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DYT10 Locus

genetic locus   GIFtS: 13
GCID: GC16U901119

Dystonia 10

  See DYT10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dystonia 101 2
Paroxysmal Kinesigenic Choreoathetosis1
EKD12
PKC2

External Ids:    HGNC: 371991   Entrez Gene: 508182   OMIM: 1282005   

Export aliases for DYT10 gene to outside databases

Previous GC identifer: GC00U926060


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DYT10 Gene:
DYT10 (dystonia 10) is a genetic locus. Diseases associated with DYT10 include reflex epilepsy, and infantile convulsions and paroxysmal choreoathetosis, familial.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for DYT10
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYT10


Genomic Location:
Chromosome:16   

Entrez Gene cytogenetic band: 16p11.2-q12.1   HGNC cytogenetic band: 16p11.2-q12.1

GeneLoc information about chromosome 16        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DYT10 About    
See pathways by source

SuperPathContained pathways About
1Nifedipine Activity
Nifedipine Activity


1 BioSystems Pathway for DYT10
    Nifedipine Activity


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYT10
Interactions:

    Search GeneGlobe Interaction Network for DYT10

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DYT10

Selected Novoseek inferred chemical compound relationships for DYT10 gene (see all 141)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pkcs 94.3 163 12140280 (3), 19584538 (2), 9117107 (2), 18313772 (2) (see all 99)
gf 109203x 94.2 765 8904648 (3), 16777970 (3), 8900190 (3), 11781840 (3) (see all 99)
bisindolylmaleimide 91.5 420 10822275 (4), 8826855 (3), 9125669 (3), 12438545 (2) (see all 99)
12-o-tetradecanoylphorbol 13-acetate 90.2 1051 1563835 (5), 15670752 (5), 10545022 (4), 9191847 (4) (see all 99)
rottlerin 90.2 142 12941843 (2), 17932622 (2), 10670587 (2), 17895603 (2) (see all 99)
bryostatin 1 90.1 270 8432975 (6), 8892972 (5), 8144186 (5), 8504423 (4) (see all 99)
phorbol 12,13-dibutyrate 89.8 442 2155187 (7), 10370088 (5), 1945751 (5), 9536018 (4) (see all 99)
phorbol 89.7 272 12387861 (3), 8180129 (3), 10397677 (3), 1544233 (2) (see all 99)
chelerythrine 89.5 448 9677417 (5), 7526660 (4), 11914646 (4), 9810275 (3) (see all 99)
go 6976 87 98 11992627 (3), 17320279 (2), 15496505 (2), 19185618 (2) (see all 67)



Find genes that share compounds with DYT10           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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miRNA
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Search for qRT-PCR Assays for microRNAs that regulate DYT10
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Primer
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

DYT10 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for DYT10
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing DYT10
DNA2.0 Custom Variant and Variant Library Synthesis for DYT10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 128200    OMIM disorders: --

15 diseases for DYT10:    
About MalaCards
reflex epilepsy    infantile convulsions and paroxysmal choreoathetosis, familial    dystonia 10    benign familial infantile seizures 2
episodic kinesigenic dyskinesia 1    keloid formation    paroxysmal choreoathetosis    gastroesophageal junction adenocarcinoma
arachnoid cysts    paroxysmal dyskinesia    gitelman syndrome    chediak-higashi syndrome
diabetic angiopathy    olivopontocerebellar atrophy    diabetic macular edema


Find genes that share disorders with DYT10           About GenesLikeMe

Selected Novoseek inferred disease relationships for DYT10 gene (see all 93)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
choreoathetosis 61.9 39 17387577 (2), 9916526 (1), 10403218 (1), 9844411 (1) (see all 31)
promyelocytic leukemia 55.6 10 1879193 (1), 8569755 (1), 2096263 (1), 9141489 (1) (see all 10)
glioma 51.6 198 1407458 (5), 8963653 (5), 7999012 (5), 15842253 (5) (see all 83)
tumors 50.6 464 12468631 (4), 11470753 (4), 17922632 (4), 1407458 (3) (see all 99)
necrosis 49.1 58 18463227 (6), 16488439 (2), 7543950 (1), 9395855 (1) (see all 47)
myeloid leukemia 48.9 16 11880362 (2), 1423278 (1), 8622627 (1), 1939341 (1) (see all 15)
hyperglycemia 47.5 68 10588370 (4), 10342822 (4), 10592293 (3), 7698515 (2) (see all 45)
erythroleukemia 46.8 28 8569755 (4), 1568447 (3), 1423278 (3), 7961988 (1) (see all 17)
cholera 46.1 15 8243300 (2), 8200555 (2), 1826686 (1), 7730606 (1) (see all 11)
monocytic leukemia 41 7 8256116 (1), 17878267 (1), 8412301 (1), 8892972 (1) (see all 7)


Export disorders for DYT10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DYT10 gene, integrated from 10 sources (see all 4872):
(articles sorted by number of sources associating them with DYT10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Localization and mutation detection for paroxysmal kinesigenic choreoathetosis. (PubMed id 17952630)1, 3, 9 Du T....Liu Y. (J. Mol. Neurosci. 2008)
  2. Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation. (PubMed id 20110267)1, 9 Kroviarski Y....Dang P.M. (FASEB J. 2010)
  3. AKAP-Lbc nucleates a protein kinase D activation scaffold. (PubMed id 15383279)1, 9 Carnegie G.K....Scott J.D. (Mol. Cell 2004)
  4. The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer. (PubMed id 10542228)1, 9 Tseng C.P....Hsieh J.T. (J. Biol. Chem. 1999)
  5. Paroxysmal kinesigenic choreoathetosis locus maps to chromosome 16p11.2-q12.1. (PubMed id 10577923)1, 9 Tomita H.a....Niikawa N. (Am. J. Hum. Genet. 1999)
  6. Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch. (PubMed id 10531036)1, 9 Santy L.C....Casanova J.E. (Curr. Biol. 1999)
  7. PKC phosphorylation regulates mGluR5 trafficking by enhancing binding of Siah-1A. (PubMed id 23152621)1 Ko S.J....Roche K.W. (J. Neurosci. 2012)
  8. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)
  9. Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. (PubMed id 21209460)1 Wang Y....Correia M.A. (J. Biol. Chem. 2011)
  10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 50818 HGNC: 37199 euGenes: HUgn50818 ECgene: DYT10 H-InvDB: DYT10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DYT10 gene:
Search GeneIP for patents involving DYT10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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