Aliases for DYX1C1 Gene
External Ids for DYX1C1 Gene
Previous GeneCards Identifiers for DYX1C1 Gene
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for DYX1C1 Gene
DYX1C1 (Dyslexia Susceptibility 1 Candidate 1) is a Protein Coding gene. Diseases associated with DYX1C1 include primary ciliary dyskinesia25: dyx1c1-related primary ciliary dyskinesia and dyslexia 1. GO annotations related to this gene include estrogen receptor binding.
UniProtKB/Swiss-Prot for DYX1C1 Gene
Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility.