DYX1 Locus
genetic locus GIFtS: 13
GCID: GC15U990015
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dyslexia susceptibility 1
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Aliases
for DYX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
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| Aliases |
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| Dyslexia Susceptibility 11 2 | | RD1 2 |
Export aliases for DYX1 gene to outside databases |
Summaries
for DYX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Gene Wiki entry for DYX1
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Genomic Views
for DYX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DYX1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYX1 |
Genomic Location:
Chromosome:15
HGNC chromosome: 15GeneLoc information about chromosome 15 |
Proteins
for DYX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
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UniProtKB: --
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Protein
Domains /
Families
for DYX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
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Function
for DYX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
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Pathways & Interactions
for DYX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYX1
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Drugs & Compounds
for DYX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
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 Browse Tocris compounds for DYX1
Search CenterWatch for drugs/clinical trials and news about DYX1 
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Transcripts
for DYX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
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Expression
for DYX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for DYX1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DYX1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYX1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYX1 |
Orthologs
for DYX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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Paralogs
for DYX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for DYX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Human Gene Mutation Database (HGMD): DYX1
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DYX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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DYX1 for disorders About GeneDecksing
OMIM gene information: 127700
OMIM disorders: --
1  disease for DYX1: About MalaCardsdyslexia
Human Genome Epidemiology (HuGE) Navigator: DYX1 (12 documents)
Export disorders for DYX1 gene to outside databases
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Publications
for DYX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for DYX1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DYX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. (PubMed id 8981944)1, 3 Grigorenko E.L....Pauls D.L. (1997)
- Dyslexia and chromosome 15 heteromorphism: negative lod score in a Danish material. (PubMed id 3652490)1, 3 Bisgaard M.L....Mohr J. (1987)
- A cohort of balanced reciprocal translocations associ ated with dyslexia: identification of two putative candidate genes at DYX1. (PubMed id 20798984)1 Buonincontri R....Tommerup N. (2011)
- Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. (PubMed id 17450541)1 Brkanac Z....Raskind W.H. (2007)
- No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. (PubMed id 15477871)1 Cope N.A....O'Donovan M.C. (2005)
- Support for EKN1 as the susceptibility locus for dyslexia on 15q21. (PubMed id 15249932)1 Wigg K.G....Barr C.L. (2004)
- Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK. (PubMed id 15520411)1 Scerri T.S....Monaco A.P. (2004)
- Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. (PubMed id 10749993)1 Morris D.W....Williams J. (2000)
- Genetic linkage analysis with dyslexia: evidence for linkage of spelling disability to chromosome 15. (PubMed id 10638372)1 Nothen M.M....Remschmidt H. (1999)
- Evidence for linkage of spelling disability to chromosome 15. (PubMed id 9634517)1 Schulte-Korne G....Remschmidt H. (1998)
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External Searches for DYX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DYX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing DYX1 gene
(According to HUGE)
About This Section
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Specialized Databases showing DYX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for DYX1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DYX1 gene:
Search GeneIP for patents involving DYX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DYX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYX1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYX1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYX1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYX1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYX1 |
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| | | | Search Tocris compounds for DYX1 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for DYX1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DYX1 |
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