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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DZIP1L Gene

protein-coding GIFtS: 41
GCID: GC03M137780

DAZ interacting protein 1-like

Search for DZIP1L
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DAZ Interacting Protein 1-Like¹ ²
DZIP2¹ ²
DAZ-Interacting Protein 1-Like Protein² ³
FLJ32844¹
Zinc Finger Protein DZIP1L²

External Ids:	HGNC: 26551¹	Entrez Gene: 199221²	Ensembl: ENSG00000158163⁷	UniProtKB: Q8IYY4³

Export aliases for DZIP1L gene to outside databases

Previous GC identifers: GC03M139264 GC03M135155

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DZIP1L gene promoter:
Bach1 E2F-3a E2F-4 E2F-5 Brachyury E2F-2 E2F-1 E2F POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DZIP1L promoter sequence

Search SABiosciences Chromatin IP Primers for DZIP1L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DZIP1L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q22.3

DZIP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DZIP1L gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M137780: view genomic region (about GC identifiers)

Start:	137,780,827 bp from pter	End:	137,834,660 bp from pter
Size:	53,834 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DZI1L_HUMAN, Q8IYY4 (See protein sequence)

Recommended Name: Zinc finger protein DZIP1L

Size: 767 amino acids; 86848 Da

Secondary accessions: C9JUG5 Q96M38

Alternative splicing: 2 isoforms: Q8IYY4-1 Q8IYY4-2

Explore the universe of human proteins at neXtProt for DZIP1L: NX_Q8IYY4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IYY4

DZIP1L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001164009.1 NP_775814.2

ENSEMBL proteins:

ENSP00000332148 ENSP00000417228 ENSP00000419486 ENSP00000420600 ENSP00000420051

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005814	colocalizes with centriole	IDA	19852954
GO:0036064	cilium basal body	IDA	19852954

DZIP1L for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DZIP1L for domains About GeneDecksing

2 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8IYY4

ProtoNet protein and cluster: Q8IYY4

UniProtKB/Swiss-Prot: DZI1L_HUMAN, Q8IYY4

Similarity: Belongs to the DZIP C2H2-type zinc-finger protein family

Similarity: Contains 1 C2H2-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

DZIP1L for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DZIP1L

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042384	cilium assembly	IMP	19852954

DZIP1L for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for DZIP1L gene (2 alternative transcripts):

NM_001170538.1 NM_173543.2

Unigene Cluster for DZIP1L:

DAZ interacting protein 1-like

Hs.351403 [show with all ESTs]

Unigene Representative Sequence: BC033308

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000327532(uc003erq.3) ENST00000486487 ENST00000488595 ENST00000469243(uc003err.1)

ENST00000466301 ENST00000473850 ENST00000490472 ENST00000467030 ENST00000492010

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Additional cDNA sequence:

AK057406.1 BC033308.1

5 DOTS entries:

DT.97804639 DT.95239681 DT.40274473 DT.91962733 DT.102841437

24 AceView cDNA sequences:

BC033308 NM_173543 BQ686868 BX475020 CN479011 BX280707 AI148239 AA729786

CB266770 BE252951 BX475019 BF340245 BF590078 BQ424578 AI283643 AK057406

BM973367 BF984904 BG912394 CD701720 AA194020 AA626922 BF935374 AA194199

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DZIP1L About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19
SP1:					-		-		-																								-
SP2:
SP3:					-

ECgene alternative splicing isoforms for DZIP1L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DZIP1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGGGAAGG

About this image

DZIP1L expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DZIP1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DZIP1L

SOURCE GeneReport for Unigene cluster: Hs.351403

SABiosciences Custom PCR Arrays for DZIP1L

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DZIP1L gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dzip1l^{1 , 5}	DAZ interacting protein 1-like^{1, 5}	81.56(n)¹ 77.46(a)¹		9 (51.93 cM)⁵ 72507¹ NM_028258.3¹ NP_082534.2¹ 99629496⁵
chicken (Gallus gallus)	Aves	DZIP1L⁶	Uncharacterized protein	34(a)	1 ↔ 1	9(5139819-5146083)
lizard (Anolis carolinensis)	Reptilia	DZIP1L⁶	--	45(a)	1 ↔ 1	3(33045453-33074115)
zebrafish (Danio rerio)	Actinopterygii	zgc:123017¹	zgc:123017	50.87(n) 38.65(a)		553313 NM_001037227.1 NP_001032304.1
fruit fly (Drosophila melanogaster)	Insecta	CG13617⁶	--	13(a)	1 → many	3R(20341317-20343759)

ENSEMBL Gene Tree for DZIP1L (if available)
TreeFam Gene Tree for DZIP1L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DZIP1L gene

DZIP1²

1 SIMAP similar gene for DZIP1L using alignment to 5 protein entries: DZI1L_HUMAN (see all proteins):

DZIP1

DZIP1L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115718439^1,2	F	--	137780482(+)	`CATGAG/AAGCCT`	1	--	ds500¹		1		WA	118
rs116212785^1,2	F	--	137780513(+)	`GACTCC/TCAAGT`	1	--	ds500¹		1		WA	118
rs114758211^1,2	F	--	137780586(+)	`CCTGAG/ATTCTC`	1	--	ds500¹		1		WA	118
rs79537884^1,2	C,F	--	137780848(+)	`GTACTA/CTATTT`	1	--	ut3¹		1		WA	118
rs184591456^1,2		--	137780972(+)	`TACAAC/GGTCCA`	1	--	ut3¹		0	--	--	--	--
rs114147197^1,2		--	137781014(+)	`AGTAGG/ACCTGC`	1	--	ut3¹		1		WA	118
rs189849921^1,2		--	137781024(+)	`CCACAC/TATCAC`	1	--	ut3¹		0	--	--	--	--
rs72991157^1,2	C	--	137781041(+)	`GGGAAA/CCTCTC`	1	--	ut3¹		2		WA	120
rs147741948^1,2		--	137781181(+)	`AACTCA/GGTAGT`	1	--	ut3¹		0	--	--	--	--
rs59771921^1,2	C	--	137781193(+)	`AGAGGC/TTAGAG`	1	--	ut3¹		3		WA CSA	122

HapMap Linkage Disequilibrium report for DZIP1L (137780827 - 137834660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for DZIP1L
4 CNVs: 8991 50942 3449 31122
1 Indel: 33373

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DZIP1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with DZIP1L)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
The Zn finger protein Iguana impacts Hedgehog signali ng by promoting ciliogenesis. (PubMed id 19852954)¹ Glazer A.M....Reddien P.W. (2010)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 199221	HGNC: 26551	AceView: FLJ32844	Ensembl:ENSG00000158163	euGenes: HUgn199221
ECgene: DZIP1L	H-InvDB: DZIP1L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DZIP1L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DZIP1L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DZIP1L gene:
Search GeneIP for patents involving DZIP1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DZIP1L		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DZIP1L
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DZIP1L
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DZIP1L

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DZIP1L

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DZIP1L

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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DZIP1L Gene

DAZ interacting protein 1-like

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Export list of displayed genes

DZIP1L Gene

DAZ interacting protein 1-like

Aliasesfor DZIP1L gene

Summariesfor DZIP1L gene

Genomic Viewsfor DZIP1L gene

Proteinsfor DZIP1L gene

Protein Domains /Familiesfor DZIP1L gene

Functionfor DZIP1L gene

Pathways & Interactionsfor DZIP1L gene

Drugs & Compoundsfor DZIP1L gene

Transcriptsfor DZIP1L gene

Expression for DZIP1L gene

Orthologsfor DZIP1L gene

Paralogsfor DZIP1L gene

Genomic Variantsfor DZIP1L gene

Disorders / Diseasesfor DZIP1L gene

Publicationsfor DZIP1L gene

External Searches for DZIP1L gene

Genome Databases showing DZIP1L gene

Other Databases showing DZIP1L gene

Specialized Databases showing DZIP1L gene

Intellectual Propertyfor DZIP1L gene

Productsfor DZIP1L gene

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Aliases
for DZIP1L gene

Summaries
for DZIP1L gene

Genomic Views
for DZIP1L gene

Proteins
for DZIP1L gene

Protein Domains /
Families
for DZIP1L gene

Function
for DZIP1L gene

Pathways & Interactions
for DZIP1L gene

Drugs & Compounds
for DZIP1L gene

Transcripts
for DZIP1L gene

Expression
for DZIP1L gene

Orthologs
for DZIP1L gene

Paralogs
for DZIP1L gene

Genomic Variants
for DZIP1L gene

Disorders / Diseases
for DZIP1L gene

Publications
for DZIP1L gene

Intellectual Property
for DZIP1L gene

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for DZIP1L gene