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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DGKZ Gene

protein-coding GIFtS: 62
GCID: GC11P046311

diacylglycerol kinase, zeta

(Previous names: diacylglycerol kinase, zeta 104kDa )

Explore 7 diseases affiliated with
DGKZ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Diacylglycerol Kinase, Zeta¹ ²		Diglyceride Kinase Zeta² ³
DAGK6¹ ² ³		DAG Kinase Zeta² ³
DAGK5¹ ²		EC 2.7.1.107³ ⁸
DGK-ZETA¹ ²		Diacylglycerol Kinase Zeta²
Diacylglycerol Kinase, Zeta 104kDa¹ ²		DGK-Zeta¹
HDGKzeta¹

External Ids:	HGNC: 2857¹	Entrez Gene: 8525²	Ensembl: ENSG00000149091⁷	OMIM: 601441⁵	UniProtKB: Q13574³

Export aliases for DGKZ gene to outside databases

Previous GC identifers: GC11P048153 GC11P047058 GC11P046398 GC11P046333 GC11P046318 GC11P046061

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGKZ:

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein

kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction.

Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been

identified. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574

Function: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate

specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1

activity

summary for DGKZ:

Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,

DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce

phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich

Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are

widely distributed throughout mammalian tissues and different isozymes have different subcellular

localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is

associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological

roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular

responses to extracellular stimuli.

Gene Wiki entry for DGKZ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DGKZ gene promoter:
ER-alpha NF-1 STAT3 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DGKZ promoter sequence

Search SABiosciences Chromatin IP Primers for DGKZ

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKZ

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

DGKZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKZ gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P046311: view genomic region (about GC identifiers)

Start:	46,354,455 bp from pter	End:	46,402,104 bp from pter
Size:	47,650 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574 (See protein sequence)

Recommended Name: Diacylglycerol kinase zeta

Size: 1117 amino acids; 124128 Da

Subunit: Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex

with RASGRP1 and HRAS

Subcellular location: Cytoplasm. Nucleus. Cell membrane

Sequence caution: Sequence=AAB60859.1; Type=Frameshift; Positions=166, 167;

Secondary accessions: G3V0F6 O00542 Q6ZVG7 Q8IVW9

Alternative splicing: 4 isoforms: Q13574-1 Q13574-2 Q13574-3 Q13574-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DGKZ: NX_Q13574

Post-translational modifications:

Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13574

4/15 DME Specific Peptides for DGKZ (Q13574) (see all 15)

VNPKSGG

ETNVSGD

DLTPKIQ

PEKFNSR

DGKZ Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001099010.1 NP_001186195.1 NP_001186196.1 NP_003637.2 NP_963290.1 NP_963291.2 NP_001186197.1

ENSEMBL proteins:

ENSP00000343065 ENSP00000435332 ENSP00000434719 ENSP00000437060 ENSP00000436273

ENSP00000436291 ENSP00000435435 ENSP00000395684 ENSP00000391021 ENSP00000412178

ENSP00000435763 ENSP00000434016 ENSP00000378941 ENSP00000438417 ENSP00000320340

Reactome Protein details: Q13574
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	--

DGKZ for ontologies About GeneDecksing

DGKZ Antibody Products:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DGKZ for domains About GeneDecksing

5 InterPro domains/families:

IPR001206 Diacylglycerol_kinase_cat_dom

IPR002219 Prot_Kinase_C-like_PE/DAG-bd

IPR000756 Diacylglycerol_kin_accessory

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q13574

ProtoNet protein and cluster: Q13574

1 Blocks protein family: IPB000756 Diacylglycerol kinase accessory domain (presumed)

UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574

Similarity: Belongs to the eukaryotic diacylglycerol kinase family

Similarity: Contains 2 ANK repeats

Similarity: Contains 1 DAGKc domain

Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574

Function: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate

specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1

activity

Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Enzyme Number (IUBMB): EC 2.7.1.107¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): DGKZ Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGKZ
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DGKZ (see all 19):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-3673 hsa-miR-30d hsa-miR-449a hsa-miR-4267 hsa-miR-30a hsa-miR-613

		SwitchGear 3'UTR luciferase reporter plasmid: DGKZ 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DGKZ (see all 7) OriGene shRNA RFP: DGKZ OriGene siRNA: DGKZ
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKZ

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001727	lipid kinase activity	IDA	16286473
GO:0004143	diacylglycerol kinase activity	IEA	--
GO:0004857	enzyme inhibitor activity	IEA	--
GO:0005515	protein binding	IPI	16286473
GO:0005524	ATP binding	IEA	--

DGKZ for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for DGKZ:

Increased cell death in DLD-1

Paclitaxel antagonistic effect

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dgkz):

cellular

hematopoietic system

homeostasis/metabolism

immune system

DGKZ for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Effects of PIP2 hydrolysis

Effects of PIP2 hydrolysis

1.00

Glycerolipid metabolism

Glycerolipid metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DGKZ

mTOR Pathway

1 BioSystems Pathway for DGKZ

Myometrial Relaxation and Contraction Pathways

5/8 Reactome Pathways for DGKZ (see all 8)

	GPCR downstream signaling
	Hemostasis
	Effects of PIP2 hydrolysis
	Signal Transduction
	Gastrin-CREB signalling pathway via PKC and MAPK

4 Kegg Pathways (Kegg details for DGKZ):

	Glycerolipid metabolism
	Glycerophospholipid metabolism
	Metabolic pathways
	Phosphatidylinositol signaling system

DGKZ for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DGKZ

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for DGKZ (Q13574^{1, 2, 3} ENSP00000320340⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8260977 I2D: score=2
RB1	P06400¹^,³, ENSP00000267163⁴	EBI-715527,EBI-491274 I2D: score=2 STRING: ENSP00000267163
RBL1	P28749¹^,³, ENSP00000362768⁴	EBI-715527,EBI-971402 I2D: score=1 STRING: ENSP00000362768
RBL2	Q08999¹^,³, ENSP00000262133⁴	EBI-715527,EBI-971439 I2D: score=1 STRING: ENSP00000262133
GCOM1	P0CAP1³, ENSP00000369943⁴	I2D: score=3 STRING: ENSP00000369943

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0016477	cell migration	NAS	15157668
GO:0030168	platelet activation	TAS	--
GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint	IGI	16286473

DGKZ for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DGKZ for compounds About GeneDecksing

EMD Millipore small molecules for DGKZ:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for DGKZ available from Tocris Bioscience About this table

Compound	Action	CAS #
R 59-022	Diacylglycerol kinase inhibitor; increases PKC activity	[93076-89-2]
Dioctanoylglycol	Diacylglycerol kinase inhibitor	[627-86-1]

10/862 HMDB Compounds for DGKZ (see all 862) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--

2 Novoseek chemical compound relationships for DGKZ gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipid	30	5	16055737 (1), 17239975 (1)
zinc	21.6	2	12015310 (1), 8626588 (1)

Search CenterWatch for drugs/clinical trials and news about DGKZ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DGKZ gene (7 alternative transcripts):

NM_001105540.1 NM_001199266.1 NM_001199267.1 NM_003646.3 NM_201532.2 NM_201533.3 NM_001199268.1

Unigene Cluster for DGKZ:

Diacylglycerol kinase, zeta

Hs.502461 [show with all ESTs]

Unigene Representative Sequence: NM_001105540

18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):

ENST00000343674(uc001nch.2) ENST00000525242 ENST00000528615 ENST00000531879(uc010rgq.2)

ENST00000527674(uc001nci.2) ENST00000524984(uc001nck.2) ENST00000532868

ENST00000527911 ENST00000533376 ENST00000456247(uc001ncm.2 uc001ncl.2 uc009yky.1 uc010rgs.1)

ENST00000421244 ENST00000525434 ENST00000454345(uc001ncn.1) ENST00000534215

ENST00000528173 ENST00000524448 ENST00000527903 ENST00000524869

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		hsa-miR-30c hsa-miR-3607-3p hsa-miR-3673 hsa-miR-30d hsa-miR-449a hsa-miR-4267 hsa-miR-30a hsa-miR-613

		SwitchGear 3'UTR luciferase reporter plasmid: DGKZ 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGKZ

Additional cDNA sequence:

AK124594.1 AK126970.1 AK225774.1 AK293615.1 AK294888.1 AK300577.1 AK312398.1 BC008018.1

BC041770.1 U51477.1 U94905.1

20 DOTS entries:

DT.100728082 DT.91728110 DT.95169731 DT.95169907 DT.101987058 DT.120787047 DT.414665 DT.100744628

DT.101956168 DT.120692124 DT.40132610 DT.40243028 DT.100660685 DT.91756091 DT.101957582 DT.120787027

DT.97801251 DT.120692113 DT.120692125 DT.95231937

24/225 AceView cDNA sequences (see all 225):

BE350725 NM_201533 BU521182 AK126970 BM828440 BQ898217 BI160861 BM772925

U51477 BM740688 BC008018 AW298591 BM742137 BQ420734 AW026836 BU849628

AW468443 BX952233 CB854733 AK123378 AK097960 BU956842 BQ427900 BM796623

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for DGKZ (see all 14) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	24	^	25	^	26	^	27	^	28a	·	28b	^	29a	·	29b	^	30	^	31a	·	31b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DGKZ

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DGKZ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACAGCTG

About this image

DGKZ expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DGKZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DGKZ

SOURCE GeneReport for Unigene cluster: Hs.502461

UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574

Tissue specificity: Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1

is predominantly expressed in muscle

SABiosciences Expression via Pathway-Focused PCR Array including DGKZ:

T-Cell Anergy & Immune Tolerance in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKZ gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DGKZ¹	diacylglycerol kinase, zeta	77.82(n) 82.13(a)		423197 NM_001031192.1 NP_001026363.1
lizard (Anolis carolinensis)	Reptilia	DGKZ⁶	--	67(a)	1 ↔ 1	1(42516476-42570043)
zebrafish (Danio rerio)	Actinopterygii	Dr.11340²	Transcribed sequence with weak similarity to protein more	75.16(n)		BG308608.1
fruit fly (Drosophila melanogaster)	Insecta	rdgA^{1 , 3}	deactivation of rhodopsin mediated signaling diacylglycerol more³ retinal degeneration A¹	40(a)³ 53.06(n)¹ 44.44(a)¹		31826¹ NM_001103447.2¹ NP_001096917.1¹
worm (Caenorhabditis elegans)	Secernentea	K06A1.6³ dgk-5¹	DIACYLGLYCEROL KINASE³ Protein DGK-5¹	39(a)³ 48(n)¹ 45.66(a)¹		II(6456806-6467586)³ 174068¹ NM_062900.2¹ NP_495301.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	DGK6⁶ DGK2⁶ (see all 7)	diacylglycerol kinase 2 (see all 7)	25(a) 23(a) (see all 7)	possible ortholog many ↔ many (see all 7)	4(13971552-13974323) 5(25518641-25523621)
rice (Oryza sativa)	Liliopsida	-- -- (see all 8)	diacylglycerol kinase 1, putative, expressed (see all 8)	23(a) 23(a) (see all 8)	possible ortholog many ↔ many (see all 8)	4(32101553-32106351) 12(6728516-6733263)

ENSEMBL Gene Tree for DGKZ (if available)
TreeFam Gene Tree for DGKZ (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DGKZ gene

DGKA² DGKH² DGKQ² DGKG² DGKB² DGKD² DGKI² DGKE²

2 SIMAP similar genes for DGKZ using alignment to 13 protein entries: DGKZ_HUMAN (see all proteins):

DGKI DGKA

DGKZ for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DGKZ
PGOHUM00000248578

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149323364^1,2		--	46352556(+)	`AGGAAC/GCTCCC`	1	--	us2k¹		0	--	--	--	--
rs144465333^1,2		--	46352597(+)	`TCATCC/TGACAG`	1	--	us2k¹		0	--	--	--	--
rs79548917^1,2		--	46352605(+)	`CAGGGA/TAGTAC`	1	--	us2k¹		1		NA	120
rs184804342^1,2		--	46352652(+)	`AGCTAC/TTCCCT`	1	--	us2k¹		0	--	--	--	--
rs147971089^1,2		--	46352706(+)	`CAGGAA/GGCTGC`	1	--	us2k¹		0	--	--	--	--
rs75629536^1,2	F,	--	46352750(+)	`AGGGCG/ATGAGT`	1	--	us2k¹		1		EA	120
rs141151326^1,2		--	46352859(+)	`CTCCA-/TTAAGA`	1	--	us2k¹		0	--	--	--	--
rs141684853^1,2		--	46352869(+)	`ACGGAA/GGAAGT`	1	--	us2k¹		0	--	--	--	--
rs74987957^1,2		--	46353215(+)	`ACACTC/TATAGT`	1	--	us2k¹		1		WA	118
rs189671459^1,2		--	46353342(+)	`GAAGAC/GGAGGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DGKZ (46354455 - 46402104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DGKZ: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DGKZ for disorders           About GeneDecksing

OMIM gene information: 601441    OMIM disorders: --

7 diseases for DGKZ:    About MalaCards

retinal degeneration cerebral infarction bipolar disorder retinoblastoma

cerebritis retinitis malaria

1 Novoseek disease relationship for DGKZ gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	31.3	5	17239975 (2), 16286473 (1)

Export disorders for DGKZ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DGKZ gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with DGKZ)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of a novel human diacylglycerol kinase zeta. (PubMed id 8626588)^{1, 2, 3, 9} Bunting M.... Prescott S.M. (1996)
Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. (PubMed id 11352924)^{1, 2, 9} Hogan A.... Gee S.H. (2001)
Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PubMed id 17351151)^{1, 2, 9} Rincon E.... Merida I. (2007)
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. (PubMed id 9716136)^{1, 2, 9} Topham M.K.... Prescott S.M. (1998)
Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. (PubMed id 11257115)^{1, 2, 9} Topham M.K. and Prescott S.M. (2001)
Alternative splicing of the human diacylglycerol kinase zeta gene in muscle. (PubMed id 9159104)^{1, 2, 9} Ding L....Prescott S.M. (1997)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. (PubMed id 16286473)^{1, 9} Los A.P....Divecha N. (2006)
Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta. (PubMed id 12890670)^{1, 9} Luo B....Topham M.K. (2003)
Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity. (PubMed id 12015310)^{1, 9} Santos T....Eguinoa A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8525	HGNC: 2857	AceView: DGKZ	Ensembl:ENSG00000149091	euGenes: HUgn8525
ECgene: DGKZ	Kegg: 8525	H-InvDB: DGKZ

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DGKZ	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DGKZ gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DGKZ gene:
Search GeneIP for patents involving DGKZ

GeneCards and IP:
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diacylglycerol kinase, zeta

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DGKZ Gene

diacylglycerol kinase, zeta

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