DYTN Gene
protein-coding GIFtS: 32
GCID: GC02M207516
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dystrotelin
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Aliases
for DYTN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Export aliases for DYTN gene to outside databasesPrevious GC identifers: GC02M207260 GC02M199365 |
Summaries
for DYTN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DYTN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DYTN gene promoter:
Tal-1 FOXD3 Tal-1beta Gfi-1 E47 HFH-1 FOXJ2 (long isoform) FOXJ2 ITF-2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYTN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYTN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.3 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q33.3DYTN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M207516: view genomic region
(about GC identifiers)
Start:
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207,516,345 bp from pter |
End:
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207,583,120 bp from pter |
Size:
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66,776 bases |
Orientation:
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minus strand |
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Proteins
for DYTN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DYTN_HUMAN, A2CJ06 (See
protein sequence)Recommended Name: Dystrotelin Size: 578 amino acids; 65320 Da
Subcellular location: Cell membrane (By similarity)Explore the universe of human proteins at neXtProt for DYTN: NX_A2CJ06
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A2CJ06
DYTN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001087199.1
ENSEMBL proteins: ENSP00000396593
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- |
DYTN for ontologies About GeneDecksing
DYTN Antibody Products:
Assay Products for DYTN: |
Protein
Domains /
Families
for DYTN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DYTN for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A2CJ06ProtoNet protein and cluster: A2CJ06 UniProtKB/Swiss-Prot: DYTN_HUMAN, A2CJ06Similarity: Contains 1 ZZ-type zinc finger |
Function
for DYTN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYTN (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYTN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DYTN (NM_001093730) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYTN | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DYTN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYTN |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
DYTN for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DYTN:
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Pathways & Interactions
for DYTN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYTN
|
Drugs & Compounds
for DYTN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DYTN
Search CenterWatch for drugs/clinical trials and news about DYTN
|
Transcripts
for DYTN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DYTN gene: NM_001093730.1 Unigene Cluster for DYTN: Dystrotelin Hs.640667 [show with all ESTs]Unigene Representative Sequence: DQ5163472 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452335(uc002vbr.1) ENST00000477734
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYTN (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYTN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DYTN (NM_001093730) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYTN | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DYTN |
Additional cDNA sequence: DQ516347.1 1 DOTS entry: DT.120991706
GeneLoc Exon Structure
|
Expression
for DYTN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DYTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTGTACA
About this image
See DYTN Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.640667
SABiosciences Custom PCR Arrays for DYTN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYTN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYTN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYTN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYTN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYTN |
Orthologs
for DYTN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DYTN gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for DYTN (if available)
TreeFam Gene Tree for DYTN (if available) |
Paralogs
for DYTN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DYTN gene
- DTNA2 UTRN2 DTNB2 DMD2 DRP22
DYTN for paralogs About GeneDecksing
|
Genomic Variants
for DYTN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DYTN (207516345 - 207583120 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DYTN: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYTN |
|
Disorders
/ Diseases
for DYTN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 DYTN for disorders About MalaCards
DYTN for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: DYTN (1 document)
Export disorders for DYTN gene to outside databases
|
Publications
for DYTN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for DYTN gene integrated from 9 sources:
(articles sorted by number of sources associating them with DYTN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms. (PubMed id 17233888)1, 2, 3 Jin H.... Roberts R.G. (2007)
|
External Searches for DYTN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DYTN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYTN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYTN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DYTN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DYTN gene:
Search GeneIP for patents involving DYTN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYTN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DYTN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DYTN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYTN | | | OriGene Protein Over-expression Lysate for DYTN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DYTN | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYTN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYTN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DYTN | | OriGene Custom Protein Services for DYTN | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYTN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYTN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYTN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYTN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYTN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYTN |
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| | | | Search Tocris compounds for DYTN |
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 | | | DYTN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYTN |
|  |  |  | | | | Search ThermoFisher Antibodies for DYTN |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DYTN |
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