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DYRK4 Gene

protein-coding   GIFtS: 52
GCID: GC12P004671

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 41 2
EC 2.7.12.13 8
Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 42
EC 2.7.128

External Ids:    HGNC: 30951   Entrez Gene: 87982   Ensembl: ENSG000000102197   OMIM: 6091815   UniProtKB: Q9NR203   

Export aliases for DYRK4 gene to outside databases

Previous GC identifers: GC12P004436 GC12P004591 GC12P004569 GC12P004699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYRK4 Gene:
This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of
this dual specificity kinase family are thought to function in the regulation of cell differentiation and
proliferation, survival, and in development. Alternate splicing results in multiple transcript variants.
Additional alternatively spliced transcript variants of this gene have been described, but their full-length
nature is not known. (provided by RefSeq, Aug 2013)

GeneCards Summary for DYRK4 Gene:
DYRK4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4) is a protein-coding gene. Diseases associated with DYRK4 include rickets, and down syndrome. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot: DYRK4_HUMAN, Q9NR20
Function: Possible non-essential role in spermiogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYRK4 gene promoter:
         TBP   Sox5   AML1a   Nkx2-2   C/EBPalpha   AREB6   FAC1   Nkx6-1   SEF-1 (1)   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYRK4 promoter sequence
   Search Chromatin IP Primers for DYRK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYRK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.32   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13.32

DYRK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P004671:  view genomic region     (about GC identifiers)

Start:
4,671,370 bp from pter      End:
4,723,325 bp from pter
Size:
51,956 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DYRK4_HUMAN, Q9NR20 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 4  
Size: 520 amino acids; 59608 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=AAF91393.1; Type=Erroneous initiation;
Secondary accessions: Q8NEF2 Q92631
Alternative splicing: 2 isoforms:  Q9NR20-1   Q9NR20-2   (May be due to a competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DYRK4: NX_Q9NR20

Explore proteomics data for DYRK4 at MOPED

Post-translational modifications: 

  • Autophosphorylated on tyrosine residues (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for DYRK4 (Q9NR20)
     VALKIIRN  IGKGSFGQV  KVIDFGSSC 


    See DYRK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269214.1  NP_001269215.1  NP_003836.1  

    ENSEMBL proteins: 
     ENSP00000437534   ENSP00000441996   ENSP00000444842   ENSP00000439168   ENSP00000441755  
     ENSP00000439697   ENSP00000438769   ENSP00000010132   ENSP00000446005  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
    Dyrk1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NR20

    ProtoNet protein and cluster: Q9NR20

    UniProtKB/Swiss-Prot: DYRK4_HUMAN, Q9NR20
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    DYRK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYRK4_HUMAN, Q9NR20
    Function: Possible non-essential role in spermiogenesis (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.12.11 2 EC 2.7.122

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
         
    DYRK4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DYRK4:
     Decreased substrate adherent c  Increased mitotic index 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dyrk4):
     reproductive system 

    DYRK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dyrk4tm1Dgen for DYRK4

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    hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-let-7g* hsa-miR-520d-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYRK4_HUMAN, Q9NR20: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005794Golgi apparatus ----
    GO:0043231intracellular membrane-bounded organelle IDA--

    DYRK4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYRK4
    Interactions:

        Search GeneGlobe Interaction Network for DYRK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for DYRK4 (Q9NR201 ENSP000000101324) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYRK2Q926301EBI-3914009,EBI-749432
    KLHDC2ENSP000002983074STRING: ENSP00000298307
    HCFC1ENSP000003095554STRING: ENSP00000309555
    HCFC2ENSP000002293304STRING: ENSP00000229330
    PPP6CENSP000003921474STRING: ENSP00000392147
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    DYRK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYRK4

    3 HMDB Compounds for DYRK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DYRK4 gene (3 alternative transcripts): 
    NM_001282285.1  NM_001282286.1  NM_003845.2  

    Unigene Cluster for DYRK4:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
    Hs.439530  [show with all ESTs]
    Unigene Representative Sequence: GU139743
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000542744(uc009zeh.1) ENST00000539701 ENST00000537719 ENST00000539309
    ENST00000538520 ENST00000539490 ENST00000540757 ENST00000536157 ENST00000542905
    ENST00000536645 ENST00000543431(uc001qmz.2 uc001qna.2 uc010ser.2)
    ENST00000540644 ENST00000545571 ENST00000536137 ENST00000541024 ENST00000544671
    ENST00000544050 ENST00000010132(uc001qmx.3 uc001qmy.2 uc021qtq.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DYRK4 (see all 17):
    hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-let-7g* hsa-miR-520d-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat DYRK4
      QuantiFast Probe-based Assays in human, mouse, rat DYRK4

    Additional mRNA sequence: 

    AF263541.1 AK292322.1 AK298979.1 AK303744.1 AK308260.1 AK308702.1 AK311576.1 BC031244.1 
    GU139739.1 GU139740.1 GU139741.1 GU139742.1 GU139743.1 GU139744.1 GU139745.1 GU139746.1 
    Y09305.1 

    12 DOTS entries:

    DT.445124  DT.91746354  DT.100745792  DT.91746364  DT.121205606  DT.121205585  DT.121205675  DT.91734568 
    DT.92066883  DT.95121205  DT.99961770  DT.91667533 

    18 AceView cDNA sequences:

    BC031244 CR609016 BM452073 AI829636 AA968719 N55863 AA314672 N67478 
    BX091456 NM_003845 W78116 AL561586 BG057711 CR615549 AA481704 W79823 
    AL582755 W03407 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DYRK4 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
    SP1:                                            -     -     -           -     -                                               -           -     -               
    SP2:              -     -     -     -           -     -     -           -     -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -     -           -     -     -           -     -                                                                                 

    ExUns: 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c
    SP1:  -                                       
    SP2:                                          
    SP3:  -                                       
    SP4:  -                                       
    SP5:                                          


    ECgene alternative splicing isoforms for DYRK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYRK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCCCCAG
    DYRK4 Expression
    About this image

    DYRK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYRK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439530
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DYRK4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dyrk41 , 5 dual-specificity tyrosine-(Y)-phosphorylation regulated more1, 5 82.33(n)1
    77.86(a)1
      6 (61.92 cM)5
    1013201  NM_207210.21  NP_997093.21 
     1268760205 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    1 → many
    5(80909936-80948329)
    zebrafish
    (Danio rerio)
    Actinopterygii dyrk41 dual-specificity tyrosine-(Y)-phosphorylation regulated more 68.48(n)
    69.43(a)
      564976  XM_005174364.1  XP_005174421.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta smi35A1 , 3 olfaction protein serine/threonine
    kinase3
    smell impaired 35A1
    59(a)3
    60.56(n)1
    57.76(a)1
      348311  NM_001273527.11  NP_001260456.11 
    rice
    (Oryza sativa)
    Liliopsida Os.126532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 79.19(n)    AK100925.1 


    ENSEMBL Gene Tree for DYRK4 (if available)
    TreeFam Gene Tree for DYRK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYRK4 gene
    DYRK1A2  DYRK22  DYRK32  HIPK12  ENSG000002729212  HIPK32  HIPK42  HIPK22  
    DYRK1B2  
    Selected SIMAP similar genes for DYRK4 using alignment to 12 protein entries:     DYRK4_HUMAN (see all proteins) (see all similar genes):
    CDK11B    PRPF4B    MAPK3    DYRK2    CDK10    CDK7
    MAPK4    MAPK7    NLK    DYRK3    CDK16    CSNK2A3
    MAPK10    CSNK2A2    CDKL1    CDK12    MAPK9    DYRK1A

    DYRK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYRK4 (see all 634)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs582591351,2
    C--4567769(+) TGTGT-/GT/   
      GTGTGT
    ATCTT
    2 -- int1 cds10--------
    rs1412349181,2
    --4697333(+) TGATCC/GTCCCA 1 -- us2k10--------
    rs1507686391,2
    --4697356(+) AAAGCA/GCTGGG 1 -- us2k10--------
    rs1143519771,2
    F--4697445(+) CCACAA/TCGTTA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1394573541,2
    --4697447(+) ACAACA/GTTACA 1 -- us2k10--------
    rs1838371251,2
    --4697542(+) CACATG/TACGTC 1 -- us2k10--------
    rs1889517911,2
    --4697572(+) TTGCCA/GCCCTC 1 -- us2k10--------
    rs1929961841,2
    --4697718(+) GCCACA/CCTCAG 1 -- us2k10--------
    rs177740401,2
    C,F--4697726(+) CAGGGC/AGAAAA 1 -- us2k112Minor allele frequency- A:0.25NA WA CSA EA 511
    rs1426430611,2
    --4697733(+) AAAAGA/GCTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DYRK4 (4671370 - 4723325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DYRK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1346n71CNV Loss21882294
    nsv832318CNV Gain17160897
    nsv7226OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609181    OMIM disorders: --

    2 diseases for DYRK4:    
    About MalaCards
    rickets    down syndrome

    1 disease from the University of Copenhagen DISEASES database for DYRK4:
    Down syndrome

    DYRK4 for disorders           About GeneDecksing


    Export disorders for DYRK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYRK4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DYRK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PubMed id 9748265)1, 2, 3 Becker W....Joost H.-G. (J. Biol. Chem. 1998)
    2. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. (PubMed id 17292540)1, 2 Sacher F.... Fritsch M. (Mol. Cell. Endocrinol. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. (PubMed id 21127067)1 Papadopoulos C....de la Luna S. (J. Biol. Chem. 2011)
    8. Identification of the human testis protein phosphatase 1 interactome. (PubMed id 21382349)1 Fardilha M....da Cruz e Silva E.F. (Biochem. Pharmacol. 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8798 HGNC: 3095 AceView: DYRK4 Ensembl:ENSG00000010219 euGenes: HUgn8798
    ECgene: DYRK4 H-InvDB: DYRK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYRK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYRK4 gene:
    Search GeneIP for patents involving DYRK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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