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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

E2F1 Gene

protein-coding   GIFtS: 67
GCID: GC20M032263

E2F Transcription Factor 1


(Previous symbol: RBBP3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
E2F Transcription Factor 11 2     PBR32 3
RBBP31 2 3     RBAP-12 3
PRB-Binding Protein E2F-12 3     RBBP-32 3
Retinoblastoma-Associated Protein 12 3     RBAP12
Retinoblastoma-Binding Protein 32 3     RBP32
E2F-12 3     Transcription Factor E2F12

External Ids:    HGNC: 31131   Entrez Gene: 18692   Ensembl: ENSG000001014127   OMIM: 1899715   UniProtKB: Q010943   

Export aliases for E2F1 gene to outside databases

Previous GC identifers: GC20M032022 GC20M031981 GC20M032931 GC20M032979 GC20M031727 GC20M029049


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for E2F1 Gene:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a
crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the
transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved
domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain
which determines interaction with the differentiation regulated transcription factor proteins (DP), a
transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is
embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional
cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent
manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. (provided by RefSeq, Jul
2008)

GeneCards Summary for E2F1 Gene: 
E2F1 (E2F transcription factor 1) is a protein-coding gene. Diseases associated with E2F1 include retinoblastoma, and meninges hemangiopericytoma, and among its related super-pathways are Glioma and Cyclins and Cell Cycle Regulation. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is E2F3.

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell
proliferation and TP53/p53-dependent apoptosis

Gene Wiki entry for E2F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the E2F1 gene promoter:
         Sp1   GCNF-1   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidE2F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for E2F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat E2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11

E2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E2F1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M032263:  view genomic region     (about GC identifiers)

Start:
32,263,292 bp from pter      End:
32,274,210 bp from pter
Size:
10,919 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094 (See protein sequence)
Recommended Name: Transcription factor E2F1  
Size: 437 amino acids; 46920 Da
Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The
E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes
phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally
active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing
the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase
complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with
TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional
activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional
activity. Interacts with BIRC2/c-IAP1 (via BIR domains). Interacts with human cytomegalovirus/HHV-5 protein UL123
Subcellular location: Nucleus
Sequence caution: Sequence=AAB24289.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for E2F1:
1H24 (3D)        1O9K (3D)        2AZE (3D)    
Secondary accessions: Q13143 Q92768

Explore the universe of human proteins at neXtProt for E2F1: NX_Q01094

Explore proteomics data for E2F1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon
    DNA damage and regulates its effect on transcription and apoptosis
  • UniProtKB: Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by
    retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation.
    Acetylated by P/CAF/KAT2B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01094

  • E2F1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    E2F1 Protein Expression
    REFSEQ proteins: NP_005216.1  
    ENSEMBL proteins: 
     ENSP00000345571  
    Reactome Protein details: Q01094
    Human Recombinant Protein Products for E2F1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for E2F1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12717439
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----
    GO:0005737cytoplasm IEA--
    GO:0035189Rb-E2F complex IDA--

    E2F1 for ontologies           About GeneDecksing



    E2F1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR011991 WHTH_DNA-bd_dom
     IPR015633 E2F

    Graphical View of Domain Structure for InterPro Entry Q01094

    ProtoNet protein and cluster: Q01094

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094
    Similarity: Belongs to the E2F/DP family


    E2F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: E2F1_HUMAN, Q01094
    Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
    5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
    regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
    G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell
    proliferation and TP53/p53-dependent apoptosis
    Enzyme regulation: BIRC2/c-IAP1 stimulates its transcriptional activity

         Genatlas biochemistry entry for E2F1:
    transcription factor E2F1,involved in cell proliferation and apoptosis,controlling genes regulating S phase entry
    and DNA synthesis,downregulated in post-mitotic neurons by interaction with NDN and proteolysis through the
    ubiquitin-proteasome pathway

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding IDA15735762
    GO:0003677DNA binding IMP11418595
    GO:0003700sequence-specific DNA binding transcription factor activity TAS11418595
    GO:0003714transcription corepressor activity TAS10199402
    GO:0005515protein binding IPI11418595
         
    E2F1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for E2F1:
     Decreased homologous recombina  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty  Increased G1 DNA content 

         15/22 MGI mutant phenotypes (inferred from 2 alleles(MGI details for E2f1) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 

    E2F1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for E2F1: E2f1tm1Njd E2f1tm1Meg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for E2F1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for E2F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for E2F1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for E2F1 

    10/1405 SABiosciences Target genes for E2F1 (see all 1405):
    A4GNT AACS AARS ABCE1 ABCF2 ABCF3 ABHD11 ABI2 ABTB1 ACOT7

    miRNA
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    hsa-mir-149 (MIRT005356), hsa-mir-17 (MIRT002935), hsa-mir-93 (MIRT002472), hsa-mir-106a (MIRT000374), hsa-let-7a (MIRT003904), hsa-mir-20a (MIRT000180), hsa-mir-106b (MIRT003045), hsa-mir-23b (MIRT003424), hsa-mir-330-3p (MIRT000718), hsa-mir-126 (MIRT005020), hsa-mir-223 (MIRT000632), hsa-mir-98 (MIRT001124), hsa-mir-21 (MIRT001191), hsa-mir-34a (MIRT004821)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat E2F1
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate E2F1 (see all 48):
    hsa-miR-3678-3p hsa-miR-136 hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-1258 hsa-miR-519a hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidE2F1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for E2F1 About   (see all 46)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    Cell Cycle Control by BTG Proteins0.36
    3Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation0.39
    Cell cycle ESR1 regulation of G1/S transition0.33
    Cell cycle Cell cycle (generic schema)0.38
    G0 and Early G10.31
    Cell cycle Regulation of G1/S transition (part 2)0.38
    4Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    5Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for E2F1 (see all 8)
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Start of DNA replication in early S phase
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation

    1 R&D Systems Pathway for E2F1
        Akt Signaling Pathway

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for E2F1 (see all 15)
        ErbB2-ErbB3 Heterodimers
    Cell Cycle Control by BTG Proteins
    BRCA1 Pathway
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for E2F1
        Cell Cycle / Checkpoint Control

    5/8 GeneGo (Thomson Reuters) Pathways for E2F1 (see all 8)
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription P53 signaling pathway
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation
    Cell cycle Regulation of G1/S transition (part 2)

    5/19 BioSystems Pathways for E2F1 (see all 19)
        DNA damage response
    Senescence and Autophagy
    Cell cycle
    G1 to S cell cycle control
    Adipogenesis

    5/11        Reactome Pathways for E2F1 (see all 11)
        G1 Phase
    Mitotic G1-G1/S phases
    G0 and Early G1
    Inhibition of replication initiation of damaged DNA by RB1/E2F1
    Cell Cycle


    5/13         Kegg Pathways  (Kegg details for E2F1) (see all 13):
        Cell cycle
    Hepatitis B
    HTLV-I infection
    Pathways in cancer
    MicroRNAs in cancer


    E2F1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for E2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/200 Interacting proteins for E2F1 (Q010941, 2, 3 ENSP000003455714) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCPH1Q8NEM02, 3, ENSP000003429244MINT-6804908 MINT-6804850 MINT-6804878 MINT-6804982 MINT-6804865 MINT-6804968 I2D: score=2 STRING: ENSP00000342924
    BTG3Q142012, 3, ENSP000003446094MINT-5226290 MINT-5226261 MINT-5226306 I2D: score=1 STRING: ENSP00000344609
    SP1P080471, 3, ENSP000003293574EBI-448924,EBI-298336 I2D: score=8 STRING: ENSP00000329357
    DDB2Q924661, 3, ENSP000002569964EBI-448924,EBI-1176171 I2D: score=4 STRING: ENSP00000256996
    CDK7P506131, 3, ENSP000002564434EBI-448924,EBI-1245958 I2D: score=3 STRING: ENSP00000256443
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP12717439
    GO:0000080G1 phase of mitotic cell cycle TAS10199402
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000085G2 phase of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--

    E2F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    E2F1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for E2F1

    10/65 Novoseek inferred chemical compound relationships for E2F1 gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 63.9 19 14612540 (6), 15611646 (1), 15868376 (1), 10851232 (1) (see all 6)
    thymidylate 60.1 20 10811110 (2), 18056168 (2), 10914714 (2), 14654896 (2) (see all 16)
    p202 58.3 3 12646190 (2)
    roscovitine 54 9 10851267 (4), 18458681 (2), 11912154 (2), 15611646 (1)
    dihydrofolate 53.8 17 10823896 (2), 8441401 (1), 9671466 (1), 12965081 (1) (see all 13)
    suberoylanilide hydroxamic acid 49.1 3 16476732 (1), 11250759 (1)
    4-hydroxytamoxifen 45.5 5 16617145 (1), 15897325 (1), 10918503 (1)
    tomudex 43.5 2 9106628 (2)
    vitamin e succinate 41.3 13 15883045 (5), 9205075 (2), 16505104 (1), 15144885 (1)
    butyrolactone i 37.9 1 7838523 (1)

    Search CenterWatch for drugs/clinical trials and news about E2F1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for E2F1 gene: 
    NM_005225.2  

    Unigene Cluster for E2F1:

    E2F transcription factor 1
    Hs.654393  [show with all ESTs]
    Unigene Representative Sequence: NM_005225
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343380(uc002wzu.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF086380.1 BC005098.1 BC050369.2 BC058902.1 M96577.1 S49592.1 

    9 DOTS entries:

    DT.311649  DT.100025819  DT.92427744  DT.100745520  DT.120827205  DT.100708656  DT.100788668  DT.92427743 
    DT.99953894 

    24/140 AceView cDNA sequences (see all 140):

    CR599810 BU680954 BQ057945 BQ054460 S49592 BM766189 AU131577 CR594055 
    BQ653431 F03046 AF086380 BC058902 BE266523 BG740997 BQ069913 BM916982 
    BC005098 BM848627 CA436902 CA430665 BX375969 BU193046 CR594440 BM797776 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for E2F1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                                
    SP2:                          -                     


    ECgene alternative splicing isoforms for E2F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    E2F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGTCAGA
    E2F1 Expression
    About this image


    See E2F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for E2F1

    SOURCE GeneReport for Unigene cluster: Hs.654393
        SABiosciences Expression via Pathway-Focused PCR Arrays including E2F1 (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Liver Cancer in human mouse rat
              Adipogenesis in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for E2F1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E2f11 , 5 E2F transcription factor 11, 5 84.5(n)1
    86.05(a)1
      2 (76.79 cM)5
    135551  NM_007891.41  NP_031917.11 
     1545594075 
    chicken
    (Gallus gallus)
    Aves E2F11 E2F transcription factor 1 69.73(n)
    64.43(a)
      396142  NM_205219.1  NP_990550.1 
    lizard
    (Anolis carolinensis)
    Reptilia E2F16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    4(136781529-136793423)
    zebrafish
    (Danio rerio)
    Actinopterygii E2F16
    E2F transcription factor 1
    47(a)
    1 ↔ 1
    Zv9_NA947(4606-23521)
    fruit fly
    (Drosophila melanogaster)
    Insecta E2f6
    E2F transcription factor
    14(a)
    1 → many
    3R(17446026-17486127)


    ENSEMBL Gene Tree for E2F1 (if available)
    TreeFam Gene Tree for E2F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for E2F1 gene
    E2F32  E2F22  E2F52  E2F42  E2F62  
    2 SIMAP similar genes for E2F1 using alignment to 1 protein entry:     E2F1_HUMAN:
    E2F3    E2F2

    E2F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/276 SNPs in E2F1 are shown (see all 276)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1174230751,2
    F--32264391(+) CAGACC/TCCAGA 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1449210131,2
    --32264527(+) GTCCCC/TCCAAG 1 -- ut310--------
    rs32131781,2
    C,F,H--32264529(-) GGCTTG/AGAGGG 1 -- ut313Minor allele frequency- A:0.01NS NA 278
    rs32131771,2
    C,F,H--32264533(-) ACAGGG/TCTTGG 1 -- ut31 ese315Minor allele frequency- T:0.04NS NA EU 2255
    rs1392314391,2
    C--32264568(+) CCAAAA/GTCACA 2 D syn10--------
    rs1470134051,2
    C,F--32264607(+) TCCTCG/AAGGCC 2 /L syn11Minor allele frequency- A:0.00NA 4232
    rs32131761,2,4
    C,F--32264675(-) TCTCCG/AGCCTC 2 /S /G mis1 ese35Minor allele frequency- A:0.02NS NA 3526
    rs1420098431,2
    F--32264676(+) AGGCCG/AGAGAA 2 /S syn11Minor allele frequency- A:0.00NA 3144
    rs2016071111,2
    C--32264715(+) TCGGCC/TGCCAC 2 A syn10--------
    rs2008256581,2
    --32264812(+) CAGGCC/TGGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for E2F1 (32263292 - 32274210 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for E2F1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833960CNV Loss17160897
    dgv4565n71CNV Loss21882294
    dgv4564n71CNV Loss21882294
    nsv833961CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing E2F1
    DNA2.0 Custom Variant and Variant Library Synthesis for E2F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189971    OMIM disorders: --

    20/93 diseases for E2F1 (see all 93):    About MalaCards
    retinoblastoma    meninges hemangiopericytoma    osteochondroma    hemangiopericytoma
    nijmegen breakage syndrome    gastrointestinal stromal tumor    polyploidy    colon adenocarcinoma
    prolactinoma    clear cell renal cell carcinoma    ataxia telangiectasia    colon cancer
    glioblastoma    ductal carcinoma in situ    osteosarcoma    estrogen-receptor positive breast cancer
    chondrosarcoma    squamous cell carcinoma of the head and neck    meningitis    pituitary adenoma

    1 disease from the University of Copenhagen DISEASES database for E2F1:
    Retinoblastoma

    E2F1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for E2F1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 91.8 162 12610352 (3), 15187102 (2), 8918469 (2), 16230367 (2) (see all 99)
    tumors 65.5 295 12379749 (7), 10340908 (6), 10794484 (5), 17359698 (5) (see all 99)
    cancer 60.9 100 9045954 (3), 10811110 (2), 16243973 (2), 16476732 (2) (see all 64)
    osteosarcoma 44 11 19541929 (2), 15883045 (1), 17001603 (1), 11393276 (1) (see all 7)
    colon cancer 42.1 25 10914714 (4), 12677090 (3), 11705881 (3), 11961668 (2) (see all 12)
    breast cancer 38.8 51 17535433 (5), 15985428 (3), 17201163 (3), 16158053 (3) (see all 27)
    prostate cancer 38.4 33 17349545 (5), 17178887 (5), 12947120 (3), 11577016 (3) (see all 13)
    carcinoma non-small cell lung 37.4 10 14997382 (4), 12237872 (1), 11052627 (1), 15466399 (1) (see all 5)
    neoplastic transformation 34 2 9619599 (1), 9083010 (1)
    adenovirus infections 31.2 2 11961668 (1), 10666238 (1)

    Genetic Association Database (GAD): E2F1
    Human Genome Epidemiology (HuGE) Navigator: E2F1 (6 documents)

    Export disorders for E2F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for E2F1 gene, integrated from 9 sources (see all 1178):
    (articles sorted by number of sources associating them with E2F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and partial genomic sequence of the human E2F1 gene. (PubMed id 8964493)1, 2, 3, 9 Neuman E....Kaelin W.G. Jr. (1996)
    2. Regulation of E2F1 by BRCT domain-containing protein TopBP1. (PubMed id 12697828)1, 2, 9 Liu K.... Lin W.-C. (2003)
    3. Phosphorylation of E2F-1 by cyclin A-cdk2. (PubMed id 7838523)1, 2, 9 Kitagawa M.... Okuyama A. (1995)
    4. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. (PubMed id 7969176)1, 2, 9 Xu M.... Piwnica-Worms H. (1994)
    5. Chk2 activates E2F-1 in response to DNA damage. (PubMed id 12717439)1, 2, 9 Stevens C....La Thangue N.B. (2003)
    6. P53 and E2F-1 cooperate to mediate apoptosis. (PubMed id 8170954)1, 2, 9 Wu X. and Levine A.J. (1994)
    7. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. (PubMed id 7958836)1, 2, 9 Johnson D.G.... Nevins J.R. (1994)
    8. Regulation of E2F1 function by the nuclear corepressor KAP1. (PubMed id 17704056)1, 2, 9 Wang C....Chen J. (2007)
    9. Specificity determinants of recruitment peptides bound to phospho- CDK2/cyclin A. (PubMed id 12501191)1, 2, 9 Lowe E.D.... Johnson L.N. (2002)
    10. E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595)1, 2, 9 Lang S.E.... Hearing P. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1869 HGNC: 3113 AceView: E2F1 Ensembl:ENSG00000101412 euGenes: HUgn1869
    ECgene: E2F1 Kegg: 1869 H-InvDB: E2F1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for E2F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for E2F1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/e2f1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for E2F1 gene:
    Search GeneIP for patents involving E2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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