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Aliases for DZIP1 Gene

Aliases for DZIP1 Gene

  • DAZ Interacting Zinc Finger Protein 1 2 3 5
  • DAZ-Interacting Protein 1/2 3 4
  • DAZ Interacting Protein 1 2 3
  • DZIP 3 4
  • Zinc Finger DAZ Interacting Protein 1 3
  • DAZ Interacting Protein Testis1 3
  • Zinc-Finger Protein DZIPt1 3
  • Zinc Finger Protein DZIP1 3
  • KIAA0996 4
  • DZIPt1 3
  • DZIP2 4

External Ids for DZIP1 Gene

Previous GeneCards Identifiers for DZIP1 Gene

  • GC13M094593
  • GC13M090620
  • GC13M095039
  • GC13M093931
  • GC13M093928
  • GC13M095028
  • GC13M096230
  • GC13M076828

Summaries for DZIP1 Gene

GeneCards Summary for DZIP1 Gene

DZIP1 (DAZ Interacting Zinc Finger Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR. An important paralog of this gene is DZIP1L.

UniProtKB/Swiss-Prot for DZIP1 Gene

  • May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).

Gene Wiki entry for DZIP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZIP1 Gene

Genomics for DZIP1 Gene

Regulatory Elements for DZIP1 Gene

Enhancers for DZIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F095675 1.1 ENCODE 19.9 -32.3 -32253 3.6 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 DZIP1 UGGT2 DNAJC3 DNAJC3-AS1
GH13F095684 0.8 Ensembl ENCODE 19.8 -40.0 -39995 1.4 ZNF707 HINFP SCRT2 ZNF548 DZIP1 DNAJC3 MTND5P2
GH13F095603 1.1 Ensembl ENCODE 11.8 +40.4 40415 1.2 SOX13 ZNF792 SAP130 CEBPG THRB RAD21 ZNF644 RARA SMARCC2 RCOR1 DZIP1 GC13M095581
GH13F095833 1 Ensembl ENCODE 11 -189.4 -189395 1.0 CTCF ZNF654 WRNIP1 MAX TRIM22 REST RAD21 RFX5 ZNF692 ZNF143 DZIP1 HMGN1P24 GC13M095889
GH13F095642 0.9 ENCODE 12.2 +0.6 601 2.3 TBP PKNOX1 ZNF76 ARID4B SIN3A FEZF1 ZNF48 ZEB1 GLIS2 ZNF366 DZIP1 UGGT2 DNAJC3-AS1 CLDN10 GC13M095581
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DZIP1 on UCSC Golden Path with GeneCards custom track

Promoters for DZIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000667151 406 2200 TBP PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZEB1 GLIS2 ZNF366 EGR2

Genomic Location for DZIP1 Gene

Chromosome:
13
Start:
95,578,202 bp from pter
End:
95,644,706 bp from pter
Size:
66,505 bases
Orientation:
Minus strand

Genomic View for DZIP1 Gene

Genes around DZIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DZIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DZIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZIP1 Gene

Proteins for DZIP1 Gene

  • Protein details for DZIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YF9-DZIP1_HUMAN
    Recommended name:
    Zinc finger protein DZIP1
    Protein Accession:
    Q86YF9
    Secondary Accessions:
    • Q5W078
    • Q5W079
    • Q8WY45
    • Q8WY46
    • Q9UGA5
    • Q9Y2K0

    Protein attributes for DZIP1 Gene

    Size:
    867 amino acids
    Molecular mass:
    98664 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with DAZ proteins. May participate in an RNA-binding complex that functions in both ES cells and germ cells.
    SequenceCaution:
    • Sequence=AAL36978.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA76840.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43211.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DZIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DZIP1 Gene

Post-translational modifications for DZIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DZIP1 Gene

Domains & Families for DZIP1 Gene

Protein Domains for DZIP1 Gene

Suggested Antigen Peptide Sequences for DZIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YF9

UniProtKB/Swiss-Prot:

DZIP1_HUMAN :
  • Belongs to the DZIP C2H2-type zinc-finger protein family.
  • Contains 1 C2H2-type zinc finger.
Family:
  • Belongs to the DZIP C2H2-type zinc-finger protein family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with DZIP1: view

No data available for Gene Families for DZIP1 Gene

Function for DZIP1 Gene

Molecular function for DZIP1 Gene

UniProtKB/Swiss-Prot Function:
May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).

Gene Ontology (GO) - Molecular Function for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 15081113
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DZIP1: view
genes like me logo Genes that share phenotypes with DZIP1: view

Animal Model Products

miRNA for DZIP1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DZIP1 Gene

Localization for DZIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DZIP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In testis, it is predominantly nuclear, with some cytoplasmic localization in spermatogonia. Colocalizes with DAZ and DAZL in primordial germ cells. {ECO:0000269 PubMed:15081113}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DZIP1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15081113
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 15081113
GO:0005814 colocalizes_with centriole IEA,IDA 19852954
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with DZIP1: view

Pathways & Interactions for DZIP1 Gene

genes like me logo Genes that share pathways with DZIP1: view

Pathways by source for DZIP1 Gene

3 Reactome pathways for DZIP1 Gene

Gene Ontology (GO) - Biological Process for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development NAS 15081113
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DZIP1: view

No data available for SIGNOR curated interactions for DZIP1 Gene

Transcripts for DZIP1 Gene

Unigene Clusters for DZIP1 Gene

DAZ interacting protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DZIP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10:

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25
SP1: - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DZIP1 Gene

GeneLoc Exon Structure for
DZIP1
ECgene alternative splicing isoforms for
DZIP1

Expression for DZIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DZIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DZIP1 Gene

This gene is overexpressed in Spleen (33.1), Liver (21.6), and Ovary (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DZIP1 Gene



Protein tissue co-expression partners for DZIP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DZIP1 Gene:

DZIP1

SOURCE GeneReport for Unigene cluster for DZIP1 Gene:

Hs.656580

mRNA Expression by UniProt/SwissProt for DZIP1 Gene:

Q86YF9-DZIP1_HUMAN
Tissue specificity: Predominantly expressed in testis. Also expressed in fetal brain, adult oocytes and ovary. Expressed in undifferentiated ES cells. In testis, it is probably specifically expressed in germ cells. Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary spermatocytes.
genes like me logo Genes that share expression patterns with DZIP1: view

Primer Products

No data available for mRNA differential expression in normal tissues for DZIP1 Gene

Orthologs for DZIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DZIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DZIP1 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia DZIP1 34 35
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia DZIP1 34 35
  • 85.15 (n)
rat
(Rattus norvegicus)
Mammalia Dzip1 34
  • 74.49 (n)
mouse
(Mus musculus)
Mammalia Dzip1 34 16 35
  • 74.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DZIP1 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DZIP1 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves DZIP1 34 35
  • 63.83 (n)
lizard
(Anolis carolinensis)
Reptilia DZIP1 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dzip1 34
  • 48.4 (n)
zebrafish
(Danio rerio)
Actinopterygii dzip1 34 35
  • 50.7 (n)
Dr.27118 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for DZIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DZIP1 Gene

ENSEMBL:
Gene Tree for DZIP1 (if available)
TreeFam:
Gene Tree for DZIP1 (if available)

Paralogs for DZIP1 Gene

Paralogs for DZIP1 Gene

(1) SIMAP similar genes for DZIP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DZIP1: view

Variants for DZIP1 Gene

Sequence variations from dbSNP and Humsavar for DZIP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10161637 -- 95,614,296(+) GAACC(C/T)CCCCC intron-variant
rs10539901 -- 95,637,637(+) CTCTC(-/TCTCTCTCTC)CAAAC intron-variant
rs10623878 -- 95,624,029(+) GCCAT(-/AGC/AGT/TAG)TCGCC intron-variant
rs10644647 -- 95,645,320(+) GCAGC(-/TA/TATATA)TATAT upstream-variant-2KB
rs11070136 -- 95,587,551(+) CTTGG(A/G)AGAAT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DZIP1 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER inversion 18451855
nsv976147 CNV duplication 23825009

Variation tolerance for DZIP1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.03; 84.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DZIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DZIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DZIP1 Gene

Disorders for DZIP1 Gene

Relevant External Links for DZIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DZIP1

No disorders were found for DZIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DZIP1 Gene

Publications for DZIP1 Gene

  1. Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (PMID: 15081113) Moore F.L. … Reijo-Pera R.A. (Genomics 2004) 3 4 22 64
  2. The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. (PMID: 19852954) Glazer A.M. … Reddien P.W. (Dev. Biol. 2010) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PMID: 12511597) Moore F.L. … Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64

Products for DZIP1 Gene

Sources for DZIP1 Gene

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