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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

E2F1 Gene

protein-coding GIFtS: 67
GCID: GC20M032263

E2F transcription factor 1

(Previous symbol: RBBP3)

Explore 101 diseases affiliated with
E2F1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
E2F Transcription Factor 1¹ ²		E2F-1² ³
RBBP3¹ ² ³		PBR3² ³
RBP3¹ ²		RBAP-1² ³
PRB-Binding Protein E2F-1² ³		RBBP-3² ³
Retinoblastoma-Associated Protein 1² ³		RBAP1²
Retinoblastoma-Binding Protein 3² ³		Transcription Factor E2F1²

External Ids:	HGNC: 3113¹	Entrez Gene: 1869²	Ensembl: ENSG00000101412⁷	OMIM: 189971⁵	UniProtKB: Q01094³

Export aliases for E2F1 gene to outside databases

Previous GC identifers: GC20M032022 GC20M031981 GC20M032931 GC20M032979 GC20M031727 GC20M029049

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for E2F1:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial

role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming

proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most

members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction

with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic

amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.

This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds

preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation

and p53-dependent/independent apoptosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,

5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle

regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to

S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and

TP53/p53-dependent apoptosis

Gene Wiki entry for E2F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the E2F1 gene promoter:
Sp1 GCNF-1 GCNF GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: E2F1 promoter sequence

Search SABiosciences Chromatin IP Primers for E2F1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat E2F1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11

E2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E2F1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M032263: view genomic region (about GC identifiers)

Start:	32,263,292 bp from pter	End:	32,274,210 bp from pter
Size:	10,919 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094 (See protein sequence)

Recommended Name: Transcription factor E2F1

Size: 437 amino acids; 46920 Da

Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F1

complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes

phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active.

Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active

complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes,

leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with TRIM28; the

interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional activity. Interaction

with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional activity. Interacts with

BIRC2/c-IAP1 (via BIR domains). Interacts with human cytomegalovirus/HHV-5 protein UL123

Subcellular location: Nucleus

Sequence caution: Sequence=AAB24289.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for E2F1:

1H24 (3D)

1O9K (3D)

2AZE (3D)

Secondary accessions: Q13143 Q92768

Explore the universe of human proteins at neXtProt for E2F1: NX_Q01094

Post-translational modifications:

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA

damage and regulates its effect on transcription and apoptosis¹

Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma

protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by

P/CAF/KAT2B¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01094

E2F1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005216.1

ENSEMBL proteins:

ENSP00000345571

Reactome Protein details: Q01094
Human Recombinant Protein Products:

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	OriGene Purified Protein: E2F1 OriGene Protein Over-expression Lysate: E2F1 OriGene Custom Protein Services for E2F1
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	Novus Biologicals E2F1 Protein Novus Biologicals E2F1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for E2F1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12717439
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	--	--

E2F1 for ontologies About GeneDecksing

E2F1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of E2F1
	R&D Systems Antibodies for E2F1 (E2F-1)
	Cell Signaling Technology (CST) Antibodies for E2F1
	OriGene Antibodies (see all 2): E2F1 OriGene Custom Antibody Services for E2F1
	GenScript Custom Superior Antibodies Services for E2F1
	Novus Biologicals E2F1 Antibodies
	Abcam antibodies for E2F1
	Uscn Antibodies for E2F1
	ThermoFisher Antibody for E2F1

Assay Products for E2F1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for E2F1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for E2F1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

E2F1 for domains About GeneDecksing

3 InterPro domains/families:

IPR003316 E2F_TDP

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR015633 E2F

Graphical View of Domain Structure for InterPro Entry Q01094

ProtoNet protein and cluster: Q01094

1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094

Similarity: Belongs to the E2F/DP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094

Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,

5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle

regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to

S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and

TP53/p53-dependent apoptosis

Enzyme regulation: BIRC2/c-IAP1 stimulates its transcriptional activity

Genatlas biochemistry entry for E2F1:

transcription factor E2F1,involved in cell proliferation and apoptosis,controlling genes regulating S phase entry and

DNA synthesis,downregulated in post-mitotic neurons by interaction with NDN and proteolysis through the

ubiquitin-proteasome pathway

		10/1433 SABiosciences Target genes for E2F1 (see all 1433):
		A4GNT AACS AARS ABCE1 ABCF2 ABCF3 ABHD11 ABI2 ABTB1 ACOT7

miRNA Products:		miRTarBase miRNAs that target E2F1: hsa-mir-149 (MIRT005356), hsa-mir-17 (MIRT002935), hsa-mir-93 (MIRT002472), hsa-mir-106a (MIRT000374), hsa-let-7a (MIRT003904), hsa-mir-20a (MIRT000180), hsa-mir-106b (MIRT003045), hsa-mir-23b (MIRT003424), hsa-mir-330-3p (MIRT000718), hsa-mir-126 (MIRT005020), hsa-mir-223 (MIRT000632), hsa-mir-98 (MIRT001124), hsa-mir-21 (MIRT001191), hsa-mir-34a (MIRT004821)

		OriGene 3'-UTR Clone: E2F1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat E2F1
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate E2F1 (see all 48):
		hsa-miR-3678-3p hsa-miR-136 hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-1258 hsa-miR-519a hsa-miR-223

		SwitchGear 3'UTR luciferase reporter plasmid: E2F1 3' UTR sequence

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of E2F1 Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for E2F1 (see all 7) OriGene shRNA RFP: E2F1 OriGene siRNA: E2F1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat E2F1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for E2F1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for E2F1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for E2F1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: E2F1 (NM_005225)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for E2F1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat E2F1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for E2F1
		Search LifeMap BioReagents cell lines for E2F1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001047	core promoter binding	IDA	15735762
GO:0003677	DNA binding	IMP	11418595
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	11418595
GO:0003714	transcription corepressor activity	TAS	10199402
GO:0005515	protein binding	IPI	--

E2F1 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for E2F1:

Decreased homologous recombina

Decreased influenza A/WSN/33 r

Decreased viability of wild-ty

Increased G1 DNA content

Animal Models:
Mouse knock-outs for E2F1: E2f1^tm1Njd E2f1^tm1Meg
15/21 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for E2f1) (see all 21):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	muscle	nervous system

E2F1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell cycle_Cell cycle (generic schema)

Cell cycle_Cell cycle (generic schema)	1.00	Cell cycle Regulation of G1/S transition (part 2)	0.38
Cell cycle Cell cycle (generic schema)	1.00	G0 and Early G1	0.31
Cell cycle_Regulation of G1/S transition (part 2)	0.38

Cyclins and Cell Cycle Regulation

Cyclins and Cell Cycle Regulation	1.00	Cyclin D associated events in G1	0.32
G1-S Phase Transition	0.67	G1 Phase	0.32
Cell Cycle Control by BTG Proteins	0.36

Glioma

Glioma	1.00	Prostate cancer	0.39
Non-small cell lung cancer	0.53	Signaling Pathways in Glioblastoma	0.36
Melanoma	0.43

Chks in Checkpoint Regulation

	Chks in Checkpoint Regulation	1.00			p53 Signaling	0.32
	Estrogen-mediated S-Phase Entry	0.55

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for E2F1 (see all 8)

	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Start of DNA replication in early S phase
	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Cell cycle Cell cycle (generic schema)
	Cell cycle Role of SCF complex in cell cycle regulation

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for E2F1 (see all 15)

	ErbB2-ErbB3 Heterodimers
	Cell Cycle Control by BTG Proteins
	BRCA1 Pathway
	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer

1 Cell Signaling Technology (CST) Pathway for E2F1

Cell Cycle / Checkpoint Control

5/8 GeneGo (Thomson Reuters) Pathways for E2F1 (see all 8)

	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Transcription P53 signaling pathway
	Cell cycle Cell cycle (generic schema)
	Cell cycle Role of SCF complex in cell cycle regulation
	Cell cycle Regulation of G1/S transition (part 2)

5/18 BioSystems Pathways for E2F1 (see all 18)

	Adipogenesis
	Senescence and Autophagy
	G1 to S cell cycle control
	Signaling Pathways in Glioblastoma
	DNA damage response

5/13 Reactome Pathways for E2F1 (see all 13)

	G1 Phase
	Mitotic G1-G1/S phases
	G0 and Early G1
	Inhibition of replication initiation of damaged DNA by RB1/E2F1
	Cell Cycle

5/10 Kegg Pathways (Kegg details for E2F1) (see all 10):

	Cell cycle
	Pathways in cancer
	Pancreatic cancer
	Glioma
	Prostate cancer

E2F1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for E2F1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/193 Interacting proteins for E2F1 (Q01094^{1, 2, 3} ENSP00000345571⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 193)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MCPH1	Q8NEM0²^,³, ENSP00000342924⁴	MINT-6804908 MINT-6804850 MINT-6804878 MINT-6804982 MINT-6804865 MINT-6804968 I2D: score=2 STRING: ENSP00000342924
BTG3	Q14201²^,³, ENSP00000344609⁴	MINT-5226290 MINT-5226261 MINT-5226306 I2D: score=1 STRING: ENSP00000344609
SP1	P08047¹^,³, ENSP00000329357⁴	EBI-448924,EBI-298336 I2D: score=8 STRING: ENSP00000329357
DDB2	Q92466¹^,³, ENSP00000256996⁴	EBI-448924,EBI-1176171 I2D: score=4 STRING: ENSP00000256996
SIRT1	Q96EB6¹^,³, ENSP00000212015⁴	EBI-448924,EBI-1802965 I2D: score=1 STRING: ENSP00000212015

About this table

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000077	DNA damage checkpoint	IMP	12717439
GO:0000080	G1 phase of mitotic cell cycle	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000085	G2 phase of mitotic cell cycle	TAS	--
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	--

E2F1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

E2F1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for E2F1
10/65 Novoseek chemical compound relationships for E2F1 gene (see all 65) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
flavopiridol	63.9	19	14612540 (6), 15611646 (1), 15868376 (1), 10851232 (1) (see all 6)
thymidylate	60.1	20	10811110 (2), 18056168 (2), 10914714 (2), 14654896 (2) (see all 16)
p202	58.3	3	12646190 (2)
roscovitine	54	9	10851267 (4), 18458681 (2), 11912154 (2), 15611646 (1)
dihydrofolate	53.8	17	10823896 (2), 8441401 (1), 9671466 (1), 12965081 (1) (see all 13)
suberoylanilide hydroxamic acid	49.1	3	16476732 (1), 11250759 (1)
4-hydroxytamoxifen	45.5	5	16617145 (1), 15897325 (1), 10918503 (1)
tomudex	43.5	2	9106628 (2)
vitamin e succinate	41.3	13	15883045 (5), 9205075 (2), 16505104 (1), 15144885 (1)
butyrolactone i	37.9	1	7838523 (1)

Search CenterWatch for drugs/clinical trials and news about E2F1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for E2F1 gene:

NM_005225.2

Unigene Cluster for E2F1:

E2F transcription factor 1

Hs.654393 [show with all ESTs]

Unigene Representative Sequence: NM_005225

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000343380(uc002wzu.4)

miRNA Products:		OriGene 3'-UTR Clone: E2F1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat E2F1
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate E2F1 (see all 48):
		hsa-miR-3678-3p hsa-miR-136 hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-1258 hsa-miR-519a hsa-miR-223

		SwitchGear 3'UTR luciferase reporter plasmid: E2F1 3' UTR sequence

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of E2F1 Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for E2F1 (see all 7) OriGene shRNA RFP: E2F1 OriGene siRNA: E2F1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat E2F1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for E2F1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for E2F1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: E2F1 (NM_005225)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for E2F1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat E2F1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for E2F1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat E2F1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat E2F1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat E2F1

Additional cDNA sequence:

AF086380.1 BC005098.1 BC050369.2 BC058902.1 M96577.1 S49592.1

9 DOTS entries:

DT.311649 DT.100025819 DT.92427744 DT.100745520 DT.120827205 DT.100708656 DT.100788668 DT.92427743

DT.99953894

24/140 AceView cDNA sequences (see all 140):

AU131577 BM712904 BQ057945 BM847643 BG740997 BM797776 BU680954 BC058902

CA430665 BQ898480 BQ226207 BM848627 BX375969 BQ069913 BM766189 CR593152

BM916982 F03046 CR594440 CR599810 BC050369 BE266523 S49592 CR594055

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for E2F1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7
SP1:
SP2:									-

ECgene alternative splicing isoforms for E2F1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

E2F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGGTCAGA

About this image
See E2F1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for E2F1

SOURCE GeneReport for Unigene cluster: Hs.654393

SABiosciences Expression via Pathway-Focused PCR Arrays including E2F1 (see all 9):

Oncogenes & Tumor Suppressor Genes in human mouse rat

Liver Cancer in human mouse rat

Adipogenesis in human mouse rat

Cell Cycle in human mouse rat

p53 Signaling Pathway in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for E2F1 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	E2F1¹	E2F transcription factor 1	69.73(n) 64.43(a)		396142 NM_205219.1 NP_990550.1
lizard (Anolis carolinensis)	Reptilia	E2F1⁶	--	59(a)	1 ↔ 1	4(136781529-136793423)
zebrafish (Danio rerio)	Actinopterygii	CABZ01117591.1⁶	--	46(a)	1 ↔ 1	Zv9_NA947(4606-23521)
fruit fly (Drosophila melanogaster)	Insecta	E2f⁶	E2F transcription factor	13(a)	1 → many	3R(17446026-17486127)
worm (Caenorhabditis elegans)	Secernentea	efl-2⁶	E2F-like (mammalian transcription factor) family m...	15(a)	possible ortholog	II(13406090-13411210)
thale cress (Arabidopsis thaliana)	eudicotyledons	E2FC⁶ E2F1⁶ (see all 3)	E2F transcription factor 1 (see all 3)	21(a) 20(a) (see all 3)	possible ortholog possible ortholog (see all 3)	1(17634757-17637772) 5(7360535-7364454)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	E2F family transcription factor protein, putative,... E2F family transcription factor protein, putative,... (see all 4)	25(a) 24(a) (see all 4)	possible ortholog possible ortholog (see all 4)	4(20377617-20383348) 12(2938686-2944066)

ENSEMBL Gene Tree for E2F1 (if available)
TreeFam Gene Tree for E2F1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for E2F1 gene

E2F3² E2F2² E2F5² E2F4² E2F6²

2 SIMAP similar genes for E2F1 using alignment to 1 protein entry: E2F1_HUMAN:

E2F3 E2F2

E2F1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3213184^1,2	C,	--	32262915(-)	`ggagcG/Aggata`	3	--	us2k¹ ds500¹		2		NS WA	298
rs3213183^1,2	C,F,A,H,	--	32262962(-)	`GAAAAC/TACCAA`	3	--	ds500¹ us2k¹		27		NS EA NA WA CSA	2946
rs184309312^1,2		--	32262967(+)	`GTTTTC/TTTCCT`	3	--	us2k¹ ds500¹		0	--	--	--	--
rs138381192^1,2		--	32263039(+)	`TTCCCC/GATTTT`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs189265155^1,2		--	32263086(+)	`GCACCA/GTGAAA`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs149246301^1,2		--	32263179(+)	`CCAGAA/CACGTC`	3	--	us2k¹ ds500¹		0	--	--	--	--
rs3213182^1,2	C,F,A,H,	--	32263233(-)	`TCTCCT/GTNNNN`	3	--	us2k¹ ds500¹		21		NS EA NA	2494
rs181206924^1,2		--	32263294(+)	`TTCTAC/TAACAA`	3	--	ut3¹ us2k¹		0	--	--	--	--
rs148012006^1,2		--	32263418(+)	`AGAATA/GGGCAT`	3	--	ut3¹ us2k¹		0	--	--	--	--
rs3213181^1,2	C,F,H	--	32263424(-)	`GGGGAA/GATGCC`	3	--	ut3¹ us2k¹		3		NS NA	464

HapMap Linkage Disequilibrium report for E2F1 (32263292 - 32274210 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for E2F1
1 CNV: 79180

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

E2F1 for disorders           About GeneDecksing

OMIM gene information: 189971    OMIM disorders: --

20/101 diseases for E2F1 (see all 101):    About MalaCards

retinoblastoma nijmegen breakage syndrome diffuse large b-cell lymphoma gastrointestinal stromal tumor

non-small cell lung carcinoma b-cell lymphomas clear cell renal cell carcinoma non-hodgkin lymphoma

squamous cell carcinoma osteochondroma meninges hemangiopericytoma ataxia telangiectasia

pituitary adenoma hemangiopericytoma myeloid leukemia carcinoma

oral squamous cell carcinoma malignant glioma mantle cell lymphoma squamous cell carcinoma of the head and neck

1 disease from the University of Copenhagen DISEASES database for E2F1:

Retinoblastoma

10/93 Novoseek disease relationships for E2F1 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	91.8	162	12610352 (3), 15187102 (2), 8918469 (2), 16230367 (2) (see all 99)
tumors	65.5	295	12379749 (7), 10340908 (6), 10794484 (5), 17359698 (5) (see all 99)
cancer	60.9	100	9045954 (3), 10811110 (2), 16243973 (2), 16476732 (2) (see all 64)
osteosarcoma	44	11	19541929 (2), 15883045 (1), 17001603 (1), 11393276 (1) (see all 7)
colon cancer	42.1	25	10914714 (4), 12677090 (3), 11705881 (3), 11961668 (2) (see all 12)
breast cancer	38.8	51	17535433 (5), 15985428 (3), 17201163 (3), 16158053 (3) (see all 27)
prostate cancer	38.4	33	17349545 (5), 17178887 (5), 12947120 (3), 11577016 (3) (see all 13)
carcinoma non-small cell lung	37.4	10	14997382 (4), 12237872 (1), 11052627 (1), 15466399 (1) (see all 5)
neoplastic transformation	34	2	9619599 (1), 9083010 (1)
adenovirus infections	31.2	2	11961668 (1), 10666238 (1)

Genetic Association Database (GAD): E2F1
Human Genome Epidemiology (HuGE) Navigator: E2F1 (6 documents)

Export disorders for E2F1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for E2F1 gene, integrated from 9 sources (see all 1153):
(articles sorted by number of sources associating them with E2F1)

Utopia: connect your pdf to the dynamic
world of online information

Structure and partial genomic sequence of the human E2F1 gene. (PubMed id 8964493)^{1, 2, 3, 9} Neuman E....Kaelin W.G. Jr. (1996)
Regulation of E2F1 by BRCT domain-containing protein TopBP1. (PubMed id 12697828)^{1, 2, 9} Liu K.... Lin W.-C. (2003)
Phosphorylation of E2F-1 by cyclin A-cdk2. (PubMed id 7838523)^{1, 2, 9} Kitagawa M.... Okuyama A. (1995)
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. (PubMed id 7969176)^{1, 2, 9} Xu M.... Piwnica-Worms H. (1994)
Chk2 activates E2F-1 in response to DNA damage. (PubMed id 12717439)^{1, 2, 9} Stevens C....La Thangue N.B. (2003)
P53 and E2F-1 cooperate to mediate apoptosis. (PubMed id 8170954)^{1, 2, 9} Wu X. and Levine A.J. (1994)
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. (PubMed id 7958836)^{1, 2, 9} Johnson D.G.... Nevins J.R. (1994)
Regulation of E2F1 function by the nuclear corepressor KAP1. (PubMed id 17704056)^{1, 2, 9} Wang C....Chen J. (2007)
Specificity determinants of recruitment peptides bound to phospho- CDK2/cyclin A. (PubMed id 12501191)^{1, 2, 9} Lowe E.D.... Johnson L.N. (2002)
E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595)^{1, 2, 9} Lang S.E.... Hearing P. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1869	HGNC: 3113	AceView: E2F1	Ensembl:ENSG00000101412	euGenes: HUgn1869
ECgene: E2F1	Kegg: 1869	H-InvDB: E2F1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for E2F1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for E2F1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/e2f1/

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E2F transcription factor 1

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E2F transcription factor 1

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