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Aliases for E2F1 Gene

Aliases for E2F1 Gene

  • E2F Transcription Factor 1 2 3
  • Retinoblastoma-Associated Protein 1 3 4
  • Retinoblastoma-Binding Protein 3 3 4
  • PRB-Binding Protein E2F-1 3 4
  • RBAP-1 3 4
  • RBBP-3 3 4
  • RBBP3 3 4
  • E2F-1 3 4
  • PBR3 3 4
  • Transcription Factor E2F1 3
  • RBAP1 3
  • RBP3 3

External Ids for E2F1 Gene

Previous HGNC Symbols for E2F1 Gene

  • RBBP3

Previous GeneCards Identifiers for E2F1 Gene

  • GC20M032022
  • GC20M031981
  • GC20M032931
  • GC20M032979
  • GC20M031727
  • GC20M032263
  • GC20M029049

Summaries for E2F1 Gene

Entrez Gene Summary for E2F1 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F1 Gene

E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include retinoblastoma and osteochondroma. Among its related pathways are Glioma and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is E2F5.

UniProtKB/Swiss-Prot for E2F1 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Wiki entry for E2F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F1 Gene

Genomics for E2F1 Gene

Regulatory Elements for E2F1 Gene

Genomic Location for E2F1 Gene

Start:
33,675,486 bp from pter
End:
33,686,404 bp from pter
Size:
10,919 bases
Orientation:
Minus strand

Genomic View for E2F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for E2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F1 Gene

Proteins for E2F1 Gene

  • Protein details for E2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01094-E2F1_HUMAN
    Recommended name:
    Transcription factor E2F1
    Protein Accession:
    Q01094
    Secondary Accessions:
    • Q13143
    • Q92768

    Protein attributes for E2F1 Gene

    Size:
    437 amino acids
    Molecular mass:
    46920 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional activity. Interacts with BIRC2/c-IAP1 (via BIR domains). The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target genes promoters and represses its transcriptional activity (PubMed:20176812). Interacts with human cytomegalovirus/HHV-5 protein UL123.
    SequenceCaution:
    • Sequence=AAB24289.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for E2F1 Gene

neXtProt entry for E2F1 Gene

Proteomics data for E2F1 Gene at MOPED

Post-translational modifications for E2F1 Gene

  • Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B.
  • Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for E2F1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for E2F1 (E2F1)

No data available for DME Specific Peptides for E2F1 Gene

Domains for E2F1 Gene

Protein Domains for E2F1 Gene

Suggested Antigen Peptide Sequences for E2F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01094

UniProtKB/Swiss-Prot:

E2F1_HUMAN :
  • Q01094
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F1: view

No data available for Gene Families for E2F1 Gene

Function for E2F1 Gene

Molecular function for E2F1 Gene

GENATLAS Biochemistry: transcription factor E2F1,involved in cell proliferation and apoptosis,controlling genes regulating S phase entry and DNA synthesis,downregulated in post-mitotic neurons by interaction with NDN and proteolysis through the ubiquitin-proteasome pathway
UniProtKB/Swiss-Prot EnzymeRegulation: BIRC2/c-IAP1 stimulates its transcriptional activity.
UniProtKB/Swiss-Prot Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Ontology (GO) - Molecular Function for E2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 15735762
GO:0003677 DNA binding IMP 11418595
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 11418595
GO:0005515 protein binding IPI 11418595
GO:0008134 transcription factor binding IPI 16360038
genes like me logo Genes that share ontologies with E2F1: view
genes like me logo Genes that share phenotypes with E2F1: view

Animal Models for E2F1 Gene

MGI Knock Outs for E2F1:

Animal Model Products

CRISPR Products

Transcription Factor Targeting for E2F1 Gene

Selected GeneGlobe predicted Target genes for E2F1
Targeting motifs for E2F1 Gene
HOMER Transcription Factor Regulatory Elements motif E2F1
  • Consensus sequence: CWGGCGGGAA Submotif: canonical Cell Type: Hela GeoId: GSE22478

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for E2F1 Gene

Localization for E2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F1 Gene COMPARTMENTS Subcellular localization image for E2F1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for E2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12717439
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex --
GO:0005737 cytoplasm IEA --
GO:0035189 Rb-E2F complex IDA 20224733
genes like me logo Genes that share ontologies with E2F1: view

Pathways for E2F1 Gene

genes like me logo Genes that share pathways with E2F1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for E2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 12717439
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20224733
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with E2F1: view

Compounds for E2F1 Gene

(65) Novoseek inferred chemical compound relationships for E2F1 Gene

Compound -log(P) Hits PubMed IDs
flavopiridol 63.9 11
thymidylate 60.1 20
p202 58.3 2
roscovitine 54 9
dihydrofolate 53.8 14
genes like me logo Genes that share compounds with E2F1: view

Transcripts for E2F1 Gene

mRNA/cDNA for E2F1 Gene

(140) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for E2F1 Gene

E2F transcription factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for E2F1 Gene

GeneLoc Exon Structure for
E2F1
ECgene alternative splicing isoforms for
E2F1

Expression for E2F1 Gene

mRNA expression in normal human tissues for E2F1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for E2F1 Gene

SOURCE GeneReport for Unigene cluster for E2F1 Gene Hs.654393

genes like me logo Genes that share expressions with E2F1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for E2F1 Gene

Orthologs for E2F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F1 35
  • 99.54 (n)
  • 99.08 (a)
E2F1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia E2F1 35
  • 89.93 (n)
  • 91.76 (a)
E2F1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia E2F1 35
  • 90.6 (n)
  • 92.43 (a)
E2F1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E2f1 35
  • 83.95 (n)
  • 85.12 (a)
E2f1 16
E2f1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia E2F1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f1 35
  • 84.34 (n)
  • 86.34 (a)
chicken
(Gallus gallus)
Aves E2F1 35
  • 70.45 (n)
  • 65.93 (a)
E2F1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f1 35
  • 56.73 (n)
  • 53.66 (a)
zebrafish
(Danio rerio)
Actinopterygii E2F1 36
  • 48 (a)
OneToOne
LOC101885420 35
  • 59.57 (n)
  • 54.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta E2f 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-2 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for E2F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F1 Gene

ENSEMBL:
Gene Tree for E2F1 (if available)
TreeFam:
Gene Tree for E2F1 (if available)

Paralogs for E2F1 Gene

Paralogs for E2F1 Gene

Selected SIMAP similar genes for E2F1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with E2F1: view

Variants for E2F1 Gene

Sequence variations from dbSNP and Humsavar for E2F1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2071054 -- 33,678,033(-) CCTCT(C/T)GGCCT intron-variant
rs2071055 -- 33,677,941(-) GGTTC(A/T)TGCCT intron-variant
rs2071056 -- 33,677,707(-) TGATT(C/T)CATTA intron-variant
rs3213130 -- 33,688,208(-) AAGGG(A/G)CCAGG upstream-variant-2KB
rs3213131 -- 33,687,776(-) tgggc(C/T)caaaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for E2F1 Gene

Variant ID Type Subtype PubMed ID
nsv833960 CNV Loss 17160897
nsv833961 CNV Loss 17160897
dgv4564n71 CNV Loss 21882294
dgv4565n71 CNV Loss 21882294

Relevant External Links for E2F1 Gene

HapMap Linkage Disequilibrium report
E2F1
Human Gene Mutation Database (HGMD)
E2F1

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F1 Gene

Disorders for E2F1 Gene

(1) University of Copenhagen DISEASES for E2F1 Gene

(93) Novoseek inferred disease relationships for E2F1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 91.8 111
tumors 65.5 176
cancer 60.9 82
osteosarcoma 44 8
colon cancer 42.1 22

Relevant External Links for E2F1

Genetic Association Database (GAD)
E2F1
Human Genome Epidemiology (HuGE) Navigator
E2F1
genes like me logo Genes that share disorders with E2F1: view

No data available for UniProtKB/Swiss-Prot for E2F1 Gene

Publications for E2F1 Gene

  1. Structure and partial genomic sequence of the human E2F1 gene. (PMID: 8964493) Neuman E. … Kaelin W.G. Jr. (Gene 1996) 2 3 4 23
  2. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. (PMID: 7969176) Xu M. … Piwnica-Worms H. (Mol. Cell. Biol. 1994) 3 4 23
  3. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. (PMID: 8413249) Helin K. … Fattaey A. (Mol. Cell. Biol. 1993) 3 4 23
  4. Phosphorylation of E2F-1 by cyclin A-cdk2. (PMID: 7838523) Kitagawa M. … Okuyama A. (Oncogene 1995) 3 4 23
  5. Negative regulation of the growth-promoting transcription factor E2F- 1 by a stably bound cyclin A-dependent protein kinase. (PMID: 8033208) Krek W. … Livingston D.M. (Cell 1994) 3 4 23

Products for E2F1 Gene

  • Addgene plasmids for E2F1

Sources for E2F1 Gene

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