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DGKZ Gene

protein-coding   GIFtS: 66
GCID: GC11P046354

Diacylglycerol Kinase, Zeta

(Previous names: diacylglycerol kinase, zeta 104kDa)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Diacylglycerol Kinase, Zeta1 2     DAGK52
Diacylglycerol Kinase, Zeta 104kDa1 2     DGK-ZETA2
Diglyceride Kinase Zeta2 3     Diacylglycerol Kinase Zeta2
DAGK62 3     hDGKzeta2
DAG Kinase Zeta2 3     DGK-zeta3
EC 2.7.1.1073 8     

External Ids:    HGNC: 28571   Entrez Gene: 85252   Ensembl: ENSG000001490917   OMIM: 6014415   UniProtKB: Q135743   

Export aliases for DGKZ gene to outside databases

Previous GC identifers: GC11P048153 GC11P047058 GC11P046398 GC11P046333 GC11P046318 GC11P046311 GC11P046061


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DGKZ Gene:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein
kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction.
Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been
identified. (provided by RefSeq, Nov 2010)

GeneCards Summary for DGKZ Gene:
DGKZ (diacylglycerol kinase, zeta) is a protein-coding gene. GO annotations related to this gene include NAD+ kinase activity and protein C-terminus binding. An important paralog of this gene is DGKH.

UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574
Function: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate
specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1
activity

summary for DGKZ Gene:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.

Gene Wiki entry for DGKZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DGKZ gene promoter:
         ER-alpha   NF-1   STAT3   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DGKZ promoter sequence
   Search Chromatin IP Primers for DGKZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGKZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

DGKZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKZ gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P046354:  view genomic region     (about GC identifiers)

Start:
46,354,455 bp from pter      End:
46,402,104 bp from pter
Size:
47,650 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574 (See protein sequence)
Recommended Name: Diacylglycerol kinase zeta  
Size: 1117 amino acids; 124128 Da
Subunit: Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling
complex with RASGRP1 and HRAS
Sequence caution: Sequence=AAB60859.1; Type=Frameshift; Positions=166, 167;
Secondary accessions: B7Z2M9 E9PPW4 G3V0F6 J3KNJ6 O00542 Q6ZVG7 Q8IVW9
Alternative splicing: 6 isoforms:  Q13574-1   Q13574-2   Q13574-3   Q13574-4   Q13574-5   Q13574-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DGKZ: NX_Q13574

Explore proteomics data for DGKZ at MOPED

Post-translational modifications: 

  • Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DGKZ (Q13574) (see all 15)
     VNPKSGG  ETNVSGD  DLTPKIQ  PEKFNSR 


    See DGKZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001099010.1  NP_001186195.1  NP_001186196.1  NP_003637.2  NP_963290.1  NP_963291.2  NP_001186197.1  

    ENSEMBL proteins: 
     ENSP00000343065   ENSP00000435332   ENSP00000436273   ENSP00000434719   ENSP00000437060  
     ENSP00000436291   ENSP00000435435   ENSP00000395684   ENSP00000391021   ENSP00000412178  
     ENSP00000435763   ENSP00000434016   ENSP00000378941   ENSP00000438417   ENSP00000320340  
    Reactome Protein details: Q13574

    DGKZ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DGKZ
    OriGene Protein Over-expression Lysate for DGKZ
    OriGene MassSpec for DGKZ
    OriGene Custom Protein Services for DGKZ
    GenScript Custom Purified and Recombinant Proteins Services for DGKZ
    Novus Biologicals DGKZ Proteins
    Novus Biologicals DGKZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DGKZ 

    DGKZ Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DGKZ (DGK-zeta)
    OriGene Antibodies for DGKZ
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    Novus Biologicals DGKZ Antibodies
    Abcam antibodies for DGKZ
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for DGKZ
    LSBio Antibodies in human, mouse, rat for DGKZ

    DGKZ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DGKZ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DGKZ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DGKZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR000756 Diacylglycerol_kin_accessory
     IPR002110 Ankyrin_rpt
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR016064 ATP-NAD_kinase_PpnK-typ

    Graphical View of Domain Structure for InterPro Entry Q13574

    ProtoNet protein and cluster: Q13574

    1 Blocks protein domain: IPB000756 Diacylglycerol kinase accessory domain (presumed)

    UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers


    Find genes that share domains with DGKZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKZ_HUMAN, Q13574
    Function: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate
    specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1
    activity
    Catalytic activity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001727lipid kinase activity IDA16286473
    GO:0003951NAD+ kinase activity IEA--
    GO:0004143diacylglycerol kinase activity IEA--
    GO:0004857enzyme inhibitor activity IEA--
    GO:0005515protein binding IPI16286473
         
    Find genes that share ontologies with DGKZ           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DGKZ:
     Increased cell death in DLD-1   Paclitaxel antagonistic effect 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dgkz):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with DGKZ           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DGKZ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DGKZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DGKZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DGKZ

    miRNA
    Products:
        
    miRTarBase miRNAs that target DGKZ:
    hsa-mir-331-3p (MIRT043439), hsa-mir-26b-5p (MIRT029622)

    Block miRNA regulation of human, mouse, rat DGKZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DGKZ (see all 19):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-3673 hsa-miR-30d hsa-miR-449a hsa-miR-4267 hsa-miR-30a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidDGKZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DGKZ
    Predesigned siRNA for gene silencing in human, mouse, rat DGKZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DGKZ

    Clone
    Products:
         
    OriGene clones in human, mouse for DGKZ (see all 24)
    OriGene ORF clones in mouse, rat for DGKZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): DGKZ (NM_003646)
    Sino Biological Human cDNA Clone for DGKZ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGKZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGKZ
    Addgene plasmids for DGKZ 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DGKZ
    Browse ESI BIO Cell Lines and PureStem Progenitors for DGKZ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DGKZ_HUMAN, Q13574: Cytoplasm. Nucleus. Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0030027lamellipodium IDA15157668

    Find genes that share ontologies with DGKZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DGKZ About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    5Inositol phosphate metabolism (KEGG)
    Phosphatidylinositol signaling system0.61


    Find genes that share SuperPaths with DGKZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DGKZ
        mTOR Pathway

    1 BioSystems Pathway for DGKZ
        Myometrial Relaxation and Contraction Pathways


    1 Reactome Pathway for DGKZ
        Effects of PIP2 hydrolysis


    4 Kegg Pathways  (Kegg details for DGKZ):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

        Pathway & Disease-focused RT2 Profiler PCR Array including DGKZ: 
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DGKZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DGKZ (Q135741, 2, 3 ENSP000003203404) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8260977 I2D: score=2 
    RB1P064001, 3, ENSP000002671634EBI-715527,EBI-491274 I2D: score=2 STRING: ENSP00000267163
    RBL1P287491, 3, ENSP000003627684EBI-715527,EBI-971402 I2D: score=1 STRING: ENSP00000362768
    RBL2Q089991, 3, ENSP000002621334EBI-715527,EBI-971439 I2D: score=1 STRING: ENSP00000262133
    HRASP011123, ENSP000003098454I2D: score=3 STRING: ENSP00000309845
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0016310phosphorylation IDA16286473
    GO:0016477cell migration NAS15157668
    GO:0030168platelet activation TAS--

    Find genes that share ontologies with DGKZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DGKZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    Selected HMDB Compounds for DGKZ (see all 862)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    2 Novoseek inferred chemical compound relationships for DGKZ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 30 5 16055737 (1), 17239975 (1)
    zinc 21.6 2 12015310 (1), 8626588 (1)



    Find genes that share compounds with DGKZ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DGKZ gene (7 alternative transcripts): 
    NM_001105540.1  NM_001199266.1  NM_001199267.1  NM_003646.3  NM_201532.2  NM_201533.3  NM_001199268.1  

    Unigene Cluster for DGKZ:

    Diacylglycerol kinase, zeta
    Hs.502461  [show with all ESTs]
    Unigene Representative Sequence: NM_001105540
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000343674(uc001nch.2) ENST00000525242 ENST00000532868 ENST00000528615
    ENST00000531879(uc010rgq.2) ENST00000527674(uc001nci.2) ENST00000524984(uc001nck.2)
    ENST00000527911 ENST00000533376 ENST00000456247(uc001ncm.2 uc001ncl.2 uc009yky.1 uc010rgs.1)
    ENST00000421244 ENST00000525434 ENST00000454345(uc001ncn.1) ENST00000534215
    ENST00000528173 ENST00000524448 ENST00000527903 ENST00000524869
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DGKZ (see all 19):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-3673 hsa-miR-30d hsa-miR-449a hsa-miR-4267 hsa-miR-30a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidDGKZ 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DGKZ
    Clone
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    OriGene ORF clones in mouse, rat for DGKZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): DGKZ (NM_003646)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGKZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGKZ
    Addgene plasmids for DGKZ 
    Primer
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    OriGene qPCR primer pairs and template standards for DGKZ
    OriGene qSTAR qPCR primer pairs in human, mouse for DGKZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DGKZ
      QuantiTect SYBR Green Assays in human, mouse, rat DGKZ
      QuantiFast Probe-based Assays in human, mouse, rat DGKZ

    Additional mRNA sequence: 

    AK124594.1 AK126970.1 AK225774.1 AK293615.1 AK294888.1 AK300577.1 AK312398.1 BC008018.1 
    BC041770.1 U51477.1 U94905.1 

    20 DOTS entries:

    DT.100728082  DT.91728110  DT.95169731  DT.95169907  DT.101987058  DT.120787047  DT.414665  DT.100744628 
    DT.101956168  DT.120692124  DT.40132610  DT.40243028  DT.100660685  DT.91756091  DT.101957582  DT.120787027 
    DT.97801251  DT.120692113  DT.120692125  DT.95231937 

    Selected AceView cDNA sequences (see all 225):

    AW298591 BM679137 AA326664 BM737925 BM757364 AA720639 AA252418 BU148562 
    AA564714 CB152739 NM_201532 BQ879871 BU731525 AK124594 BX648433 BI911771 
    BM796623 BM740688 BQ427900 BE350725 AK123378 NM_003646 BM722648 BE207200 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DGKZ (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for DGKZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DGKZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACAGCTG
    DGKZ Expression
    About this image


    DGKZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Eye (Sensory Organs)
             Lens
    DGKZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DGKZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502461

    UniProtKB/Swiss-Prot: DGKZ_HUMAN, Q13574
    Tissue specificity: Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas.
    Isoform 1 is predominantly expressed in muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including DGKZ: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DGKZ gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgkz1 , 5 diacylglycerol kinase zeta1, 5 86.29(n)1
    91.13(a)1
      2 (50.63 cM)5
    1044181  NM_001166597.11  NP_001160069.11 
     919328245 
    chicken
    (Gallus gallus)
    Aves DGKZ1 diacylglycerol kinase, zeta 78.05(n)
    82.47(a)
      423197  NM_001031192.1  NP_001026363.1 
    lizard
    (Anolis carolinensis)
    Reptilia DGKZ6
    diacylglycerol kinase, zeta
    72(a)
    1 ↔ 1
    1(42498607-42570076)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dgkz1 diacylglycerol kinase, zeta 69.66(n)
    73.66(a)
      100496839  XM_004913380.1  XP_004913437.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.113402 Transcribed sequence with weak similarity to protein more 75.16(n)    BG308608.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rdgA1 , 3 deactivation of rhodopsin mediated
    signaling diacylglycerol more3
    retinal degeneration A1
    40(a)3
    53.04(n)1
    44.4(a)1
      318261  NM_001272437.11  NP_001259366.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K06A1.63
    dgk-51
    DIACYLGLYCEROL KINASE3
    dgk-51
    39(a)3
    47.98(n)1
    46.25(a)1
      II(6456806-6467586)3
    1740681  NM_062900.31  NP_495301.11 


    ENSEMBL Gene Tree for DGKZ (if available)
    TreeFam Gene Tree for DGKZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DGKZ gene
    DGKH2  DGKQ2  DGKB2  DGKI2  DGKE2  DGKA2  DGKG2  DGKD2  
    2 SIMAP similar genes for DGKZ using alignment to 11 protein entries:     DGKZ_HUMAN (see all proteins):
    DGKI    DGKA

    Find genes that share paralogs with DGKZ           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DGKZ
    PGOHUM00000248578


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DGKZ (see all 912)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493233641,2
    --46352556(+) AGGAAC/GCTCCC 1 -- us2k10--------
    rs1444653331,2
    C--46352597(+) TCATCC/TGACAG 1 -- us2k10--------
    rs795489171,2
    F--46352605(+) CAGGGA/TAGTAC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1848043421,2
    --46352652(+) AGCTAC/TTCCCT 1 -- us2k10--------
    rs1479710891,2
    C--46352706(+) CAGGAA/GGCTGC 1 -- us2k10--------
    rs756295361,2
    F--46352750(+) AGGGCG/ATGAGT 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1411513261,2
    C--46352859(+) CTCCA-/TTAAGA 1 -- us2k10--------
    rs1416848531,2
    --46352869(+) ACGGAA/GGAAGT 1 -- us2k10--------
    rs749879571,2
    F--46353215(+) ACACTC/TATAGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1896714591,2
    --46353342(+) GAAGAC/GGAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DGKZ (46354455 - 46402104 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DGKZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897318CNV Loss21882294
    nsv309CNV Loss18451855
    dgv1089n71CNV Loss21882294
    dgv1090n71CNV Loss21882294
    nsv825867CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DGKZ
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601441    OMIM disorders: --


    Find genes that share disorders with DGKZ           About GenesLikeMe

    1 Novoseek inferred disease relationship for DGKZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 31.3 5 17239975 (2), 16286473 (1)

    Genetic Association Database (GAD): DGKZ

    Export disorders for DGKZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DGKZ gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with DGKZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human diacylglycerol kinase zeta. (PubMed id 8626588)1, 2, 3, 9 Bunting M.... Prescott S.M. (J. Biol. Chem. 1996)
    2. Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. (PubMed id 11352924)1, 2, 9 Hogan A.... Gee S.H. (J. Biol. Chem. 2001)
    3. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PubMed id 17351151)1, 2, 9 Rincon E.... Merida I. (Mol. Cell. Proteomics 2007)
    4. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. (PubMed id 9716136)1, 2, 9 Topham M.K.... Prescott S.M. (Nature 1998)
    5. Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. (PubMed id 11257115)1, 2, 9 Topham M.K. and Prescott S.M. (J. Cell Biol. 2001)
    6. Alternative splicing of the human diacylglycerol kinase zeta gene in muscle. (PubMed id 9159104)1, 2, 9 Ding L....Prescott S.M. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    7. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. (PubMed id 20694011)1, 4 Ferreira R.C....HammarstrAPm L. (Nat. Genet. 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. (PubMed id 16286473)1, 9 Los A.P....Divecha N. (J. Biol. Chem. 2006)
    10. Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta. (PubMed id 12890670)1, 9 Luo B....Topham M.K. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8525 HGNC: 2857 AceView: DGKZ Ensembl:ENSG00000149091 euGenes: HUgn8525
    ECgene: DGKZ Kegg: 8525 H-InvDB: DGKZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DGKZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DGKZ gene:
    Search GeneIP for patents involving DGKZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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