DZANK1 Gene
protein-coding GIFtS: 41
GCID: GC20M018364
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double zinc ribbon and ankyrin repeat domains 1(Previous name: chromosome 20 open reading frame 12 ) (Previous symbols: C20orf84, C20orf12)
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Aliases for DZANK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Double Zinc Ribbon And Ankyrin Repeat Domains 11 2 | | FLJ308921 | | C20orf121 2 3 | | Chromosome 20 Open Reading Frame 121 | | C20orf841 2 3 | | Ankyrin Repeat Domain 642 | | ANKRD641 2 | | Ankyrin Repeat-Containing Protein C20orf122 | | BA189K21.81 | | BA189K21.11 | | DJ568F9.21 | | Double Zinc Ribbon And Ankyrin Repeat-Containing Protein 12 | | FLJ106001 | | |
Export aliases for DZANK1 gene to outside databases |
Summaries for DZANK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DZANK1: This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 aminoacids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in alarge number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-proteininteraction domains. Alternative splicing has been observed for this gene but the full-length nature of additionalvariants has not been determined. (provided by RefSeq, Jul 2008)
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Genomic Views for DZANK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for DZANK1 Other transcription factors
Search SABiosciences Chromatin IP Primers for DZANK1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DZANK1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.23 Ensembl cytogenetic band: 20p11.23 HGNC cytogenetic band: 20p11.23DZANK1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M018364: view genomic region
(about GC identifiers)
Start:
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18,364,011 bp from pter |
End:
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18,447,829 bp from pter |
Size:
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83,819 bases |
Orientation:
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minus strand |
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Proteins for DZANK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DZAN1_HUMAN, Q9NVP4 (See
protein sequence)Recommended Name: Double zinc ribbon and ankyrin repeat-containing protein 1 Size: 752 amino acids; 82192 Da
Sequence caution: Sequence=BAA91706.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB70949.1; Type=Erroneous termination; Positions=569; Note=Translated as Trp;
Secondary accessions: B7ZLZ4 Q4F7X1 Q5QPD9 Q5QPE0 Q68DN8 Q6ZMX9 Q96NF0 Q9H1E0 Q9H442Alternative splicing: 5 isoforms: Q9NVP4-1 Q9NVP4-2 Q9NVP4-3 Q9NVP4-4 Q9NVP4-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DZANK1: NX_Q9NVP4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NVP4 DZANK1 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_001092877.1 ENSEMBL proteins: ENSP00000366857 ENSP00000351734 ENSP00000262547 ENSP00000328866 ENSP00000349774 Human Recombinant Protein Products for DZANK1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
DZANK1 for ontologies About GeneDecksing
DZANK1 Antibody Products: Assay Products for DZANK1: |
Protein
Domains / Families for DZANK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DZANK1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NVP4ProtoNet protein and cluster: Q9NVP4 1 Blocks protein family: IPB001876 Zn-finger
UniProtKB/Swiss-Prot: DZAN1_HUMAN, Q9NVP4Similarity: Contains 2 ANK repeatsSimilarity: Contains 2 DZANK-type zinc fingers |
Function for DZANK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
DZANK1 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DZANK1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DZANK1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for DZANK1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DZANK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DZANK1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DZANK1 |
|
Pathways & Interactions for DZANK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DZANK1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for DZANK1 (Q9NVP42, 3 ENSP000002625474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for DZANK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DZANK1 Search CenterWatch for drugs/clinical trials and news about DZANK1 / DZAN1 
|
Transcripts for DZANK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DZANK1 gene (2 alternative transcripts): NM_018152.2 NM_001099407.1 Unigene Cluster for DZANK1: Double zinc ribbon and ankyrin repeat domains 1 Hs.472225 [show with all ESTs]Unigene Representative Sequence: CR74932710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377630(uc010zrz.2 uc002wqp.4) ENST00000476058 ENST00000487128 ENST00000358866 ENST00000480488 ENST00000460891(uc002wqu.1) ENST00000470526 ENST00000262547(uc002wqr.4 uc002wqq.4 uc010zsa.2) ENST00000329494(uc010gct.1) ENST00000357236(uc002wqs.4)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DZANK1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DZANK1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for DZANK1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DZANK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DZANK1  |
Additional cDNA sequence: AK001462.1 AK026306.1 AK055544.1 AK295073.1 AK299746.1 BC130341.1 BC144153.1 CR749327.1 DQ104738.1 8 DOTS entries: DT.95255963 DT.107620 DT.120817954 DT.95255964 DT.438060 DT.120817947 DT.92065833 DT.99965554 24/31 AceView cDNA sequences (see all 31): NM_018152 AA970721 AI026140 AK001462 AI376687 BU540097 AI811688 AK026306 BQ187051 BG396689 W60535 AA737207 CR749327 AK055544 BC036231 AU129170 AK131451 AI419902 H45058 CK300111 BI559750 T62219 AA625643 AA384044 GeneLoc Exon Structure
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Expression for DZANK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DZANK1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCTTTCTGAA
 About this image See DZANK1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DZANK1
SOURCE GeneReport for Unigene cluster: Hs.472225 SABiosciences Custom PCR Arrays for DZANK1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DZANK1 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DZANK1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DZANK1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DZANK1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DZANK1 |
Orthologs for DZANK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DZANK1 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Dzank11 , 5 |
RIKEN cDNA 6330439K17 gene5 double zinc ribbon and ankyrin repeat domains 11 |
83.18(n)1 77.9(a)1 |
  |
2 (71.02 cM)5 2416881 NM_172859.21 NP_766447.21 1444705575 |
chicken (Gallus gallus) |
Aves |
DZANK11 |
double zinc ribbon and ankyrin repeat domains 1 |
62.16(n) 54.1(a) |
  |
416722 NM_001199396.1 NP_001186325.1 |
lizard (Anolis carolinensis) |
Reptilia |
DZANK16 |
-- |
44(a) |
1 ↔ 1 |
4(74534375-74568886) |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.259942 |
Danio rerio clone RK060A1D09 bA189K21.8 mRNA, complete more |
70.94(n) |
  |
AY394973.1 |
ENSEMBL Gene Tree for DZANK1 (if available) TreeFam Gene Tree for DZANK1 (if available)  |
Paralogs for DZANK1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for DZANK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 20 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DZANK1 (18364011 - 18447829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DZANK1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DZANK1 |
|
Disorders
/ Diseases for DZANK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DZANK1 for disorders About GeneDecksing
1 disease for DZANK1: About MalaCardsataxia Export disorders for DZANK1 gene to outside databases
|
Publications for DZANK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DZANK1 gene integrated from 9 sources: (articles sorted by number of sources associating them with DZANK1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The ankyrin repeat: a diversity of interactions on a common structural framework. (PubMed id 10431175)1 Sedgwick S.G. and Smerdon S.J. (1999)
|
External Searches for DZANK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DZANK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DZANK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DZANK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DZANK1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DZANK1 gene: Search GeneIP for patents involving DZANK1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DZANK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for DZANK1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DZANK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DZANK1 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for DZANK1 | | OriGene 3'-UTR Clone for DZANK1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DZANK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DZANK1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for DZANK1 | | OriGene Custom Protein Services for DZANK1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DZANK1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DZANK1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DZANK1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DZANK1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DZANK1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DZANK1 |
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 |  |  |  | |
| | | Search Tocris compounds for DZANK1 |
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 | | DZANK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DZANK1 |
|  |  |  |  | | | ThermoFisher Antibody for DZANK1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DZANK1 |
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