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Aliases for DYRK4 Gene

Aliases for DYRK4 Gene

  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4 2 3
  • EC 4 63
  • EC 2.7.12 63

External Ids for DYRK4 Gene

Previous GeneCards Identifiers for DYRK4 Gene

  • GC12P004436
  • GC12P004591
  • GC12P004699
  • GC12P004671

Summaries for DYRK4 Gene

Entrez Gene Summary for DYRK4 Gene

  • This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

GeneCards Summary for DYRK4 Gene

DYRK4 (Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is DYRK1B.

UniProtKB/Swiss-Prot for DYRK4 Gene

  • Possible non-essential role in spermiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK4 Gene

Genomics for DYRK4 Gene

Regulatory Elements for DYRK4 Gene

Genomic Location for DYRK4 Gene

4,562,204 bp from pter
4,615,302 bp from pter
53,099 bases
Plus strand

Genomic View for DYRK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYRK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK4 Gene

Proteins for DYRK4 Gene

  • Protein details for DYRK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 4
    Protein Accession:
    Secondary Accessions:
    • A8K8F7
    • Q8NEF2
    • Q92631

    Protein attributes for DYRK4 Gene

    520 amino acids
    Molecular mass:
    59608 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAF91393.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK308260; Type=Frameshift; Positions=470; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK4 Gene


neXtProt entry for DYRK4 Gene

Proteomics data for DYRK4 Gene at MOPED

Selected DME Specific Peptides for DYRK4 Gene

Post-translational modifications for DYRK4 Gene

  • Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for DYRK4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NR20
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK4: view

Function for DYRK4 Gene

Molecular function for DYRK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Possible non-essential role in spermiogenesis.

Enzyme Numbers (IUBMB) for DYRK4 Gene

Gene Ontology (GO) - Molecular Function for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 23602568
genes like me logo Genes that share ontologies with DYRK4: view

Phenotypes for DYRK4 Gene

MGI mutant phenotypes for DYRK4:
inferred from 1 alleles
GenomeRNAi human phenotypes for DYRK4:
genes like me logo Genes that share phenotypes with DYRK4: view

Animal Models for DYRK4 Gene

MGI Knock Outs for DYRK4:

Animal Model Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for DYRK4 Gene

Localization for DYRK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK4 Gene

Isoform 1: Cytoplasm.
Isoform 4: Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for DYRK4 Gene COMPARTMENTS Subcellular localization image for DYRK4 gene
Compartment Confidence
golgi apparatus 4
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with DYRK4: view

Pathways for DYRK4 Gene

SuperPathways for DYRK4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with DYRK4: view

No data available for Pathways by source for DYRK4 Gene

Compounds for DYRK4 Gene

(3) HMDB Compounds for DYRK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with DYRK4: view

Transcripts for DYRK4 Gene

Unigene Clusters for DYRK4 Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYRK4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - -
SP9: - -
SP10: - - - - -
SP13: - - -

ExUns: 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c
SP1: -
SP3: -
SP4: -
SP12: -

Relevant External Links for DYRK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DYRK4 Gene

mRNA expression in normal human tissues for DYRK4 Gene

mRNA differential expression in normal tissues according to GTEx for DYRK4 Gene

This gene is overexpressed in Testis (4.9).

Protein differential expression in normal tissues for DYRK4 Gene

This gene is overexpressed in Liver (11.4), Adrenal (9.4), Lung (9.3), Kidney (6.3), and Platelet (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DYRK4 Gene

SOURCE GeneReport for Unigene cluster for DYRK4 Gene Hs.439530

genes like me logo Genes that share expressions with DYRK4: view

Expression partners for DYRK4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DYRK4 Gene

Orthologs for DYRK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYRK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DYRK4 35
  • 84.36 (n)
  • 81.47 (a)
DYRK4 36
  • 66 (a)
(Canis familiaris)
Mammalia DYRK4 35
  • 87.08 (n)
  • 83.91 (a)
DYRK4 36
  • 83 (a)
(Mus musculus)
Mammalia Dyrk4 35
  • 82.33 (n)
  • 77.86 (a)
Dyrk4 16
Dyrk4 36
  • 63 (a)
(Pan troglodytes)
Mammalia DYRK4 35
  • 98.85 (n)
  • 97.88 (a)
DYRK4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dyrk4 35
  • 82.88 (n)
  • 80.17 (a)
(Monodelphis domestica)
Mammalia DYRK4 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia DYRK4 36
  • 74 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
(Danio rerio)
Actinopterygii dyrk4 35
  • 68.48 (n)
  • 69.43 (a)
dyrk4 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta smi35A 37
  • 59 (a)
smi35A 35
  • 60.56 (n)
  • 57.76 (a)
smi35A 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007847 35
  • 67.67 (n)
  • 69.96 (a)
(Caenorhabditis elegans)
Secernentea C36B7.1 37
  • 29 (a)
C36B7.2 37
  • 28 (a)
(Oryza sativa)
Liliopsida Os.12653 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.916 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for DYRK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DYRK4 Gene

Gene Tree for DYRK4 (if available)
Gene Tree for DYRK4 (if available)

Paralogs for DYRK4 Gene

genes like me logo Genes that share paralogs with DYRK4: view

Variants for DYRK4 Gene

Sequence variations from dbSNP and Humsavar for DYRK4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs727867 -- 4,611,974(+) GAATC(A/G)GAGTT intron-variant
rs730065 -- 4,593,978(-) TGCTG(A/G)ATAAG intron-variant
rs758532 -- 4,605,391(-) TGTCC(A/G)TCTGG intron-variant
rs997373 -- 4,607,406(+) TGTCT(A/C)ATGAG intron-variant
rs997868 -- 4,590,066(-) TTCTC(A/G)AAACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DYRK4 Gene

Variant ID Type Subtype PubMed ID
nsv832318 CNV Gain 17160897
nsv7226 OTHER Inversion 18451855
dgv1346n71 CNV Loss 21882294

Relevant External Links for DYRK4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK4 Gene

Disorders for DYRK4 Gene

(1) University of Copenhagen DISEASES for DYRK4 Gene

genes like me logo Genes that share disorders with DYRK4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for DYRK4 Gene

Publications for DYRK4 Gene

  1. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W. … Joost H.-G. (J. Biol. Chem. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. (PMID: 17292540) Sacher F. … Fritsch M. (Mol. Cell. Endocrinol. 2007) 3 4
  4. Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. (PMID: 21127067) Papadopoulos C. … de la Luna S. (J. Biol. Chem. 2011) 3 4
  5. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3

Products for DYRK4 Gene

  • Addgene plasmids for DYRK4

Sources for DYRK4 Gene

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