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E2F1 Gene

protein-coding   GIFtS: 67
GCID: GC20M032263

E2F Transcription Factor 1


(Previous symbol: RBBP3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E2F Transcription Factor 11 2     PBR32 3
RBBP31 2 3     RBAP-12 3
PRB-Binding Protein E2F-12 3     RBBP-32 3
Retinoblastoma-Associated Protein 12 3     RBAP12
Retinoblastoma-Binding Protein 32 3     RBP32
E2F-12 3     Transcription Factor E2F12

External Ids:    HGNC: 31131   Entrez Gene: 18692   Ensembl: ENSG000001014127   OMIM: 1899715   UniProtKB: Q010943   

Export aliases for E2F1 gene to outside databases

Previous GC identifers: GC20M032022 GC20M031981 GC20M032931 GC20M032979 GC20M031727 GC20M029049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for E2F1 Gene:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a
crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the
transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved
domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain
which determines interaction with the differentiation regulated transcription factor proteins (DP), a
transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is
embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional
cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent
manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. (provided by RefSeq, Jul
2008)

GeneCards Summary for E2F1 Gene:
E2F1 (E2F transcription factor 1) is a protein-coding gene. Diseases associated with E2F1 include retinoblastoma, and meninges hemangiopericytoma. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is E2F3.

UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell
proliferation and TP53/p53-dependent apoptosis

Gene Wiki entry for E2F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the E2F1 gene promoter:
         Sp1   GCNF-1   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidE2F1 promoter sequence
   Search Chromatin IP Primers for E2F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat E2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11

E2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
E2F1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M032263:  view genomic region     (about GC identifiers)

Start:
32,263,292 bp from pter      End:
32,274,210 bp from pter
Size:
10,919 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094 (See protein sequence)
Recommended Name: Transcription factor E2F1  
Size: 437 amino acids; 46920 Da
Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The
E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes
phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally
active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing
the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase
complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with
TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional
activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional
activity. Interacts with BIRC2/c-IAP1 (via BIR domains). Interacts with human cytomegalovirus/HHV-5 protein UL123
Sequence caution: Sequence=AAB24289.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for E2F1:
1H24 (3D)        1O9K (3D)        2AZE (3D)    
Secondary accessions: Q13143 Q92768

Explore the universe of human proteins at neXtProt for E2F1: NX_Q01094

Explore proteomics data for E2F1 at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon
    DNA damage and regulates its effect on transcription and apoptosis1
  • Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by
    retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation.
    Acetylated by P/CAF/KAT2B1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See E2F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005216.1  
    ENSEMBL proteins: 
     ENSP00000345571  
    Reactome Protein details: Q01094

    E2F1 Human Recombinant Protein Products:

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    OriGene MassSpec for E2F1
    OriGene Custom Protein Services for E2F1
    GenScript Custom Purified and Recombinant Proteins Services for E2F1
    Novus Biologicals E2F1 Protein
    Novus Biologicals E2F1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for E2F1

    E2F1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of E2F1
    R&D Systems Antibodies for E2F1 (E2F-1)
    Cell Signaling Technology (CST) Antibodies for E2F1 
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    Abcam antibodies for E2F1
    Cloud-Clone Corp. Antibodies for E2F1
    ThermoFisher Antibody for E2F1
    LSBio Antibodies in human, mouse, rat for E2F1

    E2F1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of E2F1
    OriGene Custom Assay Services for E2F1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for E2F1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for E2F1
    Cloud-Clone Corp. CLIAs for E2F1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR011991 WHTH_DNA-bd_dom
     IPR015633 E2F

    Graphical View of Domain Structure for InterPro Entry Q01094

    ProtoNet protein and cluster: Q01094

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: E2F1_HUMAN, Q01094
    Similarity: Belongs to the E2F/DP family


    E2F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: E2F1_HUMAN, Q01094
    Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site,
    5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle
    regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from
    G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell
    proliferation and TP53/p53-dependent apoptosis
    Enzyme regulation: BIRC2/c-IAP1 stimulates its transcriptional activity

         Genatlas biochemistry entry for E2F1:
    transcription factor E2F1,involved in cell proliferation and apoptosis,controlling genes regulating S phase entry
    and DNA synthesis,downregulated in post-mitotic neurons by interaction with NDN and proteolysis through the
    ubiquitin-proteasome pathway

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding IDA15735762
    GO:0003677DNA binding IMP11418595
    GO:0003700sequence-specific DNA binding transcription factor activity TAS11418595
    GO:0003714transcription corepressor activity TAS10199402
    GO:0005515protein binding IPI11418595
         
    E2F1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for E2F1:
     Decreased homologous recombina  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty  Increased G1 DNA content 

         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for E2f1) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 

    E2F1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for E2F1: E2f1tm1Njd E2f1tm1Meg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for E2F1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for E2F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for E2F1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for E2F1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for E2F1 (see all 1389):
    A4GNT,  AACS,  AARS,  ABCE1,  ABCF2,  ABCF3,  ABHD11,  ABI2,  ABTB1,  ACOT7

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CWGGCGGGAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target E2F1:
    hsa-mir-193b-3p (MIRT016529), hsa-mir-362-3p (MIRT007349), hsa-mir-17-5p (MIRT002935), hsa-mir-93-5p (MIRT002472), hsa-mir-106b-5p (MIRT003045), hsa-mir-23b-3p (MIRT003424), hsa-mir-223-3p (MIRT000632), hsa-mir-98-5p (MIRT001124), hsa-mir-21-5p (MIRT001191), hsa-mir-34a-5p (MIRT004821), hsa-mir-149-3p (MIRT005356), hsa-mir-106a-5p (MIRT000374), hsa-mir-24-3p (MIRT030626), hsa-mir-205-5p (MIRT003322), hsa-mir-20a-5p (MIRT000180), hsa-let-7a-5p (MIRT003904), hsa-mir-331-3p (MIRT006506), hsa-mir-130b-3p (MIRT020292), hsa-mir-10a-5p (MIRT047521), hsa-mir-330-3p (MIRT000718), hsa-mir-126-3p (MIRT005020), hsa-mir-181b-5p (MIRT035553)

    Block miRNA regulation of human, mouse, rat E2F1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate E2F1 (see all 48):
    hsa-miR-3678-3p hsa-miR-136 hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-1258 hsa-miR-519a hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidE2F1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for E2F1
    Predesigned siRNA for gene silencing in human, mouse, rat E2F1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: E2F1 (NM_005225)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    E2F1_HUMAN, Q01094: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12717439
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----
    GO:0005737cytoplasm IEA--
    GO:0035189Rb-E2F complex IDA--

    E2F1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for E2F1 About   (see all 54)  
    See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    G1/S-Specific Transcription0.00
    G1 to S cell cycle control0.35
    Inhibition of replication initiation of damaged DNA by RB1/E2F10.00
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    Cell Cycle Control by BTG Proteins0.36
    4Cell cycle Regulation of G1 S transition part 2
    Cell cycle Cell cycle generic schema 0.38
    Cell cycle ESR1 regulation of G1 S transition0.33
    Cell cycle Regulation of G1 S transition part 2 0.38
    G2 Phase0.00
    5Cell cycle
    Cell cycle0.59
    Cell cycle0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for E2F1
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for E2F1 (see all 15)
        ErbB2-ErbB3 Heterodimers
    Cell Cycle Control by BTG Proteins
    BRCA1 Pathway
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for E2F1
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for E2F1 (see all 8)
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription P53 signaling pathway
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation
    Cell cycle Regulation of G1/S transition (part 2)

    Selected BioSystems Pathways for E2F1 (see all 20)
        Cell cycle
    DNA damage response
    Senescence and Autophagy
    Adipogenesis
    G1 to S cell cycle control

    Selected Reactome Pathways for E2F1 (see all 13)
        G0 and Early G1
    Inhibition of replication initiation of damaged DNA by RB1/E2F1
    Oncogene Induced Senescence
    Activation of NOXA and translocation to mitochondria
    Activation of PUMA and translocation to mitochondria


    Selected Kegg Pathways  (Kegg details for E2F1) (see all 13):
        Cell cycle
    Hepatitis B
    HTLV-I infection
    Pathways in cancer
    MicroRNAs in cancer


    E2F1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including E2F1 (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Liver Cancer in human mouse rat
              Adipogenesis in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for E2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for E2F1 (Q010941, 2, 3 ENSP000003455714) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCPH1Q8NEM01, 2, 3, ENSP000003429244EBI-448924,EBI-1565483 MINT-6804908 MINT-6804850 MINT-6804878 MINT-6804982 MINT-6804865 MINT-6804968 I2D: score=2 STRING: ENSP00000342924
    BTG3Q142011, 2, 3, ENSP000003446094EBI-448924,EBI-948192 MINT-5226290 MINT-5226261 MINT-5226306 I2D: score=1 STRING: ENSP00000344609
    PRMT5O147441, 2EBI-448924,EBI-351098 MINT-8381872 MINT-8381798 MINT-8381780 MINT-8381789 MINT-8381889 MINT-8381834 MINT-8381854 MINT-8381817
    SP1P080471, 3, ENSP000003293574EBI-448924,EBI-298336 I2D: score=8 STRING: ENSP00000329357
    DDB2Q924661, 3, ENSP000002569964EBI-448924,EBI-1176171 I2D: score=4 STRING: ENSP00000256996
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP12717439
    GO:0000080mitotic G1 phase TAS10199402
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000085mitotic G2 phase TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--

    E2F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for E2F1

    Selected Novoseek inferred chemical compound relationships for E2F1 gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 63.9 19 14612540 (6), 15611646 (1), 15868376 (1), 10851232 (1) (see all 6)
    thymidylate 60.1 20 10811110 (2), 18056168 (2), 10914714 (2), 14654896 (2) (see all 16)
    p202 58.3 3 12646190 (2)
    roscovitine 54 9 10851267 (4), 18458681 (2), 11912154 (2), 15611646 (1)
    dihydrofolate 53.8 17 10823896 (2), 8441401 (1), 9671466 (1), 12965081 (1) (see all 13)
    suberoylanilide hydroxamic acid 49.1 3 16476732 (1), 11250759 (1)
    4-hydroxytamoxifen 45.5 5 16617145 (1), 15897325 (1), 10918503 (1)
    tomudex 43.5 2 9106628 (2)
    vitamin e succinate 41.3 13 15883045 (5), 9205075 (2), 16505104 (1), 15144885 (1)
    butyrolactone i 37.9 1 7838523 (1)



    E2F1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for E2F1 gene: 
    NM_005225.2  

    Unigene Cluster for E2F1:

    E2F transcription factor 1
    Hs.654393  [show with all ESTs]
    Unigene Representative Sequence: NM_005225
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343380(uc002wzu.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate E2F1 (see all 48):
    hsa-miR-3678-3p hsa-miR-136 hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-1258 hsa-miR-519a hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidE2F1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: E2F1 (NM_005225)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat E2F1
      QuantiFast Probe-based Assays in human, mouse, rat E2F1

    Additional mRNA sequence: 

    AF086380.1 BC005098.1 BC050369.2 BC058902.1 M96577.1 S49592.1 

    9 DOTS entries:

    DT.311649  DT.100025819  DT.92427744  DT.100745520  DT.120827205  DT.100708656  DT.100788668  DT.92427743 
    DT.99953894 

    Selected AceView cDNA sequences (see all 140):

    BQ898480 BC050369 BQ069913 BC005098 BM847643 BC058902 CR594440 S49592 
    BQ653431 BQ226207 BU193046 BX375969 CR594055 BM712904 BE266523 CR599810 
    BG740997 BU680954 BM766189 AF086380 CA430665 BM848627 BM916982 BQ054460 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for E2F1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                                
    SP2:                          -                     


    ECgene alternative splicing isoforms for E2F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    E2F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGTCAGA
    E2F1 Expression
    About this image


    E2F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    E2F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    E2F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654393
        Pathway & Disease-focused RT2 Profiler PCR Arrays including E2F1 (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Liver Cancer in human mouse rat
              Adipogenesis in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for E2F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for E2F1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E2f11 , 5 E2F transcription factor 11, 5 83.95(n)1
    85.12(a)1
      2 (76.79 cM)5
    135551  NM_007891.41  NP_031917.11 
     1545594075 
    chicken
    (Gallus gallus)
    Aves E2F11 E2F transcription factor 1 70.45(n)
    65.93(a)
      396142  NM_205219.1  NP_990550.1 
    lizard
    (Anolis carolinensis)
    Reptilia E2F16
    E2F transcription factor 1
    60(a)
    1 ↔ 1
    4(136781529-136793423)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia e2f11 E2F transcription factor 1 56.73(n)
    53.66(a)
      100493924  XM_002932857.2  XP_002932903.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018854201 transcription factor E2F1-like 59.57(n)
    54.29(a)
      101885420  XM_005174533.1  XP_005174590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta E2f6
    E2F transcription factor
    15(a)
    1 → many
    3R(17446026-17486127)
    worm
    (Caenorhabditis elegans)
    Secernentea efl-26
    Protein EFL-2, isoform a
    17(a)
    1 → many
    II(13406160-13411280) WBGene00001162


    ENSEMBL Gene Tree for E2F1 (if available)
    TreeFam Gene Tree for E2F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for E2F1 gene
    E2F32  E2F22  E2F52  E2F42  E2F62  
    2 SIMAP similar genes for E2F1 using alignment to 1 protein entry:     E2F1_HUMAN:
    E2F3    E2F2

    E2F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for E2F1 (see all 276)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1174230751,2
    F--32264391(+) CAGACC/TCCAGA 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1449210131,2
    --32264527(+) GTCCCC/TCCAAG 1 -- ut310--------
    rs32131781,2
    C,F,H--32264529(-) GGCTTG/AGAGGG 1 -- ut313Minor allele frequency- A:0.01NS NA 278
    rs32131771,2
    C,F,H--32264533(-) ACAGGG/TCTTGG 1 -- ut31 ese315Minor allele frequency- T:0.04NS NA EU 2255
    rs1392314391,2
    C--32264568(+) CCAAAA/GTCACA 2 D syn10--------
    rs1470134051,2
    C,F--32264607(+) TCCTCG/AAGGCC 2 /L syn11Minor allele frequency- A:0.00NA 4232
    rs32131761,2,,4
    C,F--32264675(-) TCTCCG/AGCCTC 2 /S /G mis1 ese35Minor allele frequency- A:0.02NS NA 3526
    rs1420098431,2
    F--32264676(+) AGGCCG/AGAGAA 2 /S syn11Minor allele frequency- A:0.00NA 3144
    rs2016071111,2
    C--32264715(+) TCGGCC/TGCCAC 2 A syn10--------
    rs2008256581,2
    --32264812(+) CAGGCC/TGGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for E2F1 (32263292 - 32274210 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for E2F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833960CNV Loss17160897
    dgv4565n71CNV Loss21882294
    dgv4564n71CNV Loss21882294
    nsv833961CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing E2F1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing E2F1
    DNA2.0 Custom Variant and Variant Library Synthesis for E2F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189971    OMIM disorders: --

    Selected diseases for E2F1 (see all 93):    
    About MalaCards
    retinoblastoma    meninges hemangiopericytoma    osteochondroma    glioblastoma multiforme
    hemangiopericytoma    nijmegen breakage syndrome    gastrointestinal stromal tumor    polyploidy
    spinal cord injury    colon adenocarcinoma    estrogen-receptor positive breast cancer    prolactinoma
    ataxia telangiectasia    clear cell renal cell carcinoma    ductal carcinoma in situ    osteosarcoma
    chondrosarcoma    squamous cell carcinoma of the head and neck    papilloma    meningitis

    1 disease from the University of Copenhagen DISEASES database for E2F1:
    Retinoblastoma

    E2F1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for E2F1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 91.8 162 12610352 (3), 15187102 (2), 8918469 (2), 16230367 (2) (see all 99)
    tumors 65.5 295 12379749 (7), 10340908 (6), 10794484 (5), 17359698 (5) (see all 99)
    cancer 60.9 100 9045954 (3), 10811110 (2), 16243973 (2), 16476732 (2) (see all 64)
    osteosarcoma 44 11 19541929 (2), 15883045 (1), 17001603 (1), 11393276 (1) (see all 7)
    colon cancer 42.1 25 10914714 (4), 12677090 (3), 11705881 (3), 11961668 (2) (see all 12)
    breast cancer 38.8 51 17535433 (5), 15985428 (3), 17201163 (3), 16158053 (3) (see all 27)
    prostate cancer 38.4 33 17349545 (5), 17178887 (5), 12947120 (3), 11577016 (3) (see all 13)
    carcinoma non-small cell lung 37.4 10 14997382 (4), 12237872 (1), 11052627 (1), 15466399 (1) (see all 5)
    neoplastic transformation 34 2 9619599 (1), 9083010 (1)
    adenovirus infections 31.2 2 11961668 (1), 10666238 (1)

    Genetic Association Database (GAD): E2F1
    Human Genome Epidemiology (HuGE) Navigator: E2F1 (6 documents)

    Export disorders for E2F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for E2F1 gene, integrated from 10 sources (see all 1203):
    (articles sorted by number of sources associating them with E2F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and partial genomic sequence of the human E2F1 gene. (PubMed id 8964493)1, 2, 3, 9 Neuman E....Kaelin W.G. Jr. (Gene 1996)
    2. Regulation of E2F1 by BRCT domain-containing protein TopBP1. (PubMed id 12697828)1, 2, 9 Liu K.... Lin W.-C. (Mol. Cell. Biol. 2003)
    3. Phosphorylation of E2F-1 by cyclin A-cdk2. (PubMed id 7838523)1, 2, 9 Kitagawa M.... Okuyama A. (Oncogene 1995)
    4. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. (PubMed id 7969176)1, 2, 9 Xu M.... Piwnica-Worms H. (Mol. Cell. Biol. 1994)
    5. Chk2 activates E2F-1 in response to DNA damage. (PubMed id 12717439)1, 2, 9 Stevens C.... La Thangue N.B. (Nat. Cell Biol. 2003)
    6. P53 and E2F-1 cooperate to mediate apoptosis. (PubMed id 8170954)1, 2, 9 Wu X. and Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    7. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. (PubMed id 7958836)1, 2, 9 Johnson D.G.... Nevins J.R. (Genes Dev. 1994)
    8. Regulation of E2F1 function by the nuclear corepressor KAP1. (PubMed id 17704056)1, 2, 9 Wang C.... Chen J. (J. Biol. Chem. 2007)
    9. Specificity determinants of recruitment peptides bound to phospho- CDK2/cyclin A. (PubMed id 12501191)1, 2, 9 Lowe E.D.... Johnson L.N. (Biochemistry 2002)
    10. E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595)1, 2, 9 Lang S.E.... Hearing P. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1869 HGNC: 3113 AceView: E2F1 Ensembl:ENSG00000101412 euGenes: HUgn1869
    ECgene: E2F1 Kegg: 1869 H-InvDB: E2F1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for E2F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for E2F1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/e2f1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for E2F1 gene:
    Search GeneIP for patents involving E2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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