DYT10 Locus
genetic locus GIFtS: 13
GCID: GC16U901119
|
|
dystonia 10
| |
Aliases
for DYT10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dystonia 101 2 | | PKC1 2 5 | | EKD11 2 |
Export aliases for DYT10 gene to outside databasesPrevious GC identifer: GC00U926060 |
Summaries
for DYT10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DYT10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DYT10
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYT10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYT10 |
Genomic Location:
Chromosome:16
Entrez Gene cytogenetic band: 16p11.2-q12.1 HGNC cytogenetic band: 16p11.2-q12.1GeneLoc information about chromosome 16 |
Proteins
for DYT10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for DYT10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for DYT10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
|
Pathways & Interactions
for DYT10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nifedipine Activity | |
1  BioSystems Pathway for DYT10
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYT10
|
Drugs & Compounds
for DYT10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DYT10 for compounds About GeneDecksing
 Browse Tocris compounds for DYT10
10/141 Novoseek chemical compound relationships for DYT10 gene (see all 141) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pkcs |
94.3 |
163 |
12140280 (3), 19584538 (2), 9117107 (2), 18313772 (2) (see all 99) |
| gf 109203x |
94.2 |
765 |
8904648 (3), 16777970 (3), 8900190 (3), 11781840 (3) (see all 99) |
| bisindolylmaleimide |
91.5 |
420 |
10822275 (4), 8826855 (3), 9125669 (3), 12438545 (2) (see all 99) |
| 12-o-tetradecanoylphorbol 13-acetate |
90.2 |
1051 |
1563835 (5), 15670752 (5), 10545022 (4), 9191847 (4) (see all 99) |
| rottlerin |
90.2 |
142 |
12941843 (2), 17932622 (2), 10670587 (2), 17895603 (2) (see all 99) |
| bryostatin 1 |
90.1 |
270 |
8432975 (6), 8892972 (5), 8144186 (5), 8504423 (4) (see all 99) |
| phorbol 12,13-dibutyrate |
89.8 |
442 |
2155187 (7), 10370088 (5), 1945751 (5), 9536018 (4) (see all 99) |
| phorbol |
89.7 |
272 |
12387861 (3), 8180129 (3), 10397677 (3), 1544233 (2) (see all 99) |
| chelerythrine |
89.5 |
448 |
9677417 (5), 7526660 (4), 11914646 (4), 9810275 (3) (see all 99) |
| go 6976 |
87 |
98 |
11992627 (3), 17320279 (2), 15496505 (2), 19185618 (2) (see all 67) |
Search CenterWatch for drugs/clinical trials and news about DYT10
|
Transcripts
for DYT10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
|
Expression
for DYT10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for DYT10
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DYT10 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYT10 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYT10 |
Orthologs
for DYT10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
|
Paralogs
for DYT10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DYT10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DYT10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DYT10 for disorders About GeneDecksing
OMIM gene information: 128200
OMIM disorders: --
20/217  diseases for DYT10 (see all 217): About MalaCardsdystonia 10 chediak-higashi syndrome paroxysmal kinesigenic choreoathetosis estrogen-receptor negative breast cancer
obsessive-compulsive disorder choreoathetosis down syndrome critical region neural tube defect
diabetic macular edema gastroesophageal junction adenocarcinoma paroxysmal choreoathetosis wiskott-aldrich syndrome
becker muscular dystrophy severe congenital neutropenia reflex epilepsy allergic rhinitis
soft tissue sarcoma arachnoid cysts proliferative diabetic retinopathy diabetic retinopathy
10/93 Novoseek disease relationships for DYT10 gene (see all 93) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| choreoathetosis |
61.9 |
39 |
17387577 (2), 9916526 (1), 10403218 (1), 9844411 (1) (see all 31) |
| promyelocytic leukemia |
55.6 |
10 |
1879193 (1), 8569755 (1), 2096263 (1), 9141489 (1) (see all 10) |
| glioma |
51.6 |
198 |
1407458 (5), 8963653 (5), 7999012 (5), 15842253 (5) (see all 83) |
| tumors |
50.6 |
464 |
12468631 (4), 11470753 (4), 17922632 (4), 1407458 (3) (see all 99) |
| necrosis |
49.1 |
58 |
18463227 (6), 16488439 (2), 7543950 (1), 9395855 (1) (see all 47) |
| myeloid leukemia |
48.9 |
16 |
11880362 (2), 1423278 (1), 8622627 (1), 1939341 (1) (see all 15) |
| hyperglycemia |
47.5 |
68 |
10588370 (4), 10342822 (4), 10592293 (3), 7698515 (2) (see all 45) |
| erythroleukemia |
46.8 |
28 |
8569755 (4), 1568447 (3), 1423278 (3), 7961988 (1) (see all 17) |
| cholera |
46.1 |
15 |
8243300 (2), 8200555 (2), 1826686 (1), 7730606 (1) (see all 11) |
| monocytic leukemia |
41 |
7 |
8256116 (1), 17878267 (1), 8412301 (1), 8892972 (1) (see all 7) |
Export disorders for DYT10 gene to outside databases
|
Publications
for DYT10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DYT10 gene, integrated from 9 sources (see all 4870):
(articles sorted by number of sources associating them with DYT10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Localization and mutation detection for paroxysmal kinesigenic choreoathetosis. (PubMed id 17952630)1, 3, 9 Du T....Liu Y. (2008)
- AKAP-Lbc nucleates a protein kinase D activation scaffold. (PubMed id 15383279)1, 9 Carnegie G.K....Scott J.D. (2004)
- The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer. (PubMed id 10542228)1, 9 Tseng C.P....Hsieh J.T. (1999)
- Paroxysmal kinesigenic choreoathetosis locus maps to chromosome 16p11.2-q12.1. (PubMed id 10577923)1, 9 Tomita H....Niikawa N. (1999)
- Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch. (PubMed id 10531036)1, 9 Santy L.C....Casanova J.E. (1999)
- Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
- Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. (PubMed id 21209460)1 Wang Y....Correia M.A. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. (PubMed id 16630892)1 Kumar P.P.... Galande S. (2006)
- Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. (PubMed id 15557340)1 Yamamoto A....Haass C. (2005)
|
External Searches for DYT10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DYT10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYT10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYT10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DYT10 gene:
Search GeneIP for patents involving DYT10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYT10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYT10 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYT10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYT10 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYT10 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYT10 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYT10 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DYT10 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for DYT10 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DYT10 |
|
|
|
|
