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Aliases for DZANK1 Gene

Aliases for DZANK1 Gene

  • Double Zinc Ribbon And Ankyrin Repeat Domains 1 2 3 5
  • Ankyrin Repeat Domain 64 2 3
  • C20orf12 3 4
  • C20orf84 3 4
  • Ankyrin Repeat-Containing Protein C20orf12 3
  • Chromosome 20 Open Reading Frame 12 2
  • BA189K21.1 3
  • BA189K21.8 3
  • DJ568F9.2 3
  • ANKRD64 3

External Ids for DZANK1 Gene

Previous HGNC Symbols for DZANK1 Gene

  • C20orf84
  • C20orf12

Summaries for DZANK1 Gene

Entrez Gene Summary for DZANK1 Gene

  • This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. Alternative splicing has been observed for this gene but the full-length nature of additional variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DZANK1 Gene

DZANK1 (Double Zinc Ribbon And Ankyrin Repeat Domains 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZANK1 Gene

Genomics for DZANK1 Gene

Regulatory Elements for DZANK1 Gene

Enhancers for DZANK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DZANK1 on UCSC Golden Path with GeneCards custom track

Promoters for DZANK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DZANK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DZANK1 Gene

18,383,367 bp from pter
18,467,281 bp from pter
83,915 bases
Minus strand

Genomic View for DZANK1 Gene

Genes around DZANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DZANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DZANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZANK1 Gene

Proteins for DZANK1 Gene

  • Protein details for DZANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Double zinc ribbon and ankyrin repeat-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B7ZLZ4
    • Q4F7X1
    • Q5QPD9
    • Q5QPE0
    • Q68DN8
    • Q6ZMX9
    • Q96NF0
    • Q9H1E0
    • Q9H442

    Protein attributes for DZANK1 Gene

    752 amino acids
    Molecular mass:
    82192 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91706.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70949.1; Type=Erroneous termination; Positions=569; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for DZANK1 Gene


neXtProt entry for DZANK1 Gene

Proteomics data for DZANK1 Gene at MOPED

Post-translational modifications for DZANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DZANK1 Gene

Domains & Families for DZANK1 Gene

Gene Families for DZANK1 Gene

Protein Domains for DZANK1 Gene

Suggested Antigen Peptide Sequences for DZANK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 ANK repeats.
  • Contains 2 ANK repeats.
  • Contains 2 DZANK-type zinc fingers.
genes like me logo Genes that share domains with DZANK1: view

Function for DZANK1 Gene

genes like me logo Genes that share phenotypes with DZANK1: view

Animal Model Products

CRISPR Products

miRNA for DZANK1 Gene

miRTarBase miRNAs that target DZANK1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DZANK1 Gene

Localization for DZANK1 Gene

Subcellular locations from

Jensen Localization Image for DZANK1 Gene COMPARTMENTS Subcellular localization image for DZANK1 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DZANK1 Gene

Pathways & Interactions for DZANK1 Gene

SuperPathways for DZANK1 Gene

No Data Available

Interacting Proteins for DZANK1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NVP4-DZAN1_HUMAN ENSP00000262547 for DZANK1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for DZANK1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DZANK1 Gene

Drugs & Compounds for DZANK1 Gene

No Compound Related Data Available

Transcripts for DZANK1 Gene

Unigene Clusters for DZANK1 Gene

Double zinc ribbon and ankyrin repeat domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DZANK1 Gene

No ASD Table

Relevant External Links for DZANK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DZANK1 Gene

mRNA expression in normal human tissues for DZANK1 Gene

Protein differential expression in normal tissues from HIPED for DZANK1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DZANK1 Gene

SOURCE GeneReport for Unigene cluster for DZANK1 Gene Hs.472225

genes like me logo Genes that share expression patterns with DZANK1: view

Protein tissue co-expression partners for DZANK1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DZANK1 Gene

Orthologs for DZANK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DZANK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia DZANK1 35
  • 86.49 (n)
  • 79.81 (a)
  • 77 (a)
(Mus musculus)
Mammalia Dzank1 35
  • 83.33 (n)
  • 78.57 (a)
Dzank1 16
Dzank1 36
  • 75 (a)
(Pan troglodytes)
Mammalia DZANK1 35
  • 99.34 (n)
  • 99.07 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dzank1 35
  • 83.11 (n)
  • 78.3 (a)
(Bos Taurus)
Mammalia C13H20ORF12 36
  • 77 (a)
(Monodelphis domestica)
Mammalia DZANK1 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia DZANK1 36
  • 56 (a)
(Gallus gallus)
Aves DZANK1 35
  • 62.16 (n)
  • 54.1 (a)
  • 51 (a)
(Anolis carolinensis)
Reptilia DZANK1 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dzank1 35
  • 61.74 (n)
  • 57.85 (a)
(Danio rerio)
Actinopterygii Dr.25994 35
dzank1 35
  • 55.84 (n)
  • 50.68 (a)
dzank1 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for DZANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DZANK1 Gene

Gene Tree for DZANK1 (if available)
Gene Tree for DZANK1 (if available)

Paralogs for DZANK1 Gene

(1) SIMAP similar genes for DZANK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DZANK1: view

No data available for Paralogs for DZANK1 Gene

Variants for DZANK1 Gene

Sequence variations from dbSNP and Humsavar for DZANK1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1033544 -- 18,389,987(-) CGTAG(A/G)TCAGG intron-variant
rs717581 -- 18,452,282(+) TTCAA(A/G)TAAGT intron-variant
rs725532 -- 18,447,248(+) AGGGG(A/G)GCAGA intron-variant
rs729656 -- 18,394,678(-) GATCT(A/C)AAGGT intron-variant
rs761464 -- 18,394,680(-) AGGAT(A/C)TAAAG intron-variant

Variation tolerance for DZANK1 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.62; 93.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DZANK1 Gene

Disorders for DZANK1 Gene

Relevant External Links for DZANK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DZANK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DZANK1 Gene

Publications for DZANK1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DZANK1 Gene

Sources for DZANK1 Gene