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Aliases for DYRK4 Gene

Aliases for DYRK4 Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4 2 3 5
  • EC 4 61
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4 2
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4 2
  • EC 2.7.12 61

External Ids for DYRK4 Gene

Previous GeneCards Identifiers for DYRK4 Gene

  • GC12P004436
  • GC12P004591
  • GC12P004569
  • GC12P004699
  • GC12P004671
  • GC12P004571
  • GC12P004708
  • GC12P004859
  • GC12P005015

Summaries for DYRK4 Gene

Entrez Gene Summary for DYRK4 Gene

  • This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

GeneCards Summary for DYRK4 Gene

DYRK4 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK3.

UniProtKB/Swiss-Prot for DYRK4 Gene

  • Possible non-essential role in spermiogenesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK4 Gene

Genomics for DYRK4 Gene

Regulatory Elements for DYRK4 Gene

Enhancers for DYRK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G004647 1.1 ENCODE 10.8 +86.8 86849 2.4 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 DEK ZHX2 AKAP3 LOC103568124 LOC101929549 GALNT8 DYRK4 LOC100420673 NDUFA9
GH12G004604 1 ENCODE 8.8 +42.7 42723 1.3 HDGF CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 GLIS2 LOC100420673 DYRK4 ENSG00000272921 PIR36901
GH12G004663 0.6 ENCODE 13.7 +102.0 102043 1.6 GATA3 JUND GATA2 HMBOX1 FOS REST EGR2 DYRK4 GALNT8 LOC101929549 LOC100420673 ENSG00000255639
GH12G004661 0.4 FANTOM5 10.9 +98.9 98923 0.2 PRDM1 AKAP3 LOC103568124 DYRK4 GALNT8 LOC101929549 C12orf4 RAD51AP1 ENSG00000255639
GH12G004587 0.4 ENCODE 10.9 +25.1 25126 0.2 CTCF RAD51AP1 C12orf4 DYRK4 GALNT8 LOC101929549 NDUFA9 AKAP3 LOC103568124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DYRK4 on UCSC Golden Path with GeneCards custom track

Promoters for DYRK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048096 96 201 AGO1 ARID4B KLF17 ZNF48 GLIS2 ZNF263 SP5 MXD4 REST ZNF592

Genomic Location for DYRK4 Gene

4,562,204 bp from pter
4,615,302 bp from pter
53,099 bases
Plus strand

Genomic View for DYRK4 Gene

Genes around DYRK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK4 Gene

Proteins for DYRK4 Gene

  • Protein details for DYRK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 4
    Protein Accession:
    Secondary Accessions:
    • A8K8F7
    • Q8NEF2
    • Q92631

    Protein attributes for DYRK4 Gene

    520 amino acids
    Molecular mass:
    59608 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAF91393.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK308260; Type=Frameshift; Positions=470; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK4 Gene


neXtProt entry for DYRK4 Gene

Selected DME Specific Peptides for DYRK4 Gene


Post-translational modifications for DYRK4 Gene

  • Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for DYRK4

Domains & Families for DYRK4 Gene

Protein Domains for DYRK4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK4: view

Function for DYRK4 Gene

Molecular function for DYRK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Possible non-essential role in spermiogenesis.

Enzyme Numbers (IUBMB) for DYRK4 Gene

Gene Ontology (GO) - Molecular Function for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 23602568
genes like me logo Genes that share ontologies with DYRK4: view
genes like me logo Genes that share phenotypes with DYRK4: view

Animal Models for DYRK4 Gene

MGI Knock Outs for DYRK4:

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK4

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYRK4 Gene

Localization for DYRK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK4 Gene

Isoform 1: Cytoplasm.
Isoform 4: Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYRK4 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with DYRK4: view

Pathways & Interactions for DYRK4 Gene

SuperPathways for DYRK4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DYRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with DYRK4: view

No data available for Pathways by source and SIGNOR curated interactions for DYRK4 Gene

Drugs & Compounds for DYRK4 Gene

(2) Drugs for DYRK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for DYRK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DYRK4: view

Transcripts for DYRK4 Gene

mRNA/cDNA for DYRK4 Gene

Unigene Clusters for DYRK4 Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - -
SP9: - -
SP10: - - - - -
SP13: - - -

ExUns: 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c
SP1: -
SP3: -
SP4: -
SP12: -

Relevant External Links for DYRK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DYRK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYRK4 Gene

mRNA differential expression in normal tissues according to GTEx for DYRK4 Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for DYRK4 Gene

This gene is overexpressed in Liver (11.4), Adrenal (9.4), Lung (9.3), Kidney (6.3), and Platelet (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYRK4 Gene

Protein tissue co-expression partners for DYRK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DYRK4 Gene:


SOURCE GeneReport for Unigene cluster for DYRK4 Gene:


Evidence on tissue expression from TISSUES for DYRK4 Gene

  • Nervous system(4.4)
  • Kidney(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DYRK4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK4 Gene

Orthologs for DYRK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYRK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DYRK4 34 35
  • 98.85 (n)
(Canis familiaris)
Mammalia DYRK4 34 35
  • 87.08 (n)
(Bos Taurus)
Mammalia DYRK4 34 35
  • 84.36 (n)
(Rattus norvegicus)
Mammalia Dyrk4 34
  • 82.88 (n)
(Mus musculus)
Mammalia Dyrk4 34 16 35
  • 82.33 (n)
(Ornithorhynchus anatinus)
Mammalia DYRK4 35
  • 74 (a)
(Monodelphis domestica)
Mammalia DYRK4 35
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
(Danio rerio)
Actinopterygii dyrk4 34 35
  • 68.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007847 34
  • 67.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta smi35A 36 34 35
  • 60.56 (n)
(Caenorhabditis elegans)
Secernentea C36B7.1 36
  • 29 (a)
C36B7.2 36
  • 28 (a)
(Oryza sativa)
Liliopsida Os.12653 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.916 34
Species where no ortholog for DYRK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DYRK4 Gene

Gene Tree for DYRK4 (if available)
Gene Tree for DYRK4 (if available)

Paralogs for DYRK4 Gene

Variants for DYRK4 Gene

Sequence variations from dbSNP and Humsavar for DYRK4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000015514 -- 4,614,372(+) CACAG(A/G)AATTG downstream-variant-500B
rs1000129014 -- 4,610,735(+) CCCTA(C/G)GATTT intron-variant
rs1000535195 -- 4,609,305(+) AAAAG(C/T)GAATT intron-variant
rs1000550455 -- 4,603,340(+) TCATT(A/G)GTTAA intron-variant, upstream-variant-2KB
rs1000580186 -- 4,603,676(+) AGATC(A/G)ATTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DYRK4 Gene

Variant ID Type Subtype PubMed ID
nsv1040098 CNV gain 25217958
nsv483060 CNV loss 15286789
nsv557123 CNV gain 21841781
nsv7226 OTHER inversion 18451855
nsv832318 CNV gain 17160897

Variation tolerance for DYRK4 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYRK4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK4 Gene

Disorders for DYRK4 Gene

Relevant External Links for DYRK4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DYRK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK4 Gene

Publications for DYRK4 Gene

  1. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W. … Joost H.-G. (J. Biol. Chem. 1998) 2 3 4 64
  2. Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. (PMID: 21127067) Papadopoulos C. … de la Luna S. (J. Biol. Chem. 2011) 3 4 64
  3. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. (PMID: 17292540) Sacher F. … Fritsch M. (Mol. Cell. Endocrinol. 2007) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. (PMID: 25085501) Bunyavanich S. … Weiss S.T. (BMC Med Genomics 2014) 3 64

Products for DYRK4 Gene

Sources for DYRK4 Gene

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