Aliases for DGKZ Gene
External Ids for DGKZ Gene
Previous GeneCards Identifiers for DGKZ Gene
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
GeneCards Summary for DGKZ Gene
DGKZ (Diacylglycerol Kinase Zeta) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and NAD+ kinase activity. An important paralog of this gene is DGKI.
UniProtKB/Swiss-Prot for DGKZ Gene
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.