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E2F1 Gene

protein-coding GIFtS: 69

GC20M031727

E2F transcription factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RBBP3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2F-1 ^², ³
OTTHUMP00000030661 ^²
PBR3 ^³
RBAP-1 ^³
RBAP1 ^²
RBBP-3 ^³
RBBP3 ^², ³
RBP3 ^¹, ²

Descriptions
E2F transcription factor 1 ^²
PRB-binding protein E2F-1 ^³
Retinoblastoma-associated protein 1 ^², ³
Retinoblastoma-binding protein 3 ^³

External Ids
HGNC: 3113¹
Entrez Gene: 1869²
UniProtKB: Q01094³
Ensembl: ENSG00000101412⁷

Search outside databases for aliases for E2F1 gene

Previous GC identifers: GC20M032022 GC20M031981 GC20M032931 GC20M032979

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for E2F1:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F

family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins

and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins

contain several evolutionally conserved domains found in most members of the family. These domains

include a DNA binding domain, a dimerization domain which determines interaction with the

differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in

acidic amino acids, and a tumor suppressor protein association domain which is embedded within the

transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional

cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a

cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent

apoptosis. [provided by RefSeq]

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094

Function: Transcription activator that binds DNA cooperatively with dp proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially

RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and

p53-dependent apoptosis

Gene Wiki entry for E2F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the E2F1 gene

Entrez Gene cytogenetic band: 20q11.2 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11

E2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M031727: (about GC identifiers)

Start:	31,727,150 bp from pter
End:	31,737,854 bp from pter
Size:	10,705 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_028392.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094 (See protein sequence)

Recommended Name: Transcription factor E2F1

Size: 437 amino acids; 46920 Da

Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family

members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1.

During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the

DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A,

T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex.

Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase

complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1H24 (3D)

1O9K (3D)

2AZE (3D)

Secondary accessions: Q13143 Q92768

Post-translational modifications:

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005216.1

ENSEMBL proteins:

ENSP00000385002 ENSP00000345571

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (E2F1)
	Human Recombinant Proteins from Abnova (E2F1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	9190208
GO:0005667	transcription factor complex	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for E2F1:

	Invitrogen Antibodies for E2F1
	Millipore Mono- and Polyclonal Antibodies for the study of E2F1
	Sigma-Aldrich Antibody Arrays and Antibodies for E2F1
	R&D Systems Antibodies for E2F1 (E2F-1)
	Cell Signaling Technology (CST) Antibodies for E2F1 (E2F-1)
	Antibodies from Abcam (E2F1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (E2F1)
	Novus Biologicals Antibodies for E2F1

Assays for E2F1:

	Invitrogen Assays for E2F1
	Millipore Kits and Assays for the Analysis of E2F1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q01094

ProtoNet protein and cluster: Q01094

1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094

Similarity: Belongs to the E2F/DP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F1)
		Millipore RNAi Products for the Analysis of E2F1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (E2F1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005225

Applied Biosystems Silencer® siRNAs for E2F1

Sigma-Aldrich siRNA for E2F1

Sigma-Aldrich shRNA Panels and shRNA for E2F1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005225
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005225
untagged cDNA clones in CMV expression vector (see all 2): NM_005225

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005225

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094

Function: Transcription activator that binds DNA cooperatively with dp proteins through the E2

recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose

products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex

functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially

RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and

p53-dependent apoptosis

Genatlas biochemistry entry for E2F1:

transcription factor E2F1,involved in cell proliferation and apoptosis,controlling genes regulating

S phase entry and DNA synthesis,downregulated in post-mitotic neurons by interaction with NDN and

proteolysis through the ubiquitin-proteasome pathway

15/22 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for E2f1) (see all 22 ):

	adipose tissue	behavior/neurological	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	11418595
GO:0003714	transcription corepressor activity	TAS	10199402
GO:0005515	protein binding	IPI	11418595 11486038
GO:0016563	transcription activator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for E2F1 (Your Favorite Gene powered by Ingenuity) (see all 14 )

Prostate Cancer Signaling
Aryl Hydrocarbon Receptor Signaling
Melanoma Signaling
Small Cell Lung Cancer Signaling
p53 Signaling

GeneDecks E2F1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for E2F1

5/184 Interacting proteins for E2F1 (ENSP00000345571³ Q01094^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 184 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDB2	Q92466¹	STRING (score=.974) EBI-448924, EBI-1176171
PARP1	P09874¹	STRING (score=.977) EBI-448924, EBI-355676
PRMT2	P55345¹	STRING (score=.772) EBI-448924, EBI-78458
SP1	P08047¹	STRING (score=.933) EBI-448924, EBI-298336
TRRAP	Q9Y4A5¹	STRING (score=.965) EBI-448924, EBI-399128

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000080	G1 phase of mitotic cell cycle	TAS	10199402
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	10199402
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006915	apoptosis	TAS	8653790

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for E2F1
10/24 Novoseek chemical compound relationships for E2F1 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
p202	59.22	3	12646190 (2)
dihydrofolate	55.54	17	10823896 (2), 8441401 (1), 9671466 (1), 12965081 (1) (see all 13)
noxa	34.01	2	17146434 (1), 14684737 (1)
thymidine	22.85	13	14654896 (2), 9671466 (1), 15911984 (1), 7623816 (1) (see all 10)
bromodeoxyuridine	17.92	2	9188631 (1), 10235113 (1)
benzo(a)pyrene	13.50	12	16406622 (4), 16944783 (3), 16600106 (2), 18448277 (1) (see all 5)
hoechst 33342	9.90	3	11151061 (3)
oligonucleotide	6.43	2	11313881 (1), 11159908 (1)
steroid	5.28	4	16916939 (2), 8918469 (1), 9238849 (1)
atp	1.90	1	16972274 (1)

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2 PharmGKB drug compound relationships for E2F1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
5-fluorouracil	FA	12084458
methotrexate	FA	12084458

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (E2F1)
		Millipore RNAi Products for the Analysis of E2F1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (E2F1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005225

Sigma-Aldrich siRNA for E2F1

Sigma-Aldrich shRNA Panels and shRNA for E2F1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005225

REFSEQ mRNAs for E2F1 gene:

NM_005225.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005225

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005225
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005225
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005225

Additional cDNA sequence:

AF086380.1 BC005098.1 BC050369.2 BC058902.1 CR593152.1 CR594055.1 CR594440.1 CR599810.1

M96577.1 S49592.1

9 DOTS entries:

DT.311649 DT.100025819 DT.92427744 DT.120827205 DT.100745520 DT.100788668 DT.92427743 DT.99953894

DT.100708656

24/140 AceView cDNA sequences (see all 140 ):

BM848627 BX375969 BC005098 BQ069913 BQ898480 BU680954 BG740997 CR594440

F03046 BE266523 BM766189 S49592 BM712904 AF086380 BU193046 BM847643

BQ226207 CR599810 CA430665 AU131577 BM916982 BM797776 CR593152 BC058902

highest scoring ESTs for E2F1:

BX325312 M96577 AW440969 BM785165 BM847643 BM848627 BE560911 BF512764 BI829428 BQ064525

Unigene Cluster for E2F1:

E2F transcription factor 1

Hs.654393 [show with all ESTs]

Unigene Representative Sequence: NM_005225

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for E2F1

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7
SP1:
SP2:									-

About this scheme

ECgene alternative splicing isoforms for E2F1

2 Ensembl transcripts including schematic representations:

ENST00000402461 ENST00000343380

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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E2F1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for E2F1

¹ / ² / ³

6 probe-sets matching E2F1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1322_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.88	U47677	0.20	1.00	0.72	1
2028_s_at²^{, 3}	U133-A	1	1.00	1.00	0.80	1.13	M96577	0.80	0.80	0.80	1
204947_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005225	0.40	0.67	0.55	1
2028_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M96577	0.80	0.80	0.80	1
204947_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
2028_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks E2F1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGTGGTCAGA

SOURCE GeneReport for Unigene cluster: Hs.654393
Expression variation in blood from EXPOLDB for E2F1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for E2F1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	E2F1¹	--	E2F transcription factor 1	90.67(n) 92.66(a)	485839 XM_542963.2 XP_542963.2
cow (Bos taurus)	E2F1¹	--	E2F transcription factor 1	89.93(n) 91.76(a)	535369 XM_615437.3 XP_615437.3
rat (Rattus norvegicus)	E2f1¹	--	E2F transcription factor 1	84.34(n) 86.34(a)	399489 XM_230765.4 XP_230765.4
mouse (Mus musculus)	E2f1^{1, 5}	2 (84.00 cM)⁵	E2F transcription factor 1^{1, 5}	84.5(n)¹ 86.05(a)¹	13555¹ NM_007891.2¹ NP_031917.1¹ AA544773⁵ AF483514⁵ (see all 16)
chicken (Gallus gallus)	E2F1¹	--	E2F transcription factor 1	69.73(n) 64.43(a)	396142 NM_205219.1 NP_990550.1

About this table Species with no ortholog for E2F1

ENSEMBL Gene Tree for E2F1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for E2F1 gene

E2F3² E2F2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/97 NCBI SNPs in E2F1 are shown (see all 97 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3213173^1,2	C,F,H	31728907(-)	`AAGCCG/ATGGAC`	1	M/V	mis¹ ese³		11	NS EU EA WA	1248
	rs3213132^1,2	C,F,H	31738984(-)	`TAGAGG/AAAGTG`	1	--	ng3¹		11	NS EU EA WA	1254
--	rs3213131^1,2	C,F	31739243(-)	`tgggcC/Tcaaaa`	1	--	ng3¹		7	NS	836
--	rs3213177^1,2	C,F	31728194(-)	`ACAGGG/TCTTGG`	1	--	ut3¹ ese³		7	NS	836
--	rs3213138^1,2	C,F	31738177(-)	`AAAGGT/CCAGTG`	1	--	ng3¹		7	NS	832
	rs3213136^1,2	F,H	31738624(-)	`AACGTC/GTGTTA`	1	--	ng3¹		5	NS EU EA WA	598
--	rs3213141^1,2	C,F	31738041(-)	`GcgccC/Tcgccc`	1	--	ng3¹		1	NS	180
--	rs3213142^1,2	C,F	31737941(-)	`TTGTTC/GCCGTC`	1	--	ng3¹ tfbs³		1	NS	178
	rs3213176^1,2	F,H	31728336(-)	`TCTCCG/AGCCTC`	1	S/G	mis¹ ese³		5	NS EU EA WA	594
--	rs3213134^1,2	C,F	31738751(-)	`gatggG/Atcttc`	1	--	ng3¹		1	NS	180

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HapMap Linkage Disequilibrium images for E2F1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 189971

10/93 Novoseek disease relationships for E2F1 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	91.80	153	12610352 (3), 15187102 (2), 8918469 (2), 16230367 (2) (see all 99)
tumors	64.56	259	12379749 (7), 10340908 (6), 10794484 (5), 17359698 (5) (see all 99)
cancer	57.39	79	9045954 (3), 10811110 (2), 16243973 (2), 16476732 (2) (see all 51)
osteosarcoma	39.96	7	15883045 (1), 17001603 (1), 11393276 (1), 16849574 (1) (see all 6)
carcinoma non-small cell lung	39.89	10	14997382 (4), 12237872 (1), 11052627 (1), 15466399 (1) (see all 5)
prostate cancer	38.67	30	17349545 (5), 17178887 (5), 12947120 (3), 11577016 (3) (see all 12)
colon cancer	35.72	24	10914714 (4), 12677090 (3), 11705881 (3), 11961668 (2) (see all 11)
adenovirus infections	33.53	2	11961668 (1), 10666238 (1)
neoplastic transformation	33.03	2	9619599 (1), 9083010 (1)
carcinoma squamous cell	32.64	26	10871839 (3), 14506162 (3), 9748148 (2), 16126868 (2) (see all 15)

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1 PharmGKB disease relationship for E2F1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia	FA	12084458

About this table

Genetic Association Database: E2F1
Human Genome Epidemiology Navigator: E2F1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/924 PubMed articles for E2F1 gene (see all 924 ):

Structure and partial genomic sequence of the human E2F1 gene. (PubMed id 8964493)^{1, 2, 3, 4} Neuman E....Kaelin W.G. Jr. (1996)
Regulation of E2F1 by BRCT domain-containing protein TopBP1. (PubMed id 12697828)^{1, 3, 4} Liu K.... Lin W.-C. (2003)
Phosphorylation of E2F-1 by cyclin A-cdk2. (PubMed id 7838523)^{1, 3, 4} Kitagawa M.... Okuyama A. (1995)
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. (PubMed id 7969176)^{1, 3, 4} Xu M.... Piwnica-Worms H. (1994)
P53 and E2F-1 cooperate to mediate apoptosis. (PubMed id 8170954)^{1, 3, 4} Wu X. and Levine A.J. (1994)
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. (PubMed id 7958836)^{1, 3, 4} Johnson D.G.... Nevins J.R. (1994)
Specificity determinants of recruitment peptides bound to phospho- CDK2/cyclin A. (PubMed id 12501191)^{1, 3, 4} Lowe E.D.... Johnson L.N. (2002)
E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595)^{1, 3, 4} Lang S.E.... Hearing P. (2001)
Specific regulation of E2F family members by cyclin-dependent kinases. (PubMed id 9199321)^{1, 3, 4} Dynlacht B.D.... Zhu L. (1997)
Negative regulation of the growth-promoting transcription factor E2F- 1 by a stably bound cyclin A-dependent protein kinase. (PubMed id 8033208)^{1, 3, 4} Krek W....Livingston D.M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1869	HGNC: 3113	AceView: E2F1	Ensembl:ENSG00000101412	euGenes: HUgn1869
ECgene: E2F1	H-InvDB: E2F1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for E2F1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/e2f1/

Licensable Technologies for E2F1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for E2F1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for E2F1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for E2F1		Antibodies for E2F1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for E2F1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (E2F1)
	Antibodies (E2F1)
	Chimera RNAi (E2F1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for E2F1 (E2F-1)

	Recombinant Proteins (E2F1)
	Antibodies (E2F1)

Search OriGene for E2F1

Search Tocris compounds for E2F1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for E2F1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
E2F1 Gene at Home site.
Version 2.41.1
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E2F1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for E2F1

Summaries
for E2F1

Genomic Location
for E2F1

Proteins
for E2F1

Protein Domains/
Families
for E2F1

Gene Function
for E2F1

Pathways & Interactions
for E2F1

Drugs & Compounds
for E2F1

Transcripts
for E2F1

Expression
for E2F1

Orthologs
for E2F1

Paralogs
for E2F1

SNPs/Variants
for E2F1

Disorders & Mutations
for E2F1

Medical News
for E2F1

Publications
for E2F1

Search for E2F1

Genome Databases showing E2F1

Other Databases showing E2F1

Specialized Databases showing E2F1

Licensable Technologies
for E2F1

Services
for E2F1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

E2F1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor E2F1

Summariesfor E2F1

Genomic Locationfor E2F1

Proteinsfor E2F1

Protein Domains/Familiesfor E2F1

Gene Functionfor E2F1

Pathways & Interactionsfor E2F1

Drugs & Compoundsfor E2F1

Transcriptsfor E2F1

Expression for E2F1

Orthologsfor E2F1

Paralogsfor E2F1

SNPs/Variantsfor E2F1

Disorders & Mutationsfor E2F1

Medical Newsfor E2F1

Publicationsfor E2F1

Search for E2F1

Genome Databases showing E2F1

Other Databases showing E2F1

Specialized Databases showing E2F1

Licensable Technologiesfor E2F1

Servicesfor E2F1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for E2F1

Summaries
for E2F1

Genomic Location
for E2F1

Proteins
for E2F1

Protein Domains/
Families
for E2F1

Gene Function
for E2F1

Pathways & Interactions
for E2F1

Drugs & Compounds
for E2F1

Transcripts
for E2F1

Expression
for E2F1

Orthologs
for E2F1

Paralogs
for E2F1

SNPs/Variants
for E2F1

Disorders & Mutations
for E2F1

Medical News
for E2F1

Publications
for E2F1

Licensable Technologies
for E2F1

Services
for E2F1