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Aliases for DZIP1L Gene

Aliases for DZIP1L Gene

  • DAZ Interacting Zinc Finger Protein 1 Like 2 3
  • DAZ Interacting Zinc Finger Protein 1-Like 2 3 5
  • DAZ-Interacting Protein 1-Like Protein 3 4
  • DAZ Interacting Protein 1-Like 2 3
  • DZIP2 3

External Ids for DZIP1L Gene

Previous GeneCards Identifiers for DZIP1L Gene

  • GC03M139264
  • GC03M137780
  • GC03M135155

Summaries for DZIP1L Gene

GeneCards Summary for DZIP1L Gene

DZIP1L (DAZ Interacting Zinc Finger Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is DZIP1.

UniProtKB/Swiss-Prot for DZIP1L Gene

  • Has a role in primary cilium formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZIP1L Gene

Genomics for DZIP1L Gene

Regulatory Elements for DZIP1L Gene

Promoters for DZIP1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DZIP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for DZIP1L Gene

Chromosome:
3
Start:
138,061,985 bp from pter
End:
138,115,818 bp from pter
Size:
53,834 bases
Orientation:
Minus strand

Genomic View for DZIP1L Gene

Genes around DZIP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DZIP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DZIP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZIP1L Gene

Proteins for DZIP1L Gene

  • Protein details for DZIP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYY4-DZI1L_HUMAN
    Recommended name:
    Zinc finger protein DZIP1L
    Protein Accession:
    Q8IYY4
    Secondary Accessions:
    • C9JUG5
    • Q96M38

    Protein attributes for DZIP1L Gene

    Size:
    767 amino acids
    Molecular mass:
    86848 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DZIP1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DZIP1L Gene

Proteomics data for DZIP1L Gene at MOPED

Post-translational modifications for DZIP1L Gene

  • Ubiquitination at Lys 272
  • Modification sites at PhosphoSitePlus

Other Protein References for DZIP1L Gene

No data available for DME Specific Peptides for DZIP1L Gene

Domains & Families for DZIP1L Gene

Protein Domains for DZIP1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DZIP1L Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYY4

UniProtKB/Swiss-Prot:

DZI1L_HUMAN :
  • Belongs to the DZIP C2H2-type zinc-finger protein family.
  • Contains 1 C2H2-type zinc finger.
Family:
  • Belongs to the DZIP C2H2-type zinc-finger protein family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with DZIP1L: view

No data available for Gene Families for DZIP1L Gene

Function for DZIP1L Gene

Molecular function for DZIP1L Gene

UniProtKB/Swiss-Prot Function:
Has a role in primary cilium formation.

Phenotypes for DZIP1L Gene

genes like me logo Genes that share phenotypes with DZIP1L: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DZIP1L Gene

Localization for DZIP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DZIP1L Gene

Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DZIP1L Gene COMPARTMENTS Subcellular localization image for DZIP1L gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DZIP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036064 ciliary basal body IDA 19852954
genes like me logo Genes that share ontologies with DZIP1L: view

Pathways & Interactions for DZIP1L Gene

SuperPathways for DZIP1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DZIP1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DZIP1L Gene

Drugs & Compounds for DZIP1L Gene

No Compound Related Data Available

Transcripts for DZIP1L Gene

Unigene Clusters for DZIP1L Gene

DAZ interacting protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DZIP1L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - - -
SP2:
SP3: -

Relevant External Links for DZIP1L Gene

GeneLoc Exon Structure for
DZIP1L
ECgene alternative splicing isoforms for
DZIP1L

Expression for DZIP1L Gene

mRNA expression in normal human tissues for DZIP1L Gene

Protein differential expression in normal tissues from HIPED for DZIP1L Gene

This gene is overexpressed in Cervix (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DZIP1L Gene



SOURCE GeneReport for Unigene cluster for DZIP1L Gene Hs.351403

genes like me logo Genes that share expression patterns with DZIP1L: view

Protein tissue co-expression partners for DZIP1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DZIP1L Gene

Orthologs for DZIP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for DZIP1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DZIP1L 36
  • 99 (a)
OneToOne
DZIP1L 35
  • 99.44 (n)
  • 99.22 (a)
cow
(Bos Taurus)
Mammalia DZIP1L 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DZIP1L 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dzip1l 16
Dzip1l 36
  • 75 (a)
OneToOne
Dzip1l 35
  • 81.7 (n)
  • 77.59 (a)
oppossum
(Monodelphis domestica)
Mammalia DZIP1L 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dzip1l 35
  • 82.11 (n)
  • 77.15 (a)
chicken
(Gallus gallus)
Aves DZIP1L 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DZIP1L 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dzip1l 35
  • 54.75 (n)
  • 46.14 (a)
zebrafish
(Danio rerio)
Actinopterygii dzip1l 35
  • 51.29 (n)
  • 40.71 (a)
dzip1l 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for DZIP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DZIP1L Gene

ENSEMBL:
Gene Tree for DZIP1L (if available)
TreeFam:
Gene Tree for DZIP1L (if available)

Paralogs for DZIP1L Gene

Paralogs for DZIP1L Gene

(1) SIMAP similar genes for DZIP1L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DZIP1L: view

Variants for DZIP1L Gene

Sequence variations from dbSNP and Humsavar for DZIP1L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2724693 - 138,088,417(-) AGGCA(C/T)GGGAG nc-transcript-variant, reference, missense
rs446644 - 138,068,350(+) CAGTG(A/C/T)GCTCT nc-transcript-variant, reference, synonymous-codon, missense
rs11917468 - 138,068,331(+) GCTGG(A/G)CCTCT nc-transcript-variant, reference, missense
rs374045 - 138,068,205(-) TCCAC(A/G)CCCCG nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs442800 - 138,067,600(+) ATCCT(C/T)GGGCC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DZIP1L Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
dgv1511e1 CNV Complex 17122850
esv2751978 CNV Loss 17911159
dgv1512e1 CNV Complex 17122850
dgv298n21 CNV Gain 19592680
nsv10329 CNV Gain 18304495
nsv10330 CNV Gain 18304495

Variation tolerance for DZIP1L Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DZIP1L Gene

HapMap Linkage Disequilibrium report
DZIP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DZIP1L Gene

Disorders for DZIP1L Gene

Relevant External Links for DZIP1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DZIP1L

No disorders were found for DZIP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DZIP1L Gene

Publications for DZIP1L Gene

  1. The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. (PMID: 19852954) Glazer A.M. … Reddien P.W. (Dev. Biol. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for DZIP1L Gene

Sources for DZIP1L Gene

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