ABCF2,  ABCF3,  ABHD11,  ABI2,  ABTB1,  ACOT7,  ADAMTS12

    miRNA
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    hsa-mir-22-3p (MIRT030648), hsa-mir-24-3p (MIRT000122), hsa-mir-98-5p (MIRT001126), hsa-mir-21-5p (MIRT001121), hsa-mir-7-5p (MIRT047757), hsa-mir-125b-5p (MIRT006974), hsa-mir-155-5p (MIRT021062), hsa-mir-331-3p (MIRT043574), hsa-let-7a-5p (MIRT005477), hsa-mir-193b-3p (MIRT016577)

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    Selected qRT-PCR Assays for microRNAs that regulate E2F2 (see all 90):
    hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-761 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidE2F2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    E2F2_HUMAN, Q14209: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with E2F2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for E2F2 About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    Cell Cycle Control by BTG Proteins0.36
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    4CDK-mediated phosphorylation and removal of Cdc6
    Regulation of DNA replication0.93
    DNA Replication Pre-Initiation0.81
    DNA Replication0.92
    Association of licensing factors with the pre-replicative complex0.00
    Assembly of the pre-replicative complex0.89
    CDC6 association with the ORC-origin complex0.00
    M/G1 Transition0.81
    5Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Bladder cancer0.31
    Melanoma0.43


    Find genes that share SuperPaths with E2F2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for E2F2
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for E2F2 (see all 14)
        ErbB2-ErbB3 Heterodimers
    Cell Cycle Control by BTG Proteins
    BRCA1 Pathway
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for E2F2
        Cell cycle Cell cycle (generic schema)

    4 BioSystems Pathways for E2F2
        Cell cycle
    G1 to S cell cycle control
    RB in Cancer
    E2F transcription factor network


    5 Reactome Pathways for E2F2
        Oxidative Stress Induced Senescence
    CDC6 association with the ORC:origin complex
    Oncogene Induced Senescence
    Cyclin D associated events in G1
    Association of licensing factors with the pre-replicative complex


    Selected Kegg Pathways  (Kegg details for E2F2) (see all 13):
        Cell cycle
    Hepatitis B
    HTLV-I infection
    Pathways in cancer
    MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for E2F2
    Interactions:

        GeneGlobe Interaction Network for E2F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for E2F2 (Q142091, 2, 3 ENSP000003552494) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCPH1Q8NEM02, 3, ENSP000003429244MINT-6804894 I2D: score=1 STRING: ENSP00000342924
    ENSG00000234507P254403, ENSP000004109944I2D: score=2 STRING: ENSP00000410994
    BRD2P254403I2D: score=2 
    ENSG00000215077P254403I2D: score=2 
    ENSG00000234704P254403I2D: score=2 
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS8246996
    GO:0006915apoptotic process ----
    GO:0051726regulation of cell cycle IEA--

    Find genes that share ontologies with E2F2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for E2F2

    2 Novoseek inferred chemical compound relationships for E2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrofolate 44.2 1 9671466 (1)
    oligonucleotide 0 1 11159908 (1)



    Find genes that share compounds with E2F2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for E2F2 gene: 
    NM_004091.3  

    Unigene Cluster for E2F2:

    E2F transcription factor 2
    Hs.194333  [show with all ESTs]
    Unigene Representative Sequence: NM_004091
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361729(uc001bhe.2) ENST00000487237
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    hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-761 hsa-miR-130b
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      QuantiFast Probe-based Assays in human, mouse, rat E2F2

    Additional mRNA sequence: 

    AF086395.1 AK092799.1 AK313939.1 BC007609.1 BC053676.1 BT019523.1 L22846.1 

    5 DOTS entries:

    DT.409341  DT.97806337  DT.95165608  DT.95165607  DT.121371445 

    Selected AceView cDNA sequences (see all 86):

    BE513711 AW673479 CN481365 BQ059687 AA380435 BE221639 AI494253 BC007609 
    BU167730 BM476248 BE257610 BQ435306 AW137640 L22846 BQ059440 NM_004091 
    AF086395 AI362968 BU184108 BM832308 AW474186 BM916950 BM542474 BU602197 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for E2F2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                                                                  
    SP2:              -                                                   
    SP3:                    -                                             


    ECgene alternative splicing isoforms for E2F2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    E2F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGCCTCCT
    E2F2 Expression
    About this image


    E2F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    E2F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    E2F2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194333

    UniProtKB/Swiss-Prot: E2F2_HUMAN, Q14209
    Tissue specificity: Highest level of expression is found in placenta, low levels are found in lung. Found as well
    in many immortalized cell lines derived from tumor samples

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for E2F2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E2f21 , 5 E2F transcription factor 21, 5 84.21(n)1
    83.75(a)1
      4 (68.34 cM)5
    2427051  NM_177733.61  NP_808401.11 
     1361723945 
    chicken
    (Gallus gallus)
    Aves E2F26
    E2F transcription factor 2
    57(a)
    1 ↔ 1
    23(2156714-2160039)
    lizard
    (Anolis carolinensis)
    Reptilia E2F26
    E2F transcription factor 2
    63(a)
    1 ↔ 1
    GL344429.1(27276-34193)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5688461 transcription factor E2F2-like 59.01(n)
    57.66(a)
      568846  XM_003200347.2  XP_003200395.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta E2f3 positive regulation of nurse cell
    apoptosis DNA more
    43(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea efl-26
    Protein EFL-2, isoform a
    18(a)
    1 → many
    II(13406160-13411280) WBGene00001162
    rice
    (Oryza sativa)
    Liliopsida AB041725.12   -- 72.52(n)    AB041725.1 


    ENSEMBL Gene Tree for E2F2 (if available)
    TreeFam Gene Tree for E2F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for E2F2 gene
    E2F12  E2F32  E2F52  E2F42  E2F62  
    3 SIMAP similar genes for E2F2 using alignment to 1 protein entry:     E2F2_HUMAN:
    E2F6    E2F3    E2F1

    Find genes that share paralogs with E2F2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for E2F2 (see all 597)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907817471,2
    --23832614(+) GGACTA/GCAGTT 1 -- ds50010--------
    rs1168056721,2
    F--23832622(+) GTTGGA/GCCCAC 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1807467271,2
    --23832670(+) ACCTTA/TCAGGA 1 -- ds50010--------
    rs1435754431,2
    C--23832815(+) CTGGGC/TAATCA 1 -- ds50010--------
    rs1139353281,2
    C--23832862(+) CCAGCC/TTGCGG 1 -- ds50012Minor allele frequency- T:0.10CSA WA 120
    rs1465144131,2
    C--23832996(+) AGACAC/GGACCA 1 -- ut310--------
    rs1838826681,2
    --23833170(+) CCTCGA/TGGGAG 1 -- ut310--------
    rs1884929001,2
    --23833361(+) AGAACA/GAAGTC 1 -- ut310--------
    rs1813089351,2
    --23833434(+) CCAGCC/TGATCC 1 -- ut310--------
    rs120267681,2
    C,F--23833611(+) TAGGGT/GGGCTG 1 -- ut315Minor allele frequency- G:0.44NA EA 246

    HapMap Linkage Disequilibrium report for E2F2 (23832920 - 23857712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for E2F2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834435CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing E2F2
    DNA2.0 Custom Variant and Variant Library Synthesis for E2F2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600426    OMIM disorders: --


    Find genes that share disorders with E2F2           About GenesLikeMe

    2 Novoseek inferred disease relationships for E2F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 26.3 3 11883935 (1), 18316477 (1), 17200349 (1)
    ovarian cancer 25.2 2 19738611 (1), 16721044 (1)

    Genetic Association Database (GAD): E2F2
    Human Genome Epidemiology (HuGE) Navigator: E2F2 (7 documents)

    Export disorders for E2F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for E2F2 gene, integrated from 10 sources (see all 115):
    (articles sorted by number of sources associating them with E2F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. (PubMed id 8246995)1, 2, 3 Ivey-Hoyle M....Heimbrook D.C. (Mol. Cell. Biol. 1993)
    2. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4, 9 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    4. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. (PubMed id 19690970)1, 4 Chen J....Frazier M.L. (amp 2009)
    5. Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors. (PubMed id 19142864)1, 4 Justenhoven C....Brauch H. (Int. J. Cancer 2009)
    6. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. (PubMed id 16360038)1, 2 Rubin S.M.... Pavletich N.P. (Cell 2005)
    9. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. (PubMed id 15716352)1, 2 Novy M.... Rotheneder H. (Mol. Biol. Cell 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1870 HGNC: 3114 AceView: E2F2 Ensembl:ENSG00000007968 euGenes: HUgn1870
    ECgene: E2F2 Kegg: 1870 H-InvDB: E2F2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for E2F2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for E2F2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/e2f2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for E2F2 gene:
    Search GeneIP for patents involving E2F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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