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Aliases for DZANK1 Gene

Aliases for DZANK1 Gene

  • Double Zinc Ribbon And Ankyrin Repeat Domains 1 2 3 5
  • Ankyrin Repeat Domain 64 2 3
  • C20orf12 3 4
  • C20orf84 3 4
  • Double Zinc Ribbon And Ankyrin Repeat-Containing Protein 1 3
  • Ankyrin Repeat-Containing Protein C20orf12 3
  • Chromosome 20 Open Reading Frame 12 2
  • BA189K21.1 3
  • BA189K21.8 3
  • DJ568F9.2 3
  • ANKRD64 3

External Ids for DZANK1 Gene

Previous HGNC Symbols for DZANK1 Gene

  • C20orf84
  • C20orf12

Summaries for DZANK1 Gene

Entrez Gene Summary for DZANK1 Gene

  • This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. Alternative splicing has been observed for this gene but the full-length nature of additional variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DZANK1 Gene

DZANK1 (Double Zinc Ribbon And Ankyrin Repeat Domains 1) is a Protein Coding gene. Diseases associated with DZANK1 include Corneal Dystrophy, Posterior Polymorphous, 1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZANK1 Gene

Genomics for DZANK1 Gene

Regulatory Elements for DZANK1 Gene

Enhancers for DZANK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F018412 1.1 Ensembl ENCODE 22.2 +54.3 54318 1.9 TBP CTCF MAX ZNF704 CEBPG ZNF2 RAD21 POLR2A ZNF143 SMC3 DZANK1 POLR3F LINC00851 LINC00493 GCNT1P1
GH20F018430 0.2 ENCODE 12.4 +37.0 36960 0.2 PKNOX1 FEZF1 HIC1 ZNF366 SCRT2 ZNF239 KLF7 KLF8 EGR2 SCRT1 DZANK1 POLR3F RNA5SP476 GCNT1P1
GH20F018436 0.2 Ensembl 12.4 +30.5 30481 0.4 ZNF316 SCRT2 IKZF1 HOMEZ SP7 DZANK1 POLR3F LINC00493 RNA5SP476
GH20F018428 0.2 ENCODE 11.8 +38.3 38310 0.2 FEZF1 YY1 ZNF366 KLF7 ZNF680 YY2 CEBPB OVOL3 ZEB2 TSHZ1 DZANK1 POLR3F RBBP9 RNA5SP476 GCNT1P1
GH20F018527 0.6 ENCODE 11.7 -60.6 -60595 0.6 ZNF2 ZNF335 GLIS2 POLR2A ZNF207 PRDM10 L3MBTL2 TRIM22 MXD4 ZNF16 POLR3F DZANK1 RBBP9 SEC23B GC20P018562
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DZANK1 on UCSC Golden Path with GeneCards custom track

Promoters for DZANK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008531 81 2401 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for DZANK1 Gene

Chromosome:
20
Start:
18,383,367 bp from pter
End:
18,467,281 bp from pter
Size:
83,915 bases
Orientation:
Minus strand

Genomic View for DZANK1 Gene

Genes around DZANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DZANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DZANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZANK1 Gene

Proteins for DZANK1 Gene

  • Protein details for DZANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVP4-DZAN1_HUMAN
    Recommended name:
    Double zinc ribbon and ankyrin repeat-containing protein 1
    Protein Accession:
    Q9NVP4
    Secondary Accessions:
    • B7ZLZ4
    • Q4F7X1
    • Q5QPD9
    • Q5QPE0
    • Q68DN8
    • Q6ZMX9
    • Q96NF0
    • Q9H1E0
    • Q9H442

    Protein attributes for DZANK1 Gene

    Size:
    752 amino acids
    Molecular mass:
    82192 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91706.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70949.1; Type=Erroneous termination; Positions=569; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for DZANK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DZANK1 Gene

Post-translational modifications for DZANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DZANK1 Gene

Domains & Families for DZANK1 Gene

Gene Families for DZANK1 Gene

Protein Domains for DZANK1 Gene

Suggested Antigen Peptide Sequences for DZANK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVP4

UniProtKB/Swiss-Prot:

DZAN1_HUMAN :
  • Contains 2 ANK repeats.
Similarity:
  • Contains 2 ANK repeats.
  • Contains 2 DZANK-type zinc fingers.
genes like me logo Genes that share domains with DZANK1: view

Function for DZANK1 Gene

Gene Ontology (GO) - Molecular Function for DZANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DZANK1: view
genes like me logo Genes that share phenotypes with DZANK1: view

Animal Model Products

miRNA for DZANK1 Gene

miRTarBase miRNAs that target DZANK1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DZANK1 Gene

Localization for DZANK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DZANK1 Gene COMPARTMENTS Subcellular localization image for DZANK1 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DZANK1 Gene

Pathways & Interactions for DZANK1 Gene

SuperPathways for DZANK1 Gene

No Data Available

Interacting Proteins for DZANK1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262547%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344782%0d%0a
Selected Interacting proteins: Q9NVP4-DZAN1_HUMAN ENSP00000262547 for DZANK1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DZANK1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DZANK1 Gene

Transcripts for DZANK1 Gene

Unigene Clusters for DZANK1 Gene

Double zinc ribbon and ankyrin repeat domains 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DZANK1 Gene

No ASD Table

Relevant External Links for DZANK1 Gene

GeneLoc Exon Structure for
DZANK1
ECgene alternative splicing isoforms for
DZANK1

Expression for DZANK1 Gene

mRNA expression in normal human tissues for DZANK1 Gene

Protein differential expression in normal tissues from HIPED for DZANK1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DZANK1 Gene



Protein tissue co-expression partners for DZANK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DZANK1 Gene:

DZANK1

SOURCE GeneReport for Unigene cluster for DZANK1 Gene:

Hs.472225
genes like me logo Genes that share expression patterns with DZANK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DZANK1 Gene

Orthologs for DZANK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DZANK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DZANK1 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia DZANK1 34 35
  • 86.49 (n)
mouse
(Mus musculus)
Mammalia Dzank1 34 16 35
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Dzank1 34
  • 83.11 (n)
cow
(Bos Taurus)
Mammalia C13H20ORF12 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DZANK1 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DZANK1 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves DZANK1 34 35
  • 62.16 (n)
lizard
(Anolis carolinensis)
Reptilia DZANK1 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dzank1 34
  • 61.74 (n)
zebrafish
(Danio rerio)
Actinopterygii dzank1 34 35
  • 55.84 (n)
Dr.25994 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for DZANK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DZANK1 Gene

ENSEMBL:
Gene Tree for DZANK1 (if available)
TreeFam:
Gene Tree for DZANK1 (if available)

Paralogs for DZANK1 Gene

(1) SIMAP similar genes for DZANK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DZANK1: view

No data available for Paralogs for DZANK1 Gene

Variants for DZANK1 Gene

Sequence variations from dbSNP and Humsavar for DZANK1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1033544 -- 18,389,987(-) CGTAG(A/G)TCAGG intron-variant
rs10485581 -- 18,430,070(+) CTGGG(A/T)TAAAA intron-variant, utr-variant-5-prime
rs10618072 -- 18,415,575(+) TTTTG(-/TT)TTGTT intron-variant
rs11087255 -- 18,463,872(+) AAAAA(-/A)GGCAA intron-variant
rs111291598 -- 18,384,257(+) TTTCT(C/G)CATGT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DZANK1 Gene

Variant ID Type Subtype PubMed ID
dgv4283n100 CNV loss 25217958
esv3645437 CNV gain 21293372
esv6745 CNV gain 19470904
nsv1062244 CNV gain 25217958
nsv3313 CNV insertion 18451855
nsv509763 CNV insertion 20534489
nsv523362 CNV loss 19592680

Variation tolerance for DZANK1 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.62; 93.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DZANK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DZANK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DZANK1 Gene

Disorders for DZANK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DZANK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
corneal dystrophy, posterior polymorphous, 1
  • corneal endothelial dystrophy 1, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DZANK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DZANK1
genes like me logo Genes that share disorders with DZANK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DZANK1 Gene

Publications for DZANK1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3 64
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for DZANK1 Gene

Sources for DZANK1 Gene

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