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Aliases for DYTN Gene

Aliases for DYTN Gene

  • Dystrotelin 2 3 3 5

External Ids for DYTN Gene

Previous GeneCards Identifiers for DYTN Gene

  • GC02M207260
  • GC02M207516
  • GC02M199365

Summaries for DYTN Gene

GeneCards Summary for DYTN Gene

DYTN (Dystrotelin) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DRP2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYTN Gene

Genomics for DYTN Gene

Regulatory Elements for DYTN Gene

Enhancers for DYTN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G207225 1.2 Ensembl ENCODE dbSUPER 9.9 -508.6 -508601 2.4 ESRRA JUN CEBPG RBBP5 POLR2A GATA2 EED FOS NR2F6 NR2F1 MIR1302-4 KLF7 DYTN ENSG00000240440 ENSG00000225916 ENSG00000234902
GH02G206797 1 Ensembl ENCODE 10.6 -79.6 -79605 1.2 HDGF PKNOX1 MTA2 JUN HLF NR2F1 BHLHE40 TRIM22 RAD51 POLR2A MDH1B DYTN MYOSLID MIR3130-1 ENSG00000260171
GH02G206799 0.9 FANTOM5 Ensembl 10.6 -80.9 -80905 0.2 ELF4 MAX ELF1 ZBTB40 OSR2 ZNF335 FOSL1 PRDM6 SP7 DYTN MDH1B MIR3130-1 ENSG00000260171
GH02G206804 0.9 FANTOM5 ENCODE 10.3 -86.2 -86233 0.6 MTA2 ZNF10 BHLHE40 BACH1 REST ZNF316 RAD51 POLR2A NBN MLLT1 DYTN CPO MDH1B ENSG00000223725 ENSG00000260171 MIR3130-1
GH02G206800 0.9 Ensembl ENCODE 10.3 -82.5 -82501 1.0 ELF3 CTCF ZNF654 TRIM22 REST BMI1 EP300 RAD21 SMARCA4 SMC3 MDH1B DYTN CPO MIR3130-1 ENSG00000260171
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DYTN on UCSC Golden Path with GeneCards custom track

Genomic Location for DYTN Gene

Chromosome:
2
Start:
206,651,621 bp from pter
End:
206,718,396 bp from pter
Size:
66,776 bases
Orientation:
Minus strand

Genomic View for DYTN Gene

Genes around DYTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYTN Gene

Proteins for DYTN Gene

  • Protein details for DYTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2CJ06-DYTN_HUMAN
    Recommended name:
    Dystrotelin
    Protein Accession:
    A2CJ06

    Protein attributes for DYTN Gene

    Size:
    578 amino acids
    Molecular mass:
    65320 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DYTN Gene

Post-translational modifications for DYTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DYTN Gene

Domains & Families for DYTN Gene

Gene Families for DYTN Gene

Protein Domains for DYTN Gene

Suggested Antigen Peptide Sequences for DYTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DYTN: view

No data available for UniProtKB/Swiss-Prot for DYTN Gene

Function for DYTN Gene

Gene Ontology (GO) - Molecular Function for DYTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DYTN: view

Phenotypes for DYTN Gene

GenomeRNAi human phenotypes for DYTN:
genes like me logo Genes that share phenotypes with DYTN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DYTN Gene

Localization for DYTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYTN Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYTN gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DYTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DYTN: view

Pathways & Interactions for DYTN Gene

No Data Available

Interacting Proteins for DYTN Gene

Selected Interacting proteins: A2CJ06-DYTN_HUMAN for DYTN Gene via IID

Gene Ontology (GO) - Biological Process for DYTN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DYTN Gene

Drugs & Compounds for DYTN Gene

No Compound Related Data Available

Transcripts for DYTN Gene

mRNA/cDNA for DYTN Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DYTN Gene

Dystrotelin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYTN Gene

No ASD Table

Relevant External Links for DYTN Gene

GeneLoc Exon Structure for
DYTN
ECgene alternative splicing isoforms for
DYTN

Expression for DYTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYTN Gene

mRNA differential expression in normal tissues according to GTEx for DYTN Gene

This gene is overexpressed in Whole Blood (x23.3).

Protein differential expression in normal tissues from HIPED for DYTN Gene

This gene is overexpressed in Heart (50.5) and Adipocyte (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DYTN Gene



Protein tissue co-expression partners for DYTN Gene

NURSA nuclear receptor signaling pathways regulating expression of DYTN Gene:

DYTN

SOURCE GeneReport for Unigene cluster for DYTN Gene:

Hs.640667
genes like me logo Genes that share expression patterns with DYTN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYTN Gene

Orthologs for DYTN Gene

This gene was present in the common ancestor of animals.

Orthologs for DYTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYTN 35 34
  • 98.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYTN 34 35
  • 81.8 (n)
cow
(Bos Taurus)
Mammalia DYTN 34 35
  • 81.03 (n)
mouse
(Mus musculus)
Mammalia Dytn 34 16 35
  • 73.66 (n)
rat
(Rattus norvegicus)
Mammalia Dytn 34
  • 72.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DYTN 35
  • 5 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYTN 35 34
  • 58.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYTN 35
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dytn 35
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dys 35
  • 4 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dys-1 35
  • 3 (a)
ManyToMany
Species where no ortholog for DYTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DYTN Gene

ENSEMBL:
Gene Tree for DYTN (if available)
TreeFam:
Gene Tree for DYTN (if available)

Paralogs for DYTN Gene

Paralogs for DYTN Gene

genes like me logo Genes that share paralogs with DYTN: view

Variants for DYTN Gene

Sequence variations from dbSNP and Humsavar for DYTN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000004781 -- 206,699,456(+) AAAAC(A/G)AAGAC intron-variant
rs1000015628 -- 206,702,621(+) GACCA(C/T)TTATT intron-variant
rs1000128626 -- 206,696,277(+) CAGAC(C/G)TGCTA intron-variant
rs1000134728 -- 206,655,983(+) CTTTA(C/T)ATGTC intron-variant
rs1000159205 -- 206,702,474(+) ATAGT(A/G)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYTN Gene

Variant ID Type Subtype PubMed ID
dgv1202e212 CNV loss 25503493
nsv1011347 CNV gain 25217958

Variation tolerance for DYTN Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYTN Gene

Disorders for DYTN Gene

Relevant External Links for DYTN

Human Genome Epidemiology (HuGE) Navigator
DYTN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYTN

No disorders were found for DYTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYTN Gene

Publications for DYTN Gene

  1. The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms. (PMID: 17233888) Jin H. … Roberts R.G. (BMC Genomics 2007) 2 3 4 64

Products for DYTN Gene

Sources for DYTN Gene

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