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Aliases for DZIP1 Gene

Aliases for DZIP1 Gene

  • DAZ Interacting Zinc Finger Protein 1 2 3
  • DAZ-Interacting Protein 1/2 3 4
  • DAZ Interacting Protein 1 2 3
  • DZIP 3 4
  • Zinc Finger DAZ Interacting Protein 1 3
  • DAZ Interacting Protein Testis1 3
  • Zinc-Finger Protein DZIPt1 3
  • Zinc Finger Protein DZIP1 3
  • KIAA0996 4
  • DZIPt1 3
  • DZIP2 4

External Ids for DZIP1 Gene

Previous GeneCards Identifiers for DZIP1 Gene

  • GC13M094593
  • GC13M090620
  • GC13M095039
  • GC13M093931
  • GC13M093928
  • GC13M095028
  • GC13M096230
  • GC13M076828

Summaries for DZIP1 Gene

GeneCards Summary for DZIP1 Gene

DZIP1 (DAZ Interacting Zinc Finger Protein 1) is a Protein Coding gene. An important paralog of this gene is DZIP1L.

UniProtKB/Swiss-Prot for DZIP1 Gene

  • May participate in spermatogenesis via its interaction with DAZ.

Gene Wiki entry for DZIP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZIP1 Gene

Genomics for DZIP1 Gene

Regulatory Elements for DZIP1 Gene

Genomic Location for DZIP1 Gene

95,578,202 bp from pter
95,644,706 bp from pter
66,505 bases
Minus strand

Genomic View for DZIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DZIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZIP1 Gene

Proteins for DZIP1 Gene

  • Protein details for DZIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein DZIP1
    Protein Accession:
    Secondary Accessions:
    • Q5W078
    • Q5W079
    • Q8WY45
    • Q8WY46
    • Q9UGA5
    • Q9Y2K0

    Protein attributes for DZIP1 Gene

    867 amino acids
    Molecular mass:
    98664 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with DAZ proteins. May participate in an RNA-binding complex that functions in both ES cells and germ cells
    • Sequence=AAL36978.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA76840.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43211.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DZIP1 Gene


neXtProt entry for DZIP1 Gene

Proteomics data for DZIP1 Gene at MOPED

Post-translational modifications for DZIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DZIP1 Gene

No data available for DME Specific Peptides for DZIP1 Gene

Domains for DZIP1 Gene

Gene Families for DZIP1 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for DZIP1 Gene


Suggested Antigen Peptide Sequences for DZIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86YF9
  • Belongs to the DZIP C2H2-type zinc-finger protein family.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with DZIP1: view

Function for DZIP1 Gene

Molecular function for DZIP1 Gene

UniProtKB/Swiss-Prot Function: May participate in spermatogenesis via its interaction with DAZ.

Gene Ontology (GO) - Molecular Function for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15081113
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DZIP1: view
genes like me logo Genes that share phenotypes with DZIP1: view

miRNA for DZIP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DZIP1 Gene

Localization for DZIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DZIP1 Gene

Nucleus. Cytoplasm. Note=In testis, it is predominantly nuclear, with some cytoplasmic localization in spermatogonia. Colocalizes with DAZ and DAZL in primordial germ cells.

Subcellular locations from

Jensen Localization Image for DZIP1 Gene COMPARTMENTS Subcellular localization image for DZIP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15081113
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15081113
GO:0005813 centrosome IDA --
GO:0005814 colocalizes_with centriole IDA 19852954
genes like me logo Genes that share ontologies with DZIP1: view

Pathways for DZIP1 Gene

SuperPathways for DZIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007281 germ cell development NAS 15081113
GO:0007283 spermatogenesis IEA --
GO:0042384 cilium assembly IMP 19852954
genes like me logo Genes that share ontologies with DZIP1: view

No data available for Pathways by source for DZIP1 Gene

Transcripts for DZIP1 Gene

Unigene Clusters for DZIP1 Gene

DAZ interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DZIP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - -
SP6: - - - - - - -
SP7: -
SP9: -

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for DZIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DZIP1 Gene

mRNA expression in normal human tissues for DZIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DZIP1 Gene

SOURCE GeneReport for Unigene cluster for DZIP1 Gene Hs.656580

mRNA Expression by UniProt/SwissProt for DZIP1 Gene

Tissue specificity: Predominantly expressed in testis. Also expressed in fetal brain, adult oocytes and ovary. Expressed in undifferentiated ES cells. In testis, it is probably specifically expressed in germ cells. Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary spermatocytes.
genes like me logo Genes that share expressions with DZIP1: view

No data available for mRNA differential expression in normal tissues for DZIP1 Gene

Orthologs for DZIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DZIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DZIP1 35
  • 99.34 (n)
  • 99.18 (a)
DZIP1 36
  • 99 (a)
(Bos Taurus)
Mammalia DZIP1 35
  • 85.15 (n)
  • 79.67 (a)
DZIP1 36
  • 79 (a)
(Canis familiaris)
Mammalia DZIP1 35
  • 85.38 (n)
  • 79.79 (a)
DZIP1 36
  • 79 (a)
(Mus musculus)
Mammalia Dzip1 35
  • 74.34 (n)
  • 68 (a)
Dzip1 16
Dzip1 36
  • 68 (a)
(Monodelphis domestica)
Mammalia DZIP1 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia DZIP1 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Dzip1 35
  • 74.49 (n)
  • 66.78 (a)
(Gallus gallus)
Aves DZIP1 35
  • 63.83 (n)
  • 51.02 (a)
DZIP1 36
  • 46 (a)
(Anolis carolinensis)
Reptilia DZIP1 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dzip1 35
  • 48.4 (n)
  • 32.82 (a)
(Danio rerio)
Actinopterygii Dr.27118 35
dzip1 35
  • 50.7 (n)
  • 36.25 (a)
dzip1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for DZIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DZIP1 Gene

Gene Tree for DZIP1 (if available)
Gene Tree for DZIP1 (if available)

Paralogs for DZIP1 Gene

Paralogs for DZIP1 Gene

Selected SIMAP similar genes for DZIP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DZIP1: view

Variants for DZIP1 Gene

Sequence variations from dbSNP and Humsavar for DZIP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1197890 -- 95,617,480(-) tattt(A/C)tcttc intron-variant
rs1197891 -- 95,643,377(+) ACCCA(A/T)GCAAA intron-variant
rs1408606 -- 95,625,672(+) acaac(A/G)tgctc intron-variant
rs1408607 -- 95,625,728(+) agata(C/T)tgtga intron-variant
rs1409061 -- 95,610,662(+) taggt(A/G)tatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DZIP1 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv900934 CNV Loss 21882294

Relevant External Links for DZIP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DZIP1 Gene

Disorders for DZIP1 Gene

No disorders were found for DZIP1 Gene.

No data available for UniProtKB/Swiss-Prot for DZIP1 Gene

Publications for DZIP1 Gene

  1. Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (PMID: 15081113) Moore F.L. … Reijo-Pera R.A. (Genomics 2004) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PMID: 12511597) Moore F.L. … Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DZIP1 Gene

Sources for DZIP1 Gene

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