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Aliases for DZIP3 Gene

Aliases for DZIP3 Gene

  • DAZ Interacting Zinc Finger Protein 3 2 3
  • Human RNA-Binding Ubiquitin Ligase Of 138 KDa 2 3
  • RNA-Binding Ubiquitin Ligase Of 138 KDa 3 4
  • DAZ Interacting Protein 3, Zinc Finger 2 3
  • DAZ-Interacting Protein 3 3 4
  • HRUL138 3 4
  • Protein Phosphatase 1, Regulatory Subunit 66 3
  • Zinc Finger DAZ Interacting Protein 3 3
  • E3 Ubiquitin-Protein Ligase DZIP3 3
  • UURF2 Ubiquitin Ligase 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 66 2
  • EC 6.3.2.- 4
  • KIAA0675 4
  • PPP1R66 3
  • UURF2 3

External Ids for DZIP3 Gene

Summaries for DZIP3 Gene

GeneCards Summary for DZIP3 Gene

DZIP3 (DAZ Interacting Zinc Finger Protein 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include RNA binding and phosphatase binding. An important paralog of this gene is RNF214.

UniProtKB/Swiss-Prot for DZIP3 Gene

  • E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZIP3 Gene

Genomics for DZIP3 Gene

Genomic Location for DZIP3 Gene

Start:
108,589,490 bp from pter
End:
108,694,846 bp from pter
Size:
105,357 bases
Orientation:
Plus strand

Genomic View for DZIP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DZIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZIP3 Gene

Regulatory Elements for DZIP3 Gene

Proteins for DZIP3 Gene

  • Protein details for DZIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y13-DZIP3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase DZIP3
    Protein Accession:
    Q86Y13
    Secondary Accessions:
    • B3KN01
    • O75162
    • Q6P3R9
    • Q6PH82
    • Q86Y14
    • Q86Y15
    • Q86Y16
    • Q8IWI0
    • Q96RS9

    Protein attributes for DZIP3 Gene

    Size:
    1208 amino acids
    Molecular mass:
    138604 Da
    Quaternary structure:
    • Interacts with DAZ proteins.
    SequenceCaution:
    • Sequence=AAH39018.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH56674.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK69484.1; Type=Frameshift; Positions=1127; Evidence={ECO:0000305}; Sequence=BAA31650.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DZIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DZIP3 Gene

Proteomics data for DZIP3 Gene at MOPED

Post-translational modifications for DZIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys748, Lys846, and Lys1051

Other Protein References for DZIP3 Gene

No data available for DME Specific Peptides for DZIP3 Gene

Domains for DZIP3 Gene

Gene Families for DZIP3 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for DZIP3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

DZIP3_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q86Y13
genes like me logo Genes that share domains with DZIP3: view

Function for DZIP3 Gene

Molecular function for DZIP3 Gene

UniProtKB/Swiss-Prot Function: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.

Enzyme Numbers (IUBMB) for DZIP3 Gene

Gene Ontology (GO) - Molecular Function for DZIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 12538761
GO:0004842 ubiquitin-protein transferase activity IDA 12538761
GO:0005515 protein binding IPI 21903422
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with DZIP3: view

Phenotypes for DZIP3 Gene

GenomeRNAi human phenotypes for DZIP3:
genes like me logo Genes that share phenotypes with DZIP3: view

miRNA for DZIP3 Gene

miRTarBase miRNAs that target DZIP3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DZIP3 Gene

Localization for DZIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DZIP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DZIP3 Gene COMPARTMENTS Subcellular localization image for DZIP3 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for DZIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12538761
genes like me logo Genes that share ontologies with DZIP3: view

Pathways for DZIP3 Gene

genes like me logo Genes that share pathways with DZIP3: view

UniProtKB/Swiss-Prot Q86Y13-DZIP3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DZIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 12538761
genes like me logo Genes that share ontologies with DZIP3: view

Compounds for DZIP3 Gene

(4) HMDB Compounds for DZIP3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with DZIP3: view

Transcripts for DZIP3 Gene

Unigene Clusters for DZIP3 Gene

DAZ interacting protein 3, zinc finger:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DZIP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: -
SP2:
SP3:

ExUns: 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1: -
SP2:
SP3:

Relevant External Links for DZIP3 Gene

GeneLoc Exon Structure for
DZIP3
ECgene alternative splicing isoforms for
DZIP3

Expression for DZIP3 Gene

mRNA expression in normal human tissues for DZIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DZIP3 Gene

SOURCE GeneReport for Unigene cluster for DZIP3 Gene Hs.409210

mRNA Expression by UniProt/SwissProt for DZIP3 Gene

Q86Y13-DZIP3_HUMAN
Tissue specificity: Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
genes like me logo Genes that share expressions with DZIP3: view

Orthologs for DZIP3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DZIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DZIP3 36
  • 99.25 (n)
  • 98.59 (a)
DZIP3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DZIP3 36
  • 89.25 (n)
  • 85.62 (a)
DZIP3 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DZIP3 36
  • 91.9 (n)
  • 91.13 (a)
DZIP3 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dzip3 36
  • 86.02 (n)
  • 83.53 (a)
Dzip3 16
Dzip3 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DZIP3 37
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 19 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Dzip3 36
  • 84.91 (n)
  • 81.86 (a)
Species with no ortholog for DZIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DZIP3 Gene

ENSEMBL:
Gene Tree for DZIP3 (if available)
TreeFam:
Gene Tree for DZIP3 (if available)

Paralogs for DZIP3 Gene

Paralogs for DZIP3 Gene

genes like me logo Genes that share paralogs with DZIP3: view

Variants for DZIP3 Gene

Sequence variations from dbSNP and Humsavar for DZIP3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs969256 -- 108,628,964(+) CCACC(A/C)TATTT intron-variant
rs1454195 -- 108,617,994(-) AGACT(G/T)CTTTG intron-variant
rs1454200 -- 108,642,097(-) GCAAA(C/T)CTGGA intron-variant
rs1470910 -- 108,612,475(-) GGCCA(C/T)TGATT intron-variant
rs1470913 -- 108,625,199(+) CACTG(A/T)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DZIP3 Gene

Variant ID Type Subtype PubMed ID
nsv829658 CNV Gain 17160897
dgv5229n71 CNV Loss 21882294
nsv877325 CNV Loss 21882294
esv2725755 CNV Deletion 23290073
nsv829659 CNV Gain 17160897
esv2669006 CNV Deletion 23128226
esv24174 CNV Loss 19812545

Relevant External Links for DZIP3 Gene

HapMap Linkage Disequilibrium report
DZIP3

Disorders for DZIP3 Gene

No disorders were found for DZIP3 Gene.

No data available for UniProtKB/Swiss-Prot for DZIP3 Gene

Publications for DZIP3 Gene

  1. hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase. (PMID: 12538761) Kreft S.G. … Nassal M. (J. Cell Sci. 2003) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PMID: 12511597) Moore F.L. … Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DZIP3 Gene

Sources for DZIP3 Gene

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