DYX2 Locus
genetic locus GIFtS: 11
GCID: GC00U922111
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Dyslexia Susceptibility 2
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Aliases
for DYX2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Dyslexia Susceptibility 21 | | DLX25 | | DYLX25 | | KIAA03195 |
Export aliases for DYX2 gene to outside databasesPrevious GC identifer: GC06U990024 |
Summaries
for DYX2 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for DYX2 Gene:
DYX2 (dyslexia susceptibility 2) is a genetic locus. Diseases associated with DYX2 include dyslexia 2, and dyslexia.
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Genomic Views
for DYX2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
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TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for DYX2
Other transcription factors
Search Chromatin IP Primers for DYX2
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYX2 |
Genomic Location:
Chromosome:--
HGNC chromosome: 6 |
Proteins
for DYX2 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB: --
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Domains /
Families
for DYX2 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
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Function
for DYX2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | Browse OriGene RNAi
| | | Predesigned siRNA for gene silencing in human, mouse, rat DYX2 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for DYX2 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for DYX2  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYX2 |
Localization
for DYX2 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Pathways & Interactions
for DYX2 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYX2
Interactions:
Search GeneGlobe Interaction Network for DYX2
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Drugs & Compounds
for DYX2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
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 Browse compounds at ApexBio
 Browse Tocris compounds for DYX2
|
Transcripts
for DYX2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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Inhib. RNA
Products: | | Browse OriGene RNAi
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat DYX2 |
|
Expression
for DYX2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
DYX2 Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  --
Custom PCR Arrays for DYX2
Primer
Products: | | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat DYX2 | | | QuantiTect SYBR Green Assays in human, mouse, rat DYX2 | | | QuantiFast Probe-based Assays in human, mouse, rat DYX2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYX2 |
Orthologs
for DYX2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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--
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Paralogs
for DYX2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Genomic Variants
for DYX2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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TryGeneCards Plus | | | Site Specific Mutation Identification with PCR Assays |
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Disorders
/ Diseases
for DYX2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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OMIM gene information: 609269
OMIM disorders: 600202
2  diseases for DYX2:
About MalaCardsdyslexia 2 dyslexia
DYX2 for disorders About GeneDecksing
Genetic Association Database (GAD): DYX2
Export disorders for DYX2 gene to outside databases
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Publications
for DYX2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for DYX2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with DYX2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. (PubMed id 17450541)4 Brkanac Z....Raskind W.H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
- Quantitative trait locus for reading disability on chromosome 6. (PubMed id 7939663)3 Cardon L.R....DeFries J.C. (Science 1994)
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External Searches for DYX2 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DYX2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DYX2 gene
(According to HUGE)
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Specialized Databases showing DYX2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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TryGeneCards Plus | Patent Information for DYX2 gene:
Search GeneIP for patents involving DYX2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DYX2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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|  | Block miRNA regulation of human, mouse, rat DYX2 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing DYX2 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYX2 | | Predesigned siRNA for gene silencing in human, mouse, rat DYX2 | | | QuantiFast Probe-based Assays in human, mouse, rat DYX2 | | QuantiTect SYBR Green Assays in human, mouse, rat DYX2 | | | Custom PCR Arrays for DYX2 | | Search Chromatin IP Primers for DYX2 | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DYX2 | | Search GeneGlobe Interaction Network for DYX2 | | | Search Regulatory tfbs for DYX2 |
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| | | Search Tocris compounds for DYX2 |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYX2 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for DYX2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DYX2 |
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