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Aliases for DZANK1 Gene

Aliases for DZANK1 Gene

  • Double Zinc Ribbon And Ankyrin Repeat Domains 1 2 3
  • Ankyrin Repeat Domain 64 2 3
  • C20orf12 3 4
  • C20orf84 3 4
  • Double Zinc Ribbon And Ankyrin Repeat-Containing Protein 1 3
  • Ankyrin Repeat-Containing Protein C20orf12 3
  • Chromosome 20 Open Reading Frame 12 2
  • BA189K21.1 3
  • BA189K21.8 3
  • DJ568F9.2 3
  • ANKRD64 3

External Ids for DZANK1 Gene

Previous Symbols for DZANK1 Gene

  • C20orf84
  • C20orf12

Summaries for DZANK1 Gene

Entrez Gene Summary for DZANK1 Gene

  • This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. Alternative splicing has been observed for this gene but the full-length nature of additional variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DZANK1 Gene

DZANK1 (Double Zinc Ribbon And Ankyrin Repeat Domains 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZANK1 Gene

Genomics for DZANK1 Gene

Genomic Location for DZANK1 Gene

Start:
18,383,367 bp from pter
End:
18,467,348 bp from pter
Size:
83,982 bases
Orientation:
Minus strand

Genomic View for DZANK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DZANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZANK1 Gene

No data available for Regulatory Elements for DZANK1 Gene

Proteins for DZANK1 Gene

  • Protein details for DZANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVP4-DZAN1_HUMAN
    Recommended name:
    Double zinc ribbon and ankyrin repeat-containing protein 1
    Protein Accession:
    Q9NVP4
    Secondary Accessions:
    • B7ZLZ4
    • Q4F7X1
    • Q5QPD9
    • Q5QPE0
    • Q68DN8
    • Q6ZMX9
    • Q96NF0
    • Q9H1E0
    • Q9H442

    Protein attributes for DZANK1 Gene

    Size:
    752 amino acids
    Molecular mass:
    82192 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91706.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70949.1; Type=Erroneous termination; Positions=569; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for DZANK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DZANK1 Gene

Proteomics data for DZANK1 Gene at MOPED

Post-translational modifications for DZANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DZANK1 Gene

Domains for DZANK1 Gene

Gene Families for DZANK1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for DZANK1 Gene

UniProtKB/Swiss-Prot:

DZAN1_HUMAN
Similarity:
  • Contains 2 ANK repeats.:
    • Q9NVP4
  • Contains 2 DZANK-type zinc fingers.:
    • Q9NVP4
genes like me logo Genes that share domains with DZANK1: view

Function for DZANK1 Gene

Gene Ontology (GO) - Molecular Function for DZANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DZANK1: view

miRNA for DZANK1 Gene

miRTarBase miRNAs that target DZANK1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DZANK1 Gene

Localization for DZANK1 Gene

No data available for Gene Ontology (GO) - Cellular Components for DZANK1 Gene

Pathways for DZANK1 Gene

SuperPathways for DZANK1 Gene

No Data Available

Interacting Proteins for DZANK1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262547%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344782%0d%0a
Selected Interacting proteins: Q9NVP4-DZAN1_HUMAN ENSP00000262547 for DZANK1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for DZANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with DZANK1: view

No data available for Pathways by source for DZANK1 Gene

Transcripts for DZANK1 Gene

Unigene Clusters for DZANK1 Gene

Double zinc ribbon and ankyrin repeat domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DZANK1 Gene

No ASD Table

Relevant External Links for DZANK1 Gene

GeneLoc Exon Structure for
DZANK1
ECgene alternative splicing isoforms for
DZANK1

Expression for DZANK1 Gene

mRNA expression in normal human tissues for DZANK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DZANK1 Gene

SOURCE GeneReport for Unigene cluster for DZANK1 Gene Hs.472225

genes like me logo Genes that share expressions with DZANK1: view

Orthologs for DZANK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DZANK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DZANK1 36
  • 99.34 (n)
  • 99.07 (a)
DZANK1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C13H20ORF12 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DZANK1 36
  • 86.49 (n)
  • 79.81 (a)
DZANK1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dzank1 36
  • 83.33 (n)
  • 78.57 (a)
Dzank1 16
Dzank1 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DZANK1 37
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DZANK1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dzank1 36
  • 83.11 (n)
  • 78.3 (a)
chicken
(Gallus gallus)
Aves DZANK1 36
  • 62.16 (n)
  • 54.1 (a)
DZANK1 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DZANK1 37
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dzank1 36
  • 61.74 (n)
  • 57.85 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.25994 36
dzank1 36
  • 55.84 (n)
  • 50.68 (a)
dzank1 37
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for DZANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DZANK1 Gene

ENSEMBL:
Gene Tree for DZANK1 (if available)
TreeFam:
Gene Tree for DZANK1 (if available)

Paralogs for DZANK1 Gene

Selected SIMAP similar genes for DZANK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DZANK1: view

No data available for Paralogs for DZANK1 Gene

Variants for DZANK1 Gene

Sequence variations from dbSNP and Humsavar for DZANK1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs717581 -- 18,452,282(+) TTCAA(A/G)TAAGT intron-variant
rs725532 -- 18,447,248(+) AGGGG(A/G)GCAGA intron-variant
rs729656 -- 18,394,678(-) GATCT(A/C)AAGGT intron-variant
rs761464 -- 18,394,680(-) AGGAT(A/C)TAAAG intron-variant
rs913298 -- 18,399,692(+) acttg(A/G)gagat intron-variant

Relevant External Links for DZANK1 Gene

HapMap Linkage Disequilibrium report
DZANK1

No data available for Structural Variations from Database of Genomic Variants (DGV) for DZANK1 Gene

Disorders for DZANK1 Gene

No disorders were found for DZANK1 Gene.

No data available for UniProtKB/Swiss-Prot for DZANK1 Gene

Publications for DZANK1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The ankyrin repeat: a diversity of interactions on a common structural framework. (PMID: 10431175) Sedgwick S.G. … Smerdon S.J. (Trends Biochem. Sci. 1999) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for DZANK1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DZANK1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DZANK1
    • Block miRNA regulation of DZANK1 using miScript Target Protectors

    Sources for DZANK1 Gene

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