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DYX1C1 Gene

protein-coding   GIFtS: 50
GCID: GC15M055670

Dyslexia Susceptibility 1 Candidate 1

  See DYX1C1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dyslexia Susceptibility 1 Candidate 11 2     DYXC12 5
EKN12 3     RD2
CILD252 5     Dyslexia Susceptibility 1 Candidate Gene 1 Protein2
DYX12 5     

External Ids:    HGNC: 214931   Entrez Gene: 1615822   Ensembl: ENSG000002560617   OMIM: 6087065   UniProtKB: Q8WXU23   

Export aliases for DYX1C1 gene to outside databases

Previous GC identifers: GC00U912963 GC15M053438 GC15M053509 GC15M053434 GC15M053497 GC15M055709 GC15M032535 GC15M055648


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYX1C1 Gene:
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with
estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to
function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is
associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits
in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription
also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. (provided by RefSeq, Mar
2011)

GeneCards Summary for DYX1C1 Gene:
DYX1C1 (dyslexia susceptibility 1 candidate 1) is a protein-coding gene. Diseases associated with DYX1C1 include dyslexia 1, and articulation disorder. GO annotations related to this gene include estrogen receptor binding.

UniProtKB/Swiss-Prot: DYXC1_HUMAN, Q8WXU2
Function: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability
and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation,
survival and plasticity. Axonemal dynein assembly factor required for ciliary motility

Gene Wiki entry for DYX1C1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYX1C1 gene promoter:
         CREB   Elk-1   RFX1   deltaCREB   MIF-1   XBP-1   LUN-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYX1C1 promoter sequence
   Search Chromatin IP Primers for DYX1C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYX1C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.1

DYX1C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYX1C1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M055670:  view genomic region     (about GC identifiers)

Start:
55,702,723 bp from pter      End:
55,800,432 bp from pter
Size:
97,710 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYXC1_HUMAN, Q8WXU2 (See protein sequence)
Recommended Name: Dyslexia susceptibility 1 candidate gene 1 protein  
Size: 420 amino acids; 48527 Da
Subunit: Interacts with ESR1 and ESR2. Interacts with STUB1. Interacts with DNAAF2. Interacts with CCT3, CCT4,
CCT5 and CCT8 (By similarity)
Secondary accessions: Q6P5Y9 Q8N1S6
Alternative splicing: 3 isoforms:  Q8WXU2-1   Q8WXU2-2   Q8WXU2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DYX1C1: NX_Q8WXU2

Explore proteomics data for DYX1C1 at MOPED


See DYX1C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001028731.1  NP_001028732.1  NP_570722.2  

ENSEMBL proteins: 
 ENSP00000428097   ENSP00000403412   ENSP00000402640   ENSP00000323275   ENSP00000429219  
 ENSP00000370054   ENSP00000299561  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TTC: Tetratricopeptide (TTC) repeat domain containing

Selected InterPro protein domains (see all 6):
 IPR001440 TPR_1
 IPR011990 TPR-like_helical
 IPR008978 HSP20-like_chaperone
 IPR007052 CS_dom
 IPR013026 TPR-contain_dom

Graphical View of Domain Structure for InterPro Entry Q8WXU2

ProtoNet protein and cluster: Q8WXU2

UniProtKB/Swiss-Prot: DYXC1_HUMAN, Q8WXU2
Similarity: Contains 1 CS domain
Similarity: Contains 3 TPR repeats


Find genes that share domains with DYX1C1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DYXC1_HUMAN, Q8WXU2
Function: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability
and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation,
survival and plasticity. Axonemal dynein assembly factor required for ciliary motility

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI19423554
GO:0030331estrogen receptor binding IDA19423554
     
Find genes that share ontologies with DYX1C1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for DYX1C1:
 Increased cell number in G1, a 

     12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dyx1c1):
 cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
 hematopoietic system  immune system  mortality/aging  nervous system  no phenotypic analysis 
 respiratory system  skeleton 

Find genes that share phenotypes with DYX1C1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Dyx1c1tm1.2Jjlo for DYX1C1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYX1C1
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DYXC1_HUMAN, Q8WXU2: Nucleus. Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
mitochondrion1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA16989952
GO:0005737cytoplasm IDA--
GO:0005886plasma membrane IDA--

Find genes that share ontologies with DYX1C1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYX1C1
Interactions:

    Search GeneGlobe Interaction Network for DYX1C1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for DYX1C1 (Q8WXU21, 3 ENSP000003232754) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
InteractantInteraction Details
GeneCardExternal ID(s)
HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
ENSG00000212866P081073I2D: score=1 
ENSG00000215328P081073I2D: score=1 
ENSG00000224501P081073I2D: score=1 
ENSG00000231555P081073I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001764neuron migration ISS--
GO:0003341cilium movement IMP--
GO:0007368determination of left/right symmetry IMP--
GO:0033146regulation of intracellular estrogen receptor signaling pathway IDA19423554
GO:0036158outer dynein arm assembly IMP--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DYX1C1 (DYXC1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DYX1C1 gene (3 alternative transcripts): 
NM_001033559.2  NM_001033560.1  NM_130810.3  

Unigene Cluster for DYX1C1:

Dyslexia susceptibility 1 candidate 1
Hs.126403  [show with all ESTs]
Unigene Representative Sequence: NM_130810
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000524160(uc010ugi.2) ENST00000448430 ENST00000457155 ENST00000321149(uc002adc.3)
ENST00000522437 ENST00000519017 ENST00000380679(uc002adb.3) ENST00000348518(uc002add.3)

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat DYX1C1
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GenScript: all cDNA clones in your preferred vector (see all 3): DYX1C1 (NM_130810)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYX1C1
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYX1C1
  QuantiTect SYBR Green Assays in human, mouse, rat DYX1C1
  QuantiFast Probe-based Assays in human, mouse, rat DYX1C1

Additional mRNA sequence: 

AF337549.1 AK095201.1 BC017392.1 BC062564.1 

7 DOTS entries:

DT.92420550  DT.100747122  DT.65288218  DT.99955962  DT.97788301  DT.318388  DT.99947043 

Selected AceView cDNA sequences (see all 44):

AA724419 AI094704 AF337549 AK095201 BG540324 AI359890 NM_130810 CA422987 
AA912610 BM820152 CD107587 BF372375 AI360851 BG192162 AW080470 AA317003 
AI783611 BC017392 BM984145 BE463906 AI674107 BE972748 AI073572 BC062564 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DYX1C1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGAAGATTG
DYX1C1 Expression
About this image


DYX1C1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Cerebral Cortex
         Septum   
 
 Testis (Reproductive System)
DYX1C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DYX1C1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.126403

UniProtKB/Swiss-Prot: DYXC1_HUMAN, Q8WXU2
Tissue specificity: Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to
a fraction of cortical neurons and white matter glial cells

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DYX1C1 gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dyx1c11 , 5 dyslexia susceptibility 1 candidate 1 homolog (human)1, 5 80.22(n)1
79.67(a)1
  9 (40.08 cM)5
676851  NM_026314.31  NP_080590.31 
 729587855 
chicken
(Gallus gallus)
Aves DYX1C11 dyslexia susceptibility 1 candidate 1 70.35(n)
66.11(a)
  415409  NM_001008674.1  NP_001008674.1 
lizard
(Anolis carolinensis)
Reptilia DYX1C16
dyslexia susceptibility 1 candidate 1
44(a)
1 ↔ 1
AAWZ02041743(1093-5038)
African clawed frog
(Xenopus laevis)
Amphibia Xl.159252 Xenopus laevis transcribed sequence with weak similarity more 72.27(n)    BJ056709.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.150372 Transcribed sequence with moderate similarity to protein more 70.9(n)    CK026536.1 
mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP0017271 AgaP_AGAP001727 43.4(n)
34.9(a)
  4577322  XM_001238467.1  XP_001238468.1 


ENSEMBL Gene Tree for DYX1C1 (if available)
TreeFam Gene Tree for DYX1C1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DYX1C1 (see all 2037)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs578099071,2
C,Fother135785157(+) TAGTTC/ATGTTC 4 /E /* int1 stg1 ut318Minor allele frequency- A:0.20WA CSA NA EU 6098
rs1826990951,2
--35771807(+) AGTCAA/GTCTTA 1 -- ds50010--------
rs789835061,2
C,F--35771840(+) ATGGCT/CTTCCC 1 -- ds50013Minor allele frequency- C:0.15WA NA EA 358
rs1492067951,2
--35771873(+) ACCCCC/TATTCT 1 -- ds50010--------
rs1153975641,2
F--35772085(+) TTACAG/CATTTT 1 -- ds50011Minor allele frequency- C:0.02WA 118
rs1438901401,2
--35772263(+) CCTGGA/GTGGAG 1 -- ut310--------
rs285013381,2
C,F--35772374(+) TTCTGA/TGGCGG 1 -- ut310--------
rs1407760981,2
--35772452(+) TAATGG/TCATCA 1 -- ut310--------
rs1995649971,2
C--35772565(+) CTTGGA/GCTCAG 2 P S mis10--------
rs734069831,2
C,F--35772625(+) AGTGGG/ATGGGA 1 -- int13Minor allele frequency- A:0.01WA EU 1425

HapMap Linkage Disequilibrium report for DYX1C1 (55702723 - 55800432 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for DYX1C1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1542CNV Insertion18451855
nsv904243CNV Loss21882294
nsv817693CNV Loss17921354
nsv904244CNV Loss21882294
nsv520799CNV Loss19592680
nsv833016CNV Gain17160897

Human Gene Mutation Database (HGMD): DYX1C1
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing DYX1C1
DNA2.0 Custom Variant and Variant Library Synthesis for DYX1C1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608706   
OMIM disorders: 127700  615482  
UniProtKB/Swiss-Prot: DYXC1_HUMAN, Q8WXU2
  • Dyslexia 1 (DYX1) [MIM:127700]: A relatively common, complex cognitive disorder characterized by an
    impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It
    is a multifactorial trait, with evidence for familial clustering and heritability. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry. A chromosomal aberration involving
    DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21)
  • Ciliary dyskinesia, primary, 25 (CILD25) [MIM:615482]: A disorder characterized by abnormalities of
    motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to
    defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs
    inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs
    inversus is referred to as Kartagener syndrome. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 5 diseases for DYX1C1:    
    About MalaCards
    dyslexia 1    articulation disorder    dyslexia    ciliary dyskinesia, primary, 25
    ciliary dyskinesia, primary, 19

    2 diseases from the University of Copenhagen DISEASES database for DYX1C1:
    Dyslexia     Articulation disorder

    Find genes that share disorders with DYX1C1           About GenesLikeMe

    Genetic Association Database (GAD): DYX1C1
    Human Genome Epidemiology (HuGE) Navigator: DYX1C1 (14 documents)

    Export disorders for DYX1C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYX1C1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with DYX1C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. (PubMed id 12954984)1, 2, 3, 9 Taipale M.... Kere J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. DYX1C1 is required for axonemal dynein assembly and ciliary motility. (PubMed id 23872636)1, 2 Tarkar A.... Omran H. (Nat. Genet. 2013)
    3. Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation. (PubMed id 19901951)1, 4 Bates T.C....Wright M.J. (Mol. Psychiatry 2010)
    4. Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. (PubMed id 19423554)1, 2 Massinen S....Kere J. (Hum. Mol. Genet. 2009)
    5. Further evidence for DYX1C1 as a susceptibility factor for dyslexia. (PubMed id 19240663)1, 4 Dahdouh F....Zucchelli M. (Psychiatr. Genet. 2009)
    6. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    7. Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. (PubMed id 19076634)1, 4 Wigg K.G....Barr C.L. (Genes Brain Behav. 2008)
    8. Association of short-term memory with a variant within DYX1C1 in developmental dyslexia. (PubMed id 17309662)1, 4 Marino C....Molteni M. (Genes Brain Behav. 2007)
    9. DYX1C1 functions in neuronal migration in developing neocortex. (PubMed id 16989952)1, 2 Wang Y.... Loturco J.J. (Neuroscience 2006)
    10. A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia. (PubMed id 15702132)1, 4 Marino C....Molteni M. (Eur. J. Hum. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 161582 HGNC: 21493 AceView: DYX1C1 Ensembl:ENSG00000256061 euGenes: HUgn161582
    ECgene: DYX1C1 H-InvDB: DYX1C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYX1C1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYX1C1 gene:
    Search GeneIP for patents involving DYX1C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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