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DZIP1L Gene

protein-coding   GIFtS: 43
GCID: GC03M137780

DAZ Interacting Zinc Finger Protein 1-Like

(Previous name: DAZ interacting protein 1-like)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DAZ Interacting Zinc Finger Protein 1-Like1 2
DAZ Interacting Protein 1-Like1 2
DAZ-Interacting Protein 1-Like Protein2 3
DZIP22
Zinc Finger Protein DZIP1L2

External Ids:    HGNC: 265511   Entrez Gene: 1992212   Ensembl: ENSG000001581637   UniProtKB: Q8IYY43   

Export aliases for DZIP1L gene to outside databases

Previous GC identifers: GC03M139264 GC03M135155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DZIP1L Gene:
DZIP1L (DAZ interacting zinc finger protein 1-like) is a protein-coding gene. An important paralog of this gene is DZIP1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DZIP1L gene promoter:
         Bach1   E2F-3a   E2F-4   E2F-5   Brachyury   E2F-2   E2F-1   E2F   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDZIP1L promoter sequence
   Search Chromatin IP Primers for DZIP1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DZIP1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

DZIP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DZIP1L gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M137780:  view genomic region     (about GC identifiers)

Start:
137,780,827 bp from pter      End:
137,834,660 bp from pter
Size:
53,834 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DZI1L_HUMAN, Q8IYY4 (See protein sequence)
Recommended Name: Zinc finger protein DZIP1L  
Size: 767 amino acids; 86848 Da
Secondary accessions: C9JUG5 Q96M38
Alternative splicing: 2 isoforms:  Q8IYY4-1   Q8IYY4-2   

Explore the universe of human proteins at neXtProt for DZIP1L: NX_Q8IYY4

Explore proteomics data for DZIP1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys272
  • Modification sites at PhosphoSitePlus

  • See DZIP1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001164009.1  NP_775814.2  

    ENSEMBL proteins: 
     ENSP00000332148   ENSP00000417228   ENSP00000419486   ENSP00000420600   ENSP00000420051  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for DZIP1L (3 products) 

     
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    antibodies-online antibodies for DZIP1L (2 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IYY4

    ProtoNet protein and cluster: Q8IYY4

    UniProtKB/Swiss-Prot: DZI1L_HUMAN, Q8IYY4
    Similarity: Belongs to the DZIP C2H2-type zinc-finger protein family
    Similarity: Contains 1 C2H2-type zinc finger


    Find genes that share domains with DZIP1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with DZIP1L           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DZIP1L

    miRNA
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    miRTarBase miRNAs that target DZIP1L:
    hsa-mir-122-5p (MIRT023219)

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    5 qRT-PCR Assays for microRNAs that regulate DZIP1L:
    hsa-miR-369-3p hsa-miR-374b hsa-miR-374a hsa-miR-514b-5p hsa-miR-513c
    SwitchGear 3'UTR luciferase reporter plasmidDZIP1L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DZIP1L

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DZIP1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus3
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814colocalizes with centriole IDA19852954
    GO:0036064ciliary basal body IDA19852954

    Find genes that share ontologies with DZIP1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DZIP1L
    Interactions:

        Search GeneGlobe Interaction Network for DZIP1L

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042384cilium assembly IMP19852954

    Find genes that share ontologies with DZIP1L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DZIP1L (DZI1L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DZIP1L gene (2 alternative transcripts): 
    NM_001170538.1  NM_173543.2  

    Unigene Cluster for DZIP1L:

    DAZ interacting protein 1-like
    Hs.351403  [show with all ESTs]
    Unigene Representative Sequence: BC033308
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327532(uc003erq.3) ENST00000486487 ENST00000488595 ENST00000469243(uc003err.1)
    ENST00000466301 ENST00000473850 ENST00000490472 ENST00000467030 ENST00000492010

    miRNA
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    Block miRNA regulation of human, mouse, rat DZIP1L using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DZIP1L:
    hsa-miR-369-3p hsa-miR-374b hsa-miR-374a hsa-miR-514b-5p hsa-miR-513c
    SwitchGear 3'UTR luciferase reporter plasmidDZIP1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DZIP1L
    Predesigned siRNA for gene silencing in human, mouse, rat DZIP1L
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    GenScript: all cDNA clones in your preferred vector (see all 2): DZIP1L (NM_173543)
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    Primer
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    OriGene qPCR primer pairs and template standards for DZIP1L
    OriGene qSTAR qPCR primer pairs in human, mouse for DZIP1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DZIP1L
      QuantiTect SYBR Green Assays in human, mouse, rat DZIP1L
      QuantiFast Probe-based Assays in human, mouse, rat DZIP1L

    Additional mRNA sequence: 

    AK057406.1 BC033308.1 

    5 DOTS entries:

    DT.97804639  DT.95239681  DT.40274473  DT.91962733  DT.102841437 

    24 AceView cDNA sequences:

    BC033308 BX475020 BX280707 BQ686868 CN479011 NM_173543 AI148239 CB266770 
    BF340245 BM973367 AI283643 AA729786 BQ424578 AK057406 BF590078 BX475019 
    BE252951 BF984904 BG912394 AA194020 CD701720 AA626922 BF935374 AA194199 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DZIP1L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:              -     -     -                                                                       -                           
    SP2:                                                                                                                              
    SP3:              -                                                                                                               


    ECgene alternative splicing isoforms for DZIP1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DZIP1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGGAAGG
    DZIP1L Expression
    About this image

    DZIP1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DZIP1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351403
        Custom PCR Arrays for DZIP1L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DZIP1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DZIP1L gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dzip1l1 , 5 DAZ interacting protein 1-like1, 5 81.7(n)1
    77.59(a)1
      9 (51.93 cM)5
    725071  NM_028258.31  NP_082534.21 
     996294965 
    chicken
    (Gallus gallus)
    Aves DZIP1L6
    DAZ interacting zinc finger protein 1-like
    35(a)
    1 ↔ 1
    9(3613513-3623335)
    lizard
    (Anolis carolinensis)
    Reptilia DZIP1L6
    DAZ interacting zinc finger protein 1-like
    41(a)
    1 ↔ 1
    3(33041740-33077913)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dzip1l1 DAZ interacting zinc finger protein 1-like 54.75(n)
    46.14(a)
      780329  NM_001079400.1  NP_001072868.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dzip1l1 DAZ interacting zinc finger protein 1-like 51.29(n)
    40.71(a)
      553313  NM_001037227.1  NP_001032304.1 


    ENSEMBL Gene Tree for DZIP1L (if available)
    TreeFam Gene Tree for DZIP1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DZIP1L gene
    DZIP12  
    1 SIMAP similar gene for DZIP1L using alignment to 5 protein entries:     DZI1L_HUMAN (see all proteins):
    DZIP1

    Find genes that share paralogs with DZIP1L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DZIP1L (see all 1057)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556977331,2
    C--137780354(+) AAAAA-/A/AA  
            
    TGCCA
    1 -- ds50011NA 2
    rs1157184391,2
    F--137780482(+) CATGAG/AAGCCT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1162127851,2
    C,F--137780513(+) GACTCC/TCAAGT 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1147582111,2
    C,F--137780586(+) CCTGAG/ATTCTC 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs795378841,2
    C,F--137780848(+) GTACTA/CTATTT 1 -- ut311Minor allele frequency- C:0.07WA 118
    rs1845914561,2
    --137780972(+) TACAAC/GGTCCA 1 -- ut310--------
    rs1141471971,2
    C,F--137781014(+) AGTAGG/ACCTGC 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1898499211,2
    --137781024(+) CCACAC/TATCAC 1 -- ut310--------
    rs729911571,2
    C,F--137781041(+) GGGAAA/CCTCTC 1 -- ut312Minor allele frequency- C:0.12WA 120
    rs1477419481,2
    C--137781181(+) AACTCA/GGTAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DZIP1L (137780827 - 137834660 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DZIP1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2751978CNV Loss17911159
    nsv10329CNV Gain18304495
    nsv10330CNV Gain18304495
    dgv298n21CNV Gain19592680
    nsv428422CNV Gain+Loss18775914
    dgv1512e1CNV Complex17122850
    dgv1511e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DZIP1L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DZIP1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. (PubMed id 19852954)1 Glazer A.M....Reddien P.W. (Dev. Biol. 2010)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1 Moore F.L.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 199221 HGNC: 26551 AceView: FLJ32844 Ensembl:ENSG00000158163 euGenes: HUgn199221
    ECgene: DZIP1L H-InvDB: DZIP1L

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DZIP1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DZIP1L gene:
    Search GeneIP for patents involving DZIP1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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